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The map label for this gene is gyaR [H]

Identifier: 146337824

GI number: 146337824

Start: 742755

End: 743738

Strand: Direct

Name: gyaR [H]

Synonym: BRADO0705

Alternate gene names: 146337824

Gene position: 742755-743738 (Clockwise)

Preceding gene: 146337823

Following gene: 146337825

Centisome position: 9.96

GC content: 67.17

Gene sequence:

>984_bases
ATGGCGGCCACTTCGTCTGACAAGGTCGATGTTCTGATCTATGGGCCGCTGCGGCCGATCCTGGAGAAGGGGTTCCCGGA
CAGCTTCAACGTGCACCATGCGACGACGCAGGCCGATCTCGAAGCGCTGCCGGCGGATGTGAAGGGCCGCATCCGCGGCG
TTGCCGTCACCTTCCACACCGTCAAGACCGATGCGGCGGTCATGGCCTCGCTGCCGAAGCTCGAGATCATCGCCAGCTTC
GGCGTCGGCTATGACCACATCGCCGCCGCCCATGCGGGACAGCACGGTATCATCGTCACCAACACACCTGACGTGCTGAC
GGAAGAGGTCGCCGACGTCGCGCTCGGTCTCTTGATCGCCACCTGCCGCGAGTTCATCAAGGCCGACCGCTTCGTGCGCG
CGGGCGAGTGGAGCGCGAAGGCCTATCCGCTCAGCGTCGGCTCGCTGCGCGACCGCACCGTCGGCATGGTCGGCATGGGC
CGCATCGGCCAGGCGATCGCGCGCCGGCTCGAGGCCTCGCTGGTGCCGGTGGTCTATCACTCGCGCAATCCCGCCGCCGG
CGTCGCCAACAAGCACTATCCGGACCTGCTGCAGATGGCGAAGGATGTCGACACGCTGGTGGTGATCGTGCCCGGCGGCG
CCAGCACCAACCGAATCGTCAACGCCGAGGTGCTCAAGGCGCTGGGACCGCGCGGCGTCGTCGTCAACGTGGCCCGCGGC
TCGGTGATCGACGAGCAGGCCTTGGTCGAGGCGCTGCAGTCGGGCACGATCCTTGCCGCCGGCCTCGACGTGTTCGAGAA
GGAGCCGGCGGTGCCGGACGCGCTCAAGGCGATGGACAATGTCGTGCTGCTGCCACACATCGGCTCCGCTGCCATCGTAA
CCCGCAACGCGATGGATCAGCTGGTCGTCGACAACCTCAAGGTCTGGTTTGCCGGCAAGCCGCCGCTGACACCCGTTCCG
GAAACGCCGGCGAAAGGCCGCTGA

Upstream 100 bases:

>100_bases
TGCTGTCGGTCGCCGGGATTGTCATCTATGGCTTGCTGGCGCTAGTTTCGCACCTCGTTTTGCGGCGCTGGCACGAGAGC
GCGCTTGGAAAGGATAGCTG

Downstream 100 bases:

>100_bases
TGTCACGCCTGCTCCCATTGCTGATCGCGCTGTCGTCAGTGGCTGCCATTCCCGCGATTGCGCAGGACGCGGCAAGCCTG
AAGAAGGCGATGATCGGGCA

Product: putative NAD-dependent phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAATSSDKVDVLIYGPLRPILEKGFPDSFNVHHATTQADLEALPADVKGRIRGVAVTFHTVKTDAAVMASLPKLEIIASF
GVGYDHIAAAHAGQHGIIVTNTPDVLTEEVADVALGLLIATCREFIKADRFVRAGEWSAKAYPLSVGSLRDRTVGMVGMG
RIGQAIARRLEASLVPVVYHSRNPAAGVANKHYPDLLQMAKDVDTLVVIVPGGASTNRIVNAEVLKALGPRGVVVNVARG
SVIDEQALVEALQSGTILAAGLDVFEKEPAVPDALKAMDNVVLLPHIGSAAIVTRNAMDQLVVDNLKVWFAGKPPLTPVP
ETPAKGR

Sequences:

>Translated_327_residues
MAATSSDKVDVLIYGPLRPILEKGFPDSFNVHHATTQADLEALPADVKGRIRGVAVTFHTVKTDAAVMASLPKLEIIASF
GVGYDHIAAAHAGQHGIIVTNTPDVLTEEVADVALGLLIATCREFIKADRFVRAGEWSAKAYPLSVGSLRDRTVGMVGMG
RIGQAIARRLEASLVPVVYHSRNPAAGVANKHYPDLLQMAKDVDTLVVIVPGGASTNRIVNAEVLKALGPRGVVVNVARG
SVIDEQALVEALQSGTILAAGLDVFEKEPAVPDALKAMDNVVLLPHIGSAAIVTRNAMDQLVVDNLKVWFAGKPPLTPVP
ETPAKGR
>Mature_326_residues
AATSSDKVDVLIYGPLRPILEKGFPDSFNVHHATTQADLEALPADVKGRIRGVAVTFHTVKTDAAVMASLPKLEIIASFG
VGYDHIAAAHAGQHGIIVTNTPDVLTEEVADVALGLLIATCREFIKADRFVRAGEWSAKAYPLSVGSLRDRTVGMVGMGR
IGQAIARRLEASLVPVVYHSRNPAAGVANKHYPDLLQMAKDVDTLVVIVPGGASTNRIVNAEVLKALGPRGVVVNVARGS
VIDEQALVEALQSGTILAAGLDVFEKEPAVPDALKAMDNVVLLPHIGSAAIVTRNAMDQLVVDNLKVWFAGKPPLTPVPE
TPAKGR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=38.3064516129032, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI23308577, Length=289, Percent_Identity=30.7958477508651, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI4557497, Length=243, Percent_Identity=29.2181069958848, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI61743967, Length=243, Percent_Identity=29.2181069958848, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=27.9835390946502, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=27.9835390946502, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI145580575, Length=243, Percent_Identity=27.9835390946502, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87082289, Length=317, Percent_Identity=35.3312302839117, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=29.4573643410853, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787645, Length=209, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081824, Length=234, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=28.2894736842105, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=26.5625, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=317, Percent_Identity=34.0694006309148, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321253, Length=327, Percent_Identity=25.0764525993884, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=233, Percent_Identity=27.0386266094421, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=241, Percent_Identity=26.1410788381743, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=36, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=24, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=39.7727272727273, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24585514, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574282, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45551003, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45552429, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574284, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=34.1085271317829, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=31.8725099601594, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=27.3722627737226, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921140, Length=226, Percent_Identity=29.646017699115, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34522; Mature: 34391

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATSSDKVDVLIYGPLRPILEKGFPDSFNVHHATTQADLEALPADVKGRIRGVAVTFHT
CCCCCCCCEEEEEECCCHHHHHCCCCCCCCCEECCCHHHHHHCCCCCCCCEEEEEEEEEE
VKTDAAVMASLPKLEIIASFGVGYDHIAAAHAGQHGIIVTNTPDVLTEEVADVALGLLIA
ECCCHHHHHCCCCCEEHHHCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
TCREFIKADRFVRAGEWSAKAYPLSVGSLRDRTVGMVGMGRIGQAIARRLEASLVPVVYH
HHHHHHHHHHEEECCCCCCCEEEEECCCCCCCEECEECCHHHHHHHHHHHHHCCEEEEEE
SRNPAAGVANKHYPDLLQMAKDVDTLVVIVPGGASTNRIVNAEVLKALGPRGVVVNVARG
CCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHCCCCCEEEEECCC
SVIDEQALVEALQSGTILAAGLDVFEKEPAVPDALKAMDNVVLLPHIGSAAIVTRNAMDQ
CCCCHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHCCEEEEECCCCCCEEEHHHHHH
LVVDNLKVWFAGKPPLTPVPETPAKGR
HHHCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AATSSDKVDVLIYGPLRPILEKGFPDSFNVHHATTQADLEALPADVKGRIRGVAVTFHT
CCCCCCCEEEEEECCCHHHHHCCCCCCCCCEECCCHHHHHHCCCCCCCCEEEEEEEEEE
VKTDAAVMASLPKLEIIASFGVGYDHIAAAHAGQHGIIVTNTPDVLTEEVADVALGLLIA
ECCCHHHHHCCCCCEEHHHCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
TCREFIKADRFVRAGEWSAKAYPLSVGSLRDRTVGMVGMGRIGQAIARRLEASLVPVVYH
HHHHHHHHHHEEECCCCCCCEEEEECCCCCCCEECEECCHHHHHHHHHHHHHCCEEEEEE
SRNPAAGVANKHYPDLLQMAKDVDTLVVIVPGGASTNRIVNAEVLKALGPRGVVVNVARG
CCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHCCCCCEEEEECCC
SVIDEQALVEALQSGTILAAGLDVFEKEPAVPDALKAMDNVVLLPHIGSAAIVTRNAMDQ
CCCCHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHCCEEEEECCCCCCEEEHHHHHH
LVVDNLKVWFAGKPPLTPVPETPAKGR
HHHCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA