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The map label for this gene is ffh [H]

Identifier: 146337525

GI number: 146337525

Start: 383656

End: 385203

Strand: Reverse

Name: ffh [H]

Synonym: BRADO0379

Alternate gene names: 146337525

Gene position: 385203-383656 (Counterclockwise)

Preceding gene: 146337527

Following gene: 146337524

Centisome position: 5.17

GC content: 68.28

Gene sequence:

>1548_bases
TTGTTCGACAATCTGTCGGAAAGGCTTGGCGGCATTCTCGATCGGCTGACGGGGCGCGGTTCGCTCTCGGAGGCCGATGT
CGACGCCGCGATGCGCGAGGTCCGTCGGGCGCTGCTCGAGGCCGACGTCGCGCTGGAGGTTGTCCGCAGCTTCACTGACC
GCGTGCGCGAGCAGGCGATCGGCGCCACCGTCGTCAAGTCGGTCACCCCCGGCCAGATGGTCGTGAAGATCGTCCATGAC
GAACTGGTCAAGACGCTCGGCGACGACGGCCAGACCATCGACCTCAATGCGGTGCCGCCGGTGCCGATCATGATGGTCGG
CCTGCAGGGCTCCGGCAAGACCACCACGACGGCCAAGCTCGCCCGCCGCATGGTCCAGCGCGACAAGCGCAAGGTGCTGA
TGGCCTCGCTCGACGTCTACCGTCCGGCCGCCATGGAGCAGCTCGCGGTGCTCGGCCGCGACCTGGACATCCCGACCCTG
CCGATCGTCGCCGGCCAGATGCCGCCGCAGATCGCGCGCCGCGCCATCGAGGCCGCCAAGCTCGGCGGCTATGACGTCGT
GCTGCTCGATACCGCCGGCCGCACCACGCTCGACGAGGACATGATGAAGGAGGCCGCCGAGATCAAGGCGGTCGCCAACC
CGCACGAGGTGCTGCTGGTCGCGGATTCGCTGACCGGTCAGGACGCGGTCAATCTCGCCCGCTCGTTCGACCAGCGCGTC
GGCCTCACCGGCATCGCGCTGACCCGGATCGACGGCGACGGCCGCGGCGGCGCGGCGCTGTCGATGCGCGCGGTCACCGG
CAAGCCGATCAAGCTGCTCGGCACCGGCGAAAAGACCGATGCGCTGGAGGACTTCTATCCCTCGCGGATCGCTGGCCGCA
TCCTCGGCATGGGCGACATCGTCTCGCTGGTCGAGAAGGCCGCGGCGAACATCGACGCCGAGAAGGCCGCGCGCGCCGCC
GAGAAGATGCGCAAGGGTCAGTTCGACCTCAACGACATGCGCGAGCAGCTGCTGCAGATGTCGCAGATGGGCGGCATCAG
CGGGCTGATGGGCATGATGCCCGGCATCTCCAAGATGAAGAACCAGATCGCTGCCGCCGGAATCGACGACAAGATCCTCA
AGCGCCAGGTCGCGATCATCGATTCGATGACCCGCGAGGAGCGCAAGCATCCCGACCTGCTCAAGGCGAGCCGCAAGAAG
CGTATCGCCGCAGGCTCCGGCCAGAGCGTCGAGCACGTCAACAAGCTGCTCAAGATGCACCGGAACATGGCCGACGTGAT
GAAGGCCATGGGCTCCGGCAAGCGCGGCCCGCTCGCCGGCATCGCCCAGGCGATGGGCTTCGGCGGCGGTGGCGGCATGC
CCTCGCCCGAGCAGCTCAAGGCGCTGGCCGACAAGATGCCGGGCGGCATGCCCGGCGGCCTGCCGAACTTGCCGAAGGAT
CTTCCCGCCGGCCTGCGTGGCGGTTTGCCCAATCTGCCGGGGCTTACCGGTCTCAGCGGCAAGCCGACGCTCCCCGGCCT
CGGGCTTCCTCCGGGGAAGAAGAAATGA

Upstream 100 bases:

>100_bases
GTCTATATGGTCGTGGTCTATATAGTCGTCATGGGCCGCAGCAAGCGGCGATGACGGGCGGCAACGAAGCGAGCGCCCGA
CAAGGGCAAAGGATACGACA

Downstream 100 bases:

>100_bases
CCTCACTCCCGTCATTGCGAGGAGCGAAGCGACGAAGCAATCCAGAGTCGCGCGTGCCGCCCTGGATTGCTTCGCTTCGC
TCGCAATGACGACTTCTATC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MFDNLSERLGGILDRLTGRGSLSEADVDAAMREVRRALLEADVALEVVRSFTDRVREQAIGATVVKSVTPGQMVVKIVHD
ELVKTLGDDGQTIDLNAVPPVPIMMVGLQGSGKTTTTAKLARRMVQRDKRKVLMASLDVYRPAAMEQLAVLGRDLDIPTL
PIVAGQMPPQIARRAIEAAKLGGYDVVLLDTAGRTTLDEDMMKEAAEIKAVANPHEVLLVADSLTGQDAVNLARSFDQRV
GLTGIALTRIDGDGRGGAALSMRAVTGKPIKLLGTGEKTDALEDFYPSRIAGRILGMGDIVSLVEKAAANIDAEKAARAA
EKMRKGQFDLNDMREQLLQMSQMGGISGLMGMMPGISKMKNQIAAAGIDDKILKRQVAIIDSMTREERKHPDLLKASRKK
RIAAGSGQSVEHVNKLLKMHRNMADVMKAMGSGKRGPLAGIAQAMGFGGGGGMPSPEQLKALADKMPGGMPGGLPNLPKD
LPAGLRGGLPNLPGLTGLSGKPTLPGLGLPPGKKK

