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The map label for this gene is mltA [H]

Identifier: 146337372

GI number: 146337372

Start: 218707

End: 220335

Strand: Direct

Name: mltA [H]

Synonym: BRADO0205

Alternate gene names: 146337372

Gene position: 218707-220335 (Clockwise)

Preceding gene: 146337371

Following gene: 146337373

Centisome position: 2.93

GC content: 65.68

Gene sequence:

>1629_bases
ATGGTTCGCGAAATTTGGAAGCGGGTTTTTACCGCCCGCAGCCTCAGATATTGGACTCCCGCGCTCGCTCTGAGCGTCGC
GGCCGTTGCGCTCGCACCCTATGCCGCGGAGGCGGTTCGCGCGCGGCACCGCGCGGCCTCCCCGCCGATGCGCCACCTGC
CCTACCCGCAGCTCGACTGGCCCATGGAGATCACCAACAGCCAGTATCAACCGCTGTCCTGGAGCGACGTGCCCGGCTGG
AACGATGATGATCAGCTCGCGGCCTATCGGACGTTCCGCGCCAGCTGCAAGCCGATTGCCGCGAAGACAGACGCTACGCC
CGAGGACAAGGCCCTCGGCGATTCCTTGCGCGATCCCTGCCGTGAGGCACGAACCGCCGAGCTCGCCGACAGCGCCGCGG
CGCGCGCGTTCTTCGAACGCCATTTCGAGCCGCTGAAGATCTCCAAGCTCGGCGACGCCGACGGCTTCGTCACCGGCTAC
TACGAGCCTGTGATCGAGGGCTCGCGGACGCAGAACGAGGTCTACAACGTTCCGGTCTATCGCCGCCCCTCGAACCTCTT
CGTCCGCGGCTTCAAGCAGGACTCCGCGAGCCTGCCCAACAAGGGCCCGGTGTATCGCAAGATCGGACGGCGCAAGCTCG
TGCCCTATTACGATCGCGCCGAGATCGAGGATGGTGCCATCGAGGGGCGTGGCCTGGAGATCGCTTGGCTGAGAAATCAG
ACGGACCTGTTGTTCGCGCAGATCCAGGGCTCCGCCCGTATCAGCCTCGATGACGGCTCCACCGTACGCATCAACTACGA
CGCCTATAACGGCCATCCCTACACGCCGGTTGGCCGCATCCTGATCGAGCGCGGCATCATTCCGCGCGAGCAGATGTCGA
TGCAGCGGATCCGCGAATGGATGGAGCAGAATCCGCAAGGCGCCGACGAGCTGCGCCGGATGAACCGCTCCTACATCTTC
TTCCGCGAGGTGCAGCTGTCGGAGAAGGACGAGGCCGTCGGCGCGCAGGGCATTCCGCTGACGCCGGGCCGCTCGATCGC
CGTCGACAAGTCGCTGCACGTCTACGGCACGCCCTTCTTCATCACCGGCGAGCTGCCGATCGACTCCGAGAAGCAGAAGA
ATCCGTTCCACCGGCTGATGATCGCGCAGGATACGGGATCGGCGATCGTGGGCCCTGCCCGTGCCGATCTGTATTTCGGC
GCGGGACAGGAGGCCGGCAAGGTCTCAGGCCGGCTCAAGCACAGCATCCAGTTCGTGATGCTGGTGCCGAAGAGCCTCGA
TCCGGTCGCGCGCGGCCGCAAGATGCCGCTGCCGGATGCGCGGCCTTCGGAGAGGATCGCGAAACTTTTCCCGCAGGTTC
TGCCGAAGGAGCCGGTCAAGGACGCGCAGACGGAGCCGGCGAAGGATCAGTCAAAGGATCCGGCCAAGAGCCAGGACCAG
CCCAGCACCGCCGCCTCCTCTGTCAAGGATGCGAAGGCCCCTGCCCCGGCGGCCGGCGCGAGCGCGACGACCACGGTGGC
GCAGAACATCATCGCACCCGTGCCGCTGCCGGAGGCGCGGCCACGGCTTGAAAGTGATCGCAATTCCCGCCGATTGCGTT
ATGGCAGGCGTCACCGCAATCATCCATGA

Upstream 100 bases:

>100_bases
CGAACCCCCCACGCGAAAGAAAGACATTCGAACGGCAGCCAGATTTTCTTAACTCTGTTTTTCCGAATTTCGCGTTGAGT
GATCCTTTGATGGTGCTGGC

Downstream 100 bases:

>100_bases
ACCGCCGCCTCCATGTCGCATGACCCCGATCCTCCGCGTGGCCGCCGCAAGCGCGGCCTCTCCGAGGACGAGCGCGCGCT
GTGGGAGACGGTGGCGCGAC

Product: putative membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MVREIWKRVFTARSLRYWTPALALSVAAVALAPYAAEAVRARHRAASPPMRHLPYPQLDWPMEITNSQYQPLSWSDVPGW
NDDDQLAAYRTFRASCKPIAAKTDATPEDKALGDSLRDPCREARTAELADSAAARAFFERHFEPLKISKLGDADGFVTGY
YEPVIEGSRTQNEVYNVPVYRRPSNLFVRGFKQDSASLPNKGPVYRKIGRRKLVPYYDRAEIEDGAIEGRGLEIAWLRNQ
TDLLFAQIQGSARISLDDGSTVRINYDAYNGHPYTPVGRILIERGIIPREQMSMQRIREWMEQNPQGADELRRMNRSYIF
FREVQLSEKDEAVGAQGIPLTPGRSIAVDKSLHVYGTPFFITGELPIDSEKQKNPFHRLMIAQDTGSAIVGPARADLYFG
AGQEAGKVSGRLKHSIQFVMLVPKSLDPVARGRKMPLPDARPSERIAKLFPQVLPKEPVKDAQTEPAKDQSKDPAKSQDQ
PSTAASSVKDAKAPAPAAGASATTTVAQNIIAPVPLPEARPRLESDRNSRRLRYGRRHRNHP

Sequences:

>Translated_542_residues
MVREIWKRVFTARSLRYWTPALALSVAAVALAPYAAEAVRARHRAASPPMRHLPYPQLDWPMEITNSQYQPLSWSDVPGW
NDDDQLAAYRTFRASCKPIAAKTDATPEDKALGDSLRDPCREARTAELADSAAARAFFERHFEPLKISKLGDADGFVTGY
YEPVIEGSRTQNEVYNVPVYRRPSNLFVRGFKQDSASLPNKGPVYRKIGRRKLVPYYDRAEIEDGAIEGRGLEIAWLRNQ
TDLLFAQIQGSARISLDDGSTVRINYDAYNGHPYTPVGRILIERGIIPREQMSMQRIREWMEQNPQGADELRRMNRSYIF
FREVQLSEKDEAVGAQGIPLTPGRSIAVDKSLHVYGTPFFITGELPIDSEKQKNPFHRLMIAQDTGSAIVGPARADLYFG
AGQEAGKVSGRLKHSIQFVMLVPKSLDPVARGRKMPLPDARPSERIAKLFPQVLPKEPVKDAQTEPAKDQSKDPAKSQDQ
PSTAASSVKDAKAPAPAAGASATTTVAQNIIAPVPLPEARPRLESDRNSRRLRYGRRHRNHP
>Mature_542_residues
MVREIWKRVFTARSLRYWTPALALSVAAVALAPYAAEAVRARHRAASPPMRHLPYPQLDWPMEITNSQYQPLSWSDVPGW
NDDDQLAAYRTFRASCKPIAAKTDATPEDKALGDSLRDPCREARTAELADSAAARAFFERHFEPLKISKLGDADGFVTGY
YEPVIEGSRTQNEVYNVPVYRRPSNLFVRGFKQDSASLPNKGPVYRKIGRRKLVPYYDRAEIEDGAIEGRGLEIAWLRNQ
TDLLFAQIQGSARISLDDGSTVRINYDAYNGHPYTPVGRILIERGIIPREQMSMQRIREWMEQNPQGADELRRMNRSYIF
FREVQLSEKDEAVGAQGIPLTPGRSIAVDKSLHVYGTPFFITGELPIDSEKQKNPFHRLMIAQDTGSAIVGPARADLYFG
AGQEAGKVSGRLKHSIQFVMLVPKSLDPVARGRKMPLPDARPSERIAKLFPQVLPKEPVKDAQTEPAKDQSKDPAKSQDQ
PSTAASSVKDAKAPAPAAGASATTTVAQNIIAPVPLPEARPRLESDRNSRRLRYGRRHRNHP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=262, Percent_Identity=32.824427480916, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 60571; Mature: 60571

