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The map label for this gene is pcoA [H]

Identifier: 146338593

GI number: 146338593

Start: 1624664

End: 1625965

Strand: Reverse

Name: pcoA [H]

Synonym: BRADO1520

Alternate gene names: 146338593

Gene position: 1625965-1624664 (Counterclockwise)

Preceding gene: 146338594

Following gene: 146338592

Centisome position: 21.81

GC content: 66.82

Gene sequence:

>1302_bases
ATGTTGTCACGCCGAACCCTGCTCGGCTCCGCGGCGCTGGCCGGCGCCTCCGCCGTATCCGGCCGCGTCCAGGCCGCCGC
GATTCCCGAAGCGCCCACCATGGACAAGGCCGTGATGCAGCCGCCGCTGCATCCATCCGCCGGTGCGGACTATCAGCCGG
TGGTGACGCTCAACGGCTGGTCGCTGCCGTTTCGCATGAACGGCGACTGGAAGGAATTCCATCTCGTCGCCGAGCCGGTC
ACGCGCGAGTTCGCGCCGGGCATGACGGCGCATCTGTGGGGCTACAACGGCCAGTCGCCGGGCCCGACCCTCGAGGCGGT
CGAGGGCGACAAGGTCCGGATCTTCGTGACCAACAAGCTCCCGGAATACACCACCGTGCACTGGCACGGCGTGATCCTGC
CCTGCGGCATGGACGGTGTCGGCGGACTGACGCAGCCGCACATCAAGCCCGGCAAGACCTTCGTCTACGAGTTCGAGATG
AAGCACGCCGGCACCTTCATGTATCACCCGCACGCCGACGAGATGGTGCAGATGGCGATGGGCATGATGGGCATGATCGT
CGTGCATCCGCGCGGTTCCGTGCCGCCGCCGGTCGACCGCGACTACGTGTTCGTGATGTCGAGCTACCGGGTCGAGCCCG
GCAGCTATCTGCCGAAGGTCAACGAGATGATCGACTTCAACATGTGGACCTGGAACGCCCGCGTCTTCCCCGGCATCGAT
CCGATGCCGGCGCGGCTCGGCGACCGCGTGCGCATCCGCATCGGCAATCTCACCATGACCAACCATCCGATCCATCTGCA
CGGCCACAAGTTCAAGGTGACCGGCACCGATGGCGGCTGGCTGCCCGAGGCTGCGCAATTTCCCGAGACGACCACCGACG
TGCCGGTCGGCGCGGTCCGCGTGCTCGACTTCACCGCCGACAATCCCGGCGACTGGGCATTCCACTGCCACAAATCGCAT
CACACGATGAACGCGATGGGCCACGACATGCGCAACCTGATCGGCGTGTCGCGCAAGGAGCTCGCCGCCGCCGTCGGCAA
GCTCGCGCCCGAGGGCATGGTGATGGGACACACCGGCATGGCGATGGGTAGCATGGAGATGCCCGCGCCCGACAATACCT
TGCCGATGATGACCGGCACCGGCCAGTTCGGCCCGATCGAGATGGGCGGCATGTTCACGACGTTGAAGGTGCGCGATGGA
CTCGCGCGCGACGACTATCGCGATCCCGGCCCGTATCAGTTCCCGCAAGGCTCCGTCGCCTACGAGGTCGCCGGCGCACC
GCAGCCGGTGCGGCGCGGCTGA

Upstream 100 bases:

>100_bases
CAATGGCGGCGTCGCGGCCGGTGAGGACCCGGCGCCGCAGACCGCGCGCGCGCTCGCGCCGAACAACGACTGACACGCAA
CGATTGACAGGAGAGCATGC

Downstream 100 bases:

>100_bases
ACGCCGAGCGGCAACACTCCCGCATTCCACCTCAGGAGGACGACACGATGACCAGGACAATCCCCTTGACGACTGCCGCG
CTGCTCCTTGGCTTCATCGC

Product: putative multicopper oxidase copper resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLSRRTLLGSAALAGASAVSGRVQAAAIPEAPTMDKAVMQPPLHPSAGADYQPVVTLNGWSLPFRMNGDWKEFHLVAEPV
TREFAPGMTAHLWGYNGQSPGPTLEAVEGDKVRIFVTNKLPEYTTVHWHGVILPCGMDGVGGLTQPHIKPGKTFVYEFEM
KHAGTFMYHPHADEMVQMAMGMMGMIVVHPRGSVPPPVDRDYVFVMSSYRVEPGSYLPKVNEMIDFNMWTWNARVFPGID
PMPARLGDRVRIRIGNLTMTNHPIHLHGHKFKVTGTDGGWLPEAAQFPETTTDVPVGAVRVLDFTADNPGDWAFHCHKSH
HTMNAMGHDMRNLIGVSRKELAAAVGKLAPEGMVMGHTGMAMGSMEMPAPDNTLPMMTGTGQFGPIEMGGMFTTLKVRDG
LARDDYRDPGPYQFPQGSVAYEVAGAPQPVRRG

Sequences:

>Translated_433_residues
MLSRRTLLGSAALAGASAVSGRVQAAAIPEAPTMDKAVMQPPLHPSAGADYQPVVTLNGWSLPFRMNGDWKEFHLVAEPV
TREFAPGMTAHLWGYNGQSPGPTLEAVEGDKVRIFVTNKLPEYTTVHWHGVILPCGMDGVGGLTQPHIKPGKTFVYEFEM
KHAGTFMYHPHADEMVQMAMGMMGMIVVHPRGSVPPPVDRDYVFVMSSYRVEPGSYLPKVNEMIDFNMWTWNARVFPGID
PMPARLGDRVRIRIGNLTMTNHPIHLHGHKFKVTGTDGGWLPEAAQFPETTTDVPVGAVRVLDFTADNPGDWAFHCHKSH
HTMNAMGHDMRNLIGVSRKELAAAVGKLAPEGMVMGHTGMAMGSMEMPAPDNTLPMMTGTGQFGPIEMGGMFTTLKVRDG
LARDDYRDPGPYQFPQGSVAYEVAGAPQPVRRG
>Mature_433_residues
MLSRRTLLGSAALAGASAVSGRVQAAAIPEAPTMDKAVMQPPLHPSAGADYQPVVTLNGWSLPFRMNGDWKEFHLVAEPV
TREFAPGMTAHLWGYNGQSPGPTLEAVEGDKVRIFVTNKLPEYTTVHWHGVILPCGMDGVGGLTQPHIKPGKTFVYEFEM
KHAGTFMYHPHADEMVQMAMGMMGMIVVHPRGSVPPPVDRDYVFVMSSYRVEPGSYLPKVNEMIDFNMWTWNARVFPGID
PMPARLGDRVRIRIGNLTMTNHPIHLHGHKFKVTGTDGGWLPEAAQFPETTTDVPVGAVRVLDFTADNPGDWAFHCHKSH
HTMNAMGHDMRNLIGVSRKELAAAVGKLAPEGMVMGHTGMAMGSMEMPAPDNTLPMMTGTGQFGPIEMGGMFTTLKVRDG
LARDDYRDPGPYQFPQGSVAYEVAGAPQPVRRG

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=229, Percent_Identity=27.9475982532751, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323703, Length=155, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=207, Percent_Identity=27.536231884058, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI18859919, Length=215, Percent_Identity=31.1627906976744, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 47306; Mature: 47306

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
7.4 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
7.4 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRRTLLGSAALAGASAVSGRVQAAAIPEAPTMDKAVMQPPLHPSAGADYQPVVTLNGW
CCCCCCCHHHHHHCCCHHHCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCCEEEEECCC
SLPFRMNGDWKEFHLVAEPVTREFAPGMTAHLWGYNGQSPGPTLEAVEGDKVRIFVTNKL
EEEEEECCCCEEEEEEECHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEEEEECCC
PEYTTVHWHGVILPCGMDGVGGLTQPHIKPGKTFVYEFEMKHAGTFMYHPHADEMVQMAM
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHH
GMMGMIVVHPRGSVPPPVDRDYVFVMSSYRVEPGSYLPKVNEMIDFNMWTWNARVFPGID
CCEEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHEEEEEEEECCEECCCCC
PMPARLGDRVRIRIGNLTMTNHPIHLHGHKFKVTGTDGGWLPEAAQFPETTTDVPVGAVR
CCHHHCCCEEEEEECCEEEECCCEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCCCEEE
VLDFTADNPGDWAFHCHKSHHTMNAMGHDMRNLIGVSRKELAAAVGKLAPEGMVMGHTGM
EEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCC
AMGSMEMPAPDNTLPMMTGTGQFGPIEMGGMFTTLKVRDGLARDDYRDPGPYQFPQGSVA
EECCCCCCCCCCCCCEEECCCCCCCEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
YEVAGAPQPVRRG
EEECCCCCCCCCC
>Mature Secondary Structure
MLSRRTLLGSAALAGASAVSGRVQAAAIPEAPTMDKAVMQPPLHPSAGADYQPVVTLNGW
CCCCCCCHHHHHHCCCHHHCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCCEEEEECCC
SLPFRMNGDWKEFHLVAEPVTREFAPGMTAHLWGYNGQSPGPTLEAVEGDKVRIFVTNKL
EEEEEECCCCEEEEEEECHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEEEEECCC
PEYTTVHWHGVILPCGMDGVGGLTQPHIKPGKTFVYEFEMKHAGTFMYHPHADEMVQMAM
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHH
GMMGMIVVHPRGSVPPPVDRDYVFVMSSYRVEPGSYLPKVNEMIDFNMWTWNARVFPGID
CCEEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHEEEEEEEECCEECCCCC
PMPARLGDRVRIRIGNLTMTNHPIHLHGHKFKVTGTDGGWLPEAAQFPETTTDVPVGAVR
CCHHHCCCEEEEEECCEEEECCCEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCCCEEE
VLDFTADNPGDWAFHCHKSHHTMNAMGHDMRNLIGVSRKELAAAVGKLAPEGMVMGHTGM
EEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCC
AMGSMEMPAPDNTLPMMTGTGQFGPIEMGGMFTTLKVRDGLARDDYRDPGPYQFPQGSVA
EECCCCCCCCCCCCCEEECCCCCCCEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
YEVAGAPQPVRRG
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]