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The map label for this gene is pncB1 [H]

Identifier: 145296514

GI number: 145296514

Start: 2665207

End: 2666547

Strand: Direct

Name: pncB1 [H]

Synonym: cgR_2425

Alternate gene names: 145296514

Gene position: 2665207-2666547 (Clockwise)

Preceding gene: 145296513

Following gene: 145296515

Centisome position: 80.42

GC content: 56.45

Gene sequence:

>1341_bases
GTGAATACCAATCCTTCTGAATTCTCCTCGAACCGTTCGACAGCTCTACTAACTGATAAATATGAGCTGACCATGCTTCA
AGCAGCGCTCGCTGATGGTTCTGCAGAGCGTCCCTCAACGTTTGAGGTCTTTAGCCGCCGCCTTCCCAACGAGCGCCGAT
ACGGTGTCGTCGCAGGAACAGCACGAGTGTTGAAGGCGATCCGTGACTTTGTATTCACAGAGGAACAACTCGCCGATCTC
GACTTCTTAGACGACCGCACCCTGGAATACCTCCGCAACTACCGCTTCACCGGCCAAGTTGATGGATACCGCGAAGGCGA
AATCTACTTCCCACAGTCCCCTCTTCTGACTGTGCGCGGCACTTTTGCAGAATGCGTCATCCTAGAGACCGTCATTTTGT
CCATCATGAATGCAGATTCTGCCGTCGCTTCCGCCGCTGCGCGCATGGTCACCGCAGCTGATGGTCGCCCCATCATCGAA
ATGGGATCCAGGCGCACCCATGAATACTCGGCAGTCACCGCATCCCGCGCAGCATACCTCGCTGGATTCTCCACCACCTC
CAACCTCGAGGCGGCCTACCGCTACGGAATTCCAGCTTCCGGAACCTCCGCCCACGCATGGACTTTGCTGCACATCAACG
ATGACGGCACCCCCAACGAAGCAGCAGCTTTCAAAGCACAGGTTGAATCCCTCGGGGTGGACACCACCTTGCTGGTAGAT
ACTTATGACATCACCCAAGGTGTGGCCACTGCCATTGAAGTTGCAGGTCCAGACCTTGGTGGCGTACGCATCGACTCCGG
CGACCTAGGTGTGCTTGCACGCAAGGTCCGCAAGCAGCTCGACGATCTCAACGCCCACAACACCAAGATTGTGGTCTCCT
CCGACCTGGATGAATTCGCCATCGCGGGCCTTCGCGGCGAACCAGTTGACGTCTTTGGCGTTGGCACCTCCGTTGTCACA
GGTTCTGGCGCACCAACCGCTGGCCTCGTGTACAAGATCGTGGAAGTTGCCGGTCACCCTGTGGCCAAGCGTTCCCGAAA
CAAGGAAAGCTACGGTGGTGGCAAGAAGGCTGTACGCACCCACCGCAAGTCCGGTACCGCAATCGAAGAAATCGTCTACC
CATTCAATGCCGAAGCACCAGATACTGGAAAGCTCGACACCTTGAACCTAACCATCCCATTGATGCGCGACGGTGAAATC
GTTCCAGGTCTGCCTACTTTGGAAGATTCCCGCGCATATTTGGCCAAGCAGTTGGTCTCTTTGCCATGGGAAGGCCTTGC
ACTGTCTCGCGATGAGCCTGTGCTGCACACTCGTTTTGTGGGATTCCCGCCGGTCGCTTAG

Upstream 100 bases:

>100_bases
AGTACGATGCCCTCGGAGTTGGTGTGGCCTACAAGGACGAACGCGCATGGATAGTGGTGGAGTTCACTGAGCCCGCTGGT
GATTCCGTAGAATCAACAGA

Downstream 100 bases:

>100_bases
GCAATTCGGTCTCACCAAACCACAGTGCCCACGGATCGGGTTTTCCGATTTCGTGGGCACTCTGGTTTGGTTTGTCGCCC
TCGAAACCGGACACAGCTGC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNTNPSEFSSNRSTALLTDKYELTMLQAALADGSAERPSTFEVFSRRLPNERRYGVVAGTARVLKAIRDFVFTEEQLADL
DFLDDRTLEYLRNYRFTGQVDGYREGEIYFPQSPLLTVRGTFAECVILETVILSIMNADSAVASAAARMVTAADGRPIIE
MGSRRTHEYSAVTASRAAYLAGFSTTSNLEAAYRYGIPASGTSAHAWTLLHINDDGTPNEAAAFKAQVESLGVDTTLLVD
TYDITQGVATAIEVAGPDLGGVRIDSGDLGVLARKVRKQLDDLNAHNTKIVVSSDLDEFAIAGLRGEPVDVFGVGTSVVT
GSGAPTAGLVYKIVEVAGHPVAKRSRNKESYGGGKKAVRTHRKSGTAIEEIVYPFNAEAPDTGKLDTLNLTIPLMRDGEI
VPGLPTLEDSRAYLAKQLVSLPWEGLALSRDEPVLHTRFVGFPPVA

Sequences:

>Translated_446_residues
MNTNPSEFSSNRSTALLTDKYELTMLQAALADGSAERPSTFEVFSRRLPNERRYGVVAGTARVLKAIRDFVFTEEQLADL
DFLDDRTLEYLRNYRFTGQVDGYREGEIYFPQSPLLTVRGTFAECVILETVILSIMNADSAVASAAARMVTAADGRPIIE
MGSRRTHEYSAVTASRAAYLAGFSTTSNLEAAYRYGIPASGTSAHAWTLLHINDDGTPNEAAAFKAQVESLGVDTTLLVD
TYDITQGVATAIEVAGPDLGGVRIDSGDLGVLARKVRKQLDDLNAHNTKIVVSSDLDEFAIAGLRGEPVDVFGVGTSVVT
GSGAPTAGLVYKIVEVAGHPVAKRSRNKESYGGGKKAVRTHRKSGTAIEEIVYPFNAEAPDTGKLDTLNLTIPLMRDGEI
VPGLPTLEDSRAYLAKQLVSLPWEGLALSRDEPVLHTRFVGFPPVA
>Mature_446_residues
MNTNPSEFSSNRSTALLTDKYELTMLQAALADGSAERPSTFEVFSRRLPNERRYGVVAGTARVLKAIRDFVFTEEQLADL
DFLDDRTLEYLRNYRFTGQVDGYREGEIYFPQSPLLTVRGTFAECVILETVILSIMNADSAVASAAARMVTAADGRPIIE
MGSRRTHEYSAVTASRAAYLAGFSTTSNLEAAYRYGIPASGTSAHAWTLLHINDDGTPNEAAAFKAQVESLGVDTTLLVD
TYDITQGVATAIEVAGPDLGGVRIDSGDLGVLARKVRKQLDDLNAHNTKIVVSSDLDEFAIAGLRGEPVDVFGVGTSVVT
GSGAPTAGLVYKIVEVAGHPVAKRSRNKESYGGGKKAVRTHRKSGTAIEEIVYPFNAEAPDTGKLDTLNLTIPLMRDGEI
VPGLPTLEDSRAYLAKQLVSLPWEGLALSRDEPVLHTRFVGFPPVA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=486, Percent_Identity=30.2469135802469, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71997947, Length=499, Percent_Identity=29.8597194388778, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71997952, Length=499, Percent_Identity=29.8597194388778, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71997955, Length=235, Percent_Identity=32.3404255319149, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24581587, Length=494, Percent_Identity=26.7206477732794, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI161076680, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581595, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574709, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581593, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581591, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48080; Mature: 48080

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNPSEFSSNRSTALLTDKYELTMLQAALADGSAERPSTFEVFSRRLPNERRYGVVAGT
CCCCCCHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEHH
ARVLKAIRDFVFTEEQLADLDFLDDRTLEYLRNYRFTGQVDGYREGEIYFPQSPLLTVRG
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCEEECCCCCCEEEEC
TFAECVILETVILSIMNADSAVASAAARMVTAADGRPIIEMGSRRTHEYSAVTASRAAYL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHEE
AGFSTTSNLEAAYRYGIPASGTSAHAWTLLHINDDGTPNEAAAFKAQVESLGVDTTLLVD
EECCCCCCCHHHEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEE
TYDITQGVATAIEVAGPDLGGVRIDSGDLGVLARKVRKQLDDLNAHNTKIVVSSDLDEFA
EHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
IAGLRGEPVDVFGVGTSVVTGSGAPTAGLVYKIVEVAGHPVAKRSRNKESYGGGKKAVRT
HCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHH
HRKSGTAIEEIVYPFNAEAPDTGKLDTLNLTIPLMRDGEIVPGLPTLEDSRAYLAKQLVS
HHCCCCCHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
LPWEGLALSRDEPVLHTRFVGFPPVA
CCCCCEEECCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNTNPSEFSSNRSTALLTDKYELTMLQAALADGSAERPSTFEVFSRRLPNERRYGVVAGT
CCCCCCHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEHH
ARVLKAIRDFVFTEEQLADLDFLDDRTLEYLRNYRFTGQVDGYREGEIYFPQSPLLTVRG
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCEEECCCCCCEEEEC
TFAECVILETVILSIMNADSAVASAAARMVTAADGRPIIEMGSRRTHEYSAVTASRAAYL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHEE
AGFSTTSNLEAAYRYGIPASGTSAHAWTLLHINDDGTPNEAAAFKAQVESLGVDTTLLVD
EECCCCCCCHHHEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEE
TYDITQGVATAIEVAGPDLGGVRIDSGDLGVLARKVRKQLDDLNAHNTKIVVSSDLDEFA
EHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
IAGLRGEPVDVFGVGTSVVTGSGAPTAGLVYKIVEVAGHPVAKRSRNKESYGGGKKAVRT
HCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHH
HRKSGTAIEEIVYPFNAEAPDTGKLDTLNLTIPLMRDGEIVPGLPTLEDSRAYLAKQLVS
HHCCCCCHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
LPWEGLALSRDEPVLHTRFVGFPPVA
CCCCCEEECCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]