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The map label for this gene is aroB [H]

Identifier: 146337737

GI number: 146337737

Start: 633392

End: 635194

Strand: Direct

Name: aroB [H]

Synonym: BRADO0609

Alternate gene names: 146337737

Gene position: 633392-635194 (Clockwise)

Preceding gene: 146337730

Following gene: 146337738

Centisome position: 8.49

GC content: 69.27

Gene sequence:

>1803_bases
ATGACCGAACTGACGCAACCCGCATCCGGCCCAGGCGCTCCGGAGGCCGCGATCCTCGCGGGCCTCGGCAAGCGGCTGAT
CGTGCTGGTCGGCATGATGGGCGTCGGCAAGTCGACGGTCGGCCGGCGGCTCGCGGCGCGGCTGCGGCTGCCCTTCGTCG
ACGCGGACACCGAGATCGAGACCGCGGCCGGCATGAGCATACCGGAGATCTTCGAATCGCGCGGCGAAGACTATTTCCGC
AACGGCGAGGCACGGGTGATCGCCCGCCTGCTCGAAAGCGGGCCGGCGGTGCTGGCCACCGGCGGCGGCGCCTTCATGCG
CGAGGAGACCCGCCGCCGCATCCACGAGAAGGCGGTCTCGGTGTGGCTGAAGGCCGATGCCGAGGTGATCATGCGCCGCG
TCCGGCGCCGCGCCGACCGGCCGCTGCTGCAGACTGCCGACCCCGAAGGCACGGTGACGCGGCTCCTGAGCGAGCGCGAG
CCGGTCTACGGGCTCGCCGATCTCAAGATCTGCTCGCGCGACGTGCCGCATGACAGGGTCGTGGAGGACTGCCTGCAGGA
GCTGCAGACGTTCCTGTCCCCGGCCATGGCCGCGGCTCCGGCGGCGGAGCCGCAGCCCCATTCCCTCTCCTCCGATTCCG
TACAGGGCGTTTCGATGACGGCACCATTGAAGTCTTCCGATCCGATCATCGTCGACGTCGCGCTCGGCGAGCGCGCCTAT
GACATCGTCATCGGCCGCGGCGTGCTGGACACGCTGGGCCGGCGCATCGCAGCGCTGCGGCCGGGCGTGCGCACCGCCAT
CGTCACCGACCGCACCGTCGCTGCGCATTGGCTCAAGCCGACCGAGGCGATTCTGGCGGAGGCGGGGATCCCGTCATCCA
CCATCGTGGTTGAGGAGGGGGAGGGCTCCAAGACCTATGCCGGCCTCGAAAAGGTCAGCGAGGCGCTTATCTCGGCAAAG
ATCGAGCGCAACGATCTCGTCATCGCGCTCGGCGGCGGCGTGGTCGGCGATCTCGCCGGCTTTGCGGCTTCGATCCTGCG
CCGCGGCGTCGATTTCGTGCAGGTGCCGACCTCGCTGCTGGCGCAGGTCGATTCCTCCGTCGGCGGCAAAACGGGGATCA
ACTCGCCGCAGGGCAAGAACCTGCTCGGCGCCTTCCACCAGCCGGTGCTGGTGATCGCCGACACCGCGGTGCTCGACACC
TTGTCGCCGCGCCAGTTCCGCGCCGGCTATGCCGAGGTCGCCAAATACGGCCTGCTCGGCGACGCCGGCTTCTTCGCCTG
GCTCGAGGCCAACCAAGCCGAGATCGTCACGGGCGGCGCCGCGCGCGAGCATGCGGTCGCGACCTCCTGCCGCGCCAAGG
CCGCGATCGTCGCCCGCGACGAGCGCGAGACCGGCGACCGCGCGCTGCTCAATCTCGGCCACACCTTCGGGCATGCGCTC
GAGGCCATCACCGGCTTCTCCGACCGGCTGTTCCATGGCGAGGGCGTCTCGGTCGGCATGGTGCTGGCGGCGCAGTTTTC
GGCTGAGCTCGGCATGCTGCCGCCCGGCGACGTCACCAGGATCGAGCGTCACCTTGCCGCAGTGGGCCTGCCGACCCATC
TGCAGGACATCGCCGGCTTCGCCCAGGAAGGGATCGGCGACGCCGAACGGCTTTTGGCCTTGATGGCGCAGGACAAGAAG
GTCAAGCGCGGCAAGCTCACCTTCATCCTGATGGAAGCGATCGGCCGCGCGGTCATTGCGAATGACGTCGACCCGGCAAG
GGTCCGTGACTTCCTGCAGGCCAAATTGGACAGAAGCGGCTGA

