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The map label for this gene is groEL

Identifier: 145294768

GI number: 145294768

Start: 776564

End: 778180

Strand: Direct

Name: groEL

Synonym: cgR_0716

Alternate gene names: 145294768

Gene position: 776564-778180 (Clockwise)

Preceding gene: 145294767

Following gene: 145294770

Centisome position: 23.43

GC content: 56.09

Gene sequence:

>1617_bases
ATGGCAAAGCTCATTGCTTTTGACCAGGACGCCCGCGAAGGCATTCTCCGGGGCGTCGACGCTCTGGCAAACGCTGTCAA
GGTAACCCTCGGCCCACGTGGCCGCAATGTGGTTCTTGATAAGGCATTCGGCGGACCTCTGGTCACCAACGACGGTGTCA
CCATTGCCCGCGACATCGACCTTGAGGATCCTTTTGAGAACCTCGGTGCACAGCTGGTGAAGTCCGTTGCTGTTAAGACC
AACGATATCGCTGGCGACGGCACCACCACCGCAACTCTGCTTGCTCAGGCACTCATTGCTGAAGGCCTACGCAACGTTGC
TGCTGGCGCAAACCCAATGGAGCTTAACAAGGGTATTGCTGCAGCTGCAGAAAAGACCCTGGAAGAGCTGAAGGCACGCG
CAACCGAGGTGTCTGACACCAAGGAAATCGCAAACGTCGCAACCGTTTCATCCCGCGATGAAGTTGTCGGCGAAATCGTT
GCTGCAGCAATGGAGAAGGTTGGCAAAGACGGTGTCGTCACCGTTGAGGAGTCCCAGTCCATCGAGACTGCTCTCGAGGT
CACCGAAGGTATTTCCTTCGACAAGGGCTACCTTTCCCCTTACTTCATCAACGACAACGACACTCAGCAGGCTGTCCTGG
ACAACCCTGCAGTGCTGCTTGTCCGCAATAAGATTTCTTCCCTCCCAGACTTCCTCCCACTGTTGGAGAAGGTTGTGGAG
TCCAACCGTCCTTTGCTGATCATCGCAGAAGACGTCGAGGGTGAGCCTTTGCAGACCCTGGTTGTGAACTCCATCCGCAA
GACCATCAAGGTCGTTGCAGTGAAGTCCCCTTACTTCGGTGACCGCCGCAAGGCGTTCATGGATGACCTGGCTATTGTCA
CCAAGGCAACTGTCGTGGATCCAGAGGTAGGCATCAACCTCAACGAAGCTGGCGAAGAAGTTTTCGGTACCGCACGTCGC
ATCACCGTTTCCAAGGACGAGACCGTCATTGTTGACGGCGCTGGTTCCGCAGAAGAGGTTGAGGCACGTCGCGCCCAGAT
CCGTCGCGAAATCGCCAACACCGATTCCACCTGGGATCGCGAAAAGGCAGAAGAGCGTTTGGCTAAGCTCTCCGGTGGTA
TTGCTGTCATCCGCGTTGGTGCAGCAACTGAAACCGAAGTCAACGACCGCAAGCTGCGTGTCGAAGATGCCATCAACGCT
GCTCGCGCAGCAGCACAAGAAGGCGTTATCGCTGGTGGCGGTTCCGCTTTGGTTCAGATCGCTGAGACTCTGAAGGCTTA
CGCCGAAGAGTTCGAAGGCGACCAGAAGGTCGGCGTTCGCGCACTGGCTACTGCTTTGGGCAAGCCAGCGTACTGGATCG
CCTCCAACGCAGGCCTTGACGGCTCTGTTGTTGTTGCACGCACTGCTGCTCTGCCAAACGGCGAGGGCTTCAACGCTGCA
ACTTTGGAATACGGAAACCTGATCAACGACGGTGTCATCGACCCAGTCAAGGTCACCCATTCCGCAGTAGTGAATGCAAC
CTCTGTTGCACGCATGGTTCTGACCACTGAGGCTTCTGTTGTTGAGAAGCCTGCAGAAGAAGCAGCCGATGCACATGCAG
GACATCATCACCACTAA

Upstream 100 bases:

>100_bases
CCCGTTACGGTGGCACCGAGATCAAGTTCGGTGGCGTGGAGTACTTGCTCCTCTCCGCTCGTGACATCCTCGCAATCGTC
GAGAAGTAGGGGATAAGTTC

Downstream 100 bases:

>100_bases
AGTTCTGTGAAAAACACCGTGGGGCAGTTTCTGCTTCGCGGTGTTTTTTATTTGTGGGGCAGAAGTGATGGTTAGAGTTA
CTGTGCAAAAGAGCTCTGCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MAKLIAFDQDAREGILRGVDALANAVKVTLGPRGRNVVLDKAFGGPLVTNDGVTIARDIDLEDPFENLGAQLVKSVAVKT
NDIAGDGTTTATLLAQALIAEGLRNVAAGANPMELNKGIAAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIV
AAAMEKVGKDGVVTVEESQSIETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVE
SNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARR
ITVSKDETVIVDGAGSAEEVEARRAQIRREIANTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINA
ARAAAQEGVIAGGGSALVQIAETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAA
TLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAHAGHHHH

Sequences:

>Translated_538_residues
MAKLIAFDQDAREGILRGVDALANAVKVTLGPRGRNVVLDKAFGGPLVTNDGVTIARDIDLEDPFENLGAQLVKSVAVKT
NDIAGDGTTTATLLAQALIAEGLRNVAAGANPMELNKGIAAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIV
AAAMEKVGKDGVVTVEESQSIETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVE
SNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARR
ITVSKDETVIVDGAGSAEEVEARRAQIRREIANTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINA
ARAAAQEGVIAGGGSALVQIAETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAA
TLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAHAGHHHH
>Mature_537_residues
AKLIAFDQDAREGILRGVDALANAVKVTLGPRGRNVVLDKAFGGPLVTNDGVTIARDIDLEDPFENLGAQLVKSVAVKTN
DIAGDGTTTATLLAQALIAEGLRNVAAGANPMELNKGIAAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVA
AAMEKVGKDGVVTVEESQSIETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVES
NRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARRI
TVSKDETVIVDGAGSAEEVEARRAQIRREIANTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAA
RAAAQEGVIAGGGSALVQIAETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAAT
LEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAHAGHHHH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=42.9924242424242, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=42.9924242424242, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI38455427, Length=141, Percent_Identity=31.2056737588652, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI4502643, Length=529, Percent_Identity=23.6294896030246, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=53.3962264150943, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=42.2641509433962, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI193210679, Length=217, Percent_Identity=39.1705069124424, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI25144674, Length=545, Percent_Identity=22.7522935779817, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=46.1977186311787, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322524, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=43.9393939393939, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=43.9393939393939, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=43.1818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=43.1818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=43.1818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=38.3587786259542, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=34.1555977229602, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=34.1555977229602, Blast_Score=268, Evalue=7e-72,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_CORGB (A4QBU0)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137589.1
- ProteinModelPortal:   A4QBU0
- SMR:   A4QBU0
- STRING:   A4QBU0
- GeneID:   4993795
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0716
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   WIASNAG
- ProtClustDB:   PRK12849
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56744; Mature: 56612

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIAFDQDAREGILRGVDALANAVKVTLGPRGRNVVLDKAFGGPLVTNDGVTIARDID
CCCEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCEEEEEECC
LEDPFENLGAQLVKSVAVKTNDIAGDGTTTATLLAQALIAEGLRNVAAGANPMELNKGIA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHH
AAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGVVTVEESQS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCH
IETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVE
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHH
SNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAIVTKATVVD
CCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEC
PEVGINLNEAGEEVFGTARRITVSKDETVIVDGAGSAEEVEARRAQIRREIANTDSTWDR
CCCCCCCCHHHHHHHCCHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
EKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAGGGSALVQI
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEECCCHHHHHH
AETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEE
TLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAHAGHHHH
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKLIAFDQDAREGILRGVDALANAVKVTLGPRGRNVVLDKAFGGPLVTNDGVTIARDID
CCEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCEEEEEECC
LEDPFENLGAQLVKSVAVKTNDIAGDGTTTATLLAQALIAEGLRNVAAGANPMELNKGIA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHH
AAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGVVTVEESQS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCH
IETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVE
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHH
SNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAIVTKATVVD
CCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEC
PEVGINLNEAGEEVFGTARRITVSKDETVIVDGAGSAEEVEARRAQIRREIANTDSTWDR
CCCCCCCCHHHHHHHCCHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
EKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAGGGSALVQI
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEECCCHHHHHH
AETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEE
TLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAHAGHHHH
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA