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The map label for this gene is ppiA [H]

Identifier: 145300103

GI number: 145300103

Start: 3465407

End: 3465958

Strand: Direct

Name: ppiA [H]

Synonym: ASA_3203

Alternate gene names: 145300103

Gene position: 3465407-3465958 (Clockwise)

Preceding gene: 145300102

Following gene: 145300104

Centisome position: 73.69

GC content: 60.51

Gene sequence:

>552_bases
ATGAAGAAACTCTGGTTACTGGCCATGCTGATCGCCCCGCTGGCGTTTGCCGGCCCCAAGGTCAGGATGGAGACCAACCA
CGGCAATATAGTGGTGGAGCTGGCATCCAAACAGGCGCCGCAGACGGTGAAGAACTTCCTGCGCTACGTGGCGGACGGCA
GTTATGACGGCAGCCTGTTCCACCGGGTGATCCAGGATTTCGTGGTGCAGGGGGGCGGCTACAACCAGCAGTTCCAGCAA
CTGCCGACCTTCGATCCCGTGGTCAACGAGTCCAAGGGCGGCCTGCCCAACAAACGCGGCAGCATCGCCATGGCCCGCAC
CCAGGCCGTGGACAGCGCCACTCGCCAGTTCTACTTCAACCTGACCGACAACAATAACCTCAACGCCAATGCAGGCGCCG
GTTATACCGTATTCGGCCAGGTCGTGCAGGGTATGGAGGTGCTGGACAAGCTGGCCCAGGTGCAGACGGGTTACAGCTCC
ATTCTGCGCGCCAACGACGTACCCACCAGCCCCATCATCCTGAAGAAGGTGGTGTTGCTGGCGGAGAAATAA

Upstream 100 bases:

>100_bases
TGAACCAGCAATTGGGCAGCCTGCTGCAACAGATCATGGCGGATGACGCTCTGCGTGGTTACCTCAAAGGTCAGCCGAGC
TGAGAAAGGAGAGCTAAACA

Downstream 100 bases:

>100_bases
CGCGAGCCGGATCACATTCCGCTGCGTCTTTGCCCGGGTCACCGGCGCACCTTTCTATACTCTGGCCCTGCCCCGTTTCC
CGGGGCATGGCCCACCCGAG

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MKKLWLLAMLIAPLAFAGPKVRMETNHGNIVVELASKQAPQTVKNFLRYVADGSYDGSLFHRVIQDFVVQGGGYNQQFQQ
LPTFDPVVNESKGGLPNKRGSIAMARTQAVDSATRQFYFNLTDNNNLNANAGAGYTVFGQVVQGMEVLDKLAQVQTGYSS
ILRANDVPTSPIILKKVVLLAEK

Sequences:

>Translated_183_residues
MKKLWLLAMLIAPLAFAGPKVRMETNHGNIVVELASKQAPQTVKNFLRYVADGSYDGSLFHRVIQDFVVQGGGYNQQFQQ
LPTFDPVVNESKGGLPNKRGSIAMARTQAVDSATRQFYFNLTDNNNLNANAGAGYTVFGQVVQGMEVLDKLAQVQTGYSS
ILRANDVPTSPIILKKVVLLAEK
>Mature_183_residues
MKKLWLLAMLIAPLAFAGPKVRMETNHGNIVVELASKQAPQTVKNFLRYVADGSYDGSLFHRVIQDFVVQGGGYNQQFQQ
LPTFDPVVNESKGGLPNKRGSIAMARTQAVDSATRQFYFNLTDNNNLNANAGAGYTVFGQVVQGMEVLDKLAQVQTGYSS
ILRANDVPTSPIILKKVVLLAEK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=157, Percent_Identity=32.484076433121, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI64276486, Length=134, Percent_Identity=35.0746268656716, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI22547212, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI7657473, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI22547215, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=46.6257668711656, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789763, Length=178, Percent_Identity=43.8202247191011, Blast_Score=140, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=163, Percent_Identity=28.2208588957055, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=30.5389221556886, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20032; Mature: 20032

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLWLLAMLIAPLAFAGPKVRMETNHGNIVVELASKQAPQTVKNFLRYVADGSYDGSLF
CCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHH
HRVIQDFVVQGGGYNQQFQQLPTFDPVVNESKGGLPNKRGSIAMARTQAVDSATRQFYFN
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHEEEEE
LTDNNNLNANAGAGYTVFGQVVQGMEVLDKLAQVQTGYSSILRANDVPTSPIILKKVVLL
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AEK
CCC
>Mature Secondary Structure
MKKLWLLAMLIAPLAFAGPKVRMETNHGNIVVELASKQAPQTVKNFLRYVADGSYDGSLF
CCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHH
HRVIQDFVVQGGGYNQQFQQLPTFDPVVNESKGGLPNKRGSIAMARTQAVDSATRQFYFN
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHEEEEE
LTDNNNLNANAGAGYTVFGQVVQGMEVLDKLAQVQTGYSSILRANDVPTSPIILKKVVLL
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AEK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7948017 [H]