Sequences:

>Translated_515_residues
MFDNLSERLGGILDRLTGRGSLSEADVDAAMREVRRALLEADVALEVVRSFTDRVREQAIGATVVKSVTPGQMVVKIVHD
ELVKTLGDDGQTIDLNAVPPVPIMMVGLQGSGKTTTTAKLARRMVQRDKRKVLMASLDVYRPAAMEQLAVLGRDLDIPTL
PIVAGQMPPQIARRAIEAAKLGGYDVVLLDTAGRTTLDEDMMKEAAEIKAVANPHEVLLVADSLTGQDAVNLARSFDQRV
GLTGIALTRIDGDGRGGAALSMRAVTGKPIKLLGTGEKTDALEDFYPSRIAGRILGMGDIVSLVEKAAANIDAEKAARAA
EKMRKGQFDLNDMREQLLQMSQMGGISGLMGMMPGISKMKNQIAAAGIDDKILKRQVAIIDSMTREERKHPDLLKASRKK
RIAAGSGQSVEHVNKLLKMHRNMADVMKAMGSGKRGPLAGIAQAMGFGGGGGMPSPEQLKALADKMPGGMPGGLPNLPKD
LPAGLRGGLPNLPGLTGLSGKPTLPGLGLPPGKKK
>Mature_515_residues
MFDNLSERLGGILDRLTGRGSLSEADVDAAMREVRRALLEADVALEVVRSFTDRVREQAIGATVVKSVTPGQMVVKIVHD
ELVKTLGDDGQTIDLNAVPPVPIMMVGLQGSGKTTTTAKLARRMVQRDKRKVLMASLDVYRPAAMEQLAVLGRDLDIPTL
PIVAGQMPPQIARRAIEAAKLGGYDVVLLDTAGRTTLDEDMMKEAAEIKAVANPHEVLLVADSLTGQDAVNLARSFDQRV
GLTGIALTRIDGDGRGGAALSMRAVTGKPIKLLGTGEKTDALEDFYPSRIAGRILGMGDIVSLVEKAAANIDAEKAARAA
EKMRKGQFDLNDMREQLLQMSQMGGISGLMGMMPGISKMKNQIAAAGIDDKILKRQVAIIDSMTREERKHPDLLKASRKK
RIAAGSGQSVEHVNKLLKMHRNMADVMKAMGSGKRGPLAGIAQAMGFGGGGGMPSPEQLKALADKMPGGMPGGLPNLPKD
LPAGLRGGLPNLPGLTGLSGKPTLPGLGLPPGKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=523, Percent_Identity=30.7839388145315, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI226371618, Length=454, Percent_Identity=31.9383259911894, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=28.5234899328859, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=28.5234899328859, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI89061728, Length=139, Percent_Identity=32.3741007194245, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=52.3584905660377, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=36.6533864541833, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=428, Percent_Identity=31.7757009345794, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=30.6122448979592, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=487, Percent_Identity=33.0595482546201, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6320498, Length=320, Percent_Identity=25, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=29.6380090497738, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641198, Length=303, Percent_Identity=30.03300330033, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54520; Mature: 54520

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSERLGGILDRLTGRGSLSEADVDAAMREVRRALLEADVALEVVRSFTDRVREQAI
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATVVKSVTPGQMVVKIVHDELVKTLGDDGQTIDLNAVPPVPIMMVGLQGSGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHH
ARRMVQRDKRKVLMASLDVYRPAAMEQLAVLGRDLDIPTLPIVAGQMPPQIARRAIEAAK
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHHHH
LGGYDVVLLDTAGRTTLDEDMMKEAAEIKAVANPHEVLLVADSLTGQDAVNLARSFDQRV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GLTGIALTRIDGDGRGGAALSMRAVTGKPIKLLGTGEKTDALEDFYPSRIAGRILGMGDI
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHH
VSLVEKAAANIDAEKAARAAEKMRKGQFDLNDMREQLLQMSQMGGISGLMGMMPGISKMK
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
NQIAAAGIDDKILKRQVAIIDSMTREERKHPDLLKASRKKRIAAGSGQSVEHVNKLLKMH
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RNMADVMKAMGSGKRGPLAGIAQAMGFGGGGGMPSPEQLKALADKMPGGMPGGLPNLPKD
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
LPAGLRGGLPNLPGLTGLSGKPTLPGLGLPPGKKK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDNLSERLGGILDRLTGRGSLSEADVDAAMREVRRALLEADVALEVVRSFTDRVREQAI
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATVVKSVTPGQMVVKIVHDELVKTLGDDGQTIDLNAVPPVPIMMVGLQGSGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHH
ARRMVQRDKRKVLMASLDVYRPAAMEQLAVLGRDLDIPTLPIVAGQMPPQIARRAIEAAK
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHHHH
LGGYDVVLLDTAGRTTLDEDMMKEAAEIKAVANPHEVLLVADSLTGQDAVNLARSFDQRV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GLTGIALTRIDGDGRGGAALSMRAVTGKPIKLLGTGEKTDALEDFYPSRIAGRILGMGDI
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHH
VSLVEKAAANIDAEKAARAAEKMRKGQFDLNDMREQLLQMSQMGGISGLMGMMPGISKMK
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
NQIAAAGIDDKILKRQVAIIDSMTREERKHPDLLKASRKKRIAAGSGQSVEHVNKLLKMH
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RNMADVMKAMGSGKRGPLAGIAQAMGFGGGGGMPSPEQLKALADKMPGGMPGGLPNLPKD
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
LPAGLRGGLPNLPGLTGLSGKPTLPGLGLPPGKKK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]