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The map label for this gene is guaA [H]

Identifier: 145294778

GI number: 145294778

Start: 785908

End: 787479

Strand: Direct

Name: guaA [H]

Synonym: cgR_0726

Alternate gene names: 145294778

Gene position: 785908-787479 (Clockwise)

Preceding gene: 145294777

Following gene: 145294779

Centisome position: 23.71

GC content: 58.72

Gene sequence:

>1572_bases
GTGAGCCTTCAGACAAATCATCGCCCAGTACTCGTCGTTGACTTCGGCGCACAGTACGCGCAGCTGATCGCACGTCGTGT
GCGTGAGGCCGGCATCTACTCCGAAGTCATCCCGCACACCGCCACCGCAGACGATGTGCGCGCTAAAAATGCAGCAGCCC
TCGTCCTTTCCGGTGGTCCATCCTCCGTGTACGCCGAGGGAGCACCATCCCTTGACGCTGAGATCTTAGATCTCGGATTG
CCAGTATTTGGCATTTGCTACGGCTTCCAAGCCATGACCCACGCGCTTGGTGGCACCGTTGCCAACACCGGTAAGCGCGA
ATACGGACGTACCGACATCAACGTTGCCGGTGGCGTCCTCCACGAAGGCCTCGAAGCCTGCCACAAGGTGTGGATGAGCC
ACGGCGACGCCGTCTCTGAAGCCCCAGAAGGTTTCGTAGTCACCGCGTCCTCCGAAGGTGCGCCTGTCGCAGCTTTCGAA
AACAAGGAACGCAAAATGGCTGGCGTGCAGTACCACCCAGAGGTATTGCACTCACCACACGGCCAGGCAGTTCTGACCCG
CTTCCTCACTGAGATCGCAGGTCTAGAGCAGAACTGGACCGCAGCAAACATCGCTGAAGAACTCATCGAGAAGGTCCGCG
AGCAGATCGGCGAAGATGGCCGCGCTATTTGTGGCCTTTCCGGTGGTGTGGACTCCGCAGTCGCAGGTGCACTGGTTCAG
CGCGCTATTGGCGACCGTTTGACCTGTGTCTTTGTTGACCACGGTCTGCTTCGTGCCGGTGAGCGCGAGCAGGTTGAAAA
GGACTTCGTCGCAGCAACCGGCGCCAAGCTGGTTACCGTTGATGAGCGCCAGGCATTCCTATCCAAGCTGGCCGGAGTTA
CCGAACCAGAAGCAAAGCGCAAGGCTATCGGCGCTGAGTTCATCCGCTCCTTCGAGCGCGCAGTTGCCGGTGTGTTGGAA
GAAGCTCCAGAAGGTTCCACCGTGGACTTCCTGGTTCAGGGCACCCTGTACCCAGACGTTGTTGAATCCGGTGGTGGATC
TGGTACCGCAAACATCAAGAGCCACCACAACGTCGGCGGACTGCCAGACGACGTGGAATTCAAGCTCGTTGAGCCACTGC
GTGATCTGTTCAAGGACGAAGTTCGTGCCGTTGGCCGTGAACTTGGCCTCCCTGAGGAAATCGTTGGCCGCCAGCCATTC
CCAGGACCAGGACTTGGTATTCGCATCATCGGTGAAGTCACCGAAGAGCGCCTAGAAACCCTCCGCCACGCTGACCTGAT
CGCACGCACCGAGCTGACAGCAGCTGGCCTTGACGGAGTGATCTGGCAGTGCCCAGTAGTCCTCCTGGCAGATGTCCGCT
CTGTTGGTGTTCAAGGCGATGGCCGCACCTACGGACACCCAATCGTGCTGCGCCCAGTGTCTTCCGAAGACGCCATGACG
GCTGACTGGACTCGACTTCCATACGAGGTTCTTGAGAAGATCTCCACCCGCATCACCAACGAAGTTCCAGATGTGAACCG
CGTGGTTTTGGACGTAACCTCCAAGCCACCAGGAACCATTGAATGGGAGTAG

Upstream 100 bases:

>100_bases
AGGGCGCCAGGGGCATCCAGCCATTAAAGCTTTTCGACGAGCCCTCGCCCATGTGGCCAAAGAATCTTATTTGGAGGCTC
GTCTAGTAGAGTGAGTTCTT

Downstream 100 bases:

>100_bases
GCCTTAAATGAGCCTTCGTTAAGCGGCAATCACCTTATTGGAGATTGTCGCTTTTCCCATTTCTCCGGGTTTTCTGGAAC
TTTTTGGGCGTATGCTGGGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGL
PVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFE
NKERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLE
EAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPF
PGPGLGIRIIGEVTEERLETLRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE

Sequences:

>Translated_523_residues
MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGL
PVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFE
NKERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLE
EAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPF
PGPGLGIRIIGEVTEERLETLRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE
>Mature_522_residues
SLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGLP
VFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFEN
KERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQR
AIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLEE
APEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPFP
GPGLGIRIIGEVTEERLETLRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTA
DWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=551, Percent_Identity=36.1161524500907, Blast_Score=290, Evalue=3e-78,
Organism=Escherichia coli, GI1788854, Length=534, Percent_Identity=47.1910112359551, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789760, Length=152, Percent_Identity=34.2105263157895, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787517, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=36.013986013986, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=36.013986013986, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=36.013986013986, Blast_Score=287, Evalue=8e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=517, Percent_Identity=45.8413926499033, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=34.5454545454545, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 55943; Mature: 55812

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGP
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHCCCCEEEEEECCC
SSVYAEGAPSLDAEILDLGLPVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVL
CCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCHHHHHH
HEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFENKERKMAGVQYHPEVLHSPH
HHHHHHHHHHHHHCCCHHHCCCCCEEEEECCCCCCEEEECCCHHHHCCCCCCHHHHCCCC
GQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKR
HHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCHHHH
KAIGAEFIRSFERAVAGVLEEAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCC
LPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPFPGPGLGIRIIGEVTEERLET
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
LRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE
CCHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGP
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHCCCCEEEEEECCC
SSVYAEGAPSLDAEILDLGLPVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVL
CCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCHHHHHH
HEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFENKERKMAGVQYHPEVLHSPH
HHHHHHHHHHHHHCCCHHHCCCCCEEEEECCCCCCEEEECCCHHHHCCCCCCHHHHCCCC
GQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKR
HHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCHHHH
KAIGAEFIRSFERAVAGVLEEAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCC
LPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPFPGPGLGIRIIGEVTEERLET
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
LRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE
CCHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]