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The map label for this gene is adk [H]

Identifier: 145294722

GI number: 145294722

Start: 728150

End: 728695

Strand: Direct

Name: adk [H]

Synonym: cgR_0670

Alternate gene names: 145294722

Gene position: 728150-728695 (Clockwise)

Preceding gene: 145294720

Following gene: 145294723

Centisome position: 21.97

GC content: 56.04

Gene sequence:

>546_bases
ATGCGACTCGTACTCCTCGGACCTCCCGGTGCTGGTAAGGGCACCCAGGCTGCAATTCTCTCTGAGAAGCTTGGCATTCC
TCACATTTCTACTGGCGATCTTTTCCGCGCCAACATTGGCGAGGGTACCCCTCTGGGTATCGAGGCCAAGCAGTACATCG
ACGCTGGCAAGCTGGTTCCAACCGACGTGACTGCACGTATGGTTGCTTCCCGCCTTGCTGAGTCCGATGCTGCAGAAGGC
TTCCTTTTGGATGGTTTCCCACGCACCGTTGAGCAGGCTGACATCTTGGCTAACCTGCTTTCCGAAGCTGGCCAGACCCT
CGATGGTGTTGTTAACTACCAGGTTTCTGAAGACGTCGTCGTGGAGCGCATGCTGTCCCGCGGTCGCGCTGATGACAACG
AAGAGACCATCCGCACCCGTCTCGGTGTCTACCGCGATGAGACTGCTCCTCTGATCGATCACTACGGTGACAAGATCATC
AACATTGAGGCTGAAGGCGAAGTCGAAGAGATCAACGCTCGTACCCTCAAGGCACTGGGCAAATAA

Upstream 100 bases:

>100_bases
GCGGAACCGCAATCTTGATTCTTGTATCTGTTGCACTGACCACAGTGAAGCAGATTGAGAGCCAGCTCCTGCAAAGCAAC
TACGAAGGACTTCTAAAATA

Downstream 100 bases:

>100_bases
GATTTCTTCTCTCGTGCTGCTGAATCTACGATGATAGGTAGATAGCAAGCAGTGACGTGGAAGCACTCACCTCAAGGTGG
CCGGAACCGCATGCATTGTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVPTDVTARMVASRLAESDAAEG
FLLDGFPRTVEQADILANLLSEAGQTLDGVVNYQVSEDVVVERMLSRGRADDNEETIRTRLGVYRDETAPLIDHYGDKII
NIEAEGEVEEINARTLKALGK

Sequences:

>Translated_181_residues
MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVPTDVTARMVASRLAESDAAEG
FLLDGFPRTVEQADILANLLSEAGQTLDGVVNYQVSEDVVVERMLSRGRADDNEETIRTRLGVYRDETAPLIDHYGDKII
NIEAEGEVEEINARTLKALGK
>Mature_181_residues
MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVPTDVTARMVASRLAESDAAEG
FLLDGFPRTVEQADILANLLSEAGQTLDGVVNYQVSEDVVVERMLSRGRADDNEETIRTRLGVYRDETAPLIDHYGDKII
NIEAEGEVEEINARTLKALGK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=34.5794392523364, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=34.5794392523364, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=32.8042328042328, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=33.1521739130435, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=33.8709677419355, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI310110345, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI53832003, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI8051579, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI53832001, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=29.9212598425197, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=39.4495412844037, Blast_Score=144, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17552384, Length=193, Percent_Identity=35.2331606217617, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=36.3636363636364, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=162, Percent_Identity=35.1851851851852, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=180, Percent_Identity=35, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=178, Percent_Identity=32.0224719101124, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=32.512315270936, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=40.2173913043478, Blast_Score=143, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=32.6086956521739, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=32.6086956521739, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=32.2751322751323, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=32.2751322751323, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=177, Percent_Identity=33.8983050847458, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356893, Length=177, Percent_Identity=33.8983050847458, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 19427; Mature: 19427

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCC
TDVTARMVASRLAESDAAEGFLLDGFPRTVEQADILANLLSEAGQTLDGVVNYQVSEDVV
CHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHEECCCCHHHH
VERMLSRGRADDNEETIRTRLGVYRDETAPLIDHYGDKIINIEAEGEVEEINARTLKALG
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MRLVLLGPPGAGKGTQAAILSEKLGIPHISTGDLFRANIGEGTPLGIEAKQYIDAGKLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCC
TDVTARMVASRLAESDAAEGFLLDGFPRTVEQADILANLLSEAGQTLDGVVNYQVSEDVV
CHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHEECCCCHHHH
VERMLSRGRADDNEETIRTRLGVYRDETAPLIDHYGDKIINIEAEGEVEEINARTLKALG
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]