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The map label for this gene is upp [H]

Identifier: 146338847

GI number: 146338847

Start: 1905355

End: 1905984

Strand: Reverse

Name: upp [H]

Synonym: BRADO1786

Alternate gene names: 146338847

Gene position: 1905984-1905355 (Counterclockwise)

Preceding gene: 146338848

Following gene: 146338843

Centisome position: 25.56

GC content: 67.46

Gene sequence:

>630_bases
ATGGAAGGCGTCACGGTCGTCGATCATCCGCTGGTGCAGCATAAGCTGACCCTGATCCGCGACAAGTCGATCTCGACCAA
GTCGTTCCGCGAGCTCTTGAAGGAGATCGGCATGCTCCTCTGCTACGAGGTCACGCGCGATCTGCCGCTCGCGGAGGTCG
AAGTCGAGACGCCGCTGGCGCGGATGCAGTCGGCCAAGATTGCCGGCAAGAAGCTGGTGTTCGTGCCGGTCCTGCGCGCC
GGCGTCACCTTCGTCGACGGCATGCTCGATCTGGTGCCGACCGCCCGCGTCGCCCATATCGGCCTCTACCGTGAGCCGCA
CACCTTCACCGCCGTGGAGTACTTCTTCAAGGCCCCGTCCGATCTGCAGGAGCGCCTCGCCGTCGTGGTCACCCCGGTGC
TGGCGACCGGCAACAGCGCCGTCGCCGCCTTCGACCGGCTCAAGGAGCGTGGCGCCAAGGACATCCGCATGGTCTGCATG
ATCGCCGCTCCCGAAGGCGTCGAGCGCGTCCGCGGCCTGCATCCCGACGTCACGCTGTGGACCGCCGCCATCGACGACGG
CCTCGACGACGACGCCTTCATCGTCCCCGGCCTCGGCGACGCCGGCGACCGCGCGTATGGGACTCGCTAA

Upstream 100 bases:

>100_bases
AGGGTGGGCAAAGCGCAGCGTGCCCACCATTCCAGTCTGAGCTAAGATCGCGGTGGGCACGGCGCGTCGCGCCTTTGCCC
ACCCTACGGAGATGAAAGCC

Downstream 100 bases:

>100_bases
GGCTGTCGGTCAATGTTGCGGCCCATCCTTCGAGACGCATCGCTGACGCGATGCTCCTCAGGATGAGGTCGAGTTCGCGG
GTCGAATTAAGCTCCTGCCA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MEGVTVVDHPLVQHKLTLIRDKSISTKSFRELLKEIGMLLCYEVTRDLPLAEVEVETPLARMQSAKIAGKKLVFVPVLRA
GVTFVDGMLDLVPTARVAHIGLYREPHTFTAVEYFFKAPSDLQERLAVVVTPVLATGNSAVAAFDRLKERGAKDIRMVCM
IAAPEGVERVRGLHPDVTLWTAAIDDGLDDDAFIVPGLGDAGDRAYGTR

Sequences:

>Translated_209_residues
MEGVTVVDHPLVQHKLTLIRDKSISTKSFRELLKEIGMLLCYEVTRDLPLAEVEVETPLARMQSAKIAGKKLVFVPVLRA
GVTFVDGMLDLVPTARVAHIGLYREPHTFTAVEYFFKAPSDLQERLAVVVTPVLATGNSAVAAFDRLKERGAKDIRMVCM
IAAPEGVERVRGLHPDVTLWTAAIDDGLDDDAFIVPGLGDAGDRAYGTR
>Mature_209_residues
MEGVTVVDHPLVQHKLTLIRDKSISTKSFRELLKEIGMLLCYEVTRDLPLAEVEVETPLARMQSAKIAGKKLVFVPVLRA
GVTFVDGMLDLVPTARVAHIGLYREPHTFTAVEYFFKAPSDLQERLAVVVTPVLATGNSAVAAFDRLKERGAKDIRMVCM
IAAPEGVERVRGLHPDVTLWTAAIDDGLDDDAFIVPGLGDAGDRAYGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.2178217821782, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.2178217821782, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=48.2758620689655, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=33.8541666666667, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45550449, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573516, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573514, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573512, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22882; Mature: 22882

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGVTVVDHPLVQHKLTLIRDKSISTKSFRELLKEIGMLLCYEVTRDLPLAEVEVETPLA
CCCCEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
RMQSAKIAGKKLVFVPVLRAGVTFVDGMLDLVPTARVAHIGLYREPHTFTAVEYFFKAPS
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCH
DLQERLAVVVTPVLATGNSAVAAFDRLKERGAKDIRMVCMIAAPEGVERVRGLHPDVTLW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCCCCCCEEE
TAAIDDGLDDDAFIVPGLGDAGDRAYGTR
EEECCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MEGVTVVDHPLVQHKLTLIRDKSISTKSFRELLKEIGMLLCYEVTRDLPLAEVEVETPLA
CCCCEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
RMQSAKIAGKKLVFVPVLRAGVTFVDGMLDLVPTARVAHIGLYREPHTFTAVEYFFKAPS
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCH
DLQERLAVVVTPVLATGNSAVAAFDRLKERGAKDIRMVCMIAAPEGVERVRGLHPDVTLW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCCCCCCEEE
TAAIDDGLDDDAFIVPGLGDAGDRAYGTR
EEECCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]