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The map label for this gene is dinB

Identifier: 145296105

GI number: 145296105

Start: 2230898

End: 2232301

Strand: Reverse

Name: dinB

Synonym: cgR_2026

Alternate gene names: 145296105

Gene position: 2232301-2230898 (Counterclockwise)

Preceding gene: 145296106

Following gene: 145296103

Centisome position: 67.36

GC content: 54.34

Gene sequence:

>1404_bases
ATGCAACGCTGGGTGCTTCACATCGATATGGATGCCTTCTTCGCATCCTGCGAACAACTGACCCGGCCCACTTTAAGAGG
CCGCCCCGTCTTGGTCGGTGGAGTCTCCGGTAGGGGAGTTGTCGCCGGAGCATCCTATGAAGCCAGAAAATTTGGCGCCC
GCTCAGCGATGCCCATGCACCAAGCCAAAGCCCGAGTAGGTTTTGGGGCAGTGGTGGTGACACCCCGTCATATCGTTTAC
TCCGCAGCCTCGCGCCGGGTGTTCCAAATCGTGGAAAAACGCGCCGGAATTGTCGAACGCCTCAGCATCGATGAAGGCTT
CATGGAACCAGAGGCTCTCGTTGGCGCCACCCCAGAAGAGGTGAAACAGTGGGCGGAAGAATTACGCGCGGAAATTAAAG
AAGTTACTGGCTTACCCTCCTCGGTTGGTGCTGGCTCCGGTAAGCAGATCGCCAAAATTGGTTCAGGCGAAGCAAAGCCA
GATGGTGTGTTTGTCGTGCCAGTAGACAAGCAACATGACTTGCTTGATCCACTTCCTGTGGGCGCACTTTGGGGAGTGGG
TCCTGTGACAGGCTCCAAGCTTGCCTCAATGGGGGTGGAAACAATTGGTGATCTAGCAGCGCTAACCCAAAAAGAAGTAG
AAATCAGCCTCGGTGCAACCATCGGAATATCACTGTGGAACCTTGCCCGAGGAATCGACGACCGCCCTGTGGAACCCCGT
GCCGAAGCAAAACAGATCTCCCAAGAGCACACCTATGAAAAAGACCTCCTCACCAGGCAACAAGTAGATGCTGCCATCAT
TCGATCAGCCGAAGGCGCACACCGACGACTCCTCAAAGACGGACGCGGTGCCAGAACTGTCAGCGTGAAACTGCGGATGG
CCGACTTTCGTATTGAGTCTCGTTCCTACACCTTGTCCTATGCCACCGATGATTACGCAACTCTTGAGGCAACAGCATTC
CGACTTGCCCGCTACCCCGGAGAAGTAGGCCCCATCCGCCTTGTCGGAGTAAGTTTTTCTGGTTTGGAAGAATCCCGCCA
AGACATCCTCTTCCCGGAACTTGACCAACAAATCATTGTACCACCAGCACCCGACACCGATTATGAGGTAGGCGTGCAAT
CCTCTTCTAGTTCCGAAAGTACTCAAGTTGAAGCGCCGCAAGATGTCGCGTTGAGTATGTGGCGCGCAACGCAAGATGTC
TACCACCCAGAATATGGCCACGGTTGGGTACAAGGTGCCGGTCACGGTGTTGTGTCAGTACGTTTTGAAACCCGCAGCAC
CACAAAAGGGCGAACTAAAAGTTTTTCCATGGATGACCCGGACCTCACCCCGGCAGACCCTCTAGATAGTTTGGATTGGG
CTGACTGGTTTGCTGAAAATGGTGAAACGGGGGATGACGAATAG

Upstream 100 bases:

>100_bases
ACGCCCCTCCTAGCGGTTTCCCACACCGCCAGTCTTCTCAAACTAATCGTTGACCTGTTCGATTAACCTAATTTTCGGCT
GGTCAACTACCATAAAAAGC

Downstream 100 bases:

>100_bases
GGTTTCATCGGGTTTCGGGGTGCTTTTTGGGCGGTGGTTGCCCATGAATAGACGCAAAGGGAAAGAATGTTCTAATATTC
ACCACAAATTGCTGCCGAAA

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGARSAMPMHQAKARVGFGAVVVTPRHIVY
SAASRRVFQIVEKRAGIVERLSIDEGFMEPEALVGATPEEVKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKP
DGVFVVPVDKQHDLLDPLPVGALWGVGPVTGSKLASMGVETIGDLAALTQKEVEISLGATIGISLWNLARGIDDRPVEPR
AEAKQISQEHTYEKDLLTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIESRSYTLSYATDDYATLEATAF
RLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDQQIIVPPAPDTDYEVGVQSSSSSESTQVEAPQDVALSMWRATQDV
YHPEYGHGWVQGAGHGVVSVRFETRSTTKGRTKSFSMDDPDLTPADPLDSLDWADWFAENGETGDDE

Sequences:

>Translated_467_residues
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGARSAMPMHQAKARVGFGAVVVTPRHIVY
SAASRRVFQIVEKRAGIVERLSIDEGFMEPEALVGATPEEVKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKP
DGVFVVPVDKQHDLLDPLPVGALWGVGPVTGSKLASMGVETIGDLAALTQKEVEISLGATIGISLWNLARGIDDRPVEPR
AEAKQISQEHTYEKDLLTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIESRSYTLSYATDDYATLEATAF
RLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDQQIIVPPAPDTDYEVGVQSSSSSESTQVEAPQDVALSMWRATQDV
YHPEYGHGWVQGAGHGVVSVRFETRSTTKGRTKSFSMDDPDLTPADPLDSLDWADWFAENGETGDDE
>Mature_467_residues
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGARSAMPMHQAKARVGFGAVVVTPRHIVY
SAASRRVFQIVEKRAGIVERLSIDEGFMEPEALVGATPEEVKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKP
DGVFVVPVDKQHDLLDPLPVGALWGVGPVTGSKLASMGVETIGDLAALTQKEVEISLGATIGISLWNLARGIDDRPVEPR
AEAKQISQEHTYEKDLLTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIESRSYTLSYATDDYATLEATAF
RLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDQQIIVPPAPDTDYEVGVQSSSSSESTQVEAPQDVALSMWRATQDV
YHPEYGHGWVQGAGHGVVSVRFETRSTTKGRTKSFSMDDPDLTPADPLDSLDWADWFAENGETGDDE

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=377, Percent_Identity=26.790450928382, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7706681, Length=378, Percent_Identity=26.7195767195767, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7705344, Length=158, Percent_Identity=31.0126582278481, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI5729982, Length=213, Percent_Identity=27.6995305164319, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786425, Length=364, Percent_Identity=31.5934065934066, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787432, Length=305, Percent_Identity=27.5409836065574, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17537959, Length=368, Percent_Identity=25.2717391304348, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115534089, Length=336, Percent_Identity=27.0833333333333, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193205702, Length=223, Percent_Identity=31.8385650224215, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193205700, Length=223, Percent_Identity=31.8385650224215, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19923006, Length=415, Percent_Identity=26.2650602409639, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24668444, Length=135, Percent_Identity=31.1111111111111, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_CORGB (A4QFK8)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138926.1
- ProteinModelPortal:   A4QFK8
- SMR:   A4QFK8
- STRING:   A4QFK8
- GeneID:   4992206
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2026
- eggNOG:   COG0389
- HOGENOM:   HBG734504
- OMA:   VICAASY
- ProtClustDB:   PRK03348
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 50742; Mature: 50742

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGARSAMPMH
CCEEEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEECCCCHHHHHCCCCCCCHH
QAKARVGFGAVVVTPRHIVYSAASRRVFQIVEKRAGIVERLSIDEGFMEPEALVGATPEE
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCHHH
VKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKPDGVFVVPVDKQHDLLDPLPV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCC
GALWGVGPVTGSKLASMGVETIGDLAALTQKEVEISLGATIGISLWNLARGIDDRPVEPR
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEHHHHHHHHCCCCCCCCCCC
AEAKQISQEHTYEKDLLTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEEEEEEEEEC
RSYTLSYATDDYATLEATAFRLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDQQIIV
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEEEE
PPAPDTDYEVGVQSSSSSESTQVEAPQDVALSMWRATQDVYHPEYGHGWVQGAGHGVVSV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEE
RFETRSTTKGRTKSFSMDDPDLTPADPLDSLDWADWFAENGETGDDE
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGARSAMPMH
CCEEEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEECCCCHHHHHCCCCCCCHH
QAKARVGFGAVVVTPRHIVYSAASRRVFQIVEKRAGIVERLSIDEGFMEPEALVGATPEE
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCHHH
VKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKPDGVFVVPVDKQHDLLDPLPV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCC
GALWGVGPVTGSKLASMGVETIGDLAALTQKEVEISLGATIGISLWNLARGIDDRPVEPR
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEHHHHHHHHCCCCCCCCCCC
AEAKQISQEHTYEKDLLTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEEEEEEEEEC
RSYTLSYATDDYATLEATAFRLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDQQIIV
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEEEE
PPAPDTDYEVGVQSSSSSESTQVEAPQDVALSMWRATQDVYHPEYGHGWVQGAGHGVVSV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEE
RFETRSTTKGRTKSFSMDDPDLTPADPLDSLDWADWFAENGETGDDE
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA