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The map label for this gene is hemE [H]

Identifier: 146338935

GI number: 146338935

Start: 2001248

End: 2002279

Strand: Reverse

Name: hemE [H]

Synonym: BRADO1875

Alternate gene names: 146338935

Gene position: 2002279-2001248 (Counterclockwise)

Preceding gene: 146338938

Following gene: 146338931

Centisome position: 26.85

GC content: 67.25

Gene sequence:

>1032_bases
GTGAACAAGCCTTTCATCGACGTGCTGGCAGGTCAGCGCCAGAGCGTGCCTCCGATATGGATGATGCGGCAGGCCGGCCG
CTATCTGCCGGAATATCGCGAGGTGCGCGCCAAGGCCGGGGGCTTCCTCGACCTTTGCTTCAATCCGGAGCTCGCGGCCG
AAGTCACCTTGCAGCCGATCCGGCGGTTCGGCTTCGACGCGGCGATCATCTTCTCCGACATTCTGGTCATCCCGCACGCC
CTCGGCCGCAGCGTCCGATTCGAAGTCGGCGAAGGCCCGCGACTGGATCCGCTGGATACGCCCGAGAAGATCTCCACGCT
GTCCGGCGAGGCGGATCTGTCCAAGCTCGAGGCCGTGTTCGAGGCGCTACGCCGCGTCCGCAGCGAGCTGCCGCAGAGCA
CCGCGCTGATCGGCTTTTGCGGTGCGCCATGGACGGTCGCGACCTACATGGTCGCTGGCCAGGGCACGCCGGACCAGGCT
CCGGCGAGACTGCTCGCCTACCGCGCCCCCGAGGCGTTCCAGAGGATCATCGACGCACTCGTCGACAGCTCCATCGCCTA
TCTGTTGAAGCAGCTCGATGCCGGTGCCGACGCACTGCAGATCTTCGATACCTGGGCCGGCGTGCTGTCGCCGCGCGAAT
TCGCGCGCTGGTCGGTGGCACCGACGCGGCGCATCGTCGAGGGCGTGCGCAAGATCAGGCCCGATGCCAAGATCATCGGC
TTTCCGCGCGGCGCCGGCGCGCTGCTGCCGGGCTATGTGACGGAGACTGGCGTCGATGCCGTCAGCATCGACTGGACGGC
GGAGCCCGGGCTGGTGCGCGAGCGGGTACAGAGCAAGGTCGCCGTGCAGGGCAATCTCGATCCGCTGGCGCTGATCACCG
GCGGTGCTGCGCTCGACCAGGCGGTCGACGACGTGCTGGCGAGCTATGCGGGCGGCCGGCACATCTTCAATCTCGGCCAC
GGCATCACGCCAGAAACCCCGATCGCCCATGTCGAGCAGATGCTGGCGCGTGTACGGGCCTACAAAGGATGA

Upstream 100 bases:

>100_bases
CTCAGTCGGATGGGAGCTTGGCCGGAACCGTCCGGCCATGTATCACGGACGGTAAACTGTTCCCACAGGGTTGCGGAGCC
CCAGCGTGAGTGAGACTGCC

Downstream 100 bases:

>100_bases
TGACCTAACGCGGCCGGCTGCGCTCGATCAGCGCGGCCGCGCCGCTGGCGAGCAATTCGAGCCCGACCGCCCGGCCGAGC
TCGCGCGGACGATCGGCGGG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MNKPFIDVLAGQRQSVPPIWMMRQAGRYLPEYREVRAKAGGFLDLCFNPELAAEVTLQPIRRFGFDAAIIFSDILVIPHA
LGRSVRFEVGEGPRLDPLDTPEKISTLSGEADLSKLEAVFEALRRVRSELPQSTALIGFCGAPWTVATYMVAGQGTPDQA
PARLLAYRAPEAFQRIIDALVDSSIAYLLKQLDAGADALQIFDTWAGVLSPREFARWSVAPTRRIVEGVRKIRPDAKIIG
FPRGAGALLPGYVTETGVDAVSIDWTAEPGLVRERVQSKVAVQGNLDPLALITGGAALDQAVDDVLASYAGGRHIFNLGH
GITPETPIAHVEQMLARVRAYKG

