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The map label for this gene is macA [H]

Identifier: 145299911

GI number: 145299911

Start: 3237316

End: 3238479

Strand: Direct

Name: macA [H]

Synonym: ASA_3003

Alternate gene names: 145299911

Gene position: 3237316-3238479 (Clockwise)

Preceding gene: 145299910

Following gene: 145299912

Centisome position: 68.84

GC content: 61.08

Gene sequence:

>1164_bases
ATGAACATAACTCCCAAGCAGAGAAAATTTGCCCTGCTCGCACTCATCCCCCTGGCCGCCATCACCTGGCTGGCCTGGCC
GAATACGACCCCGGACCCGGTGCTGAGCGCGCCAGTGACCCGCCAGGATGTGGAGCAGACAGTGCTGGCCAGCGGCGTCT
TGCAGGCCATAGAGCAGGTGGATGTGGGTGCCCAGGTCTCGGGTCAGGTGACCTATCTGGCCGTCGAGGCGGGACAGAGC
GTCAAGCAGGGTGACCTGCTGGCCGAGATAGATCCCCTGATCGCCCAGAACAACCTCAAGACCGCCGAGGCGGATCTCGC
TAGTCGCCGTGCCCAGCTCAAGATCAAGCAGGCACAGCTCAAGCAAAACGAGCTGGCCTGGCGCCGTCAGCAGCAGATGT
TCAAGCAGGAAGCCAGCTCCCGCGCAGATCTGGAGAGCGCCGAAGCCCAGTTGGCGGTCACCCGGGCCGAGCTGCAGAGC
GCCCAAGCCGAGATCGAAAATGCGCTGATCAAGGTGGATCGCACCAAGACGGAGCTAGGCTATAACCGCATTCTGGCCCC
CATGGATGGCACAGTCGTCAGCATAGTGACCCGCCAGGGCCAGACTCTGGCCGCCAGCCAGACTGTGCCCACCCTGCTCA
AGCTCGCCAATCTGGAGACAATGACGGTCAAGGCACAGATCTCTGAGGCGGATGTCACCCGGGTAAAGGCAGGCATGCCT
GTCTATTTCACCCTGATGGGCGATGCGGATACCCGTTATCACGGCACCCTGCGCACGGTCGAACTGGCCCCCACCAACAT
CAACGAGCAGGCCACCAGCACCACGGCCACCAGCAATGCCGCCGTCTATTACTACGCCCTGTTCGATGTGCCCAATCCGG
ATCACACCCTGCGAGTCGCCATGACCACGCAAGTCACCATAGTGCTCGGCGAGCGCAAGCAGGTGCTGACCATTCCACAG
ACGGCCCTTGGCAAGAAGCTGGGGGAGAACGAGTACGAAGTCACCCTGATCAAGGATGACGATCAGAAAGAGACACGCCG
CATCAAGACCGGCATGAAAGATGACATCAAGGTCGAGGTAGTCAGCGGCCTCACCGAGCAGGACAAGGTCAAGCTGGGTC
AAAGTGCTCCCGTCAACGGCCCCGATGTGGAGATGATGTTGTGA

Upstream 100 bases:

>100_bases
TGTCTACATGTTTCCTTACATATTCATCGCTGTTTTTTAAGCCTCGTTTGCTGCAGGATATTGCCCTTGCATGCCTTCGC
ACGTTTCATTCAGGTGATAA

Downstream 100 bases:

>100_bases
GTGAGCCACTGATCCAGCTCAAAGGGATAGAGCGACGCTACCAGAGCGGAGAGCAGGAGGTCACAGTCCTGCATCCGCTG
GATCTGACCATTGAAGCGGG

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNITPKQRKFALLALIPLAAITWLAWPNTTPDPVLSAPVTRQDVEQTVLASGVLQAIEQVDVGAQVSGQVTYLAVEAGQS
VKQGDLLAEIDPLIAQNNLKTAEADLASRRAQLKIKQAQLKQNELAWRRQQQMFKQEASSRADLESAEAQLAVTRAELQS
AQAEIENALIKVDRTKTELGYNRILAPMDGTVVSIVTRQGQTLAASQTVPTLLKLANLETMTVKAQISEADVTRVKAGMP
VYFTLMGDADTRYHGTLRTVELAPTNINEQATSTTATSNAAVYYYALFDVPNPDHTLRVAMTTQVTIVLGERKQVLTIPQ
TALGKKLGENEYEVTLIKDDDQKETRRIKTGMKDDIKVEVVSGLTEQDKVKLGQSAPVNGPDVEMML

