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The map label for this gene is arsC [H]

Identifier: 146284583

GI number: 146284583

Start: 86795

End: 87220

Strand: Direct

Name: arsC [H]

Synonym: Ent638_4257

Alternate gene names: 146284583

Gene position: 86795-87220 (Clockwise)

Preceding gene: 146284582

Following gene: 146284584

Centisome position: 55.02

GC content: 46.95

Gene sequence:

>426_bases
ATGAGCAACATTACCATCTATCACAACCCGGCCTGTGGTACTTCACGCAACACACTGGAGATGATCCGCAACAGCGGCAA
TGAACCGACGATAATTTATTATCTCGATACGCCCCCGACCCGTGATGAGCTGATTAAACTTATTTCAGATATGGGAATTA
CGGTTCGTGGATTGCTGCGTAAGAATGTTGAGCCTTATGAACAACTGGGACTTGCAGAAGACAAGTTTACCGATGGGCAA
CTGCTAGAATTTATGCTGCAACATCCAGTCTTGATTAACAGGCCAATTGTTGTAACGCCTGCAGGAACCCGCCTGTGTAG
GCCTTCAGAGGTGGTTCTGGAAATTATTCCGGAACCTCAACAGGGTGCCTTCACGAAAGAAGATGGCGAAAAGGTTATTG
ATGAAACAGGGAAGCGGGTGAACTAG

Upstream 100 bases:

>100_bases
TTACTTCCGTACCGGCATTGTTATGACTGTACCTGTGCTGTTTGTCACTCTGGCCGCGCTGGCGTGGCGGCTCTCTGTCA
CTTTGTAATGAGATACTGAT

Downstream 100 bases:

>100_bases
TAAGCAACGAAATGAATAATTCGATTGTGGAACACGTTATTTAGCTTTAACAGGAAACAAATAAGAGCCCATGTATTTCA
TGGACTCTTTCTTAGATGCC

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRGLLRKNVEPYEQLGLAEDKFTDGQ
LLEFMLQHPVLINRPIVVTPAGTRLCRPSEVVLEIIPEPQQGAFTKEDGEKVIDETGKRVN

Sequences:

>Translated_141_residues
MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRGLLRKNVEPYEQLGLAEDKFTDGQ
LLEFMLQHPVLINRPIVVTPAGTRLCRPSEVVLEIIPEPQQGAFTKEDGEKVIDETGKRVN
>Mature_140_residues
SNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRGLLRKNVEPYEQLGLAEDKFTDGQL
LEFMLQHPVLINRPIVVTPAGTRLCRPSEVVLEIIPEPQQGAFTKEDGEKVIDETGKRVN

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=141, Percent_Identity=83.6879432624114, Blast_Score=255, Evalue=9e-70,
Organism=Escherichia coli, GI1788841, Length=114, Percent_Identity=38.5964912280702, Blast_Score=91, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15849; Mature: 15718

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRGLLR
CCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
KNVEPYEQLGLAEDKFTDGQLLEFMLQHPVLINRPIVVTPAGTRLCRPSEVVLEIIPEPQ
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCEEECCCEEEECCCCCCCCHHHHHHEECCCCC
QGAFTKEDGEKVIDETGKRVN
CCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
SNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRGLLR
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
KNVEPYEQLGLAEDKFTDGQLLEFMLQHPVLINRPIVVTPAGTRLCRPSEVVLEIIPEPQ
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCEEECCCEEEECCCCCCCCHHHHHHEECCCCC
QGAFTKEDGEKVIDETGKRVN
CCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]