Upstream 100 bases:

>100_bases
CGGGCTCGCGCGGCGCGCGCCCTGGAATGACGGCGGTGGGGCGGCCGAAGCGGAACAGGATGCCTTTGAAAGCAGCAGGG
CCTGGGTTAGAAGCCCGGAT

Downstream 100 bases:

>100_bases
TCCCAGGTGCTTTACGCCGCGTTGAGCAGTAGCGGCGCATGATCGGCGGCTTCCCTCGAGAGTGATATGGCGTCATGGAC
TGGCTCACACTCACCATCGT

Product: bifunctional shikimate kinase/dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MTELTQPASGPGAPEAAILAGLGKRLIVLVGMMGVGKSTVGRRLAARLRLPFVDADTEIETAAGMSIPEIFESRGEDYFR
NGEARVIARLLESGPAVLATGGGAFMREETRRRIHEKAVSVWLKADAEVIMRRVRRRADRPLLQTADPEGTVTRLLSERE
PVYGLADLKICSRDVPHDRVVEDCLQELQTFLSPAMAAAPAAEPQPHSLSSDSVQGVSMTAPLKSSDPIIVDVALGERAY
DIVIGRGVLDTLGRRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEGEGSKTYAGLEKVSEALISAK
IERNDLVIALGGGVVGDLAGFAASILRRGVDFVQVPTSLLAQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDT
LSPRQFRAGYAEVAKYGLLGDAGFFAWLEANQAEIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHAL
EAITGFSDRLFHGEGVSVGMVLAAQFSAELGMLPPGDVTRIERHLAAVGLPTHLQDIAGFAQEGIGDAERLLALMAQDKK
VKRGKLTFILMEAIGRAVIANDVDPARVRDFLQAKLDRSG

Sequences:

>Translated_600_residues
MTELTQPASGPGAPEAAILAGLGKRLIVLVGMMGVGKSTVGRRLAARLRLPFVDADTEIETAAGMSIPEIFESRGEDYFR
NGEARVIARLLESGPAVLATGGGAFMREETRRRIHEKAVSVWLKADAEVIMRRVRRRADRPLLQTADPEGTVTRLLSERE
PVYGLADLKICSRDVPHDRVVEDCLQELQTFLSPAMAAAPAAEPQPHSLSSDSVQGVSMTAPLKSSDPIIVDVALGERAY
DIVIGRGVLDTLGRRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEGEGSKTYAGLEKVSEALISAK
IERNDLVIALGGGVVGDLAGFAASILRRGVDFVQVPTSLLAQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDT
LSPRQFRAGYAEVAKYGLLGDAGFFAWLEANQAEIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHAL
EAITGFSDRLFHGEGVSVGMVLAAQFSAELGMLPPGDVTRIERHLAAVGLPTHLQDIAGFAQEGIGDAERLLALMAQDKK
VKRGKLTFILMEAIGRAVIANDVDPARVRDFLQAKLDRSG
>Mature_599_residues
TELTQPASGPGAPEAAILAGLGKRLIVLVGMMGVGKSTVGRRLAARLRLPFVDADTEIETAAGMSIPEIFESRGEDYFRN
GEARVIARLLESGPAVLATGGGAFMREETRRRIHEKAVSVWLKADAEVIMRRVRRRADRPLLQTADPEGTVTRLLSEREP
VYGLADLKICSRDVPHDRVVEDCLQELQTFLSPAMAAAPAAEPQPHSLSSDSVQGVSMTAPLKSSDPIIVDVALGERAYD
IVIGRGVLDTLGRRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEGEGSKTYAGLEKVSEALISAKI
ERNDLVIALGGGVVGDLAGFAASILRRGVDFVQVPTSLLAQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDTL
SPRQFRAGYAEVAKYGLLGDAGFFAWLEANQAEIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHALE
AITGFSDRLFHGEGVSVGMVLAAQFSAELGMLPPGDVTRIERHLAAVGLPTHLQDIAGFAQEGIGDAERLLALMAQDKKV
KRGKLTFILMEAIGRAVIANDVDPARVRDFLQAKLDRSG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=352, Percent_Identity=44.6022727272727, Blast_Score=258, Evalue=1e-69,
Organism=Escherichia coli, GI87082255, Length=153, Percent_Identity=43.1372549019608, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320332, Length=373, Percent_Identity=36.1930294906166, Blast_Score=202, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 63683; Mature: 63552

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTQPASGPGAPEAAILAGLGKRLIVLVGMMGVGKSTVGRRLAARLRLPFVDADTEIE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCHH
TAAGMSIPEIFESRGEDYFRNGEARVIARLLESGPAVLATGGGAFMREETRRRIHEKAVS
HHCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
VWLKADAEVIMRRVRRRADRPLLQTADPEGTVTRLLSEREPVYGLADLKICSRDVPHDRV
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
VEDCLQELQTFLSPAMAAAPAAEPQPHSLSSDSVQGVSMTAPLKSSDPIIVDVALGERAY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCEE
DIVIGRGVLDTLGRRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEG
EEEECCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHCCCCCCEEEEECC
EGSKTYAGLEKVSEALISAKIERNDLVIALGGGVVGDLAGFAASILRRGVDFVQVPTSLL
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDTLSPRQFRAGYAEVAKYGLLG
HHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEECHHHHHCCCCHHHHCCHHHHHHHCCCC
DAGFFAWLEANQAEIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHAL
CCCEEEEEECCCCEEEECCCCHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHH
EAITGFSDRLFHGEGVSVGMVLAAQFSAELGMLPPGDVTRIERHLAAVGLPTHLQDIAGF
HHHHCCHHHEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AQEGIGDAERLLALMAQDKKVKRGKLTFILMEAIGRAVIANDVDPARVRDFLQAKLDRSG
HHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TELTQPASGPGAPEAAILAGLGKRLIVLVGMMGVGKSTVGRRLAARLRLPFVDADTEIE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCHH
TAAGMSIPEIFESRGEDYFRNGEARVIARLLESGPAVLATGGGAFMREETRRRIHEKAVS
HHCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
VWLKADAEVIMRRVRRRADRPLLQTADPEGTVTRLLSEREPVYGLADLKICSRDVPHDRV
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
VEDCLQELQTFLSPAMAAAPAAEPQPHSLSSDSVQGVSMTAPLKSSDPIIVDVALGERAY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCEE
DIVIGRGVLDTLGRRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEG
EEEECCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHCCCCCCEEEEECC
EGSKTYAGLEKVSEALISAKIERNDLVIALGGGVVGDLAGFAASILRRGVDFVQVPTSLL
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDTLSPRQFRAGYAEVAKYGLLG
HHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEECHHHHHCCCCHHHHCCHHHHHHHCCCC
DAGFFAWLEANQAEIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHAL
CCCEEEEEECCCCEEEECCCCHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHH
EAITGFSDRLFHGEGVSVGMVLAAQFSAELGMLPPGDVTRIERHLAAVGLPTHLQDIAGF
HHHHCCHHHEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AQEGIGDAERLLALMAQDKKVKRGKLTFILMEAIGRAVIANDVDPARVRDFLQAKLDRSG
HHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA