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The map label for this gene is matE [H]

Identifier: 145299786

GI number: 145299786

Start: 3085783

End: 3087129

Strand: Direct

Name: matE [H]

Synonym: ASA_2866

Alternate gene names: 145299786

Gene position: 3085783-3087129 (Clockwise)

Preceding gene: 145299785

Following gene: 145299787

Centisome position: 65.62

GC content: 62.36

Gene sequence:

>1347_bases
ATGCAAACTCAACCCCACGCGGGCCCGGGCACACTTTTCTCCCTGACCTGGCCGCTGTTTATCGATCTCGCCCTGCACTT
TCTGACCGGGGCCCTCAACACCTTCATGGTGGGCCACGTCTCCTATCAGGGCGTCGCCGCACTGGCGGTCGGCAACCAGG
TGTTCGATCTGGCCATCACCTTGTTCAGCTTCGTCAGCATAGGCACCAGCGTGGTGATCACCCAGTATCTGGGGGCTGGC
GATCGGGAAAAAGCCCGCATCGTCATCCACACCGCCATCGGCTTCAACCTGCTGGTGGGGCTGGTGGCCGCGGTCGGCGT
GCTCGCCGGTGCCGGCACCATGCTCTCCCTGATGAACCTGCCCGCCCACCTGATGGGCGATGCCACCCTTTATTTGCAGA
TCATCGGTCTGTGCCTGTTGCCGGAGGCGGCAGCCCTCTGTCTGGCCGCCACCCTGCGCGCCCACGGTCATACCCGTCAG
GCCATGTACGTGACCCTGACCGTCAACCTCATCACCTTCGTCGGCAACCTGCTGCTGCTCTACGGCGGGTTCGGCCTGCC
CCAGCTTGGGGTGGCCGGAGTCGCCATCAGCACTGTGGCGGGTCGCATCGTTGGTGTAGTGCTGCTGGTGTGGCTGGTGA
CGCGCAAGACAGGCATCCGCTTGCGTCTGCCCGAGATTGTCCGTCCCAGCAAGGTCATGCTGGACAAGGTGCTGCACATA
GGCCTGCCGGCGGCGGGGGAGAACCTATCCTGGATGCTGCAGTTCATGGTGGTCACCGCCTTCGTCGGCCTGCTCGGCGA
CAAGGCGCTGGCAACCCAGTCCTACTTCTTCCAGATCTGCCTGTTCATTCTGCTGTTCGGCCTCTCCATCGGCCTTGGCA
ACGAGATCATCATCGGCCATCTGGCGGGAGCGCGCCGCTTCGAGCAGGCCTATAACCAGCTGATGAAGAGCCTCAAGTTG
GGCCTCATCGTCACTACCCTGATCGCCATCGCCGCCGCCCTGAACGGCCGCGCCATCATCAGCCTGTTCACCGACGATCC
GGACATCATCACCCAGGTGGCACAGCTGTTTCTCATCAGCCTCATCCTCGAACCCGGCCGCACCTTCAATCTGGTGGTGA
TCAACGCCCTGCGTGCCACCGGGGATGCCCGTTTCCCGCTCTACATGGCGCTCGTCTCCATGTGGGGGATTGCCGTTCCG
CTCGCCTATTTCCTTGGTATCATGCAGGGTTATGGACTGGTCGGCATCTGGTTGGCGCTCGCCTGCGATGAGTGGGTGCG
CGGTCTGGCCATGTTCTGGCGCTGGCGCAGTCGTCGCTGGCAAAACAAAATTCTTGTTGAAACATAA

Upstream 100 bases:

>100_bases
CACTCTCCTCCCAAGGCAAGATTGCACCCCGCAGGCTCTTGGTGTTAAATGCCCGTCCAGATGGCGCTGACGAGGGCCAT
CCCCAGTATTTGGACATCCC

Downstream 100 bases:

>100_bases
GCGGAATCACAATGAAGAAAATCGGACTCTTGTTGGCTGCCATCCTGCTCAGCCCGCTGGCCATGGCGCAAACCGCGCCC
GCGGCTCCCAAGGCGCAGGC

Product: multi-anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MQTQPHAGPGTLFSLTWPLFIDLALHFLTGALNTFMVGHVSYQGVAALAVGNQVFDLAITLFSFVSIGTSVVITQYLGAG
DREKARIVIHTAIGFNLLVGLVAAVGVLAGAGTMLSLMNLPAHLMGDATLYLQIIGLCLLPEAAALCLAATLRAHGHTRQ
AMYVTLTVNLITFVGNLLLLYGGFGLPQLGVAGVAISTVAGRIVGVVLLVWLVTRKTGIRLRLPEIVRPSKVMLDKVLHI
GLPAAGENLSWMLQFMVVTAFVGLLGDKALATQSYFFQICLFILLFGLSIGLGNEIIIGHLAGARRFEQAYNQLMKSLKL
GLIVTTLIAIAAALNGRAIISLFTDDPDIITQVAQLFLISLILEPGRTFNLVVINALRATGDARFPLYMALVSMWGIAVP
LAYFLGIMQGYGLVGIWLALACDEWVRGLAMFWRWRSRRWQNKILVET

Sequences:

>Translated_448_residues
MQTQPHAGPGTLFSLTWPLFIDLALHFLTGALNTFMVGHVSYQGVAALAVGNQVFDLAITLFSFVSIGTSVVITQYLGAG
DREKARIVIHTAIGFNLLVGLVAAVGVLAGAGTMLSLMNLPAHLMGDATLYLQIIGLCLLPEAAALCLAATLRAHGHTRQ
AMYVTLTVNLITFVGNLLLLYGGFGLPQLGVAGVAISTVAGRIVGVVLLVWLVTRKTGIRLRLPEIVRPSKVMLDKVLHI
GLPAAGENLSWMLQFMVVTAFVGLLGDKALATQSYFFQICLFILLFGLSIGLGNEIIIGHLAGARRFEQAYNQLMKSLKL
GLIVTTLIAIAAALNGRAIISLFTDDPDIITQVAQLFLISLILEPGRTFNLVVINALRATGDARFPLYMALVSMWGIAVP
LAYFLGIMQGYGLVGIWLALACDEWVRGLAMFWRWRSRRWQNKILVET
>Mature_448_residues
MQTQPHAGPGTLFSLTWPLFIDLALHFLTGALNTFMVGHVSYQGVAALAVGNQVFDLAITLFSFVSIGTSVVITQYLGAG
DREKARIVIHTAIGFNLLVGLVAAVGVLAGAGTMLSLMNLPAHLMGDATLYLQIIGLCLLPEAAALCLAATLRAHGHTRQ
AMYVTLTVNLITFVGNLLLLYGGFGLPQLGVAGVAISTVAGRIVGVVLLVWLVTRKTGIRLRLPEIVRPSKVMLDKVLHI
GLPAAGENLSWMLQFMVVTAFVGLLGDKALATQSYFFQICLFILLFGLSIGLGNEIIIGHLAGARRFEQAYNQLMKSLKL
GLIVTTLIAIAAALNGRAIISLFTDDPDIITQVAQLFLISLILEPGRTFNLVVINALRATGDARFPLYMALVSMWGIAVP
LAYFLGIMQGYGLVGIWLALACDEWVRGLAMFWRWRSRRWQNKILVET

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=437, Percent_Identity=26.5446224256293, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI48994890, Length=421, Percent_Identity=24.4655581947743, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48398; Mature: 48398

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQPHAGPGTLFSLTWPLFIDLALHFLTGALNTFMVGHVSYQGVAALAVGNQVFDLAIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHH
LFSFVSIGTSVVITQYLGAGDREKARIVIHTAIGFNLLVGLVAAVGVLAGAGTMLSLMNL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
PAHLMGDATLYLQIIGLCLLPEAAALCLAATLRAHGHTRQAMYVTLTVNLITFVGNLLLL
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHH
YGGFGLPQLGVAGVAISTVAGRIVGVVLLVWLVTRKTGIRLRLPEIVRPSKVMLDKVLHI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCHHHHHHHHHHH
GLPAAGENLSWMLQFMVVTAFVGLLGDKALATQSYFFQICLFILLFGLSIGLGNEIIIGH
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LAGARRFEQAYNQLMKSLKLGLIVTTLIAIAAALNGRAIISLFTDDPDIITQVAQLFLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
LILEPGRTFNLVVINALRATGDARFPLYMALVSMWGIAVPLAYFLGIMQGYGLVGIWLAL
HHHCCCCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ACDEWVRGLAMFWRWRSRRWQNKILVET
HHHHHHHHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MQTQPHAGPGTLFSLTWPLFIDLALHFLTGALNTFMVGHVSYQGVAALAVGNQVFDLAIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHH
LFSFVSIGTSVVITQYLGAGDREKARIVIHTAIGFNLLVGLVAAVGVLAGAGTMLSLMNL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
PAHLMGDATLYLQIIGLCLLPEAAALCLAATLRAHGHTRQAMYVTLTVNLITFVGNLLLL
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHH
YGGFGLPQLGVAGVAISTVAGRIVGVVLLVWLVTRKTGIRLRLPEIVRPSKVMLDKVLHI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCHHHHHHHHHHH
GLPAAGENLSWMLQFMVVTAFVGLLGDKALATQSYFFQICLFILLFGLSIGLGNEIIIGH
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LAGARRFEQAYNQLMKSLKLGLIVTTLIAIAAALNGRAIISLFTDDPDIITQVAQLFLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
LILEPGRTFNLVVINALRATGDARFPLYMALVSMWGIAVPLAYFLGIMQGYGLVGIWLAL
HHHCCCCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ACDEWVRGLAMFWRWRSRRWQNKILVET
HHHHHHHHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]