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The map label for this gene is lpd [H]

Identifier: 145294484

GI number: 145294484

Start: 490847

End: 492256

Strand: Direct

Name: lpd [H]

Synonym: cgR_0439

Alternate gene names: 145294484

Gene position: 490847-492256 (Clockwise)

Preceding gene: 145294483

Following gene: 145294485

Centisome position: 14.81

GC content: 52.27

Gene sequence:

>1410_bases
GTGACTGAACATTATGATGTAGTAGTACTCGGAGCGGGCCCCGGTGGCTACGTCTCCGCCATCCGCGCGGCCCAGCTTGG
CAAGAAGGTTGCTGTTATTGAGAAGCAGTATTGGGGTGGTATCTGCCTTAACGTTGGCTGCATTCCTTCCAAGTCTCTGA
TCAAAAACGCTGAGGTTGCCCATACCTTTACTCACGAGAAGAAGACCTTCGGCATTAACGGCGAAGTCACCTTCAACTAC
GAGGATGCTCACAAGCGTTCCCGTGGCGTTTCTGACAAGATCGTCGGTGGCGTTCACTACCTGATGAAGAAGAACAAGAT
CACCGAAATCCACGGTCTTGGTAACTTCAAGGATGCAAAGACCATTGAGGTAACTGACGGCAAGGATGCCGGCAAGACTG
TTACTTTTGATGACTGCATCATCGCAACTGGTTCTGTTGTGAACACCCTTCGTGGCGTTGAGTTCTCTAAGAACGTTGTT
TCCTTCGAAGAGCAGATCCTGGATCCTGTTGCACCTAAGAAGATGGTAATTGTCGGTGCTGGCGCAATCGGTATGGAATT
CGCTTATGTTCTCGGCAACTACGGTGTCGATGTAACTGTCATCGAGTTCATGGATCGCGTTCTTCCAAACGAAGATGCTG
AGGTCTCCAAGGTTATTGCTAAGGCTTACAAGAAGATGGGCGTTAAGCTCCTTCCTGGCCACGCAACTACCGCAGTTCGT
GACAACGGTGATTCTGTTGAGGTTGATTACCAGAAGAAGGGATCTGACAAGACTGAGACCCTCACTGTTGATCGCGTCAT
GGTTTCCGTTGGTTTCCGCCCACGTGTTGAGGGCTTCGGTCTGGAGAACACCGGCGTTAAGCTCACCGAGCGTGGCGCAA
TTGACATCGACGATTACATGCGTACCAACGTTCCTGGCATCTACGCTATCGGTGACGTCACCGCTAAGCTGCAGCTTGCT
CACGTCGCAGAAGCACAGGGCATTGTTGCTGCTGAGACCATCGCTGGTGCAGAGACCCAGGCCCTTGGTGATTACATGAT
GATGCCTCGCGCAACGTTCTGTAACCCACAGGTTGCTTCCTTCGGTTACACCGAGGAGCAGGCTAAGCAGAAGTGGCCTG
ATCGTGAGATCAAGGTTGCGTCCTTCCCATTCTCTGCAAACGGTAAGGCAGTCGGCCTGGCTGAGACCGATGGCTTCGCA
AAGATCGTTGCGGATGCTGAATTCGGTGAGCTGCTCGGTGGACACCTCGTTGGTGCTAACGCTTCCGAGCTCATCAACGA
ACTGGTTCTGGCACAGAACTGGGATCTCACCACTGAGGAGATCTCACGCAGCGTTCACATTCACCCAACGCTGTCTGAAG
CTGTTAAGGAAGCCGCTCACGGTATTTCCGGACACATGATCAACTTCTAG

Upstream 100 bases:

>100_bases
CAACATCGTGGGCTTTCTTGTTCCCCCTATTTAGTGTGGATTGGTCTTTCTGTAGACCACGTGCACGACAAGACAATCCT
AAACACGTATCCTTGAATGC

Downstream 100 bases:

>100_bases
TTCGAAGATTCAAAAGGCCCTGATTGTAAGTGCAATCAGGGCTTTTTTCTTTGGTTTTCTGAAGTTATAACTGACTTTTT
ATTAAGTGTTCATGCTCACA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGICLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNY
EDAHKRSRGVSDKIVGGVHYLMKKNKITEIHGLGNFKDAKTIEVTDGKDAGKTVTFDDCIIATGSVVNTLRGVEFSKNVV
SFEEQILDPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
DNGDSVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIDIDDYMRTNVPGIYAIGDVTAKLQLA
HVAEAQGIVAAETIAGAETQALGDYMMMPRATFCNPQVASFGYTEEQAKQKWPDREIKVASFPFSANGKAVGLAETDGFA
KIVADAEFGELLGGHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF

Sequences:

>Translated_469_residues
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGICLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNY
EDAHKRSRGVSDKIVGGVHYLMKKNKITEIHGLGNFKDAKTIEVTDGKDAGKTVTFDDCIIATGSVVNTLRGVEFSKNVV
SFEEQILDPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
DNGDSVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIDIDDYMRTNVPGIYAIGDVTAKLQLA
HVAEAQGIVAAETIAGAETQALGDYMMMPRATFCNPQVASFGYTEEQAKQKWPDREIKVASFPFSANGKAVGLAETDGFA
KIVADAEFGELLGGHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
>Mature_468_residues
TEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGICLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNYE
DAHKRSRGVSDKIVGGVHYLMKKNKITEIHGLGNFKDAKTIEVTDGKDAGKTVTFDDCIIATGSVVNTLRGVEFSKNVVS
FEEQILDPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVRD
NGDSVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIDIDDYMRTNVPGIYAIGDVTAKLQLAH
VAEAQGIVAAETIAGAETQALGDYMMMPRATFCNPQVASFGYTEEQAKQKWPDREIKVASFPFSANGKAVGLAETDGFAK
IVADAEFGELLGGHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=38.135593220339, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=29.5258620689655, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=27.9317697228145, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI148277065, Length=471, Percent_Identity=28.2377919320594, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI33519430, Length=471, Percent_Identity=28.2377919320594, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI33519428, Length=471, Percent_Identity=28.2377919320594, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI33519426, Length=471, Percent_Identity=28.2377919320594, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI148277071, Length=471, Percent_Identity=28.2377919320594, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=27.1367521367521, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI22035672, Length=462, Percent_Identity=27.0562770562771, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1786307, Length=465, Percent_Identity=34.1935483870968, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=30.6345733041575, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87081717, Length=477, Percent_Identity=26.2054507337526, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=27.0562770562771, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=37.6086956521739, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=27.3291925465839, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=28.6353467561521, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=28.6353467561521, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=476, Percent_Identity=25.2100840336134, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=197, Percent_Identity=35.5329949238579, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=38.0851063829787, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=28.997867803838, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=28.3298097251586, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=40, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=28.1512605042017, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=28.1512605042017, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=28.1512605042017, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=27.9411764705882, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50501; Mature: 50370

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGICLNVGCIPSKSLIKNAEVA
CCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCHHH
HTFTHEKKTFGINGEVTFNYEDAHKRSRGVSDKIVGGVHYLMKKNKITEIHGLGNFKDAK
HHCCCCCEEECCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCC
TIEVTDGKDAGKTVTFDDCIIATGSVVNTLRGVEFSKNVVSFEEQILDPVAPKKMVIVGA
EEEEECCCCCCCEEEECCEEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
GAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
CHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEE
DNGDSVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIDIDDYM
CCCCEEEEEHHCCCCCCCCEEEEEHEEEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
RTNVPGIYAIGDVTAKLQLAHVAEAQGIVAAETIAGAETQALGDYMMMPRATFCNPQVAS
HCCCCCEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHC
FGYTEEQAKQKWPDREIKVASFPFSANGKAVGLAETDGFAKIVADAEFGELLGGHLVGAN
CCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCEEECCC
ASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
HHHHHHHHHHHCCCCCCHHHHCCEEEECCCHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure 
TEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGICLNVGCIPSKSLIKNAEVA
CCCEEEEEEECCCCHHHHHHHHHHHCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCHHH
HTFTHEKKTFGINGEVTFNYEDAHKRSRGVSDKIVGGVHYLMKKNKITEIHGLGNFKDAK
HHCCCCCEEECCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCC
TIEVTDGKDAGKTVTFDDCIIATGSVVNTLRGVEFSKNVVSFEEQILDPVAPKKMVIVGA
EEEEECCCCCCCEEEECCEEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
GAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
CHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEE
DNGDSVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIDIDDYM
CCCCEEEEEHHCCCCCCCCEEEEEHEEEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
RTNVPGIYAIGDVTAKLQLAHVAEAQGIVAAETIAGAETQALGDYMMMPRATFCNPQVAS
HCCCCCEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHC
FGYTEEQAKQKWPDREIKVASFPFSANGKAVGLAETDGFAKIVADAEFGELLGGHLVGAN
CCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCEEECCC
ASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
HHHHHHHHHHHCCCCCCHHHHCCEEEECCCHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]