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREIWKRVFTARSLRYWTPALALSVAAVALAPYAAEAVRARHRAASPPMRHLPYPQLDW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCC
PMEITNSQYQPLSWSDVPGWNDDDQLAAYRTFRASCKPIAAKTDATPEDKALGDSLRDPC
CHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
REARTAELADSAAARAFFERHFEPLKISKLGDADGFVTGYYEPVIEGSRTQNEVYNVPVY
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCHHHHHCCCCCCCCEECCCCE
RRPSNLFVRGFKQDSASLPNKGPVYRKIGRRKLVPYYDRAEIEDGAIEGRGLEIAWLRNQ
ECCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
TDLLFAQIQGSARISLDDGSTVRINYDAYNGHPYTPVGRILIERGIIPREQMSMQRIREW
CCEEEEEECCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
MEQNPQGADELRRMNRSYIFFREVQLSEKDEAVGAQGIPLTPGRSIAVDKSLHVYGTPFF
HHCCCCCHHHHHHCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCEEECCCEEEEECCEE
ITGELPIDSEKQKNPFHRLMIAQDTGSAIVGPARADLYFGAGQEAGKVSGRLKHSIQFVM
EECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCEEECCCCCCHHHHHHHHHCEEEEE
LVPKSLDPVARGRKMPLPDARPSERIAKLFPQVLPKEPVKDAQTEPAKDQSKDPAKSQDQ
ECCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSTAASSVKDAKAPAPAAGASATTTVAQNIIAPVPLPEARPRLESDRNSRRLRYGRRHRN
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
HP
CC
>Mature Secondary Structure
MVREIWKRVFTARSLRYWTPALALSVAAVALAPYAAEAVRARHRAASPPMRHLPYPQLDW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCC
PMEITNSQYQPLSWSDVPGWNDDDQLAAYRTFRASCKPIAAKTDATPEDKALGDSLRDPC
CHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
REARTAELADSAAARAFFERHFEPLKISKLGDADGFVTGYYEPVIEGSRTQNEVYNVPVY
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCHHHHHCCCCCCCCEECCCCE
RRPSNLFVRGFKQDSASLPNKGPVYRKIGRRKLVPYYDRAEIEDGAIEGRGLEIAWLRNQ
ECCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
TDLLFAQIQGSARISLDDGSTVRINYDAYNGHPYTPVGRILIERGIIPREQMSMQRIREW
CCEEEEEECCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
MEQNPQGADELRRMNRSYIFFREVQLSEKDEAVGAQGIPLTPGRSIAVDKSLHVYGTPFF
HHCCCCCHHHHHHCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCEEECCCEEEEECCEE
ITGELPIDSEKQKNPFHRLMIAQDTGSAIVGPARADLYFGAGQEAGKVSGRLKHSIQFVM
EECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCEEECCCCCCHHHHHHHHHCEEEEE
LVPKSLDPVARGRKMPLPDARPSERIAKLFPQVLPKEPVKDAQTEPAKDQSKDPAKSQDQ
ECCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSTAASSVKDAKAPAPAAGASATTTVAQNIIAPVPLPEARPRLESDRNSRRLRYGRRHRN
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
HP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]