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The map label for this gene is nhaK [H]

Identifier: 146300385

GI number: 146300385

Start: 3126921

End: 3128192

Strand: Reverse

Name: nhaK [H]

Synonym: Fjoh_2630

Alternate gene names: 146300385

Gene position: 3128192-3126921 (Counterclockwise)

Preceding gene: 146300391

Following gene: 146300384

Centisome position: 51.31

GC content: 34.51

Gene sequence:

>1272_bases
ATGGAAAATTACAGCATCATTATATTCATACTTGCCATTGTTATCGGACTATCTGCCTTTGCTGATAAAGCAAAACTTCC
CTACCCTATTCTTTTAGTGATTGTGGGAATTGCCATTGGTTTTATTCCAACGATGACCGAAATTGAAATCAATCCTGAAA
TTATTTTTTTATTATTTCTGCCGCCATTATTATATGATGCATCATTTAATATCTCTCCTAAAGATTTCAAAACCAATATC
AATACGATAAGCACACTAGCCATTACTTTAGTTTTTCTTACTACATTCTGGATTGCTGTTGTGGCTCATTATATGATTCC
TAATATAACCTGGCCTCTCGCATTTGTACTCGGAGCTATTCTTTCTGCAACCGATGCCGTTGCCGCTGTAAGTATCACAA
AAGGATTAGGAATATCTCATAAAACCATTACCATTCTTGAAGGCGAAAGTTTGATAAATGATGCTTCGGCATTAGTAGCT
TACAGATTTGCTGTTGCTGCCGTACTGGGATCTGCTTTTATAATCTGGCAGGCAGCACTGCAGTTTATTTTATTATTAGG
AGGAGGTTTTCTGGCAGGATTTGTAATGTCAAAAATTCTGGCTGTTATTTTAAAAAAAGTCCACAAAAATTCAAATGTCA
CGATTAGTTTCATGCTTTTAATGCCTTTTGTAACTTATTTAATTGCAGAGCATTTACATGTTTCCGGAGTTATTGCCGTG
GTTATTTCCGGGTTGGCGATTGCGCGTTTCAGCAAAAAAATATTTCCTGAAAGTTTAAAAAACAGTTCCCGAAGTTTATG
GGATATTATCATCTTTTTATTAAACGGATTAATCTTTATCCTGATTGGACTTAATTTTAGATATGTATTAAAGGATATTG
AAGATGATATGATATTACCTTATATTGGCTATGCATTCATTATAACCATCGTTGCCTTATTGATACGATTCGTAAGGATA
TTTCTTCAAAAAATTAATCTTCAAAAAGCGTTTCAAAAAAATCGAAAAGGAAGAAGAAAAATCAGCGAAGATGCTCTTTT
AGACTTTAAGAACAGTATAATTTTAGGATGGTCAGGAATGCGCGGTATTGTATCACTTGCCATTGCCATTGGGCTTCCAA
GGTTTCTTGAAGACGGAAATCCGTTTCCTGAACGTAACGCAATTATTTTTATTTCTGTCGCCGTAGTGCTTTTTACGCTT
ATTGGGCAGGGACTTACACTTCCATTTATTGTTAAAAAATTAAACTCTAAACCAGAACAAATAGAATCTTAG

Upstream 100 bases:

>100_bases
AAGTCAATAATTTTCATTAGAACTTTTACATTTACCAAATCAGAATATTTTTAATTAAATACCGAAATTAATTACATTAG
CATTTTTCTAAATCTAAAAA

Downstream 100 bases:

>100_bases
AAAAGTTAGAAAAAAAATAAAAAAAATATGCACGCATAGCAATTTCATGCTATTCGTTTATTTTTTATTCGTAATTTCGA
TTCTCATTAAAATTACAACT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MENYSIIIFILAIVIGLSAFADKAKLPYPILLVIVGIAIGFIPTMTEIEINPEIIFLLFLPPLLYDASFNISPKDFKTNI
NTISTLAITLVFLTTFWIAVVAHYMIPNITWPLAFVLGAILSATDAVAAVSITKGLGISHKTITILEGESLINDASALVA
YRFAVAAVLGSAFIIWQAALQFILLLGGGFLAGFVMSKILAVILKKVHKNSNVTISFMLLMPFVTYLIAEHLHVSGVIAV
VISGLAIARFSKKIFPESLKNSSRSLWDIIIFLLNGLIFILIGLNFRYVLKDIEDDMILPYIGYAFIITIVALLIRFVRI
FLQKINLQKAFQKNRKGRRKISEDALLDFKNSIILGWSGMRGIVSLAIAIGLPRFLEDGNPFPERNAIIFISVAVVLFTL
IGQGLTLPFIVKKLNSKPEQIES

Sequences:

>Translated_423_residues
MENYSIIIFILAIVIGLSAFADKAKLPYPILLVIVGIAIGFIPTMTEIEINPEIIFLLFLPPLLYDASFNISPKDFKTNI
NTISTLAITLVFLTTFWIAVVAHYMIPNITWPLAFVLGAILSATDAVAAVSITKGLGISHKTITILEGESLINDASALVA
YRFAVAAVLGSAFIIWQAALQFILLLGGGFLAGFVMSKILAVILKKVHKNSNVTISFMLLMPFVTYLIAEHLHVSGVIAV
VISGLAIARFSKKIFPESLKNSSRSLWDIIIFLLNGLIFILIGLNFRYVLKDIEDDMILPYIGYAFIITIVALLIRFVRI
FLQKINLQKAFQKNRKGRRKISEDALLDFKNSIILGWSGMRGIVSLAIAIGLPRFLEDGNPFPERNAIIFISVAVVLFTL
IGQGLTLPFIVKKLNSKPEQIES
>Mature_423_residues
MENYSIIIFILAIVIGLSAFADKAKLPYPILLVIVGIAIGFIPTMTEIEINPEIIFLLFLPPLLYDASFNISPKDFKTNI
NTISTLAITLVFLTTFWIAVVAHYMIPNITWPLAFVLGAILSATDAVAAVSITKGLGISHKTITILEGESLINDASALVA
YRFAVAAVLGSAFIIWQAALQFILLLGGGFLAGFVMSKILAVILKKVHKNSNVTISFMLLMPFVTYLIAEHLHVSGVIAV
VISGLAIARFSKKIFPESLKNSSRSLWDIIIFLLNGLIFILIGLNFRYVLKDIEDDMILPYIGYAFIITIVALLIRFVRI
FLQKINLQKAFQKNRKGRRKISEDALLDFKNSIILGWSGMRGIVSLAIAIGLPRFLEDGNPFPERNAIIFISVAVVLFTL
IGQGLTLPFIVKKLNSKPEQIES

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=420, Percent_Identity=23.5714285714286, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI41872703, Length=409, Percent_Identity=22.9828850855746, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI148727259, Length=409, Percent_Identity=23.7163814180929, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI5454070, Length=286, Percent_Identity=25.1748251748252, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI194239733, Length=387, Percent_Identity=22.9974160206718, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110227626, Length=266, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI294997330, Length=266, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI14211919, Length=387, Percent_Identity=25.0645994832041, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI27734935, Length=347, Percent_Identity=23.6311239193084, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4759144, Length=385, Percent_Identity=25.1948051948052, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI27777632, Length=409, Percent_Identity=23.7163814180929, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790501, Length=426, Percent_Identity=32.6291079812207, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25150332, Length=408, Percent_Identity=26.4705882352941, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147678, Length=442, Percent_Identity=24.6606334841629, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987535, Length=410, Percent_Identity=23.9024390243902, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71987537, Length=410, Percent_Identity=23.9024390243902, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=392, Percent_Identity=21.6836734693878, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993590, Length=415, Percent_Identity=25.7831325301205, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=415, Percent_Identity=25.7831325301205, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=418, Percent_Identity=21.2918660287081, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=418, Percent_Identity=21.2918660287081, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=418, Percent_Identity=21.2918660287081, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71990924, Length=388, Percent_Identity=23.4536082474227, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71987559, Length=415, Percent_Identity=21.9277108433735, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71990932, Length=388, Percent_Identity=23.4536082474227, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71987545, Length=414, Percent_Identity=21.9806763285024, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=247, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992107, Length=247, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320663, Length=370, Percent_Identity=22.7027027027027, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510740, Length=386, Percent_Identity=22.279792746114, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585580, Length=386, Percent_Identity=22.279792746114, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585578, Length=386, Percent_Identity=22.279792746114, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281360447, Length=410, Percent_Identity=24.1463414634146, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281364513, Length=400, Percent_Identity=24.5, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221473222, Length=400, Percent_Identity=24.5, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221473215, Length=400, Percent_Identity=24.5, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221473212, Length=400, Percent_Identity=24.5, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=23.5732009925558, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=23.5732009925558, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46655; Mature: 46655

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENYSIIIFILAIVIGLSAFADKAKLPYPILLVIVGIAIGFIPTMTEIEINPEIIFLLFL
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHH
PPLLYDASFNISPKDFKTNINTISTLAITLVFLTTFWIAVVAHYMIPNITWPLAFVLGAI
HHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSATDAVAAVSITKGLGISHKTITILEGESLINDASALVAYRFAVAAVLGSAFIIWQAAL
HHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFILLLGGGFLAGFVMSKILAVILKKVHKNSNVTISFMLLMPFVTYLIAEHLHVSGVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VISGLAIARFSKKIFPESLKNSSRSLWDIIIFLLNGLIFILIGLNFRYVLKDIEDDMILP
HHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHH
YIGYAFIITIVALLIRFVRIFLQKINLQKAFQKNRKGRRKISEDALLDFKNSIILGWSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCH
RGIVSLAIAIGLPRFLEDGNPFPERNAIIFISVAVVLFTLIGQGLTLPFIVKKLNSKPEQ
HHHHHHHHHHCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
IES
CCC
>Mature Secondary Structure
MENYSIIIFILAIVIGLSAFADKAKLPYPILLVIVGIAIGFIPTMTEIEINPEIIFLLFL
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHH
PPLLYDASFNISPKDFKTNINTISTLAITLVFLTTFWIAVVAHYMIPNITWPLAFVLGAI
HHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSATDAVAAVSITKGLGISHKTITILEGESLINDASALVAYRFAVAAVLGSAFIIWQAAL
HHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFILLLGGGFLAGFVMSKILAVILKKVHKNSNVTISFMLLMPFVTYLIAEHLHVSGVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VISGLAIARFSKKIFPESLKNSSRSLWDIIIFLLNGLIFILIGLNFRYVLKDIEDDMILP
HHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHH
YIGYAFIITIVALLIRFVRIFLQKINLQKAFQKNRKGRRKISEDALLDFKNSIILGWSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCH
RGIVSLAIAIGLPRFLEDGNPFPERNAIIFISVAVVLFTLIGQGLTLPFIVKKLNSKPEQ
HHHHHHHHHHCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
IES
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA