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The map label for this gene is hemB [H]

Identifier: 145294550

GI number: 145294550

Start: 560257

End: 561276

Strand: Direct

Name: hemB [H]

Synonym: cgR_0501

Alternate gene names: 145294550

Gene position: 560257-561276 (Clockwise)

Preceding gene: 145294549

Following gene: 145294551

Centisome position: 16.9

GC content: 55.1

Gene sequence:

>1020_bases
ATGAGCACTTCTTCTGATTACTCCCACGCACTAATTCGTCGTCCGCGCCGACTTCGCGCCAACCCTGCGATGCGGGAACT
AGTCGCGGAAACCGCATTGCGCCCGGCGGATCTTATTTTGCCAATGTTCTTTGCGGATGGAATCACCGAGGCACGTGAGA
TCTCCTCCATGCCTGGCGTTTATCAGCACACGGAAGATTCACTGCTGCGTGCCGCCCATGAGGCTTTAGATGCGGGTGTT
CGTTGCGTTGATTTGTTCGGTGTTCCAATGGATGCGGACAAGGACTTCAATGGTTCCCAGGCATGGTCTGAAACCGGTGT
GTTGAACCGTGCCCTTGCATCGCTGCGTAAGGAATTCGGCGATGACCTGCTGATTATGGCCGATACTTGCCTTGATGAGT
TCACGGATCATGGTCACTGCGGCGTCGTTACCGAGGACCGTCATGGAAATGCAATCGTGGACAACGATGCCACGTTGCCG
CTGTACCAGCAGATGGCTGTTGCTCAGGCTCGTGCCGGTGCACATATTGTGAGCCCTTCCGGAATGATGGACGGCCAGAT
CGCTGCTATTCGTGCAGCGTTGGATGAGGAAGGCTACCAGGATGTCGCCATCATGGCGTATTCCGCTAAGTATGCATCAG
CATTCTTCGGACCTTTCCGCGAAGCAGTGGGATCCTCCCTCCAAGGAGATCGACGCACCTACCAGCAAGATCCTGCCAAC
CTGCGGGAATCATTGCTTGAGGCAGAACTAGATATCGCAGAAGGCGCGGACTTCATCATGGTCAAACCTGCATTGCCCTA
CCTTGATGTGCTGACCCGCATCGCTGATACCTCACCTGTCCCAGTGGCTGCCTACCAAGTTTCTGGTGAGTACGCGATGA
TCCAAGCAGCAGGCCGCAACGGTTGGGTTGACCTTGATGCAGTGATGATGGAATCTTTGACCTCCATCAAGCGTGCCGGT
GCAAACCAAATCCTCACGTACTTTGCCGTTGACGCTGCCCGCGCACTGCGAAACGCTTAA

Upstream 100 bases:

>100_bases
CAACTGCAGTGAAAATAGTAGCGGACGTGGTCGTGTCCACCGCTGACTCTATGATTGGACAAAGGACCTAGAAATTTCAA
GAGAGCAAAGGTTACAAGCA

Downstream 100 bases:

>100_bases
CAAGAACTAACTGATTAGTAGGACTCCCCATGAGCATGCTTCCCAATCTCACACCGAAGAAATCTGCCCCGCCTTCATCT
TCAGCTTCTGCGAAAAATGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSTSSDYSHALIRRPRRLRANPAMRELVAETALRPADLILPMFFADGITEAREISSMPGVYQHTEDSLLRAAHEALDAGV
RCVDLFGVPMDADKDFNGSQAWSETGVLNRALASLRKEFGDDLLIMADTCLDEFTDHGHCGVVTEDRHGNAIVDNDATLP
LYQQMAVAQARAGAHIVSPSGMMDGQIAAIRAALDEEGYQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPAN
LRESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRNGWVDLDAVMMESLTSIKRAG
ANQILTYFAVDAARALRNA

Sequences:

>Translated_339_residues
MSTSSDYSHALIRRPRRLRANPAMRELVAETALRPADLILPMFFADGITEAREISSMPGVYQHTEDSLLRAAHEALDAGV
RCVDLFGVPMDADKDFNGSQAWSETGVLNRALASLRKEFGDDLLIMADTCLDEFTDHGHCGVVTEDRHGNAIVDNDATLP
LYQQMAVAQARAGAHIVSPSGMMDGQIAAIRAALDEEGYQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPAN
LRESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRNGWVDLDAVMMESLTSIKRAG
ANQILTYFAVDAARALRNA
>Mature_338_residues
STSSDYSHALIRRPRRLRANPAMRELVAETALRPADLILPMFFADGITEAREISSMPGVYQHTEDSLLRAAHEALDAGVR
CVDLFGVPMDADKDFNGSQAWSETGVLNRALASLRKEFGDDLLIMADTCLDEFTDHGHCGVVTEDRHGNAIVDNDATLPL
YQQMAVAQARAGAHIVSPSGMMDGQIAAIRAALDEEGYQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPANL
RESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRNGWVDLDAVMMESLTSIKRAGA
NQILTYFAVDAARALRNA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=312, Percent_Identity=40.7051282051282, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI87081728, Length=323, Percent_Identity=48.9164086687306, Blast_Score=300, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=36.4217252396166, Blast_Score=189, Evalue=8e-49,
Organism=Drosophila melanogaster, GI21358291, Length=297, Percent_Identity=39.7306397306397, Blast_Score=204, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36810; Mature: 36679

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSDYSHALIRRPRRLRANPAMRELVAETALRPADLILPMFFADGITEAREISSMPGV
CCCCCHHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCC
YQHTEDSLLRAAHEALDAGVRCVDLFGVPMDADKDFNGSQAWSETGVLNRALASLRKEFG
HHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DDLLIMADTCLDEFTDHGHCGVVTEDRHGNAIVDNDATLPLYQQMAVAQARAGAHIVSPS
CCEEEEHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCEEECCC
GMMDGQIAAIRAALDEEGYQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPAN
CCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHH
LRESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRN
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCC
GWVDLDAVMMESLTSIKRAGANQILTYFAVDAARALRNA
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSSDYSHALIRRPRRLRANPAMRELVAETALRPADLILPMFFADGITEAREISSMPGV
CCCCHHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCC
YQHTEDSLLRAAHEALDAGVRCVDLFGVPMDADKDFNGSQAWSETGVLNRALASLRKEFG
HHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DDLLIMADTCLDEFTDHGHCGVVTEDRHGNAIVDNDATLPLYQQMAVAQARAGAHIVSPS
CCEEEEHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCEEECCC
GMMDGQIAAIRAALDEEGYQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPAN
CCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHH
LRESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRN
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCC
GWVDLDAVMMESLTSIKRAGANQILTYFAVDAARALRNA
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]