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The map label for this gene is ilvD [H]

Identifier: 146300963

GI number: 146300963

Start: 3834221

End: 3835909

Strand: Direct

Name: ilvD [H]

Synonym: Fjoh_3218

Alternate gene names: 146300963

Gene position: 3834221-3835909 (Clockwise)

Preceding gene: 146300962

Following gene: 146300964

Centisome position: 62.89

GC content: 41.21

Gene sequence:

>1689_bases
ATGAGAAGCGATGAAGTAAAAAAAGGAGTTCAAAGAACCCCTCACAGATCCTTATTGAGAGCAACAGGATTAAAAAATGA
AGATTTTGGAAAACCATTTATCGGCGTTGCCAATTCATTTATTGAAATTATTCCGGGGCATTTTTTCCTAAATAAAGTAT
CTGAAATTATTAAGGAAGAAATCAGGGCAAACGGCTGTGTTCCTTTTGAGTTCAATACAATTGGAATCGACGACGGAATT
GCAATGGGCCACGACGGAATGCTGTACTCACTGCCAAGCCGTGAAATTATCGCCAACTCTATCGAAAGCGTTATGAATGC
ACATAAACTCGACGCTATGATTGCCATTCCTAACTGCGACAAAATCGTTCCGGGAATGATTATGGGCGCTCTGCGGGTTG
ATGTTCCAACTATTTTTGTAAGCGGCGGGCCAATGTCGAAAGGATATACAAAAAATGGTACTCCAATTGATCTGGCTACA
GCTTTTGAAGCCGTTGGAAAACACGAAGCAGGAAGCATTACAGATGAAGAATTATACGATATTGAATGCAATGCCTGCCC
TAGCGGCGGAAGCTGTTCTGGAATGTTTACAGCAAATTCTATGAATACTTTAATGGAAGCCATGGGAATTGCACTGCCCG
GCAACGGAACTATTTTGGCTCAAACTCCGGAAAGAGAACAATTATACCGCAAGGCAGCACGAAGAATTTGTGCCATTGCA
AAAGACCAGCACGATATTGAAAAGTTTAAACTAAAGAACATTCTAAACGAAAATGCGGTACGAAATGCTTTTGCGGTTGA
TATGGCTATGGGCGGCAGCAGCAACACTGTTCTGCATATGCTAGCCATTGCGAATGAAGCCAATGTAGATTTTAAACTAA
AAGACATTAATACCATTTCCGGCAATGTATCGCATATTGCTAAAATATCGCCAAGTTTAAGCACCGTTCACATGGAAGAC
ATAAACAGAGCCGGAGGCGTTAATGCGGTTATGAAAGAAATGAACAAAAGAGGTTCTGGTGTTTTAATTGATAATCTGAC
TATAAGCGGCGAAACTTTACTGGAAAAAATTGATAATGCAGAAATTAAAGACACGACGATTATTCATACCATTGATAATC
CGTACAGCAGTGTGGGCGGACTTGCTGTTTTATATGGAAATCTTGCCGAAGAAGGCGCTGTAATTAAAACGGCAGGACTT
ACAGGCGCAAGAGTTTTTACAGGAAAAGCGGTTTGTTTTGACGGTCAGGCCGAAGCCATTGCCGGAATCATGATGGGAAA
AGTAAAAGCCGGAAATGTAGTTGTTATTCGATACGAAGGTCCAAAAGGCGGTCCCGGAATGCAGGAAATGCTGGCTCCAA
CGAGTTTAATTATGGGTATGGGACTAGGAAGTTCTGTAGCTTTAATTACAGACGGAAGGTTCAGCGGTGCTACAAGAGGC
GCTTCTATTGGACATGTTTCTCCCGAAGCTGCAGAAGGCGGTATGATTGGCCTGCTTAAAGACGGCGATGAAATTCATAT
TGATGTCGATCAGTATATCTTGTCGGTTAACTTATCTGATGAAGAAATTAAAACCAGAAAAGCCGCTTTTCAACCCATAA
AAAAAGTATTAAACTCAAAATGGCTTGGGCAGTACAGAGCTTTAGTTACCAATGCAAGTAATGGCGCCATTTTAAAAACT
GATTTATAA

Upstream 100 bases:

>100_bases
GCTTATCTTAATATTTCTCCGGAAACATTAAGCCGTATAAAGTCGCAGATTTAACTTTTTATACTTCGGCACACCAATTC
AAAAAACAAAAAAACATATA

Downstream 100 bases:

>100_bases
GATTTTAAATACTATTGAAAACCGAAAACTTCTCGTTTCTTATGGGAAGTTTTTTTATTTTAAGAAATATCGTAATCTAA
AAGTTTGCAAAAAAATCTAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRSDEVKKGVQRTPHRSLLRATGLKNEDFGKPFIGVANSFIEIIPGHFFLNKVSEIIKEEIRANGCVPFEFNTIGIDDGI
AMGHDGMLYSLPSREIIANSIESVMNAHKLDAMIAIPNCDKIVPGMIMGALRVDVPTIFVSGGPMSKGYTKNGTPIDLAT
AFEAVGKHEAGSITDEELYDIECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILAQTPEREQLYRKAARRICAIA
KDQHDIEKFKLKNILNENAVRNAFAVDMAMGGSSNTVLHMLAIANEANVDFKLKDINTISGNVSHIAKISPSLSTVHMED
INRAGGVNAVMKEMNKRGSGVLIDNLTISGETLLEKIDNAEIKDTTIIHTIDNPYSSVGGLAVLYGNLAEEGAVIKTAGL
TGARVFTGKAVCFDGQAEAIAGIMMGKVKAGNVVVIRYEGPKGGPGMQEMLAPTSLIMGMGLGSSVALITDGRFSGATRG
ASIGHVSPEAAEGGMIGLLKDGDEIHIDVDQYILSVNLSDEEIKTRKAAFQPIKKVLNSKWLGQYRALVTNASNGAILKT
DL

Sequences:

>Translated_562_residues
MRSDEVKKGVQRTPHRSLLRATGLKNEDFGKPFIGVANSFIEIIPGHFFLNKVSEIIKEEIRANGCVPFEFNTIGIDDGI
AMGHDGMLYSLPSREIIANSIESVMNAHKLDAMIAIPNCDKIVPGMIMGALRVDVPTIFVSGGPMSKGYTKNGTPIDLAT
AFEAVGKHEAGSITDEELYDIECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILAQTPEREQLYRKAARRICAIA
KDQHDIEKFKLKNILNENAVRNAFAVDMAMGGSSNTVLHMLAIANEANVDFKLKDINTISGNVSHIAKISPSLSTVHMED
INRAGGVNAVMKEMNKRGSGVLIDNLTISGETLLEKIDNAEIKDTTIIHTIDNPYSSVGGLAVLYGNLAEEGAVIKTAGL
TGARVFTGKAVCFDGQAEAIAGIMMGKVKAGNVVVIRYEGPKGGPGMQEMLAPTSLIMGMGLGSSVALITDGRFSGATRG
ASIGHVSPEAAEGGMIGLLKDGDEIHIDVDQYILSVNLSDEEIKTRKAAFQPIKKVLNSKWLGQYRALVTNASNGAILKT
DL
>Mature_562_residues
MRSDEVKKGVQRTPHRSLLRATGLKNEDFGKPFIGVANSFIEIIPGHFFLNKVSEIIKEEIRANGCVPFEFNTIGIDDGI
AMGHDGMLYSLPSREIIANSIESVMNAHKLDAMIAIPNCDKIVPGMIMGALRVDVPTIFVSGGPMSKGYTKNGTPIDLAT
AFEAVGKHEAGSITDEELYDIECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILAQTPEREQLYRKAARRICAIA
KDQHDIEKFKLKNILNENAVRNAFAVDMAMGGSSNTVLHMLAIANEANVDFKLKDINTISGNVSHIAKISPSLSTVHMED
INRAGGVNAVMKEMNKRGSGVLIDNLTISGETLLEKIDNAEIKDTTIIHTIDNPYSSVGGLAVLYGNLAEEGAVIKTAGL
TGARVFTGKAVCFDGQAEAIAGIMMGKVKAGNVVVIRYEGPKGGPGMQEMLAPTSLIMGMGLGSSVALITDGRFSGATRG
ASIGHVSPEAAEGGMIGLLKDGDEIHIDVDQYILSVNLSDEEIKTRKAAFQPIKKVLNSKWLGQYRALVTNASNGAILKT
DL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=45.7990115321252, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1788157, Length=515, Percent_Identity=28.5436893203883, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786464, Length=508, Percent_Identity=31.496062992126, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI2367371, Length=563, Percent_Identity=30.3730017761989, Blast_Score=178, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=39.7137745974955, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59813; Mature: 59813

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDEVKKGVQRTPHRSLLRATGLKNEDFGKPFIGVANSFIEIIPGHFFLNKVSEIIKEE
CCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IRANGCVPFEFNTIGIDDGIAMGHDGMLYSLPSREIIANSIESVMNAHKLDAMIAIPNCD
HHCCCCCEEEEEEEECCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCC
KIVPGMIMGALRVDVPTIFVSGGPMSKGYTKNGTPIDLATAFEAVGKHEAGSITDEELYD
HHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEE
IECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILAQTPEREQLYRKAARRICAIA
EECCCCCCCCCCCEEEECCHHHHHHHHHCEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
KDQHDIEKFKLKNILNENAVRNAFAVDMAMGGSSNTVLHMLAIANEANVDFKLKDINTIS
CCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCCC
GNVSHIAKISPSLSTVHMEDINRAGGVNAVMKEMNKRGSGVLIDNLTISGETLLEKIDNA
CCHHHHEECCCCCEEEEHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECHHHHHHHHCCC
EIKDTTIIHTIDNPYSSVGGLAVLYGNLAEEGAVIKTAGLTGARVFTGKAVCFDGQAEAI
CCCCEEEEEECCCCCHHHCCEEEEECCCCCCCCEEEECCCCCCEEEECCEEEECCCHHHH
AGIMMGKVKAGNVVVIRYEGPKGGPGMQEMLAPTSLIMGMGLGSSVALITDGRFSGATRG
HHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
ASIGHVSPEAAEGGMIGLLKDGDEIHIDVDQYILSVNLSDEEIKTRKAAFQPIKKVLNSK
CCCCCCCCCCCCCCEEEEEECCCEEEEEHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WLGQYRALVTNASNGAILKTDL
HHHHHHHEEEECCCCEEEEECC
>Mature Secondary Structure
MRSDEVKKGVQRTPHRSLLRATGLKNEDFGKPFIGVANSFIEIIPGHFFLNKVSEIIKEE
CCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IRANGCVPFEFNTIGIDDGIAMGHDGMLYSLPSREIIANSIESVMNAHKLDAMIAIPNCD
HHCCCCCEEEEEEEECCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCC
KIVPGMIMGALRVDVPTIFVSGGPMSKGYTKNGTPIDLATAFEAVGKHEAGSITDEELYD
HHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEE
IECNACPSGGSCSGMFTANSMNTLMEAMGIALPGNGTILAQTPEREQLYRKAARRICAIA
EECCCCCCCCCCCEEEECCHHHHHHHHHCEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
KDQHDIEKFKLKNILNENAVRNAFAVDMAMGGSSNTVLHMLAIANEANVDFKLKDINTIS
CCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCCC
GNVSHIAKISPSLSTVHMEDINRAGGVNAVMKEMNKRGSGVLIDNLTISGETLLEKIDNA
CCHHHHEECCCCCEEEEHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECHHHHHHHHCCC
EIKDTTIIHTIDNPYSSVGGLAVLYGNLAEEGAVIKTAGLTGARVFTGKAVCFDGQAEAI
CCCCEEEEEECCCCCHHHCCEEEEECCCCCCCCEEEECCCCCCEEEECCEEEECCCHHHH
AGIMMGKVKAGNVVVIRYEGPKGGPGMQEMLAPTSLIMGMGLGSSVALITDGRFSGATRG
HHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
ASIGHVSPEAAEGGMIGLLKDGDEIHIDVDQYILSVNLSDEEIKTRKAAFQPIKKVLNSK
CCCCCCCCCCCCCCEEEEEECCCEEEEEHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WLGQYRALVTNASNGAILKTDL
HHHHHHHEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA