Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 145295919

GI number: 145295919

Start: 2048911

End: 2050089

Strand: Reverse

Name: dxr

Synonym: cgR_1844

Alternate gene names: 145295919

Gene position: 2050089-2048911 (Counterclockwise)

Preceding gene: 145295921

Following gene: 145295918

Centisome position: 61.86

GC content: 56.74

Gene sequence:

>1179_bases
ATGGGAGTCGTGACTAAAAAGATCCTTATTTTGGGAAGCACTGGTTCGATTGGAACTCAGGCGCTGGACGTTATTGCTGA
TAACTCAGACAAGTTTGAGGTGGTGGGTATCGCTGCGGGCGGTTCTCAGCCAGACCTCGTTATTTCGCAGGCGCAGCAGT
TGGGGCTGGCTGCAGACAAGGTTGCGGTTGCTGATGCACAGGCTGCCGCAGTAGTTTCGAAGGCTCTCGGCGGCGAGATC
ATCTCTGGAACCGATGCTGCGAAGATTCTGGTGGAAACCACAAAGGCCGACACTGTGCTTAATGCTCTGGTTGGTTCTTT
GGGGCTTGCGGCAACGCTGGCCACTCTGGAATCTGGTGCGCATCTTGCCTTGGCTAACAAAGAATCGCTGGTTGCCGGTG
GTGAATTTGTTACCTCAAAGGCGAAGCTGGGGCAGATCATTCCGGTCGATTCGGAGCACTCTGCCATGGCGCAGTGTTTG
CGTTCGGGTACTCGTGATGAGGTTGCGCGGATTGTGCTGACAGCTTCGGGCGGACCTTTCAGGGGCTGGACCAGGGAGAA
GATGTGGGAGGTGACTCCCGAGCAGGCAGCAGCGCACCCAACGTGGGCGATGGGGCAGATGAACACGTTGAACTCCGCCA
CCCTTATTAATAAAGGCCTCGAACTCATCGAGGCGACCCTGCTGTTTGAAACGGATGCGGATCTCATTGATGTGACGGTG
CATCCGCAGTCGATCATCCACTCCATGATCACTTTTACGGATGGTGCGACCATCGCGCAGGCGTCGCCACCATCGATGAA
ACTGCCGATCGCGTTGGCGCTTGATTGGCCACATCGGGTGCCGAAGGCTCAGCCGGCGCTGGATTTCACCGCTGCCCATA
CCTGGACTTTTGAGCCGGTGGATGATGCCGCATTCCCTGCGGTGCAGCTGGCTAGGCACGTCGCAAAGCAAAAAGGCACG
TACCCCGCGGTGTATAACGCTGCCAACGAGGAGGCGGCTGAGGCGTTTTTGCGCGGGCGAATCAAGTTTCCGCAGATCGT
GGACGTGGTGGACGAGGTCCTCCAAGGAGCTTCTCAGTTTGCTGGTGTAGCATCACACGTCGACGATATTTTGGCAACCG
AATCTGAGGCACGCGCGCGTGCGAATGCTTTGATCAACCGGTTGGCAACCAACTTGTAA

Upstream 100 bases:

>100_bases
ACTGCGCTTTCGCAGTCATCATGCAGGCATAACCTGAAACCCATCCGTTTGGATTGCCCCAAATGGGTGTAGTAGGTGCG
TTTACCCAACAAGTGCAAGA

Downstream 100 bases:

>100_bases
GCTAAGGAGCTTCCGCCTCGTGGCAGCCTATCTTCTTGGTGTCGTATTATTTTTCCTCGGCATCGCTGTAACCATCGCGC
TTCACGAGTGGGGGCACTTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVVSKALGGEI
ISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCL
RSGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWTFEPVDDAAFPAVQLARHVAKQKGT
YPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL

Sequences:

>Translated_392_residues
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVVSKALGGEI
ISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCL
RSGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWTFEPVDDAAFPAVQLARHVAKQKGT
YPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL
>Mature_391_residues
GVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVVSKALGGEII
SGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLR
SGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTVH
PQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWTFEPVDDAAFPAVQLARHVAKQKGTY
PAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=403, Percent_Identity=37.468982630273, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CORGB (A4QF22)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138740.1
- ProteinModelPortal:   A4QF22
- SMR:   A4QF22
- STRING:   A4QF22
- GeneID:   4992791
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1844
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 40974; Mature: 40843

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: BINDING 127-127 BINDING 152-152 BINDING 176-176 BINDING 199-199 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADK
CCCCEEEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHH
VAVADAQAAAVVSKALGGEIISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGA
HHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
HLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLRSGTRDEVARIVLTASGGPF
EEEEECCCCEEECCHHHCCHHHCCCEECCCCCHHHHHHHHHCCCHHHEEEEEEEECCCCC
RGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
CCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEEE
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWTFEPV
CHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEECCCCCCCCCCCCCEEEEECEEECCCC
DDAAFPAVQLARHVAKQKGTYPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQF
CCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGVASHVDDILATESEARARANALINRLATNL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADK
CCCEEEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHH
VAVADAQAAAVVSKALGGEIISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGA
HHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
HLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLRSGTRDEVARIVLTASGGPF
EEEEECCCCEEECCHHHCCHHHCCCEECCCCCHHHHHHHHHCCCHHHEEEEEEEECCCCC
RGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
CCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEEE
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWTFEPV
CHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEECCCCCCCCCCCCCEEEEECEEECCCC
DDAAFPAVQLARHVAKQKGTYPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQF
CCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGVASHVDDILATESEARARANALINRLATNL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA