Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 146337683

GI number: 146337683

Start: 565911

End: 567518

Strand: Reverse

Name: nhaK [H]

Synonym: BRADO0551

Alternate gene names: 146337683

Gene position: 567518-565911 (Counterclockwise)

Preceding gene: 146337684

Following gene: 146337682

Centisome position: 7.61

GC content: 65.92

Gene sequence:

>1608_bases
ATGGAAGCTCATTTTCAAATTTTCCTGATCCTGCTGGCGGTGCTGGCGGGAACCGCCCTGATTGCCCGGCGCGCCAATCT
GGCGCCGGCGATCCTCTTGATGCTCGCCGGCATTGCGCTGGCCTTCGTGCCGACGATGCCGGCGTTCGCGCTGCCGCCGG
AGCTGGTGCTGCTCGTCGTTCTGCCGCCGCTGATCTACTCTTCCAGCGTCGCGATGAGCTGGCGCGAGTTCAAACGCAAT
CTGCGGCCGATCGTGCTGCTCGCGGTCGGCTGCGTGATCTTCACGGCCTCGATGGTGGCCGTCGCCACGCATGTCCTGCT
CGGCTTGCCGTGGAGTCTCGGCTTCCTGCTCGGCGCGATCGTGGCGCCGCCGGATGTGGTCGCGCCGCTCGCCATCGCCC
GCCGGCTGCATCTGCCGCGCCGGGTGATGGTGATCCTCGAAGGCGAGGGTCTCGCCAACGATGCGACGGCGCTGATCCTT
TATCGCTTCGCGGTGGCTGCGATCACCACCGGAACGTTCTCGCTTCCGGTTGCCGCCGGCGAGTTCGCCGCGATCGTGAT
CGGGGAGATCGCCTTCGGCATCGGCGTCGGCTGGCTGATGCTTCGTGCCCGGCATTACTCCGACGACACCCGCGTCGAGA
TCACGCTGTCGCTGCTGACGCCCTATCTGGCCTATTGGATACCCGAGCATCTCGGCGGCTCCGGCGTGATCGCCACGGTC
GCCTGCGGCCTCTACATGAGCTGGAACGGACCGTTGTGGATCTCGTCGGCGACGCGTTTGCAGGGCGTATTCTTCTGGGA
CCTCGTTGTCTACCTGATCGAGGGCATGCTGTTTCTGCTGACCGGCTTCCAGATGCGGCTGATCTACGAGAAGTCGAAAG
TGTTCCCGCTCGACGAGATCATGATCGCCACCGCGCTGGTGGTCGCCATCGTGGTGATCGCGCGTTTCGCCTGGACGTTC
CCGGCGACCATTCTGCCGCGCGTGCTGAGCCGGTCCCTGCGCGCCAGGGATCCCTTGCCGCCCTGGCAGCAGACCTTCAT
CATCGGCTTCACCGGCGTGCGCGGCACGGTCTCGCTGGCCACCGCGCTGGCGCTGCCGCTGACCTTGTCGACCGGCGATC
CCTTTCCCTATCGCGACGAGATCCTGTTCATCGCCTTCGGCGTAATCTTCTTCACGCTGATCGGCCTTGGCCTCACGCTT
CCGCTCGTGGTGCGCTGGCTCGGCGTCAGCCGCGCCGGACGTGCCGAGCACGTGCGCGAGCACGAGCAGGAGATCGCAGC
GCGGCGCGAGGTGCTCGATCGCGCGCTGCAATCGCTGGAGACGATGACCAATGACCGCGAGCTGTCCGACGAGGTAGTCC
GGCTGCTGCGCGCGCGCCACGAGGTACGTGCAAATCAGCTGCCGGAGAGGCTCAATCCCGACGAGTACGACGCCTCCGCG
CTCGGCATCGAGCTGACGCGCGAGCTGATCGGCGTCGAACGCAAGACCATTCACGCCATGCTCCGCGACGGCCAGATCAC
CGACGAAACCCGCCGCCGCATCGAGCGCGATCTGGACCTGGAAGAGGCGAGCCTCGCCAACCGGGAATATGGGCAATTGC
CGTTATAG

Upstream 100 bases:

>100_bases
CGTCGCGATGAAGCTCAAGGACGGTTGGCAGATCGTGTCCAAGTCCTACCGCTACGATCTCCGGGACTGAGCCGGGCGCC
GCGTCGCCAGGCCATCGTCG

Downstream 100 bases:

>100_bases
TGGTGAGTTGAGTGGGCACAGCTCGCTCCACCGTCATTGCGAGCGCAGCGAAGCAATCCAGAATGGTGGGCGGGACTCTG
GATTGCTTCGCTGCGCTCGC

Product: putative sodium/hydrogen antiporter (exchanger) membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MEAHFQIFLILLAVLAGTALIARRANLAPAILLMLAGIALAFVPTMPAFALPPELVLLVVLPPLIYSSSVAMSWREFKRN
LRPIVLLAVGCVIFTASMVAVATHVLLGLPWSLGFLLGAIVAPPDVVAPLAIARRLHLPRRVMVILEGEGLANDATALIL
YRFAVAAITTGTFSLPVAAGEFAAIVIGEIAFGIGVGWLMLRARHYSDDTRVEITLSLLTPYLAYWIPEHLGGSGVIATV
ACGLYMSWNGPLWISSATRLQGVFFWDLVVYLIEGMLFLLTGFQMRLIYEKSKVFPLDEIMIATALVVAIVVIARFAWTF
PATILPRVLSRSLRARDPLPPWQQTFIIGFTGVRGTVSLATALALPLTLSTGDPFPYRDEILFIAFGVIFFTLIGLGLTL
PLVVRWLGVSRAGRAEHVREHEQEIAARREVLDRALQSLETMTNDRELSDEVVRLLRARHEVRANQLPERLNPDEYDASA
LGIELTRELIGVERKTIHAMLRDGQITDETRRRIERDLDLEEASLANREYGQLPL

Sequences:

>Translated_535_residues
MEAHFQIFLILLAVLAGTALIARRANLAPAILLMLAGIALAFVPTMPAFALPPELVLLVVLPPLIYSSSVAMSWREFKRN
LRPIVLLAVGCVIFTASMVAVATHVLLGLPWSLGFLLGAIVAPPDVVAPLAIARRLHLPRRVMVILEGEGLANDATALIL
YRFAVAAITTGTFSLPVAAGEFAAIVIGEIAFGIGVGWLMLRARHYSDDTRVEITLSLLTPYLAYWIPEHLGGSGVIATV
ACGLYMSWNGPLWISSATRLQGVFFWDLVVYLIEGMLFLLTGFQMRLIYEKSKVFPLDEIMIATALVVAIVVIARFAWTF
PATILPRVLSRSLRARDPLPPWQQTFIIGFTGVRGTVSLATALALPLTLSTGDPFPYRDEILFIAFGVIFFTLIGLGLTL
PLVVRWLGVSRAGRAEHVREHEQEIAARREVLDRALQSLETMTNDRELSDEVVRLLRARHEVRANQLPERLNPDEYDASA
LGIELTRELIGVERKTIHAMLRDGQITDETRRRIERDLDLEEASLANREYGQLPL
>Mature_535_residues
MEAHFQIFLILLAVLAGTALIARRANLAPAILLMLAGIALAFVPTMPAFALPPELVLLVVLPPLIYSSSVAMSWREFKRN
LRPIVLLAVGCVIFTASMVAVATHVLLGLPWSLGFLLGAIVAPPDVVAPLAIARRLHLPRRVMVILEGEGLANDATALIL
YRFAVAAITTGTFSLPVAAGEFAAIVIGEIAFGIGVGWLMLRARHYSDDTRVEITLSLLTPYLAYWIPEHLGGSGVIATV
ACGLYMSWNGPLWISSATRLQGVFFWDLVVYLIEGMLFLLTGFQMRLIYEKSKVFPLDEIMIATALVVAIVVIARFAWTF
PATILPRVLSRSLRARDPLPPWQQTFIIGFTGVRGTVSLATALALPLTLSTGDPFPYRDEILFIAFGVIFFTLIGLGLTL
PLVVRWLGVSRAGRAEHVREHEQEIAARREVLDRALQSLETMTNDRELSDEVVRLLRARHEVRANQLPERLNPDEYDASA
LGIELTRELIGVERKTIHAMLRDGQITDETRRRIERDLDLEEASLANREYGQLPL

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=471, Percent_Identity=25.2653927813163, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI148727259, Length=438, Percent_Identity=24.8858447488584, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI27734935, Length=415, Percent_Identity=23.1325301204819, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI41872703, Length=500, Percent_Identity=23, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI14211919, Length=400, Percent_Identity=26.25, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI194239733, Length=410, Percent_Identity=24.390243902439, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI5454070, Length=408, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI294997330, Length=401, Percent_Identity=25.4364089775561, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110227626, Length=401, Percent_Identity=25.4364089775561, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI4759144, Length=416, Percent_Identity=25.2403846153846, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI27777632, Length=469, Percent_Identity=24.5202558635394, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790501, Length=553, Percent_Identity=31.1030741410488, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147678, Length=465, Percent_Identity=24.7311827956989, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71980847, Length=413, Percent_Identity=24.6973365617433, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=514, Percent_Identity=20.6225680933852, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71999819, Length=514, Percent_Identity=20.6225680933852, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=514, Percent_Identity=20.6225680933852, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=336, Percent_Identity=20.5357142857143, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=336, Percent_Identity=20.5357142857143, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=465, Percent_Identity=22.1505376344086, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71987535, Length=465, Percent_Identity=22.1505376344086, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71993590, Length=390, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71993582, Length=390, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71987545, Length=425, Percent_Identity=21.8823529411765, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=425, Percent_Identity=21.8823529411765, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=410, Percent_Identity=23.9024390243902, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=410, Percent_Identity=23.6585365853659, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=337, Percent_Identity=21.0682492581602, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510738, Length=393, Percent_Identity=24.1730279898219, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221510734, Length=393, Percent_Identity=24.1730279898219, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221510732, Length=395, Percent_Identity=24.3037974683544, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510736, Length=395, Percent_Identity=24.3037974683544, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510740, Length=395, Percent_Identity=24.3037974683544, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585580, Length=395, Percent_Identity=24.3037974683544, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585578, Length=395, Percent_Identity=24.3037974683544, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360447, Length=446, Percent_Identity=24.2152466367713, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221473212, Length=419, Percent_Identity=22.673031026253, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281364513, Length=376, Percent_Identity=23.6702127659574, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221473215, Length=409, Percent_Identity=22.9828850855746, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221473222, Length=378, Percent_Identity=23.5449735449735, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59075; Mature: 59075

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAHFQIFLILLAVLAGTALIARRANLAPAILLMLAGIALAFVPTMPAFALPPELVLLVV
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LPPLIYSSSVAMSWREFKRNLRPIVLLAVGCVIFTASMVAVATHVLLGLPWSLGFLLGAI
HHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VAPPDVVAPLAIARRLHLPRRVMVILEGEGLANDATALILYRFAVAAITTGTFSLPVAAG
HCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
EFAAIVIGEIAFGIGVGWLMLRARHYSDDTRVEITLSLLTPYLAYWIPEHLGGSGVIATV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHH
ACGLYMSWNGPLWISSATRLQGVFFWDLVVYLIEGMLFLLTGFQMRLIYEKSKVFPLDEI
HHHHEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEHHCCCCCHHHH
MIATALVVAIVVIARFAWTFPATILPRVLSRSLRARDPLPPWQQTFIIGFTGVRGTVSLA
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHH
TALALPLTLSTGDPFPYRDEILFIAFGVIFFTLIGLGLTLPLVVRWLGVSRAGRAEHVRE
HHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
HEQEIAARREVLDRALQSLETMTNDRELSDEVVRLLRARHEVRANQLPERLNPDEYDASA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LGIELTRELIGVERKTIHAMLRDGQITDETRRRIERDLDLEEASLANREYGQLPL
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEAHFQIFLILLAVLAGTALIARRANLAPAILLMLAGIALAFVPTMPAFALPPELVLLVV
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LPPLIYSSSVAMSWREFKRNLRPIVLLAVGCVIFTASMVAVATHVLLGLPWSLGFLLGAI
HHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VAPPDVVAPLAIARRLHLPRRVMVILEGEGLANDATALILYRFAVAAITTGTFSLPVAAG
HCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
EFAAIVIGEIAFGIGVGWLMLRARHYSDDTRVEITLSLLTPYLAYWIPEHLGGSGVIATV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHH
ACGLYMSWNGPLWISSATRLQGVFFWDLVVYLIEGMLFLLTGFQMRLIYEKSKVFPLDEI
HHHHEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEHHCCCCCHHHH
MIATALVVAIVVIARFAWTFPATILPRVLSRSLRARDPLPPWQQTFIIGFTGVRGTVSLA
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHH
TALALPLTLSTGDPFPYRDEILFIAFGVIFFTLIGLGLTLPLVVRWLGVSRAGRAEHVRE
HHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
HEQEIAARREVLDRALQSLETMTNDRELSDEVVRLLRARHEVRANQLPERLNPDEYDASA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LGIELTRELIGVERKTIHAMLRDGQITDETRRRIERDLDLEEASLANREYGQLPL
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]