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The map label for this gene is acrE [H]

Identifier: 145299882

GI number: 145299882

Start: 3198572

End: 3199771

Strand: Direct

Name: acrE [H]

Synonym: ASA_2973

Alternate gene names: 145299882

Gene position: 3198572-3199771 (Clockwise)

Preceding gene: 145299881

Following gene: 145299883

Centisome position: 68.02

GC content: 59.33

Gene sequence:

>1200_bases
ATGAAGGTGCAAAACGTCGGGGAAAGTATGTTCAAGCGTGGCTGCATTGCTCTGGCACTGGTCAGCGTGCTGGCTGGCTG
CGGCGACAAACCAGCCAGTAGTGCCCAGGTACGCCCCCCTGTGCCCGTGGTAGTGGCCGAGGCCAGACTGACCGATGTGC
CGCTGACGACCGAGATGGTGGGAGAGACGGCGGGTTATCGCGAAATCGAAGTTCGCTCCCGGGTAAACGGCATCCTGCTT
GAACGTACTTATGTGGAAGGGCAACCCGTGACAGCAGGCCAGGAGCTGTTCCTCATCGATCCCGCCCCCTACAAGGTGGC
ACTGGAACAGGCCAAAGGGGCCCTGGCTCAGGAACAGGCCCGGTTCAACAAGGCACGCGCAGATCGGGATCGCATCATAC
CGCTGTTCAAGCGCCAGGTCGTGAGCCGCAAGGACTATGACGACACCATCGCCAACTACGAAGCGGCCATTGCCAGCCGC
CAGGCCGCACAGGCAAAAGTCAAAGAAGCAGAACTCAACCTCAGCTACACCCAGGTGACGGCACCGATTGATGGCATGGC
GAGCAAGAGCTCCCAATCCGAGGGGAGCCTTATCTCAACCAATGCCAACAGCAGCCTGCTCACCACCATCACCCAGTACA
ACCCGCTCTACGTCAATTTCTCCTACTCGGAACAGGACCGTCTCAATTTTGAAACCTCGGTGCGAAAAGGATTGATTGAG
GCCAAAGACACCACCAACTGGCGCACCCATATCCGTCTCGCTGATGGCTCCGTCTATCCCCAGGCGGGCAAGCTCAACTT
CTCCGATAACCGGGTCGACCCGCAGACGGGAACAATTCGGGCCCGCGCCATCTTTGACAACAAAGAGGGGGTCCTGCTAC
CGGGTCAATTTGTCCGACTCACCATCGACCTGGGTATTCGTAAAAACGCCATAGTGGTGCCAGCCAGAGCGATTGTGCAA
TCCCAGGCCGATCGCATGGTGATGGTGGTGGACGGCGATGACAAGGTGGTGCCACGCCCGGTCCGGCTCGGTCCGGCCAT
TGCAGAGGGGGTGCTGATCGAGAGCGGCCTTGATGCAGGCGAGCGTTACATCGTAGAGGGGCTGATGAAAGCCAGACCCG
GCAGCATAGTCAAACCTGTCTCGGCCCAAGAGATGCAGGCGATCAGCGACAAGATGGCCAGCAAGCCAGCGGCCAGGTAA

Upstream 100 bases:

>100_bases
TGTAATCCAATAAGTTGAATTATTAATCATGCAGTTGATGACATCAGTTCAGAACAGGGGTGGGCACGATGATCGCTGTC
CATTCAACAGGAGTGTGATG

Downstream 100 bases:

>100_bases
GGAGCTCGTATGTTTTCCAAGTTCTTCATTGAGCGCCCCATCTTTTCCTGTGTGATATCGATCATTATCGTACTGGCAGG
ATTGGCCGCCATGCGTTCCC

Product: multidrug efflux membrane permease

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKVQNVGESMFKRGCIALALVSVLAGCGDKPASSAQVRPPVPVVVAEARLTDVPLTTEMVGETAGYREIEVRSRVNGILL
ERTYVEGQPVTAGQELFLIDPAPYKVALEQAKGALAQEQARFNKARADRDRIIPLFKRQVVSRKDYDDTIANYEAAIASR
QAAQAKVKEAELNLSYTQVTAPIDGMASKSSQSEGSLISTNANSSLLTTITQYNPLYVNFSYSEQDRLNFETSVRKGLIE
AKDTTNWRTHIRLADGSVYPQAGKLNFSDNRVDPQTGTIRARAIFDNKEGVLLPGQFVRLTIDLGIRKNAIVVPARAIVQ
SQADRMVMVVDGDDKVVPRPVRLGPAIAEGVLIESGLDAGERYIVEGLMKARPGSIVKPVSAQEMQAISDKMASKPAAR

