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The map label for this gene is upp [H]

Identifier: 145294857

GI number: 145294857

Start: 887847

End: 888482

Strand: Direct

Name: upp [H]

Synonym: cgR_0804

Alternate gene names: 145294857

Gene position: 887847-888482 (Clockwise)

Preceding gene: 145294852

Following gene: 145294858

Centisome position: 26.79

GC content: 58.49

Gene sequence:

>636_bases
ATGGACATCACCATCGTCAACCACCCACTCGTTGCTAGCCGCCTAACCCTGTTGCGCGACGAGCGCAGCGACAACGCAGC
TTTCCGTGCAGCAGCCAACGACCTCGGCGCCATGCTGATCTACGAAGCATCCCGAGATCTGGAAGTCGAACACTTCGACA
CCAAAACCCCCGTTGCCATGGCTGAAGGTACTCGCCTGAAGCAGCCACCCATCATCGTTCCCATCATCCGTGCAGGTCTC
GGCATGATCGACCCAGCGCTGTCGATGATTCCGGATGCACAGGTCGGCTTCATTGGCCTTGCCCGCGATGAGGAAACCCA
TGAGCCAGTCCCATACCTTGAGGCGCTGCCACAGGATCTAAGCAACCAGCCTGTATTCCTTGTCGATCCCATGCTGGCCA
CCGGCGGTTCCCTCCTGCACGCGATCCGCCTTCTTGCCGATCGTGGAGCCACCGACATCACCGCCATCTGCATGGTTTCT
GCGCAGCCAGGTGTGGACGCATTGGCGGAATCTGGTCTTCCAGTTCGTTTGGTTACCGCCACCATCGACCCAGGTCTAGA
CGAAAACGCCTACATCGTGCCTGGTCTTGGAGATGCCGGTGATCGTCTCTACGGTCCGCGAAACATTGACCTTTAA

Upstream 100 bases:

>100_bases
ATACTTTGTTGGACTGGAAAAGTGGCCGTTTGGTTCCCTCCAAGCCCAAATTCGCCCGCGCGGTCTTCTTCTGGGCGGCA
ATGATTTAACATGTGAAGCT

Downstream 100 bases:

>100_bases
AAGTTTCTAAGGGCATTACAGAAAATTCTTGCCCACTGTAGTGGGCGGTGAGTATTCTTACGCATCGGCAATGTTGTCTA
TGTGTCGAAGGAAATGTCGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAMAEGTRLKQPPIIVPIIRAGL
GMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDLSNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVS
AQPGVDALAESGLPVRLVTATIDPGLDENAYIVPGLGDAGDRLYGPRNIDL

Sequences:

>Translated_211_residues
MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAMAEGTRLKQPPIIVPIIRAGL
GMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDLSNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVS
AQPGVDALAESGLPVRLVTATIDPGLDENAYIVPGLGDAGDRLYGPRNIDL
>Mature_211_residues
MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAMAEGTRLKQPPIIVPIIRAGL
GMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDLSNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVS
AQPGVDALAESGLPVRLVTATIDPGLDENAYIVPGLGDAGDRLYGPRNIDL

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=29.2079207920792, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=29.2079207920792, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=42.7884615384615, Blast_Score=175, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=35.4166666666667, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45550449, Length=201, Percent_Identity=28.8557213930348, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573516, Length=201, Percent_Identity=28.8557213930348, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573514, Length=201, Percent_Identity=28.8557213930348, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573512, Length=201, Percent_Identity=28.8557213930348, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21358379, Length=178, Percent_Identity=29.2134831460674, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22523; Mature: 22523

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAM
CEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCEEE
AEGTRLKQPPIIVPIIRAGLGMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDL
CCCCCCCCCCEEEHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
SNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVSAQPGVDALAESGLPVRLVTA
CCCCEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEEEE
TIDPGLDENAYIVPGLGDAGDRLYGPRNIDL
EECCCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAM
CEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCEEE
AEGTRLKQPPIIVPIIRAGLGMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDL
CCCCCCCCCCEEEHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
SNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVSAQPGVDALAESGLPVRLVTA
CCCCEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEEEE
TIDPGLDENAYIVPGLGDAGDRLYGPRNIDL
EECCCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]