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The map label for this gene is lpxC/fabZ [H]

Identifier: 146300652

GI number: 146300652

Start: 3444927

End: 3446324

Strand: Reverse

Name: lpxC/fabZ [H]

Synonym: Fjoh_2903

Alternate gene names: 146300652

Gene position: 3446324-3444927 (Counterclockwise)

Preceding gene: 146300653

Following gene: 146300651

Centisome position: 56.53

GC content: 32.9

Gene sequence:

>1398_bases
ATGGAAATAATGGTTAAACAGAAGACCATCAAAAATGAAATTTCACTAACAGGAGTTGGATTACATACTGGAAAAGAAGT
TACTATGACTTTTAAACCTGCTCCTATTAATAATGGTTTCACTTTTGTAAGAGTAGATTTGCAAGGCCAGCCAGTCATTG
AGGCTGACGCTAATTATGTTGTTAATACGCAAAGAGGAACTAATTTAGAAAAATTAGGTGTTAAAATACAAACTCCTGAA
CACGTTTTAGCTGCAGTAGTTGGTTGCGATTTGGATAATATTATTATTGAATTGAATGCCTCTGAACTACCTATTATGGA
TGGTTCATCAAAATATTTTGTTGAAGCAATTGAAAAAGCCGGAATCGAAGAACAAGACGCAAACCGTAATGTTTATGTAG
TAAAAGAAGTTATTTCGTTTACAGATGAAGCAACAGGAAGTGAAATTCTTGTTATGCCAAGCGATGAATATCAAGTAACT
ACTATGGTAGATTTTGGTACAAAAGTTTTAGGTACTCAAAATGCAACTTTAAAAAGTTTATCAGACTTTAAAGATGAAAT
TGCAAGTTCTAGAACATTCAGCTTTTTGCATGAATTAGAATCATTATTAGAACACGGTTTAATTAAAGGCGGTGATTTAA
ATAACGCAATTGTATATGTAGATAAAGAAATATCTGAGTCTACAATGGAAAATTTAAAGAAAGCTTTTGGTAAAGATGAA
ATATCTGTAAAACCAAACGGCGTTTTAGACAACCTTACTTTACATTATCCAAACGAAGCTGCAAGACACAAATTGCTTGA
TGTTATTGGAGATTTATCTCTAATTGGAGTTCGTATTCAAGGAAAAATTATTGCAAATAAACCTGGGCATTTTGTAAACA
CTCAGTTTGCTAAAAAACTGGCAAAAATCATTAAAATAGAGCAGAGAAATCATGTTCCTGTTTACGATTTGAACCAAGAA
CCATTGATGGATATTCACAAAATCATGTCAATGCTTCCTCACAGACCACCATTCTTGTTAATTGACAGAATTATCGAAAT
GTCTGATCGTCATGTGGTTGGTTTGAAAAATGTTACTATGAATGAGAACTTCTTCGTAGGACATTTCCCTGAGGCTCCAG
TAATGCCGGGAGTTTTAATTGTAGAGGCAATGGCACAAACAGGAGGAATTTTAGTTTTAAGCACAGTTCCAGATCCTGAA
AATTACTTAACATATTTCATGAAAATTGATAATGTTAAGTTTAAACACAAAGTATTGCCAGGTGATACGTTAATTTTTAA
ATGTGAATTGATTTCTCCTATCAGACGAGGAATTTGTCACATGCAGGCTAATGCTTATGCAAATGGAAAATTAGTAACTG
AGGCAGAATTAATGGCACAAATTGCAAGAAAACAATAA

Upstream 100 bases:

>100_bases
GGATATACTGATTTTAATAAATCGTATGTTCACTTTAAAAATCTTCCTAAGATAGTTGCCGAAGTTGAAGAAATAAAAAA
ACAAATAATAAACCCAAAAA

Downstream 100 bases:

>100_bases
TTAATCAAATTTATTGTTTAGGTTTGTTGCCCTAAAATTAGATTATTTTAATTTAAAATATAAAACATAGATGAATCAAC
CATTAGCATATGTTCATCCT

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MEIMVKQKTIKNEISLTGVGLHTGKEVTMTFKPAPINNGFTFVRVDLQGQPVIEADANYVVNTQRGTNLEKLGVKIQTPE
HVLAAVVGCDLDNIIIELNASELPIMDGSSKYFVEAIEKAGIEEQDANRNVYVVKEVISFTDEATGSEILVMPSDEYQVT
TMVDFGTKVLGTQNATLKSLSDFKDEIASSRTFSFLHELESLLEHGLIKGGDLNNAIVYVDKEISESTMENLKKAFGKDE
ISVKPNGVLDNLTLHYPNEAARHKLLDVIGDLSLIGVRIQGKIIANKPGHFVNTQFAKKLAKIIKIEQRNHVPVYDLNQE
PLMDIHKIMSMLPHRPPFLLIDRIIEMSDRHVVGLKNVTMNENFFVGHFPEAPVMPGVLIVEAMAQTGGILVLSTVPDPE
NYLTYFMKIDNVKFKHKVLPGDTLIFKCELISPIRRGICHMQANAYANGKLVTEAELMAQIARKQ

Sequences:

>Translated_465_residues
MEIMVKQKTIKNEISLTGVGLHTGKEVTMTFKPAPINNGFTFVRVDLQGQPVIEADANYVVNTQRGTNLEKLGVKIQTPE
HVLAAVVGCDLDNIIIELNASELPIMDGSSKYFVEAIEKAGIEEQDANRNVYVVKEVISFTDEATGSEILVMPSDEYQVT
TMVDFGTKVLGTQNATLKSLSDFKDEIASSRTFSFLHELESLLEHGLIKGGDLNNAIVYVDKEISESTMENLKKAFGKDE
ISVKPNGVLDNLTLHYPNEAARHKLLDVIGDLSLIGVRIQGKIIANKPGHFVNTQFAKKLAKIIKIEQRNHVPVYDLNQE
PLMDIHKIMSMLPHRPPFLLIDRIIEMSDRHVVGLKNVTMNENFFVGHFPEAPVMPGVLIVEAMAQTGGILVLSTVPDPE
NYLTYFMKIDNVKFKHKVLPGDTLIFKCELISPIRRGICHMQANAYANGKLVTEAELMAQIARKQ
>Mature_465_residues
MEIMVKQKTIKNEISLTGVGLHTGKEVTMTFKPAPINNGFTFVRVDLQGQPVIEADANYVVNTQRGTNLEKLGVKIQTPE
HVLAAVVGCDLDNIIIELNASELPIMDGSSKYFVEAIEKAGIEEQDANRNVYVVKEVISFTDEATGSEILVMPSDEYQVT
TMVDFGTKVLGTQNATLKSLSDFKDEIASSRTFSFLHELESLLEHGLIKGGDLNNAIVYVDKEISESTMENLKKAFGKDE
ISVKPNGVLDNLTLHYPNEAARHKLLDVIGDLSLIGVRIQGKIIANKPGHFVNTQFAKKLAKIIKIEQRNHVPVYDLNQE
PLMDIHKIMSMLPHRPPFLLIDRIIEMSDRHVVGLKNVTMNENFFVGHFPEAPVMPGVLIVEAMAQTGGILVLSTVPDPE
NYLTYFMKIDNVKFKHKVLPGDTLIFKCELISPIRRGICHMQANAYANGKLVTEAELMAQIARKQ

Specific function: Involved in saturated fatty acids biosynthesis [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=323, Percent_Identity=34.984520123839, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786377, Length=144, Percent_Identity=43.75, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF07977 FabA; PF03331 LpxC [H]

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 51704; Mature: 51704

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIMVKQKTIKNEISLTGVGLHTGKEVTMTFKPAPINNGFTFVRVDLQGQPVIEADANYV
CCEEEECHHHCCCEEEEEEEEECCCEEEEEEECCCCCCCEEEEEEEECCCCEEECCCCEE
VNTQRGTNLEKLGVKIQTPEHVLAAVVGCDLDNIIIELNASELPIMDGSSKYFVEAIEKA
EECCCCCCHHHHCEEEECHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHC
GIEEQDANRNVYVVKEVISFTDEATGSEILVMPSDEYQVTTMVDFGTKVLGTQNATLKSL
CCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCEEECCCCCHHHHH
SDFKDEIASSRTFSFLHELESLLEHGLIKGGDLNNAIVYVDKEISESTMENLKKAFGKDE
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCC
ISVKPNGVLDNLTLHYPNEAARHKLLDVIGDLSLIGVRIQGKIIANKPGHFVNTQFAKKL
EEECCCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCHHHHHHH
AKIIKIEQRNHVPVYDLNQEPLMDIHKIMSMLPHRPPFLLIDRIIEMSDRHVVGLKNVTM
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECEEE
NENFFVGHFPEAPVMPGVLIVEAMAQTGGILVLSTVPDPENYLTYFMKIDNVKFKHKVLP
CCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHEEEEEEECCEEEEEEECC
GDTLIFKCELISPIRRGICHMQANAYANGKLVTEAELMAQIARKQ
CCEEEEEEEHHHHHHHHHEEEECCCCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MEIMVKQKTIKNEISLTGVGLHTGKEVTMTFKPAPINNGFTFVRVDLQGQPVIEADANYV
CCEEEECHHHCCCEEEEEEEEECCCEEEEEEECCCCCCCEEEEEEEECCCCEEECCCCEE
VNTQRGTNLEKLGVKIQTPEHVLAAVVGCDLDNIIIELNASELPIMDGSSKYFVEAIEKA
EECCCCCCHHHHCEEEECHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHC
GIEEQDANRNVYVVKEVISFTDEATGSEILVMPSDEYQVTTMVDFGTKVLGTQNATLKSL
CCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCEEECCCCCHHHHH
SDFKDEIASSRTFSFLHELESLLEHGLIKGGDLNNAIVYVDKEISESTMENLKKAFGKDE
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCC
ISVKPNGVLDNLTLHYPNEAARHKLLDVIGDLSLIGVRIQGKIIANKPGHFVNTQFAKKL
EEECCCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCHHHHHHH
AKIIKIEQRNHVPVYDLNQEPLMDIHKIMSMLPHRPPFLLIDRIIEMSDRHVVGLKNVTM
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECEEE
NENFFVGHFPEAPVMPGVLIVEAMAQTGGILVLSTVPDPENYLTYFMKIDNVKFKHKVLP
CCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHEEEEEEECCEEEEEEECC
GDTLIFKCELISPIRRGICHMQANAYANGKLVTEAELMAQIARKQ
CCEEEEEEEHHHHHHHHHEEEECCCCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]