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The map label for this gene is fdh [H]

Identifier: 146338993

GI number: 146338993

Start: 2062911

End: 2064086

Strand: Reverse

Name: fdh [H]

Synonym: BRADO1941

Alternate gene names: 146338993

Gene position: 2064086-2062911 (Counterclockwise)

Preceding gene: 146338994

Following gene: 146338992

Centisome position: 27.68

GC content: 64.54

Gene sequence:

>1176_bases
ATGAAGGCGCTGGTCTGGCATGGCAAAGAGGACATCCGCTGCGACACAGTCAGCGATCCCGAGATCGAGCACAGCAGGGA
CGCGATCATCAAGGTGACGAGCTGCGCGATCTGCGGCTCGGACCTGCATCTGTTCCACAACTACATTCCCGCGATGATGC
CCGGCGACATCATGGGCCACGAGACGATGGGCGAGGTCGTCGAGGTCGGTTCCGGCGTCAACGGCAAGCTGAAGAAGGGC
GACCGCATCGTCGTGCCCTTCACCATCATCTGCGGCGAATGCGACCAGTGCAGGCGCGGCAATTTCTCGGTGTGCGAGAC
GACCAACCGCAACAAGCACATGGCCGAGAAGGTGTTCGGCCACAGCACCGCGGGCCTGTTCGGCTACACGCATCTGACCG
GTGGCTATCCGGGCGGCCAGGCCGAATATCTGCGCGTGCCGTACGCCGACGCCACCCACATCAAGGTGCCCGATGGCATG
AGCGACGAGCAGGCGCTGTTCCTCAGCGACATCTTCCCGACCGGATGGCAGGGCGCGGCGCAATGCGACATCGAGCCGGA
CGACACCGTCGCTGTGTGGGGCTGCGGCCCGGTCGGCCAGATGGCGATCCGCAGCGCCATCCTGCTCGGCGCCAAGCAGG
TGGTCGCGATCGACCGCATCCCGGAGCGGCTGGCGATGGCCGAGGCCGGCGGCGCGATCACCATCAATTTCGACAGGGAG
AGCGTGGTCGAAAGGCTCAACGAGCTGACCGACAACAAGGGCCCGGAGAAGTGCATCGACTGCGTCGGCTTCGAGAGCCA
TATCAGCATGGCGCAGCCCGACAGCGTGCTCGACCGCGCCAAGCAGATGTTCATGATCGAGAACGACCGGCCGCACGCGC
TGCGCGAGATCATCTATGTCTGCCGGCCCGGCGGCATCGTCTCGATCCCCGGCGTTTATTCGGGCTTTTCCGACATGGTG
CCGATGGGCGCGCTGATGAACAAGGGCCTGACGATCAGGACCGGCCAGACCCACGTCAACCGCTGGACCGACGACCTCAA
GCACCGCATCCAGGACGGCCAGATCGATCCGTCCTTCGTCATCACCCACACCGTGCCGCTCGCGCAGGGGCCGGAGATGT
ATCGCGCGTTCCGTGACAAGCAGGACAGCTGCGTCAAGGTCGTGTTGAAGCCGTAA

Upstream 100 bases:

>100_bases
AGCGTCGCAACTGCGAGCAGCGAGCTCAAAAACGAGCTTTTCGCTAGCAACCATCCGACACCTTCTGACTTTCTTCCCGG
ACATTCTCCCGGAGGATTGC

Downstream 100 bases:

>100_bases
GGAAAGCGCACATCATGTTTCATTTTTCGAATCTGGTCCGCTCCAAGGGCGATCCCAAGATCATCTCCACCGGCCCGAGC
TCGCTGACATCGGCCGACCG

Product: S-(hydroxymethyl)glutathione dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKALVWHGKEDIRCDTVSDPEIEHSRDAIIKVTSCAICGSDLHLFHNYIPAMMPGDIMGHETMGEVVEVGSGVNGKLKKG
DRIVVPFTIICGECDQCRRGNFSVCETTNRNKHMAEKVFGHSTAGLFGYTHLTGGYPGGQAEYLRVPYADATHIKVPDGM
SDEQALFLSDIFPTGWQGAAQCDIEPDDTVAVWGCGPVGQMAIRSAILLGAKQVVAIDRIPERLAMAEAGGAITINFDRE
SVVERLNELTDNKGPEKCIDCVGFESHISMAQPDSVLDRAKQMFMIENDRPHALREIIYVCRPGGIVSIPGVYSGFSDMV
PMGALMNKGLTIRTGQTHVNRWTDDLKHRIQDGQIDPSFVITHTVPLAQGPEMYRAFRDKQDSCVKVVLKP

Sequences:

>Translated_391_residues
MKALVWHGKEDIRCDTVSDPEIEHSRDAIIKVTSCAICGSDLHLFHNYIPAMMPGDIMGHETMGEVVEVGSGVNGKLKKG
DRIVVPFTIICGECDQCRRGNFSVCETTNRNKHMAEKVFGHSTAGLFGYTHLTGGYPGGQAEYLRVPYADATHIKVPDGM
SDEQALFLSDIFPTGWQGAAQCDIEPDDTVAVWGCGPVGQMAIRSAILLGAKQVVAIDRIPERLAMAEAGGAITINFDRE
SVVERLNELTDNKGPEKCIDCVGFESHISMAQPDSVLDRAKQMFMIENDRPHALREIIYVCRPGGIVSIPGVYSGFSDMV
PMGALMNKGLTIRTGQTHVNRWTDDLKHRIQDGQIDPSFVITHTVPLAQGPEMYRAFRDKQDSCVKVVLKP
>Mature_391_residues
MKALVWHGKEDIRCDTVSDPEIEHSRDAIIKVTSCAICGSDLHLFHNYIPAMMPGDIMGHETMGEVVEVGSGVNGKLKKG
DRIVVPFTIICGECDQCRRGNFSVCETTNRNKHMAEKVFGHSTAGLFGYTHLTGGYPGGQAEYLRVPYADATHIKVPDGM
SDEQALFLSDIFPTGWQGAAQCDIEPDDTVAVWGCGPVGQMAIRSAILLGAKQVVAIDRIPERLAMAEAGGAITINFDRE
SVVERLNELTDNKGPEKCIDCVGFESHISMAQPDSVLDRAKQMFMIENDRPHALREIIYVCRPGGIVSIPGVYSGFSDMV
PMGALMNKGLTIRTGQTHVNRWTDDLKHRIQDGQIDPSFVITHTVPLAQGPEMYRAFRDKQDSCVKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=253, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4501939, Length=246, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71743840, Length=262, Percent_Identity=26.3358778625954, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI262073058, Length=262, Percent_Identity=26.3358778625954, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71565154, Length=268, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4501929, Length=257, Percent_Identity=28.0155642023346, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786825, Length=395, Percent_Identity=44.5569620253165, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI87082125, Length=306, Percent_Identity=30.0653594771242, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788073, Length=369, Percent_Identity=25.7452574525745, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=405, Percent_Identity=29.6296296296296, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787863, Length=364, Percent_Identity=26.6483516483516, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI226510992, Length=376, Percent_Identity=26.063829787234, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=278, Percent_Identity=28.0575539568345, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=401, Percent_Identity=25.4364089775561, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081918, Length=226, Percent_Identity=31.858407079646, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790718, Length=373, Percent_Identity=21.4477211796247, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=238, Percent_Identity=29.8319327731092, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=214, Percent_Identity=28.9719626168224, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=304, Percent_Identity=28.2894736842105, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=296, Percent_Identity=27.7027027027027, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=254, Percent_Identity=24.4094488188976, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=254, Percent_Identity=24.4094488188976, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=246, Percent_Identity=27.2357723577236, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17137530, Length=274, Percent_Identity=28.8321167883212, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737897, Length=274, Percent_Identity=29.1970802919708, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737895, Length=274, Percent_Identity=27.7372262773723, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42903; Mature: 42903

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVWHGKEDIRCDTVSDPEIEHSRDAIIKVTSCAICGSDLHLFHNYIPAMMPGDIMGH
CCCEEECCCCCCEECCCCCCCCCCCCCEEEEEEEHEEECCHHHHHHHHCCCCCCCCCCCH
ETMGEVVEVGSGVNGKLKKGDRIVVPFTIICGECDQCRRGNFSVCETTNRNKHMAEKVFG
HHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHCCCCCEEEECCCCCHHHHHHHHC
HSTAGLFGYTHLTGGYPGGQAEYLRVPYADATHIKVPDGMSDEQALFLSDIFPTGWQGAA
CCCCCCEEEHCCCCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEHHCCCCCCCCCE
QCDIEPDDTVAVWGCGPVGQMAIRSAILLGAKQVVAIDRIPERLAMAEAGGAITINFDRE
ECCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHCCCEEEEEECHH
SVVERLNELTDNKGPEKCIDCVGFESHISMAQPDSVLDRAKQMFMIENDRPHALREIIYV
HHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCHHHHHHHHHEEEEECCCCHHHHHHHHH
CRPGGIVSIPGVYSGFSDMVPMGALMNKGLTIRTGQTHVNRWTDDLKHRIQDGQIDPSFV
CCCCCEEECCCHHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEE
ITHTVPLAQGPEMYRAFRDKQDSCVKVVLKP
EEEECCCCCCHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKALVWHGKEDIRCDTVSDPEIEHSRDAIIKVTSCAICGSDLHLFHNYIPAMMPGDIMGH
CCCEEECCCCCCEECCCCCCCCCCCCCEEEEEEEHEEECCHHHHHHHHCCCCCCCCCCCH
ETMGEVVEVGSGVNGKLKKGDRIVVPFTIICGECDQCRRGNFSVCETTNRNKHMAEKVFG
HHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHCCCCCEEEECCCCCHHHHHHHHC
HSTAGLFGYTHLTGGYPGGQAEYLRVPYADATHIKVPDGMSDEQALFLSDIFPTGWQGAA
CCCCCCEEEHCCCCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEHHCCCCCCCCCE
QCDIEPDDTVAVWGCGPVGQMAIRSAILLGAKQVVAIDRIPERLAMAEAGGAITINFDRE
ECCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHCCCEEEEEECHH
SVVERLNELTDNKGPEKCIDCVGFESHISMAQPDSVLDRAKQMFMIENDRPHALREIIYV
HHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCHHHHHHHHHEEEEECCCCHHHHHHHHH
CRPGGIVSIPGVYSGFSDMVPMGALMNKGLTIRTGQTHVNRWTDDLKHRIQDGQIDPSFV
CCCCCEEECCCHHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEE
ITHTVPLAQGPEMYRAFRDKQDSCVKVVLKP
EEEECCCCCCHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]