Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 145294528

GI number: 145294528

Start: 539970

End: 540791

Strand: Direct

Name: proC [H]

Synonym: cgR_0483

Alternate gene names: 145294528

Gene position: 539970-540791 (Clockwise)

Preceding gene: 145294527

Following gene: 145294529

Centisome position: 16.29

GC content: 57.3

Gene sequence:

>822_bases
GTGGGAACCATGACAACAATTGCTGTAATCGGCGGCGGACAAATCGGCGAGGCTTTAGTCTCAGGTTTGATCGCGGCCAA
CATGAATCCACAAAATATTCGCGTCACCAACCGTTCGGAAGAGCGCGGCCAAGAGCTGCGTGACCGCTACGGCATCCTCA
ACATGACGGATAATTCCCAAGCCGCAGACGAAGCCGACGTGGTGTTCCTGTGCGTGAAGCCGAAATTTATCGTCGAAGTG
CTCTCCGAAATCACCGGCACTTTGGATAACAATTCCGCACAAAGTGTTGTGGTCAGCATGGCCGCAGGCATCAGCATCGC
TGCCATGGAAGAAAGCGCCTCTGCGGGGCTCCCCGTCGTGCGCGTCATGCCGAACACTCCAATGCTCGTAGGCAAGGGCA
TGTCGACTGTCACCAAAGGCCGCTACGTTGACGCGGAACAGTTGGAACAAGTCAAGGACCTGTTAAGCACCGTTGGAGAC
GTCCTCGAAGTCGCGGAATCAGACATCGACGCAGTCACCGCCATGTCCGGATCCTCCCCTGCATACCTGTTCCTTGTGAC
CGAAGCGCTCATTGAGGCAGGAGTTAACCTAGGCCTGCCCCGCGCGACCGCTAAAAAGCTCGCTGTGGCCTCATTCGAAG
GTGCTGCAACCATGATGAAGGAAACCGGCAAAGAACCCTCAGAATTGCGCGCAGGCGTTTCCTCACCCGCAGGCACCACC
GTCGCAGCCATCCGAGAACTCGAAGAAAGCGGAATCCGAGGCGCTTTCTACCGCGCAGCCCAAGCCTGCGCCGACCGATC
TGAAGAACTCGGAAAGCGCTAG

Upstream 100 bases:

>100_bases
AATCGTGGGCCTAGTCATGACGTTCGGGCCGCTGGCAATCGTCATGTAATTTGTCGTTTTGGGCCCCCGCTGCTGCAAAA
CTGGGGTGGTTAGTGGCAGT

Downstream 100 bases:

>100_bases
AAACCGTTATTTCCCCGTTATCAGCTCGTTGTTTAGGAAGAAATTCACGAAAACGTTTTTCTTCCACCAACTCCAATGAC
CTGCAGATTCACATTCGAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MGTMTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEV
LSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGD
VLEVAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTT
VAAIRELEESGIRGAFYRAAQACADRSEELGKR

Sequences:

>Translated_273_residues
MGTMTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEV
LSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGD
VLEVAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTT
VAAIRELEESGIRGAFYRAAQACADRSEELGKR
>Mature_272_residues
GTMTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVL
SEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDV
LEVAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTV
AAIRELEESGIRGAFYRAAQACADRSEELGKR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=36.1623616236162, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=36.1623616236162, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=36.2637362637363, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=30.6273062730627, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=39.7003745318352, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=40.590405904059, Blast_Score=173, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=28.5211267605634, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=31.5972222222222, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=35.6617647058824, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=35.4014598540146, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=40.4761904761905, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28532; Mature: 28401

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTMTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQ
CCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCC
AADEADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVV
CCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEE
RVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSP
EECCCCCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
AYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTT
EEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCCCCCHH
VAAIRELEESGIRGAFYRAAQACADRSEELGKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GTMTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQ
CCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCC
AADEADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVV
CCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEE
RVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSP
EECCCCCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
AYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTT
EEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCCCCCHH
VAAIRELEESGIRGAFYRAAQACADRSEELGKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]