Sequences:

>Translated_343_residues
MNKPFIDVLAGQRQSVPPIWMMRQAGRYLPEYREVRAKAGGFLDLCFNPELAAEVTLQPIRRFGFDAAIIFSDILVIPHA
LGRSVRFEVGEGPRLDPLDTPEKISTLSGEADLSKLEAVFEALRRVRSELPQSTALIGFCGAPWTVATYMVAGQGTPDQA
PARLLAYRAPEAFQRIIDALVDSSIAYLLKQLDAGADALQIFDTWAGVLSPREFARWSVAPTRRIVEGVRKIRPDAKIIG
FPRGAGALLPGYVTETGVDAVSIDWTAEPGLVRERVQSKVAVQGNLDPLALITGGAALDQAVDDVLASYAGGRHIFNLGH
GITPETPIAHVEQMLARVRAYKG
>Mature_343_residues
MNKPFIDVLAGQRQSVPPIWMMRQAGRYLPEYREVRAKAGGFLDLCFNPELAAEVTLQPIRRFGFDAAIIFSDILVIPHA
LGRSVRFEVGEGPRLDPLDTPEKISTLSGEADLSKLEAVFEALRRVRSELPQSTALIGFCGAPWTVATYMVAGQGTPDQA
PARLLAYRAPEAFQRIIDALVDSSIAYLLKQLDAGADALQIFDTWAGVLSPREFARWSVAPTRRIVEGVRKIRPDAKIIG
FPRGAGALLPGYVTETGVDAVSIDWTAEPGLVRERVQSKVAVQGNLDPLALITGGAALDQAVDDVLASYAGGRHIFNLGH
GITPETPIAHVEQMLARVRAYKG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=338, Percent_Identity=40.8284023668639, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI2367337, Length=333, Percent_Identity=43.2432432432432, Blast_Score=269, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6320252, Length=327, Percent_Identity=37.6146788990826, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI19921920, Length=328, Percent_Identity=40.5487804878049, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI221330099, Length=328, Percent_Identity=40.5487804878049, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37264; Mature: 37264

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPFIDVLAGQRQSVPPIWMMRQAGRYLPEYREVRAKAGGFLDLCFNPELAAEVTLQPI
CCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
RRFGFDAAIIFSDILVIPHALGRSVRFEVGEGPRLDPLDTPEKISTLSGEADLSKLEAVF
HHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
EALRRVRSELPQSTALIGFCGAPWTVATYMVAGQGTPDQAPARLLAYRAPEAFQRIIDAL
HHHHHHHHHCCCHHEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
VDSSIAYLLKQLDAGADALQIFDTWAGVLSPREFARWSVAPTRRIVEGVRKIRPDAKIIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
FPRGAGALLPGYVTETGVDAVSIDWTAEPGLVRERVQSKVAVQGNLDPLALITGGAALDQ
CCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHEEECCCCCCEEEEECCHHHHH
AVDDVLASYAGGRHIFNLGHGITPETPIAHVEQMLARVRAYKG
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKPFIDVLAGQRQSVPPIWMMRQAGRYLPEYREVRAKAGGFLDLCFNPELAAEVTLQPI
CCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
RRFGFDAAIIFSDILVIPHALGRSVRFEVGEGPRLDPLDTPEKISTLSGEADLSKLEAVF
HHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
EALRRVRSELPQSTALIGFCGAPWTVATYMVAGQGTPDQAPARLLAYRAPEAFQRIIDAL
HHHHHHHHHCCCHHEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
VDSSIAYLLKQLDAGADALQIFDTWAGVLSPREFARWSVAPTRRIVEGVRKIRPDAKIIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
FPRGAGALLPGYVTETGVDAVSIDWTAEPGLVRERVQSKVAVQGNLDPLALITGGAALDQ
CCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHEEECCCCCCEEEEECCHHHHH
AVDDVLASYAGGRHIFNLGHGITPETPIAHVEQMLARVRAYKG
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA