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The map label for this gene is rkpK [H]

Identifier: 146337869

GI number: 146337869

Start: 797842

End: 799161

Strand: Direct

Name: rkpK [H]

Synonym: BRADO0754

Alternate gene names: 146337869

Gene position: 797842-799161 (Clockwise)

Preceding gene: 146337864

Following gene: 146337870

Centisome position: 10.7

GC content: 66.74

Gene sequence:

>1320_bases
ATGCGAATTGCGATGATCGGCACGGGGTATGTGGGGCTGGTGTCCGGGGCCTGCTTCGCCGATTTCGGCCACGAGGTCAC
TTGCGTCGACAAGGACGAGAGCAAGATCGCCGCGCTTCATCGTGGGGAAATTCCGATCTTCGAGCCGGGGCTGGATGCGC
TGGTCGCGGCCAACGTCAAGGCCAAGCGCCTCGACTTCACGACCGACCTGAAGCAGCCCGTCGCCGATGCCGACGCCGTC
TTCATCGCCGTCGGCACCCCGTCGCGGCGCGGCGACGGCCATGCCGACCTCACCTACGTCTATGCAGCGGCGCGCGAGAT
CGCGGCGTCGCTGACCGGCTTTACAGTCGTCGTGACCAAATCGACCGTGCCGGTCGGCACCGGCGACGAGGTCGAGCGCA
TCATCCGCGAGACCAATCCGGCGGCCGATGTCGTCGTCGCCTCGAATCCTGAGTTCCTGCGCGAGGGTGCGGCGATCCGC
GACTTCAAATGGCCCGACCGCATCGTGGTCGGCACCGATGACGAGCGCGGCCGCAAGGCGCTCGGCGACATCTATCGCCC
GCTGTCGCTGAACCAGGCGCCGATCATGTACACGGCGCGGCGCACCGCGGAGCTGATCAAATACGCCGCCAACGCGTTCC
TCGCCACCAAGATCACCTTCATCAACGAGGTCGCCGATCTCGCCGAGAAGGTCGGCGCCGACGTGCAGGAAGTGGCGCGC
GGCATCGGTCTCGACAACCGCATCGGCTCCAAGTTCCTCCACGCCGGTCCGGGCTTCGGCGGCTCGTGCTTCCCGAAGGA
TACCCGCGCGCTGATCAAGATCGCGCAGGACTACGACACGCAGCTGCGCATCGTCGAATCCGTGCTGGCGGTGAACGACA
ACCGCAAGCGCGCGATGGCGCGCAAGGTAGCGCATGCGGTCGGCGGCAATCTGCGCGGCAAGACGGTCGCGGTGCTCGGC
CTCACCTTCAAGCCGGAGACCGACGACATGCGCGAGGCGCCGTCGATTCCGCTGGTGACGGGTCTGCTCGACATGGGCGC
AAAGGTGCGCGCGCATGATCCGGTCGGCATCGAGCAGGCCAAGAAGGAGCTGCCCGAGATCGCCTATTTCGAGGATCCCT
ATGCCTGCGCCACCGGCGCCGACGCGATCGTGCTGGTCACCGAATGGGTGCAGTACCGCGCCATGGATCTCGACCGCCTG
AAGCAGGTCATGGCCCGGCCGGTCGTCGTCGACCTGCGCAACGTCTACCGTCCTGACGAGATGGCAGCGCACGGCTTCGT
CTATGAGAGCGTCGGCAGGCCCTCGGCGAAGGGCGCGTGA

Upstream 100 bases:

>100_bases
ACTCCTTGCTGTCATCCAAACGTCATGCCGTTTTCTAAATTCCCCCTGGGCCGCAAATGGTCTAAGACGCCAAAGTATTA
ACCTTGAAGGATGGGTTTCG

Downstream 100 bases:

>100_bases
CGCTGACTGATTGTCATACCCCGCGAAGGCGGGGTATCCAGTACGCCCGGTCGTCGTGATCAATGACGGCTGTGTGTACT
GGATCGTCCGCCTTCGCGGA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MRIAMIGTGYVGLVSGACFADFGHEVTCVDKDESKIAALHRGEIPIFEPGLDALVAANVKAKRLDFTTDLKQPVADADAV
FIAVGTPSRRGDGHADLTYVYAAAREIAASLTGFTVVVTKSTVPVGTGDEVERIIRETNPAADVVVASNPEFLREGAAIR
DFKWPDRIVVGTDDERGRKALGDIYRPLSLNQAPIMYTARRTAELIKYAANAFLATKITFINEVADLAEKVGADVQEVAR
GIGLDNRIGSKFLHAGPGFGGSCFPKDTRALIKIAQDYDTQLRIVESVLAVNDNRKRAMARKVAHAVGGNLRGKTVAVLG
LTFKPETDDMREAPSIPLVTGLLDMGAKVRAHDPVGIEQAKKELPEIAYFEDPYACATGADAIVLVTEWVQYRAMDLDRL
KQVMARPVVVDLRNVYRPDEMAAHGFVYESVGRPSAKGA

Sequences:

