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The map label for this gene is lpxD [H]

Identifier: 146300649

GI number: 146300649

Start: 3442310

End: 3443239

Strand: Reverse

Name: lpxD [H]

Synonym: Fjoh_2900

Alternate gene names: 146300649

Gene position: 3443239-3442310 (Counterclockwise)

Preceding gene: 146300650

Following gene: 146300648

Centisome position: 56.48

GC content: 34.95

Gene sequence:

>930_bases
ATGAAATTTCCAAAGAGTCATTCTTTACAAGAAATTGCAAATTTGCTTAACTGCAAATTTATTGGAGACAAAGACTTTCA
GGTTTTAGGTATGAACGAAATACAAGTCGTTGAACCTGGAGATATTGTTTTTGTTGACCATCCAAAATATTACGATAAAG
CTTTACAGTCTGCGGCCACTATCGTTTTAATTAACAAAGAAGTGGAATGCCCGGAAGGTAAAGCTCTTTTGATTTCTGAT
GATCCTTTCAGAGATTTCAATACTTTAACCAGACATTTTAAACCATTTCAATTTGCTAATGTTGCAATCTCAGCTACAGC
ACAAATTGGAGAAGGAACTGTAATTCAGCCAAATAGTTTTATTGGTAATCATGTTAAAATTGGTAAGAACTGTTTGATTC
ACTCAAATGTGTCAATTTATGATCATACCGTGATTGGTGATAATGTTATTATACATGCCGGAAGTATTTTAGGAGCTGAT
GCTTTCTATTATAAAAAACGTCCGGAAGGATTCGATCAGTTAATATCTGGCGGAAGAGTTGTTATTGAAGACAATGTTGG
TATTGGTGCTCTTTGTACAATTGACAAAGGAGTTACTGGAGATACAACAATTAAAGAAGGTACAAAACTGGATAATCAGG
TTCATGTTGGACATGATACAGTTATCGGAAAAAAATGTTTGATTGCATCACAAACAGGTATCGCCGGATGTGTTGTTATT
GAAGATGAAGTTACAATTTGGGGACAAGTAGGAACCACCAGCGGCATTACGATAGGAGCAAAGGCTGTTATTATGGGGCA
GACAGGTGTTACTAAATCTGTAGAAGGAGGGAAATCTTACTTTGGAACTCCAATTGAAGAATCAAGAGAAAAGTTAAAGC
AACTGGCTAATATCAAAAAGATTCCTGAAATTCTAAATAAATTGAAGTAA

Upstream 100 bases:

>100_bases
GACAATGAGTCAATTAGATAATTTGTGAATCGACATAATTTTGTATATTCACATTCTAATTGACTCATTTTCTAATTGAC
AAATTTTCTAATTATTATAT

Downstream 100 bases:

>100_bases
TATGTCTATAAAAGAGTTTGTTCAAAAATTTTATAAGTCGGATGCCTTGATTGATAGTGAAGTTCTAAAAACTTATCTGC
ATCCAGATGTTATCATTGAA

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKFPKSHSLQEIANLLNCKFIGDKDFQVLGMNEIQVVEPGDIVFVDHPKYYDKALQSAATIVLINKEVECPEGKALLISD
DPFRDFNTLTRHFKPFQFANVAISATAQIGEGTVIQPNSFIGNHVKIGKNCLIHSNVSIYDHTVIGDNVIIHAGSILGAD
AFYYKKRPEGFDQLISGGRVVIEDNVGIGALCTIDKGVTGDTTIKEGTKLDNQVHVGHDTVIGKKCLIASQTGIAGCVVI
EDEVTIWGQVGTTSGITIGAKAVIMGQTGVTKSVEGGKSYFGTPIEESREKLKQLANIKKIPEILNKLK

Sequences:

>Translated_309_residues
MKFPKSHSLQEIANLLNCKFIGDKDFQVLGMNEIQVVEPGDIVFVDHPKYYDKALQSAATIVLINKEVECPEGKALLISD
DPFRDFNTLTRHFKPFQFANVAISATAQIGEGTVIQPNSFIGNHVKIGKNCLIHSNVSIYDHTVIGDNVIIHAGSILGAD
AFYYKKRPEGFDQLISGGRVVIEDNVGIGALCTIDKGVTGDTTIKEGTKLDNQVHVGHDTVIGKKCLIASQTGIAGCVVI
EDEVTIWGQVGTTSGITIGAKAVIMGQTGVTKSVEGGKSYFGTPIEESREKLKQLANIKKIPEILNKLK
>Mature_309_residues
MKFPKSHSLQEIANLLNCKFIGDKDFQVLGMNEIQVVEPGDIVFVDHPKYYDKALQSAATIVLINKEVECPEGKALLISD
DPFRDFNTLTRHFKPFQFANVAISATAQIGEGTVIQPNSFIGNHVKIGKNCLIHSNVSIYDHTVIGDNVIIHAGSILGAD
AFYYKKRPEGFDQLISGGRVVIEDNVGIGALCTIDKGVTGDTTIKEGTKLDNQVHVGHDTVIGKKCLIASQTGIAGCVVI
EDEVTIWGQVGTTSGITIGAKAVIMGQTGVTKSVEGGKSYFGTPIEESREKLKQLANIKKIPEILNKLK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=27.5147928994083, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786378, Length=213, Percent_Identity=29.5774647887324, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 33421; Mature: 33421

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPKSHSLQEIANLLNCKFIGDKDFQVLGMNEIQVVEPGDIVFVDHPKYYDKALQSAAT
CCCCCCCCHHHHHHHHCEEEECCCCEEEECCCEEEEECCCCEEEECCCHHHHHHHHCCEE
IVLINKEVECPEGKALLISDDPFRDFNTLTRHFKPFQFANVAISATAQIGEGTVIQPNSF
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCEECCCCC
IGNHVKIGKNCLIHSNVSIYDHTVIGDNVIIHAGSILGADAFYYKKRPEGFDQLISGGRV
CCCCEEECCEEEEECCCEEEEEEEECCCEEEEECCEECCCCEEECCCCCCHHHHHCCCEE
VIEDNVGIGALCTIDKGVTGDTTIKEGTKLDNQVHVGHDTVIGKKCLIASQTGIAGCVVI
EEECCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEECCEEEEEECCCCEEEEEE
EDEVTIWGQVGTTSGITIGAKAVIMGQTGVTKSVEGGKSYFGTPIEESREKLKQLANIKK
ECCEEEEEECCCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IPEILNKLK
HHHHHHHCC
>Mature Secondary Structure
MKFPKSHSLQEIANLLNCKFIGDKDFQVLGMNEIQVVEPGDIVFVDHPKYYDKALQSAAT
CCCCCCCCHHHHHHHHCEEEECCCCEEEECCCEEEEECCCCEEEECCCHHHHHHHHCCEE
IVLINKEVECPEGKALLISDDPFRDFNTLTRHFKPFQFANVAISATAQIGEGTVIQPNSF
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCEECCCCC
IGNHVKIGKNCLIHSNVSIYDHTVIGDNVIIHAGSILGADAFYYKKRPEGFDQLISGGRV
CCCCEEECCEEEEECCCEEEEEEEECCCEEEEECCEECCCCEEECCCCCCHHHHHCCCEE
VIEDNVGIGALCTIDKGVTGDTTIKEGTKLDNQVHVGHDTVIGKKCLIASQTGIAGCVVI
EEECCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEECCEEEEEECCCCEEEEEE
EDEVTIWGQVGTTSGITIGAKAVIMGQTGVTKSVEGGKSYFGTPIEESREKLKQLANIKK
ECCEEEEEECCCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IPEILNKLK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA