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The map label for this gene is dut

Identifier: 145295809

GI number: 145295809

Start: 1926854

End: 1927303

Strand: Reverse

Name: dut

Synonym: cgR_1734

Alternate gene names: 145295809

Gene position: 1927303-1926854 (Counterclockwise)

Preceding gene: 145295811

Following gene: 145295808

Centisome position: 58.15

GC content: 53.33

Gene sequence:

>450_bases
GTGACTGATTTAGCACCTATTAAAATTGTCCGACTCGATAAAGAACTTCCACTGCCCAAGCGCGCTCACCGTGGCGATGC
TGGCGTTGATCTTCATGCCACCACAGATGCTGTGATTGCTCCGGGACATCGCGAAATCGTCGGCACTGGCATTGCAATTG
CTTTGCCCTTGGGAACCGTCGGATTGGTTCACCCCCGTTCGGGTCTTGCTGCACGCGAAGGCCTCAGCATTGTCAACGCG
CCGGGAACCATTGATGCTGATTACCGCGGAGAGATCAAGGTCTGCCTGATCAATCTTGATCCAGAAAAGCCCATCATGAT
TACTCGTGGCGACCGCATCGCGCAGCTTGTGATCCAAAAGGTGGAACTTGTGGATTTCGAAGAAGTCGAAGAATTAGACG
ACACCGTGCGCGGTGACCAGGGATACGGTTCCACCGGAAAAACAGCCTAA

Upstream 100 bases:

>100_bases
GAAGATGCAGAATCAGATTGTCGGGAATCAGTCACAATAGGCAATCCTATCCCACGGGTCATTTAAGGTCATTTCCCGCA
GGGTAGGTACGCTAAAAACT

Downstream 100 bases:

>100_bases
ATCCACCCTAACTGCTTAAATCGGGTGGCAGGAATACACAATCCTCCTACACTGGAACGGATTAGAAACGCGAAAGCAAA
GGACGGAAAAGAATCTCATG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MTDLAPIKIVRLDKELPLPKRAHRGDAGVDLHATTDAVIAPGHREIVGTGIAIALPLGTVGLVHPRSGLAAREGLSIVNA
PGTIDADYRGEIKVCLINLDPEKPIMITRGDRIAQLVIQKVELVDFEEVEELDDTVRGDQGYGSTGKTA

Sequences:

>Translated_149_residues
MTDLAPIKIVRLDKELPLPKRAHRGDAGVDLHATTDAVIAPGHREIVGTGIAIALPLGTVGLVHPRSGLAAREGLSIVNA
PGTIDADYRGEIKVCLINLDPEKPIMITRGDRIAQLVIQKVELVDFEEVEELDDTVRGDQGYGSTGKTA
>Mature_148_residues
TDLAPIKIVRLDKELPLPKRAHRGDAGVDLHATTDAVIAPGHREIVGTGIAIALPLGTVGLVHPRSGLAAREGLSIVNAP
GTIDADYRGEIKVCLINLDPEKPIMITRGDRIAQLVIQKVELVDFEEVEELDDTVRGDQGYGSTGKTA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=142, Percent_Identity=43.6619718309859, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4503423, Length=142, Percent_Identity=43.6619718309859, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI70906441, Length=142, Percent_Identity=43.6619718309859, Blast_Score=114, Evalue=4e-26,
Organism=Escherichia coli, GI1790071, Length=140, Percent_Identity=39.2857142857143, Blast_Score=91, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71988561, Length=141, Percent_Identity=41.1347517730496, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=142, Percent_Identity=36.6197183098592, Blast_Score=91, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24583610, Length=144, Percent_Identity=34.7222222222222, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921126, Length=144, Percent_Identity=34.7222222222222, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_CORGB (A4QER2)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138630.1
- ProteinModelPortal:   A4QER2
- SMR:   A4QER2
- STRING:   A4QER2
- GeneID:   4993152
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1734
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   GTIDEGY
- ProtClustDB:   PRK00601
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15889; Mature: 15758

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 93-93

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLAPIKIVRLDKELPLPKRAHRGDAGVDLHATTDAVIAPGHREIVGTGIAIALPLGTV
CCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCEEEEECCCCE
GLVHPRSGLAAREGLSIVNAPGTIDADYRGEIKVCLINLDPEKPIMITRGDRIAQLVIQK
EEECCCCCCCHHCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHH
VELVDFEEVEELDDTVRGDQGYGSTGKTA
HHHCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLAPIKIVRLDKELPLPKRAHRGDAGVDLHATTDAVIAPGHREIVGTGIAIALPLGTV
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCEEEEECCCCE
GLVHPRSGLAAREGLSIVNAPGTIDADYRGEIKVCLINLDPEKPIMITRGDRIAQLVIQK
EEECCCCCCCHHCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHH
VELVDFEEVEELDDTVRGDQGYGSTGKTA
HHHCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA