Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 145294508

GI number: 145294508

Start: 518724

End: 519800

Strand: Direct

Name: hmuU [H]

Synonym: cgR_0463

Alternate gene names: 145294508

Gene position: 518724-519800 (Clockwise)

Preceding gene: 145294507

Following gene: 145294509

Centisome position: 15.65

GC content: 59.15

Gene sequence:

>1077_bases
ATGGTTGTGAAGGAGGTTGACGTCGAAAAGCAAAAAGCTGGCCGGGTGCCTGGTGCTATAGCTAAGCGCCGGACCGTGCG
GATTGTGCTGTTTGTCGCGCTGGGCGCGATCGTGATTGCGGCGTCGCTGTGGTCGATTCTGGTCGGCCAATACACCATCC
CGATTCGCGATCTACCTGCGATTTTAAACGCCGGTCCGACCGGTGCACAGACGATGGCCGAACAAGTCGTGTGGCAAATC
CGCATGCCGCGCATCGTGCTGGGACTGCTCGTGGGTGCCGCTTTGGGTGTGGCCGGCGCGCTGTTGCAGGCAGTGTTTTC
CAACCCGCTGGCGGAACCGTCGATCATCGGCGTGACCTCCGGCGCGGGCGTGGGTGCTGCTGCGGTGATCGTGTTTAACC
TGACATTTTTGGGCACATCCACCGTCGCAGTCGGCGCGTTTATTACCGCGGTGATCACCACGATTTTGGTATATCAGCTG
GCCAGAAGCCGTGGACGTGTGCAAGTGATCAACCTGATCCTCACTGGCATCGCCATTAATGCAGTATCCGGCGCGCTGAC
CTCGTTCTTCATCTACATCGCGCCGACGAGCTCCCGCGAAGAAATTATTTTCTGGCAGATGGGTTCCCTCAACGGCTCGC
AATGGGCGCACGTCAACGTGGTGTTTGTGATCGTGACAATCGGCCTCGTCGCCGCATTTGGCCTGGGCAAACAGCTCGAT
GTGCTGGCGCTCGGCGAAAGCGCCGCCGGACACGTCGGCCTCAACGTGAAGAAACTGCGCATCATCGCGATCGCCGTATC
CACCCTCCTCACCGCCGGTGCCGTCGCATACGCAGGACTAATCAGCTTCGTTGGCCTGATCATCCCGCACCTGCTTCGCA
CAGTCACCGGACCTGCCAACAAAATCCTAGTACCAGCCTCCGCACTGGGCGGCGCAGCACTGATCAGCGTCTCTGACATC
CTTGCCAGAACGCTCATCCCATACGCTGACCTGCCGATCGGCATTTTCACAGCGCTGGTCGGCGGCCCAACATTCTTCAT
AATGTTGCGCCGAATGATGAAAAAGGGCGTGCACTAA

Upstream 100 bases:

>100_bases
ACTGGCGCTTCCCGATGGTCAATCATTGGCCTTTGGTGCCCAAACTGGCGAGTTGTTGCTCCGCGCATCCCGCGAACTGT
ATGTGCAGGGCGGCGAGTAG

Downstream 100 bases:

>100_bases
ATGGCCATTGTTTCCCTCGACAACGTCACCGTATCCATTGAAGGAAAAAAGCTTCTCGACGCTGTCTCCCTCAAGGCCTA
TCCCGGGGAAGTGTTGGGAC

Product: hypothetical protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVVKEVDVEKQKAGRVPGAIAKRRTVRIVLFVALGAIVIAASLWSILVGQYTIPIRDLPAILNAGPTGAQTMAEQVVWQI
RMPRIVLGLLVGAALGVAGALLQAVFSNPLAEPSIIGVTSGAGVGAAAVIVFNLTFLGTSTVAVGAFITAVITTILVYQL
ARSRGRVQVINLILTGIAINAVSGALTSFFIYIAPTSSREEIIFWQMGSLNGSQWAHVNVVFVIVTIGLVAAFGLGKQLD
VLALGESAAGHVGLNVKKLRIIAIAVSTLLTAGAVAYAGLISFVGLIIPHLLRTVTGPANKILVPASALGGAALISVSDI
LARTLIPYADLPIGIFTALVGGPTFFIMLRRMMKKGVH

Sequences:

>Translated_358_residues
MVVKEVDVEKQKAGRVPGAIAKRRTVRIVLFVALGAIVIAASLWSILVGQYTIPIRDLPAILNAGPTGAQTMAEQVVWQI
RMPRIVLGLLVGAALGVAGALLQAVFSNPLAEPSIIGVTSGAGVGAAAVIVFNLTFLGTSTVAVGAFITAVITTILVYQL
ARSRGRVQVINLILTGIAINAVSGALTSFFIYIAPTSSREEIIFWQMGSLNGSQWAHVNVVFVIVTIGLVAAFGLGKQLD
VLALGESAAGHVGLNVKKLRIIAIAVSTLLTAGAVAYAGLISFVGLIIPHLLRTVTGPANKILVPASALGGAALISVSDI
LARTLIPYADLPIGIFTALVGGPTFFIMLRRMMKKGVH
>Mature_358_residues
MVVKEVDVEKQKAGRVPGAIAKRRTVRIVLFVALGAIVIAASLWSILVGQYTIPIRDLPAILNAGPTGAQTMAEQVVWQI
RMPRIVLGLLVGAALGVAGALLQAVFSNPLAEPSIIGVTSGAGVGAAAVIVFNLTFLGTSTVAVGAFITAVITTILVYQL
ARSRGRVQVINLILTGIAINAVSGALTSFFIYIAPTSSREEIIFWQMGSLNGSQWAHVNVVFVIVTIGLVAAFGLGKQLD
VLALGESAAGHVGLNVKKLRIIAIAVSTLLTAGAVAYAGLISFVGLIIPHLLRTVTGPANKILVPASALGGAALISVSDI
LARTLIPYADLPIGIFTALVGGPTFFIMLRRMMKKGVH

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=327, Percent_Identity=33.9449541284404, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=35.6115107913669, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786804, Length=337, Percent_Identity=30.2670623145401, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790741, Length=315, Percent_Identity=31.1111111111111, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786805, Length=316, Percent_Identity=31.3291139240506, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786347, Length=276, Percent_Identity=27.8985507246377, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37163; Mature: 37163

Theoretical pI: Translated: 11.26; Mature: 11.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKEVDVEKQKAGRVPGAIAKRRTVRIVLFVALGAIVIAASLWSILVGQYTIPIRDLPA
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ILNAGPTGAQTMAEQVVWQIRMPRIVLGLLVGAALGVAGALLQAVFSNPLAEPSIIGVTS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
GAGVGAAAVIVFNLTFLGTSTVAVGAFITAVITTILVYQLARSRGRVQVINLILTGIAIN
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AVSGALTSFFIYIAPTSSREEIIFWQMGSLNGSQWAHVNVVFVIVTIGLVAAFGLGKQLD
HHHHHHHHEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VLALGESAAGHVGLNVKKLRIIAIAVSTLLTAGAVAYAGLISFVGLIIPHLLRTVTGPAN
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KILVPASALGGAALISVSDILARTLIPYADLPIGIFTALVGGPTFFIMLRRMMKKGVH
EEEEECHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVVKEVDVEKQKAGRVPGAIAKRRTVRIVLFVALGAIVIAASLWSILVGQYTIPIRDLPA
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ILNAGPTGAQTMAEQVVWQIRMPRIVLGLLVGAALGVAGALLQAVFSNPLAEPSIIGVTS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
GAGVGAAAVIVFNLTFLGTSTVAVGAFITAVITTILVYQLARSRGRVQVINLILTGIAIN
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AVSGALTSFFIYIAPTSSREEIIFWQMGSLNGSQWAHVNVVFVIVTIGLVAAFGLGKQLD
HHHHHHHHEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VLALGESAAGHVGLNVKKLRIIAIAVSTLLTAGAVAYAGLISFVGLIIPHLLRTVTGPAN
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KILVPASALGGAALISVSDILARTLIPYADLPIGIFTALVGGPTFFIMLRRMMKKGVH
EEEEECHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]