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The map label for this gene is arsR [H]

Identifier: 146284581

GI number: 146284581

Start: 85128

End: 85448

Strand: Direct

Name: arsR [H]

Synonym: Ent638_4255

Alternate gene names: 146284581

Gene position: 85128-85448 (Clockwise)

Preceding gene: 146284579

Following gene: 146284582

Centisome position: 53.96

GC content: 52.96

Gene sequence:

>321_bases
ATGCTACATCCTGTTCAGCTTTTCAAAATCCTGTCTGATGAAACACGGCTCGCCATCGTCATGATTCTGCGGGAGTCAGG
AGAAATGTGCGTGTGCGATATCTGTACAGCCACCTCCGAATCGCAGCCCAAAATCTCACGACATATGGCTATCCTTCGTG
AAGCTGAGCTGGTTATTGACCGTCGGGAAGGCAAATGGATCCACTACCGTCTGTCACCCCACATACCGGCGTGGGCAGCT
GAGATAATCGCAACGTCCTGGCAGTGTCTGCGAGAGGATGTGCGTGAATGGCTGCAAAAAGCAGCCTGCACCTCCTGCTG
A

Upstream 100 bases:

>100_bases
ACAGGAAATTGTTCCATTTTTCTCCTCCGGAGAACAGGTTATTTCAAAGTCTATAAATATGATTTACCATATGTGTATTC
TAAATGGAACGGAGTGAAAA

Downstream 100 bases:

>100_bases
GACAGGTAAACACATTTACTTAATCATATGTGATGGAGTCTGGAATGCTTTTAGCAGGGAGTATATTTTTACTGACGCTG
GTACTGGTGATCTGGCAACC

Product: DNA-binding transcriptional repressor ArsR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MLHPVQLFKILSDETRLAIVMILRESGEMCVCDICTATSESQPKISRHMAILREAELVIDRREGKWIHYRLSPHIPAWAA
EIIATSWQCLREDVREWLQKAACTSC

Sequences:

>Translated_106_residues
MLHPVQLFKILSDETRLAIVMILRESGEMCVCDICTATSESQPKISRHMAILREAELVIDRREGKWIHYRLSPHIPAWAA
EIIATSWQCLREDVREWLQKAACTSC
>Mature_106_residues
MLHPVQLFKILSDETRLAIVMILRESGEMCVCDICTATSESQPKISRHMAILREAELVIDRREGKWIHYRLSPHIPAWAA
EIIATSWQCLREDVREWLQKAACTSC

Specific function: Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arse

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789916, Length=106, Percent_Identity=61.3207547169811, Blast_Score=147, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 12235; Mature: 12235

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00846 HTH_ARSR_1 ; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
9.4 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
9.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHPVQLFKILSDETRLAIVMILRESGEMCVCDICTATSESQPKISRHMAILREAELVID
CCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEE
RREGKWIHYRLSPHIPAWAAEIIATSWQCLREDVREWLQKAACTSC
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHPVQLFKILSDETRLAIVMILRESGEMCVCDICTATSESQPKISRHMAILREAELVID
CCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEE
RREGKWIHYRLSPHIPAWAAEIIATSWQCLREDVREWLQKAACTSC
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721697; 8041620; 9278503 [H]