Sequences:

>Translated_387_residues
MNITPKQRKFALLALIPLAAITWLAWPNTTPDPVLSAPVTRQDVEQTVLASGVLQAIEQVDVGAQVSGQVTYLAVEAGQS
VKQGDLLAEIDPLIAQNNLKTAEADLASRRAQLKIKQAQLKQNELAWRRQQQMFKQEASSRADLESAEAQLAVTRAELQS
AQAEIENALIKVDRTKTELGYNRILAPMDGTVVSIVTRQGQTLAASQTVPTLLKLANLETMTVKAQISEADVTRVKAGMP
VYFTLMGDADTRYHGTLRTVELAPTNINEQATSTTATSNAAVYYYALFDVPNPDHTLRVAMTTQVTIVLGERKQVLTIPQ
TALGKKLGENEYEVTLIKDDDQKETRRIKTGMKDDIKVEVVSGLTEQDKVKLGQSAPVNGPDVEMML
>Mature_387_residues
MNITPKQRKFALLALIPLAAITWLAWPNTTPDPVLSAPVTRQDVEQTVLASGVLQAIEQVDVGAQVSGQVTYLAVEAGQS
VKQGDLLAEIDPLIAQNNLKTAEADLASRRAQLKIKQAQLKQNELAWRRQQQMFKQEASSRADLESAEAQLAVTRAELQS
AQAEIENALIKVDRTKTELGYNRILAPMDGTVVSIVTRQGQTLAASQTVPTLLKLANLETMTVKAQISEADVTRVKAGMP
VYFTLMGDADTRYHGTLRTVELAPTNINEQATSTTATSNAAVYYYALFDVPNPDHTLRVAMTTQVTIVLGERKQVLTIPQ
TALGKKLGENEYEVTLIKDDDQKETRRIKTGMKDDIKVEVVSGLTEQDKVKLGQSAPVNGPDVEMML

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=372, Percent_Identity=40.3225806451613, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1790519, Length=241, Percent_Identity=29.045643153527, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082036, Length=344, Percent_Identity=25, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789929, Length=324, Percent_Identity=25.6172839506173, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42320; Mature: 42320

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITPKQRKFALLALIPLAAITWLAWPNTTPDPVLSAPVTRQDVEQTVLASGVLQAIEQV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DVGAQVSGQVTYLAVEAGQSVKQGDLLAEIDPLIAQNNLKTAEADLASRRAQLKIKQAQL
CCCCEECCCEEEEEEECCCCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHEEEHHHHH
KQNELAWRRQQQMFKQEASSRADLESAEAQLAVTRAELQSAQAEIENALIKVDRTKTELG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCC
YNRILAPMDGTVVSIVTRQGQTLAASQTVPTLLKLANLETMTVKAQISEADVTRVKAGMP
HHEEECCCCCCEEEEEECCCCEEEHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCC
VYFTLMGDADTRYHGTLRTVELAPTNINEQATSTTATSNAAVYYYALFDVPNPDHTLRVA
EEEEEECCCCCEECCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
MTTQVTIVLGERKQVLTIPQTALGKKLGENEYEVTLIKDDDQKETRRIKTGMKDDIKVEV
EEEEEEEEECCCCEEEECCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEE
VSGLTEQDKVKLGQSAPVNGPDVEMML
ECCCCCHHHHCCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MNITPKQRKFALLALIPLAAITWLAWPNTTPDPVLSAPVTRQDVEQTVLASGVLQAIEQV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DVGAQVSGQVTYLAVEAGQSVKQGDLLAEIDPLIAQNNLKTAEADLASRRAQLKIKQAQL
CCCCEECCCEEEEEEECCCCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHEEEHHHHH
KQNELAWRRQQQMFKQEASSRADLESAEAQLAVTRAELQSAQAEIENALIKVDRTKTELG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCC
YNRILAPMDGTVVSIVTRQGQTLAASQTVPTLLKLANLETMTVKAQISEADVTRVKAGMP
HHEEECCCCCCEEEEEECCCCEEEHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCC
VYFTLMGDADTRYHGTLRTVELAPTNINEQATSTTATSNAAVYYYALFDVPNPDHTLRVA
EEEEEECCCCCEECCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
MTTQVTIVLGERKQVLTIPQTALGKKLGENEYEVTLIKDDDQKETRRIKTGMKDDIKVEV
EEEEEEEEECCCCEEEECCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEE
VSGLTEQDKVKLGQSAPVNGPDVEMML
ECCCCCHHHHCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]