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The map label for this gene is lpd [H]

Identifier: 146337555

GI number: 146337555

Start: 418246

End: 419649

Strand: Direct

Name: lpd [H]

Synonym: BRADO0409

Alternate gene names: 146337555

Gene position: 418246-419649 (Clockwise)

Preceding gene: 146337554

Following gene: 146337556

Centisome position: 5.61

GC content: 65.17

Gene sequence:

>1404_bases
ATGGCTACTTACGATCTCGTCGTCATCGGCACCGGACCCGGTGGTTATGTCTGCGCCATCCGCGCAGCGCAGCTCGGCAT
GAAGGTGGCCGTGGTCGAGAAGAACGCCACCCTCGGCGGCACCTGCCTCAATGTCGGCTGCATGCCCTCGAAGGCGCTGC
TGCACGCCTCGGAGCTGTTCGAGGAGGCCGGACACTCCTTCGCCAAGATGGGCATCAAGGTGTCGGCGCCCGAGGTCGAT
CTGCCGTCGATGATGAACTTCAAGCAGCAGGGCATCGATGGCAACGTCAAAGGCGTCGAGTTCCTGATGAAGAAGAACAA
GATCGACGTCCTCCAGGGCAAGGGCAAGATCCTCGGTACCGGCAAGGTTCAGGTCACCGGCAATGACGGCGCGGCGCAGA
CCGTCGAGACCAAGAACATCGTGATCGCCACCGGCTCGGATATCGCGCGGCTCAAGGGCATCGAGATCGACGAGAAGCGC
ATCGTGTCCTCCACCGGCGCGCTGGCGCTGGACAAGGTGCCGTCGAGCCTGCTCGTGGTCGGCGCCGGCGTGATCGGGCT
CGAGCTCGGCTCGGTGTGGCGCCGCCTCGGCGCCAAGGTCACTGTGGTCGAATTCCTCGACCGCATCCTGCCCGGCATGG
ACCTGGAGATCGCCAAACAGTTCCAGCGCATCCTCGAGAAGCAGGGCTTTGCGTTCAAGCTCGGCGCCAAGGTCACCGGC
GTCGATACGTCAGGCGCGAAGCTCTCGGCCACGATCGAGCCGGCCGCAGGCGGCGCCGCCGAGAAGATCGACGCCGATGT
CGTGCTGGTCGCGATCGGCCGCGTGCCCTACACCGACGGCCTCGGGCTGCAGGAAGCCGGCGTCGCGCTCGACAATCGCG
GCCGCGTCCAGATCGATCATCATTTCGCGACCAGCGTGCCCGGCGTCTACGCCATCGGCGACGTCGTCGCCGGCCCGATG
CTCGCGCACAAGGCCGAGGATGAAGGCGTCGCCTGCGCCGAGATCCTCGCCGGCCAGGCCGGCCACGTGAACTACGACGT
GATCCCCGGCGTGGTCTACACCACGCCGGAAGTGGCCTCGGTCGGCAAGACCGAGGACGAGCTGAAGCAGGCCGGTATTG
TTTATACCGTCGGTAAGTTTCCGTTCACCGCGAATGGACGTTCCAAGGTCAACCAGACCACTGACGGCTTCGTGAAGATT
CTCGCAGATGCGAAGACCGACCGCGTGCTCGGCGCTCACATCATCGGCCGCGAAGCCGGTGAAATGATCCACGAAGCCGC
CGTATTGATGGAGTTCGGTGGCTCGGCTGAGGATCTGGCGCGCACCTGCCACGCGCATCCGACGCGCTCGGAGGCGGTCA
AGGAAGCCGCTCTTGCGGTGGGCAAGCGCGCCATCCACATGTGA

Upstream 100 bases:

>100_bases
GGACGAGGCCTCCTATGTCACTTCGGCCATTCTCGACGTGTCGGGCGGACGCTGACGACCGTCATCATCTCTGACTACAA
AGCTTACGGAACATTCGATC

Downstream 100 bases:

>100_bases
CCGACGCCAGGCGGCGGGGATCGGCAGGTGCGACAAAATGGCCTGCCGATCACGCTGAACCAAACGGCAAGGTGTGAGGT
CCTAACGTCATAGCGGCCTC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MATYDLVVIGTGPGGYVCAIRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASELFEEAGHSFAKMGIKVSAPEVD
LPSMMNFKQQGIDGNVKGVEFLMKKNKIDVLQGKGKILGTGKVQVTGNDGAAQTVETKNIVIATGSDIARLKGIEIDEKR
IVSSTGALALDKVPSSLLVVGAGVIGLELGSVWRRLGAKVTVVEFLDRILPGMDLEIAKQFQRILEKQGFAFKLGAKVTG
VDTSGAKLSATIEPAAGGAAEKIDADVVLVAIGRVPYTDGLGLQEAGVALDNRGRVQIDHHFATSVPGVYAIGDVVAGPM
LAHKAEDEGVACAEILAGQAGHVNYDVIPGVVYTTPEVASVGKTEDELKQAGIVYTVGKFPFTANGRSKVNQTTDGFVKI
LADAKTDRVLGAHIIGREAGEMIHEAAVLMEFGGSAEDLARTCHAHPTRSEAVKEAALAVGKRAIHM

Sequences:

>Translated_467_residues
MATYDLVVIGTGPGGYVCAIRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASELFEEAGHSFAKMGIKVSAPEVD
LPSMMNFKQQGIDGNVKGVEFLMKKNKIDVLQGKGKILGTGKVQVTGNDGAAQTVETKNIVIATGSDIARLKGIEIDEKR
IVSSTGALALDKVPSSLLVVGAGVIGLELGSVWRRLGAKVTVVEFLDRILPGMDLEIAKQFQRILEKQGFAFKLGAKVTG
VDTSGAKLSATIEPAAGGAAEKIDADVVLVAIGRVPYTDGLGLQEAGVALDNRGRVQIDHHFATSVPGVYAIGDVVAGPM
LAHKAEDEGVACAEILAGQAGHVNYDVIPGVVYTTPEVASVGKTEDELKQAGIVYTVGKFPFTANGRSKVNQTTDGFVKI
LADAKTDRVLGAHIIGREAGEMIHEAAVLMEFGGSAEDLARTCHAHPTRSEAVKEAALAVGKRAIHM
>Mature_466_residues
ATYDLVVIGTGPGGYVCAIRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASELFEEAGHSFAKMGIKVSAPEVDL
PSMMNFKQQGIDGNVKGVEFLMKKNKIDVLQGKGKILGTGKVQVTGNDGAAQTVETKNIVIATGSDIARLKGIEIDEKRI
VSSTGALALDKVPSSLLVVGAGVIGLELGSVWRRLGAKVTVVEFLDRILPGMDLEIAKQFQRILEKQGFAFKLGAKVTGV
DTSGAKLSATIEPAAGGAAEKIDADVVLVAIGRVPYTDGLGLQEAGVALDNRGRVQIDHHFATSVPGVYAIGDVVAGPML
AHKAEDEGVACAEILAGQAGHVNYDVIPGVVYTTPEVASVGKTEDELKQAGIVYTVGKFPFTANGRSKVNQTTDGFVKIL
ADAKTDRVLGAHIIGREAGEMIHEAAVLMEFGGSAEDLARTCHAHPTRSEAVKEAALAVGKRAIHM

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=58.0786026200873, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI50301238, Length=469, Percent_Identity=29.8507462686567, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=30.0211416490486, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33519430, Length=493, Percent_Identity=27.9918864097363, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519428, Length=493, Percent_Identity=27.9918864097363, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519426, Length=493, Percent_Identity=27.9918864097363, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI148277065, Length=493, Percent_Identity=27.9918864097363, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI148277071, Length=493, Percent_Identity=27.9918864097363, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI291045266, Length=456, Percent_Identity=28.5087719298246, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI291045268, Length=464, Percent_Identity=28.6637931034483, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=42.0353982300885, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=31.1015118790497, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=28.695652173913, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=29.3181818181818, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=56.140350877193, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17557007, Length=493, Percent_Identity=30.2231237322515, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=26.5979381443299, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=27.0509977827051, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=27.0509977827051, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17559934, Length=259, Percent_Identity=25.4826254826255, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=51.5856236786469, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=33.3333333333333, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=28.2051282051282, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=56.1135371179039, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24640551, Length=488, Percent_Identity=30.9426229508197, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24640549, Length=488, Percent_Identity=30.9426229508197, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24640553, Length=488, Percent_Identity=30.9426229508197, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=26.6260162601626, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48697; Mature: 48566

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYDLVVIGTGPGGYVCAIRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASELF
CCEEEEEEEECCCCCEEEEEEHHHCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
EEAGHSFAKMGIKVSAPEVDLPSMMNFKQQGIDGNVKGVEFLMKKNKIDVLQGKGKILGT
HHHCCHHHHCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCEEEEC
GKVQVTGNDGAAQTVETKNIVIATGSDIARLKGIEIDEKRIVSSTGALALDKVPSSLLVV
CEEEEECCCCCCEEEEECEEEEECCCCHHHHCCCCCCHHHHHHCCCCEEECCCCCCEEEE
GAGVIGLELGSVWRRLGAKVTVVEFLDRILPGMDLEIAKQFQRILEKQGFAFKLGAKVTG
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCEEEE
VDTSGAKLSATIEPAAGGAAEKIDADVVLVAIGRVPYTDGLGLQEAGVALDNRGRVQIDH
CCCCCCEEEEEECCCCCCCCHHCCCCEEEEEECCCCCCCCCCCHHCCCEECCCCCEEEEC
HFATSVPGVYAIGDVVAGPMLAHKAEDEGVACAEILAGQAGHVNYDVIPGVVYTTPEVAS
CHHCCCCCCEEHHHHHHCCHHHCCCCCCCCHHHHHHCCCCCCCCEEECCCEEECCCCHHH
VGKTEDELKQAGIVYTVGKFPFTANGRSKVNQTTDGFVKILADAKTDRVLGAHIIGREAG
CCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHH
EMIHEAAVLMEFGGSAEDLARTCHAHPTRSEAVKEAALAVGKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATYDLVVIGTGPGGYVCAIRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASELF
CEEEEEEEECCCCCEEEEEEHHHCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
EEAGHSFAKMGIKVSAPEVDLPSMMNFKQQGIDGNVKGVEFLMKKNKIDVLQGKGKILGT
HHHCCHHHHCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCEEEEC
GKVQVTGNDGAAQTVETKNIVIATGSDIARLKGIEIDEKRIVSSTGALALDKVPSSLLVV
CEEEEECCCCCCEEEEECEEEEECCCCHHHHCCCCCCHHHHHHCCCCEEECCCCCCEEEE
GAGVIGLELGSVWRRLGAKVTVVEFLDRILPGMDLEIAKQFQRILEKQGFAFKLGAKVTG
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCEEEE
VDTSGAKLSATIEPAAGGAAEKIDADVVLVAIGRVPYTDGLGLQEAGVALDNRGRVQIDH
CCCCCCEEEEEECCCCCCCCHHCCCCEEEEEECCCCCCCCCCCHHCCCEECCCCCEEEEC
HFATSVPGVYAIGDVVAGPMLAHKAEDEGVACAEILAGQAGHVNYDVIPGVVYTTPEVAS
CHHCCCCCCEEHHHHHHCCHHHCCCCCCCCHHHHHHCCCCCCCCEEECCCEEECCCCHHH
VGKTEDELKQAGIVYTVGKFPFTANGRSKVNQTTDGFVKILADAKTDRVLGAHIIGREAG
CCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHH
EMIHEAAVLMEFGGSAEDLARTCHAHPTRSEAVKEAALAVGKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]