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The map label for this gene is mutY [H]

Identifier: 146339051

GI number: 146339051

Start: 2129104

End: 2130198

Strand: Direct

Name: mutY [H]

Synonym: BRADO2005

Alternate gene names: 146339051

Gene position: 2129104-2130198 (Clockwise)

Preceding gene: 146339042

Following gene: 146339052

Centisome position: 28.55

GC content: 69.95

Gene sequence:

>1095_bases
GTGGCTCATCACAAGGCTTCTCGAAAACACCAGCACGACGCCGCCTCTGCCGAGCGCCCGGCGCAACTGCTCGCGTGGTA
CGACCGTCACCGGCGGCGGCTGCCGTGGCGCGCGCCCTCCGGGCAGCGCTCGGATCCGTATCGGGTCTGGCTGTCGGAGA
TCATGCTGCAGCAGACCACGGTGAAGGCGGTCGGGCCGTACTTCGAGAAATTCCTGGCGCGCTGGCCGGATGTCTCGGCG
CTCGGCAGCGCCGATCTCGAGGACGTGCTGCGGATGTGGGCCGGGCTCGGCTACTACTCGCGGGCGCGCAACCTGCACGC
CTGCGCCGTGACCGTGCTGCGCGAACATGGCGGCGTGTTCCCGGACACCGAGGAGGGGCTGCGAAAGCTGCCCGGCATCG
GCCCGTACACGGCCGCCGCGATCGCGGCAATCGCCTTCGATCGCCAGACCATGCCGGTCGACGGCAACATCGAGCGCGTC
ACGACGCGGCTGTTCAGGGTCGAGCAGGCGCTGCCGCAGGCCAAGCCGCAGATCCAGGCGCTCGCCGCCACCTTGCTCGG
GCCCTCGCGCGCCGGCGACAGCGCCCAGGCGCTGATGGACCTCGGCGCCACCATCTGCACGCCGAAGAAGCCGGCCTGCT
CGCTCTGTCCCCTCAACGAGGATTGCGCGGCGCGCCAGCACGGCGATCAAGAGACGTTCCCGCGCAAGGCGGCGAAGAAG
ACGGGCACGCTGAGGCGCGGCGCGGCGTTCGTGGTCGTCAGAGGCGACGAACTGCTGGTCCGCTCGCGTCCCGCCAAAGG
CCTGCTCGGCGGTATGACCGAGGTCCCCGGCTCGAACTGGCTGGCCGGCCATGATGATGTGGAGGCGTTGGCACAGGCGC
CGGACATCGCGGCCGTGAAACGCTGGCACCGCAAGCTCGGTGTCGTCACCCACGTCTTCACGCACTTCCCGCTCGAACTT
GTGGTCTACACCGCGACAGTGCCGGCCCGCACCCGCGCCCCTGACGGAATGCGCTGGGCGAAGATCGCGACGCTCGACGG
CGAGGCGCTGCCAAACGTGATGCGCAAGGTCGTGGCGCACGGATTGGGGGAGTGA

Upstream 100 bases:

>100_bases
CGTCATAGAAGGCGAGGACATTCTGTTTGACGCCGCTTGAGCTGGGGACTTCCAGGCCGGTGCGCTGGTCCGTCCTTTGT
TTTCGCTTTATTGAGGAGAC

Downstream 100 bases:

>100_bases
GCCTGCGCTTCGCATGTCATTTGTGGTCCGCAGTAGTCCGTAGGGTGGGCAAAGGCGCGCCCCGCTGCTCTTGAGTTCGG
CGAGCTGTCTCGCGCACCGT

Product: adenine glycosylase mutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAHHKASRKHQHDAASAERPAQLLAWYDRHRRRLPWRAPSGQRSDPYRVWLSEIMLQQTTVKAVGPYFEKFLARWPDVSA
LGSADLEDVLRMWAGLGYYSRARNLHACAVTVLREHGGVFPDTEEGLRKLPGIGPYTAAAIAAIAFDRQTMPVDGNIERV
TTRLFRVEQALPQAKPQIQALAATLLGPSRAGDSAQALMDLGATICTPKKPACSLCPLNEDCAARQHGDQETFPRKAAKK
TGTLRRGAAFVVVRGDELLVRSRPAKGLLGGMTEVPGSNWLAGHDDVEALAQAPDIAAVKRWHRKLGVVTHVFTHFPLEL
VVYTATVPARTRAPDGMRWAKIATLDGEALPNVMRKVVAHGLGE

Sequences:

>Translated_364_residues
MAHHKASRKHQHDAASAERPAQLLAWYDRHRRRLPWRAPSGQRSDPYRVWLSEIMLQQTTVKAVGPYFEKFLARWPDVSA
LGSADLEDVLRMWAGLGYYSRARNLHACAVTVLREHGGVFPDTEEGLRKLPGIGPYTAAAIAAIAFDRQTMPVDGNIERV
TTRLFRVEQALPQAKPQIQALAATLLGPSRAGDSAQALMDLGATICTPKKPACSLCPLNEDCAARQHGDQETFPRKAAKK
TGTLRRGAAFVVVRGDELLVRSRPAKGLLGGMTEVPGSNWLAGHDDVEALAQAPDIAAVKRWHRKLGVVTHVFTHFPLEL
VVYTATVPARTRAPDGMRWAKIATLDGEALPNVMRKVVAHGLGE
>Mature_363_residues
AHHKASRKHQHDAASAERPAQLLAWYDRHRRRLPWRAPSGQRSDPYRVWLSEIMLQQTTVKAVGPYFEKFLARWPDVSAL
GSADLEDVLRMWAGLGYYSRARNLHACAVTVLREHGGVFPDTEEGLRKLPGIGPYTAAAIAAIAFDRQTMPVDGNIERVT
TRLFRVEQALPQAKPQIQALAATLLGPSRAGDSAQALMDLGATICTPKKPACSLCPLNEDCAARQHGDQETFPRKAAKKT
GTLRRGAAFVVVRGDELLVRSRPAKGLLGGMTEVPGSNWLAGHDDVEALAQAPDIAAVKRWHRKLGVVTHVFTHFPLELV
VYTATVPARTRAPDGMRWAKIATLDGEALPNVMRKVVAHGLGE

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI115298654, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI115298652, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI6912520, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI115298648, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=36.8421052631579, Blast_Score=225, Evalue=6e-59,
Organism=Escherichia coli, GI1789331, Length=309, Percent_Identity=39.4822006472492, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39922; Mature: 39791

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure 
AHHKASRKHQHDAASAERPAQLLAWYDRHRRRLPWRAPSGQRSDPYRVWLSEIMLQQTT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VKAVGPYFEKFLARWPDVSALGSADLEDVLRMWAGLGYYSRARNLHACAVTVLREHGGVF
HHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCC
PDTEEGLRKLPGIGPYTAAAIAAIAFDRQTMPVDGNIERVTTRLFRVEQALPQAKPQIQA
CCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
LAATLLGPSRAGDSAQALMDLGATICTPKKPACSLCPLNEDCAARQHGDQETFPRKAAKK
HHHHHHCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHH
TGTLRRGAAFVVVRGDELLVRSRPAKGLLGGMTEVPGSNWLAGHDDVEALAQAPDIAAVK
HCCCCCCCEEEEEECCEEEEECCCCCHHHCCHHCCCCCCCCCCCHHHHHHHCCCCHHHHH
RWHRKLGVVTHVFTHFPLELVVYTATVPARTRAPDGMRWAKIATLDGEALPNVMRKVVAH
HHHHHHHHHHHHHHHCCEEHEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
GLGE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]