>Translated_439_residues
MRIAMIGTGYVGLVSGACFADFGHEVTCVDKDESKIAALHRGEIPIFEPGLDALVAANVKAKRLDFTTDLKQPVADADAV
FIAVGTPSRRGDGHADLTYVYAAAREIAASLTGFTVVVTKSTVPVGTGDEVERIIRETNPAADVVVASNPEFLREGAAIR
DFKWPDRIVVGTDDERGRKALGDIYRPLSLNQAPIMYTARRTAELIKYAANAFLATKITFINEVADLAEKVGADVQEVAR
GIGLDNRIGSKFLHAGPGFGGSCFPKDTRALIKIAQDYDTQLRIVESVLAVNDNRKRAMARKVAHAVGGNLRGKTVAVLG
LTFKPETDDMREAPSIPLVTGLLDMGAKVRAHDPVGIEQAKKELPEIAYFEDPYACATGADAIVLVTEWVQYRAMDLDRL
KQVMARPVVVDLRNVYRPDEMAAHGFVYESVGRPSAKGA
>Mature_439_residues
MRIAMIGTGYVGLVSGACFADFGHEVTCVDKDESKIAALHRGEIPIFEPGLDALVAANVKAKRLDFTTDLKQPVADADAV
FIAVGTPSRRGDGHADLTYVYAAAREIAASLTGFTVVVTKSTVPVGTGDEVERIIRETNPAADVVVASNPEFLREGAAIR
DFKWPDRIVVGTDDERGRKALGDIYRPLSLNQAPIMYTARRTAELIKYAANAFLATKITFINEVADLAEKVGADVQEVAR
GIGLDNRIGSKFLHAGPGFGGSCFPKDTRALIKIAQDYDTQLRIVESVLAVNDNRKRAMARKVAHAVGGNLRGKTVAVLG
LTFKPETDDMREAPSIPLVTGLLDMGAKVRAHDPVGIEQAKKELPEIAYFEDPYACATGADAIVLVTEWVQYRAMDLDRL
KQVMARPVVVDLRNVYRPDEMAAHGFVYESVGRPSAKGA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=461, Percent_Identity=37.7440347071584, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=37.5690607734807, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI296040443, Length=312, Percent_Identity=37.1794871794872, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI48994968, Length=439, Percent_Identity=29.8405466970387, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=29.0055248618785, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=438, Percent_Identity=35.8447488584475, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=36.8763557483731, Blast_Score=264, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47440; Mature: 47440

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAMIGTGYVGLVSGACFADFGHEVTCVDKDESKIAALHRGEIPIFEPGLDALVAANVK
CEEEEEECCHHHHHCCHHHHHCCCEEEEECCCCHHHHHHCCCCCCEECCCCHHHHCCCCC
AKRLDFTTDLKQPVADADAVFIAVGTPSRRGDGHADLTYVYAAAREIAASLTGFTVVVTK
HHHCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPAADVVVASNPEFLREGAAIRDFKWPDRIVVGTDDERGRKA
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHH
LGDIYRPLSLNQAPIMYTARRTAELIKYAANAFLATKITFINEVADLAEKVGADVQEVAR
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGFGGSCFPKDTRALIKIAQDYDTQLRIVESVLAVNDNRKRAMA
HCCCCCHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH
RKVAHAVGGNLRGKTVAVLGLTFKPETDDMREAPSIPLVTGLLDMGAKVRAHDPVGIEQA
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHCCCCCHHHHHHHCCCEEECCCCCCHHHH
KKELPEIAYFEDPYACATGADAIVLVTEWVQYRAMDLDRLKQVMARPVVVDLRNVYRPDE
HHHCCCEEECCCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCHHEEHHHHCCCHH
MAAHGFVYESVGRPSAKGA
HHHCCCEECCCCCCCCCCC
>Mature Secondary Structure
MRIAMIGTGYVGLVSGACFADFGHEVTCVDKDESKIAALHRGEIPIFEPGLDALVAANVK
CEEEEEECCHHHHHCCHHHHHCCCEEEEECCCCHHHHHHCCCCCCEECCCCHHHHCCCCC
AKRLDFTTDLKQPVADADAVFIAVGTPSRRGDGHADLTYVYAAAREIAASLTGFTVVVTK
HHHCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPAADVVVASNPEFLREGAAIRDFKWPDRIVVGTDDERGRKA
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHH
LGDIYRPLSLNQAPIMYTARRTAELIKYAANAFLATKITFINEVADLAEKVGADVQEVAR
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGFGGSCFPKDTRALIKIAQDYDTQLRIVESVLAVNDNRKRAMA
HCCCCCHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH
RKVAHAVGGNLRGKTVAVLGLTFKPETDDMREAPSIPLVTGLLDMGAKVRAHDPVGIEQA
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHCCCCCHHHHHHHCCCEEECCCCCCHHHH
KKELPEIAYFEDPYACATGADAIVLVTEWVQYRAMDLDRLKQVMARPVVVDLRNVYRPDE
HHHCCCEEECCCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCHHEEHHHHCCCHH
MAAHGFVYESVGRPSAKGA
HHHCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]