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The map label for this gene is alr

Identifier: 145294758

GI number: 145294758

Start: 766877

End: 767962

Strand: Direct

Name: alr

Synonym: cgR_0706

Alternate gene names: 145294758

Gene position: 766877-767962 (Clockwise)

Preceding gene: 145294755

Following gene: 145294759

Centisome position: 23.14

GC content: 55.99

Gene sequence:

>1086_bases
ATGAACTTGCTGACCACCAAAATTGACCTGGATGCCATCGCCCATAACACGAGGGTGCTTAAACAAATGGCGGGTCCGGC
GAAGCTGATGGCGGTGGTGAAGGCGAATGCATATAACCATGGCGTGGAGAAGGTCGCTCCGGTTATTGCTGCTCATGGTG
CGGATGCGTTTGGTGTGGCAACTCTTGCGGAGGCTATGCAGTTGCGTGATATCGGCATCAGCCAAGAGGTTTTGTGTTGG
ATTTGGACACCGGAGCAGGATTTCCGCGCCGCCATTGATCGCAATATCGATTTGGCGGTTATTTCTCCCGCGCATGCCAA
AGCCTTGATCGACACTGATGCGGAGCATATTCGGGTGTCCATCAAGATTGATTCTGGGTTGCATCGTTCGGGTGTGGATG
AGCAGGAGTGGGAGGGCGTGTTCAGCGCGTTGGCTGCTGCCCCGCACATTGAGGTCACGGGCATGTTCACGCACTTGGCG
TGCGCGGATGAGCCAGAGAATCCGGAAACTGATCGCCAAATTATTGCTTTTCGACGCGCCCTTGCGCTCGCCCGCAAGCA
CGGGCTTGAGTGCCCGGTCAACCACGTATGCAACTCACCTGCATTCTTGACTCGATCTGATTTACACATGGAGATGGTCC
GACCGGGTTTGGCCTTTTATGGGTTGGAACCCGTGGCGGGACGAGAGCATGGTTTGAAGCCGGCGATGACGTGGGAAGCG
AAGGTGAGCGTCGTAAAGCAAATTGAAGCTGGACAAGGCACTTCCTATGGCCTGACCTGGCGCGCTGAGGATCGCGGCTT
TGTGGCTGTGGTGCCTGCGGGCTATGCCGATGGCATGCCGCGGCATGCCCAGGGGAAATTCTCCGTCACGATTGATGGCG
TGGACTATCCGCAGGTTGGGCGCGTGTGTATGGATCAGTTCGTTATTTCTTTGGGCGACAATCCACACGGCGTGGAAGCT
GGGGCGAAGGCCGTGATATTCGGTGAGAATGGGCATGACGCAACTGATTTTGCGGAGCGTTTAGACACCATTAACTATGA
GGTAGTGTGCCGACCAACCGGCCGAACTGTCCGCGCATATGTGTAA

Upstream 100 bases:

>100_bases
AGCCACGTGTTTAAGGATAGTTGAAAGCGTGGGGCAATACTGGCACTAACCCCGGCACCAATCGTATTTCTGTCCGCCGT
TGGTGGCACAATAGGTCAAC

Downstream 100 bases:

>100_bases
GTGAATACGTTTAAGGAGCAGCAATGAAATCTGAGTTTCCGGTATCCGGCACGAGGCGTTTTGAGCATGCCGCAGATACC
CAAAATTTTGGGGAAGAATT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVATLAEAMQLRDIGISQEVLCW
IWTPEQDFRAAIDRNIDLAVISPAHAKALIDTDAEHIRVSIKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLA
CADEPENPETDRQIIAFRRALALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGREHGLKPAMTWEA
KVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGVDYPQVGRVCMDQFVISLGDNPHGVEA
GAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAYV

Sequences:

>Translated_361_residues
MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVATLAEAMQLRDIGISQEVLCW
IWTPEQDFRAAIDRNIDLAVISPAHAKALIDTDAEHIRVSIKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLA
CADEPENPETDRQIIAFRRALALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGREHGLKPAMTWEA
KVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGVDYPQVGRVCMDQFVISLGDNPHGVEA
GAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAYV
>Mature_361_residues
MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVATLAEAMQLRDIGISQEVLCW
IWTPEQDFRAAIDRNIDLAVISPAHAKALIDTDAEHIRVSIKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLA
CADEPENPETDRQIIAFRRALALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGREHGLKPAMTWEA
KVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGVDYPQVGRVCMDQFVISLGDNPHGVEA
GAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAYV

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=377, Percent_Identity=32.3607427055703, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787439, Length=354, Percent_Identity=30.5084745762712, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_CORGB (A4QBT0)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137579.1
- ProteinModelPortal:   A4QBT0
- SMR:   A4QBT0
- STRING:   A4QBT0
- GeneID:   4994172
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0706
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   NDENIAM
- ProtClustDB:   PRK00053
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39189; Mature: 39189

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 34-34 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVA
CCEEEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHH
TLAEAMQLRDIGISQEVLCWIWTPEQDFRAAIDRNIDLAVISPAHAKALIDTDAEHIRVS
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCHHHHEEECCCCHHEEEE
IKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLACADEPENPETDRQIIAFRRA
EEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHH
LALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGREHGLKPAMTWEA
HHHHHHCCCCCCHHHHCCCCCEEECCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEHHH
KVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGVDYPQVG
HHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHH
RVCMDQFVISLGDNPHGVEAGAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAY
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEE
V
C
>Mature Secondary Structure
MNLLTTKIDLDAIAHNTRVLKQMAGPAKLMAVVKANAYNHGVEKVAPVIAAHGADAFGVA
CCEEEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHH
TLAEAMQLRDIGISQEVLCWIWTPEQDFRAAIDRNIDLAVISPAHAKALIDTDAEHIRVS
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCHHHHEEECCCCHHEEEE
IKIDSGLHRSGVDEQEWEGVFSALAAAPHIEVTGMFTHLACADEPENPETDRQIIAFRRA
EEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHH
LALARKHGLECPVNHVCNSPAFLTRSDLHMEMVRPGLAFYGLEPVAGREHGLKPAMTWEA
HHHHHHCCCCCCHHHHCCCCCEEECCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEHHH
KVSVVKQIEAGQGTSYGLTWRAEDRGFVAVVPAGYADGMPRHAQGKFSVTIDGVDYPQVG
HHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHH
RVCMDQFVISLGDNPHGVEAGAKAVIFGENGHDATDFAERLDTINYEVVCRPTGRTVRAY
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEE
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA