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The map label for this gene is ybdR [H]

Identifier: 146300409

GI number: 146300409

Start: 3159559

End: 3160725

Strand: Direct

Name: ybdR [H]

Synonym: Fjoh_2657

Alternate gene names: 146300409

Gene position: 3159559-3160725 (Clockwise)

Preceding gene: 146300406

Following gene: 146300410

Centisome position: 51.82

GC content: 46.02

Gene sequence:

>1167_bases
ATGAAAGCAGCAGTTATTCACGGACCTGGTTCGGTTAAATATGATACGGTAGAAGATCCAAAAATCATAGCACAAGATGA
TATTATTCTAAAAGTTACTTCCACGGCAATATGCGGATCGGATCTGCATATTTATTCGGGTGCCATGCCAACAACTCCTA
TGGTGCTTGGCCATGAGTTTATGGGAATCGTGGAGGAAACAGGCTCGGCTGTCACCCATCTGAAAAGAGGGGACCGCGTT
GTGGTTCCTTTCCCAATTGCCTGCGGGAATTGTTTTTTCTGCAATCACGATGTTCCGGGCAACTGTGAGCACAGCAATCC
CGAACATTACGGTCCTGAGGGTGGAATTGTCACAGAGAAAGGCGGGGCACTTTTCGGTTATACAGACCTCTATGGCGGGT
ATGACGGAGGTCAAGCACAGTATGTGCGCGTACCATATGCCAATTACGGACCCAGGGTTGTTCCCGAAGACCTAAGTGAT
GAGCAGCTTCTTTTTTTAACCGATATTTTCCCAACAGGGTATACCGGGGTTGACTGGGGGGAAGTCAAGGGCGGCGAAAC
CGTAGCGATATTTGGTTCCGGACCTGTTGGTATCATGGCTGCTAAAAGCGCCTGGCTTAGAGGCGCGGCGCAGGTAATTG
TGGTTGATACACTTCAGTTTAGACTCGATAAAGCTAAAGCTACAGCGGGCTGTACCACAATTCTATGGGAGGATGGGCCT
AAAGACGTTGTTGAACAGATACGTTCTCTTACAAACGGCCGCGGTGCTGATGTCTGCATTGACGCCGTTGGATTTGAACC
GGACCGTAATTTAGGTGACCGTATTAAGGCTACCATCAATTTCGAAAAAGGATCAACAAAAGTTTTAGAAGCCTGCATGA
GCGCCGTAAGGAGAAGCGGAATTGTTTCTGTTTTGGGTGTTTATCCTGTCAACTATGATAATTTTCCCATAGGACAGTTT
TTTGATAAAGGGATAATCCTAAAAGGAGGGCAGGCTCCAGCGCACAAACACATTGATAAACTTTTAGAATATGTGGTTCA
GGGAAAGGTAAAGCTTGATGACATTATAACGCACAGACTGCCGTTGAGTGAGATTTCACATGCTTACGATATTTTCAAAA
AACGTGAAGACGGATGTGTAAAAGTAGTACTTGATCCGTGGAAATAG

Upstream 100 bases:

>100_bases
GCACAACAGTGTTTTATCTGTAAGAATTTAAACTTATCCTGTAAAATTAATCTCTTAAATTATAGTTACTTAGCTTTCTA
TTAATTTTAAAAAGGACATC

Downstream 100 bases:

>100_bases
AAATAATTCTTCAACGCGTCATGCTTATTATATTTTAAAACCGATTGCGTTAAATATAATTATCGCTCTGGTTATTAATT
GTTTAAAGTACTAAATCTGT

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKAAVIHGPGSVKYDTVEDPKIIAQDDIILKVTSTAICGSDLHIYSGAMPTTPMVLGHEFMGIVEETGSAVTHLKRGDRV
VVPFPIACGNCFFCNHDVPGNCEHSNPEHYGPEGGIVTEKGGALFGYTDLYGGYDGGQAQYVRVPYANYGPRVVPEDLSD
EQLLFLTDIFPTGYTGVDWGEVKGGETVAIFGSGPVGIMAAKSAWLRGAAQVIVVDTLQFRLDKAKATAGCTTILWEDGP
KDVVEQIRSLTNGRGADVCIDAVGFEPDRNLGDRIKATINFEKGSTKVLEACMSAVRRSGIVSVLGVYPVNYDNFPIGQF
FDKGIILKGGQAPAHKHIDKLLEYVVQGKVKLDDIITHRLPLSEISHAYDIFKKREDGCVKVVLDPWK

Sequences:

