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The map label for this gene is lysC [H]

Identifier: 145294373

GI number: 145294373

Start: 367471

End: 368736

Strand: Direct

Name: lysC [H]

Synonym: cgR_0328

Alternate gene names: 145294373

Gene position: 367471-368736 (Clockwise)

Preceding gene: 145294370

Following gene: 145294374

Centisome position: 11.09

GC content: 54.27

Gene sequence:

>1266_bases
GTGGCCCTGGTCGTACAGAAATATGGCGGTTCCTCGCTTGAGAGTGCGGAACGCATTAGAAACGTCGCTGAACGGATCGT
TGCCACCAAGAAGGCTGGAAATGATGTCGTGGTTGTCTGCTCCGCAATGGGAGACACCACGGATGAGCTTCTAGAACTTG
CTGCGGCAGTGAATCCCGTTCCGCCAGCTCGTGAAATGGATATGCTCCTGACTGCTGGTGAGCGTATTTCTAACGCTCTC
GTCGCCATGGCTATTGAGTCCCTGGGTGCAGAGGCTCAATCTTTCACGGGTTCTCAGGCTGGTGTGCTCACCACCGAGCG
TCACGGAAACGCACGCATTGTTGATGTCACTCCAGGTCGTGTGCGTGAAGCACTCGATGAGGGCAAGATCTGCATTGTTG
CTGGTTTCCAGGGTGTCAATAAGGAAACCCGCGATGTCACCACGTTGGGTCGCGGTGGTTCTGATACCACTGCAGTTGCA
TTGGCAGCTGCTCTGAACGCTGATGTGTGTGAGATTTACTCAGATGTTGACGGCGTGTACACCGCTGACCCGCGCATCGT
TCCTAATGCTCAGAAGCTGGAAAAGCTCAGCTTCGAAGAAATGCTGGAACTTGCTGCTGTTGGCTCCAAGATTTTGGTGC
TACGCAGTGTTGAATACGCTCGTGCATTCAATGTGCCACTTCGCGTACGCTCGTCTTATAGCAATGATCCCGGCACTTTG
ATTGCCGGCTCTATGGAGGATATTCCTGTGGAAGAAGCAGTCCTTACCGGTGTCGCAACCGACAAGTCCGAAGCCAAAGT
AACCGTTCTGGGTATTTCCGATAAGCCAGGCGAGGCTGCGAAGGTTTTCCGTGCGTTGGCTGATGCAGAAATCAACATTG
ACATGGTTCTGCAGAACGTCTCCTCTGTGGAAGACGGCACCACCGACATCACGTTCACCTGCCCTCGCTCTGACGGACGC
CGTGCGATGGAGATCTTGAAGAAGCTTCAGGTTCAGGGCAACTGGACCAATGTGCTTTACGACGACCAGGTCGGCAAAGT
CTCCCTCGTGGGTGCGGGCATGAAGTCTCACCCAGGTGTTACCGCAGAGTTCATGGAAGCTCTGCGCGATGTCAACGTGA
ACATCGAATTGATTTCCACCTCTGAGATCCGCATTTCCGTGCTGATCCGTGAAGATGATCTGGATGCTGCTGCACGTGCA
CTGCACGAGCAGTTCCAGCTGGGCGGCGAAGACGAAGCCGTCGTTTATGCAGGCACCGGACGCTAA

Upstream 100 bases:

>100_bases
CTGTACAGAAAGAAAACACTCCTCTGGCTAGGTAGACACAGTTTATAAAGGTAGAGTTGAGCGGGTAACTGTCAGCACGT
AGATCGAAAGGTGCACAAAG

Downstream 100 bases:

>100_bases
AGTTTTAAAGGAGTAGTTTTACAATGACCACCATCGCAGTTGTTGGTGCAACCGGCCAGGTCGGCCAGGTTATGCGCACC
CTTTTGGAAGAGCGCAATTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNAL
VAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVA
LAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL
IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGR
RAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARA
LHEQFQLGGEDEAVVYAGTGR

Sequences:

>Translated_421_residues
MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNAL
VAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVA
LAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL
IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGR
RAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARA
LHEQFQLGGEDEAVVYAGTGR
>Mature_420_residues
ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALV
AMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVAL
AAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLI
AGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRR
AMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARAL
HEQFQLGGEDEAVVYAGTGR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=349, Percent_Identity=32.6647564469914, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790455, Length=407, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790376, Length=455, Percent_Identity=25.2747252747253, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=378, Percent_Identity=25.1322751322751, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44755; Mature: 44624

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPV
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCEEEEECCCHH
VREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY
HHHHHCCCCEEEEECCCCCCCCCCHHEECCCCCCCHHHHHHHHHHCCHHHHHHHCCCCEE
TADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL
ECCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEEEHHHHHHCCCCEEEECCCCCCCCCE
IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNV
EECCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHH
SSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGV
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCC
TAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEAVVYAGTG
CHHHHHHHHCCCCEEEEEEECCEEEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCC
R
C
>Mature Secondary Structure 
ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPV
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCEEEEECCCHH
VREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY
HHHHHCCCCEEEEECCCCCCCCCCHHEECCCCCCCHHHHHHHHHHCCHHHHHHHCCCCEE
TADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL
ECCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEEEHHHHHHCCCCEEEECCCCCCCCCE
IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNV
EECCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHH
SSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGV
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCC
TAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEAVVYAGTG
CHHHHHHHHCCCCEEEEEEECCEEEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]