Sequences:

>Translated_399_residues
MKVQNVGESMFKRGCIALALVSVLAGCGDKPASSAQVRPPVPVVVAEARLTDVPLTTEMVGETAGYREIEVRSRVNGILL
ERTYVEGQPVTAGQELFLIDPAPYKVALEQAKGALAQEQARFNKARADRDRIIPLFKRQVVSRKDYDDTIANYEAAIASR
QAAQAKVKEAELNLSYTQVTAPIDGMASKSSQSEGSLISTNANSSLLTTITQYNPLYVNFSYSEQDRLNFETSVRKGLIE
AKDTTNWRTHIRLADGSVYPQAGKLNFSDNRVDPQTGTIRARAIFDNKEGVLLPGQFVRLTIDLGIRKNAIVVPARAIVQ
SQADRMVMVVDGDDKVVPRPVRLGPAIAEGVLIESGLDAGERYIVEGLMKARPGSIVKPVSAQEMQAISDKMASKPAAR
>Mature_399_residues
MKVQNVGESMFKRGCIALALVSVLAGCGDKPASSAQVRPPVPVVVAEARLTDVPLTTEMVGETAGYREIEVRSRVNGILL
ERTYVEGQPVTAGQELFLIDPAPYKVALEQAKGALAQEQARFNKARADRDRIIPLFKRQVVSRKDYDDTIANYEAAIASR
QAAQAKVKEAELNLSYTQVTAPIDGMASKSSQSEGSLISTNANSSLLTTITQYNPLYVNFSYSEQDRLNFETSVRKGLIE
AKDTTNWRTHIRLADGSVYPQAGKLNFSDNRVDPQTGTIRARAIFDNKEGVLLPGQFVRLTIDLGIRKNAIVVPARAIVQ
SQADRMVMVVDGDDKVVPRPVRLGPAIAEGVLIESGLDAGERYIVEGLMKARPGSIVKPVSAQEMQAISDKMASKPAAR

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=370, Percent_Identity=38.9189189189189, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1786668, Length=395, Percent_Identity=39.2405063291139, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789929, Length=371, Percent_Identity=36.1185983827493, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082036, Length=364, Percent_Identity=31.8681318681319, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43401; Mature: 43401

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQNVGESMFKRGCIALALVSVLAGCGDKPASSAQVRPPVPVVVAEARLTDVPLTTEMV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCCHHHHH
GETAGYREIEVRSRVNGILLERTYVEGQPVTAGQELFLIDPAPYKVALEQAKGALAQEQA
HCCCCCEEEEHHHCCCEEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHHH
RFNKARADRDRIIPLFKRQVVSRKDYDDTIANYEAAIASRQAAQAKVKEAELNLSYTQVT
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
APIDGMASKSSQSEGSLISTNANSSLLTTITQYNPLYVNFSYSEQDRLNFETSVRKGLIE
CCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCEE
AKDTTNWRTHIRLADGSVYPQAGKLNFSDNRVDPQTGTIRARAIFDNKEGVLLPGQFVRL
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEECCCCEEEE
TIDLGIRKNAIVVPARAIVQSQADRMVMVVDGDDKVVPRPVRLGPAIAEGVLIESGLDAG
EEEECCCCCEEEECHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCH
ERYIVEGLMKARPGSIVKPVSAQEMQAISDKMASKPAAR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVQNVGESMFKRGCIALALVSVLAGCGDKPASSAQVRPPVPVVVAEARLTDVPLTTEMV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCCHHHHH
GETAGYREIEVRSRVNGILLERTYVEGQPVTAGQELFLIDPAPYKVALEQAKGALAQEQA
HCCCCCEEEEHHHCCCEEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHHH
RFNKARADRDRIIPLFKRQVVSRKDYDDTIANYEAAIASRQAAQAKVKEAELNLSYTQVT
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
APIDGMASKSSQSEGSLISTNANSSLLTTITQYNPLYVNFSYSEQDRLNFETSVRKGLIE
CCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCEE
AKDTTNWRTHIRLADGSVYPQAGKLNFSDNRVDPQTGTIRARAIFDNKEGVLLPGQFVRL
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEECCCCEEEE
TIDLGIRKNAIVVPARAIVQSQADRMVMVVDGDDKVVPRPVRLGPAIAEGVLIESGLDAG
EEEECCCCCEEEECHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCH
ERYIVEGLMKARPGSIVKPVSAQEMQAISDKMASKPAAR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]