>Translated_388_residues
MKAAVIHGPGSVKYDTVEDPKIIAQDDIILKVTSTAICGSDLHIYSGAMPTTPMVLGHEFMGIVEETGSAVTHLKRGDRV
VVPFPIACGNCFFCNHDVPGNCEHSNPEHYGPEGGIVTEKGGALFGYTDLYGGYDGGQAQYVRVPYANYGPRVVPEDLSD
EQLLFLTDIFPTGYTGVDWGEVKGGETVAIFGSGPVGIMAAKSAWLRGAAQVIVVDTLQFRLDKAKATAGCTTILWEDGP
KDVVEQIRSLTNGRGADVCIDAVGFEPDRNLGDRIKATINFEKGSTKVLEACMSAVRRSGIVSVLGVYPVNYDNFPIGQF
FDKGIILKGGQAPAHKHIDKLLEYVVQGKVKLDDIITHRLPLSEISHAYDIFKKREDGCVKVVLDPWK
>Mature_388_residues
MKAAVIHGPGSVKYDTVEDPKIIAQDDIILKVTSTAICGSDLHIYSGAMPTTPMVLGHEFMGIVEETGSAVTHLKRGDRV
VVPFPIACGNCFFCNHDVPGNCEHSNPEHYGPEGGIVTEKGGALFGYTDLYGGYDGGQAQYVRVPYANYGPRVVPEDLSD
EQLLFLTDIFPTGYTGVDWGEVKGGETVAIFGSGPVGIMAAKSAWLRGAAQVIVVDTLQFRLDKAKATAGCTTILWEDGP
KDVVEQIRSLTNGRGADVCIDAVGFEPDRNLGDRIKATINFEKGSTKVLEACMSAVRRSGIVSVLGVYPVNYDNFPIGQF
FDKGIILKGGQAPAHKHIDKLLEYVVQGKVKLDDIITHRLPLSEISHAYDIFKKREDGCVKVVLDPWK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=398, Percent_Identity=27.8894472361809, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4501939, Length=387, Percent_Identity=28.1653746770026, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501929, Length=384, Percent_Identity=28.6458333333333, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501933, Length=384, Percent_Identity=27.6041666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI34577061, Length=385, Percent_Identity=28.3116883116883, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565154, Length=377, Percent_Identity=26.525198938992, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156627571, Length=390, Percent_Identity=24.6153846153846, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI71565152, Length=354, Percent_Identity=25.7062146892655, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=43.8775510204082, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI87082125, Length=399, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI226510992, Length=380, Percent_Identity=25.5263157894737, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=24.390243902439, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787863, Length=392, Percent_Identity=24.4897959183673, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788073, Length=268, Percent_Identity=26.4925373134328, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786552, Length=389, Percent_Identity=26.2210796915167, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=234, Percent_Identity=27.3504273504274, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790718, Length=350, Percent_Identity=21.4285714285714, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87081918, Length=385, Percent_Identity=23.1168831168831, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=341, Percent_Identity=24.0469208211144, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=392, Percent_Identity=27.0408163265306, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=392, Percent_Identity=26.7857142857143, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=362, Percent_Identity=25.6906077348066, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=378, Percent_Identity=25.9259259259259, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=398, Percent_Identity=25.8793969849246, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=367, Percent_Identity=26.158038147139, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=367, Percent_Identity=26.158038147139, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=284, Percent_Identity=26.056338028169, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=387, Percent_Identity=26.0981912144703, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737897, Length=387, Percent_Identity=25.8397932816537, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=27.6422764227642, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1; 1.2.1.1

Molecular weight: Translated: 41990; Mature: 41990

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVIHGPGSVKYDTVEDPKIIAQDDIILKVTSTAICGSDLHIYSGAMPTTPMVLGHEF
CCEEEEECCCCEEECCCCCCCEEECCCEEEEEECCEECCCCCEEECCCCCCCCHHHHHHH
MGIVEETGSAVTHLKRGDRVVVPFPIACGNCFFCNHDVPGNCEHSNPEHYGPEGGIVTEK
HHHHHHCCHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEC
GGALFGYTDLYGGYDGGQAQYVRVPYANYGPRVVPEDLSDEQLLFLTDIFPTGYTGVDWG
CCEEEEEHHHCCCCCCCCEEEEEECCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCCHH
EVKGGETVAIFGSGPVGIMAAKSAWLRGAAQVIVVDTLQFRLDKAKATAGCTTILWEDGP
CCCCCCEEEEEECCCEEEEEHHHHHHCCCEEEEEEEEHHHHHHHHHCCCCEEEEEECCCH
KDVVEQIRSLTNGRGADVCIDAVGFEPDRNLGDRIKATINFEKGSTKVLEACMSAVRRSG
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCC
IVSVLGVYPVNYDNFPIGQFFDKGIILKGGQAPAHKHIDKLLEYVVQGKVKLDDIITHRL
CEEEEEEEECCCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCC
PLSEISHAYDIFKKREDGCVKVVLDPWK
CHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MKAAVIHGPGSVKYDTVEDPKIIAQDDIILKVTSTAICGSDLHIYSGAMPTTPMVLGHEF
CCEEEEECCCCEEECCCCCCCEEECCCEEEEEECCEECCCCCEEECCCCCCCCHHHHHHH
MGIVEETGSAVTHLKRGDRVVVPFPIACGNCFFCNHDVPGNCEHSNPEHYGPEGGIVTEK
HHHHHHCCHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEC
GGALFGYTDLYGGYDGGQAQYVRVPYANYGPRVVPEDLSDEQLLFLTDIFPTGYTGVDWG
CCEEEEEHHHCCCCCCCCEEEEEECCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCCHH
EVKGGETVAIFGSGPVGIMAAKSAWLRGAAQVIVVDTLQFRLDKAKATAGCTTILWEDGP
CCCCCCEEEEEECCCEEEEEHHHHHHCCCEEEEEEEEHHHHHHHHHCCCCEEEEEECCCH
KDVVEQIRSLTNGRGADVCIDAVGFEPDRNLGDRIKATINFEKGSTKVLEACMSAVRRSG
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCC
IVSVLGVYPVNYDNFPIGQFFDKGIILKGGQAPAHKHIDKLLEYVVQGKVKLDDIITHRL
CEEEEEEEECCCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCC
PLSEISHAYDIFKKREDGCVKVVLDPWK
CHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]