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The map label for this gene is qacA

Identifier: 14141855

GI number: 14141855

Start: 21593

End: 23137

Strand: Direct

Name: qacA

Synonym: SAVP032

Alternate gene names: 14141855

Gene position: 21593-23137 (Clockwise)

Preceding gene: 14141848

Following gene: 14141856

Centisome position: 86.0

GC content: 35.47

Gene sequence:

>1545_bases
ATGATTTCATTTTTTACAAAAACTACTGATATGATGACATCAAAAAAAAGATGGACTGCACTAGTAGTATTAGCTGTTAG
TTTGTTTGTTGTTACAATGGATATGACAATATTAATTATGGCTTTACCGGAATTAGTAAGAGAGTTAGAGCCTTCTGGTA
CCCAACAGTTATGGATAGTTGATATATACTCTCTTGTTTTAGCTGGCTTTATAATTCCATTGAGTGCCTTTGCTGATAAA
TGGGGAAGAAAAAAAGCATTATTAACTGGATTTGCTTTATTTGGCCTCGTTTCATTAGCTATATTTTTCGCAGAAAGTGC
AGAGTTCGTAATAGCTATTCGATTTTTACTTGGTATTGCAGGTGCTTTAATAATGCCAACTACTCTTTCAATGATAAGAG
TAATTTTTGAAAACCCTAAAGAAAGGGCCACTGCATTAGCTGTATGGTCAATCGCTTCATCGATAGGTGCTGTTTTTGGA
CCAATTATCGGAGGAGCTTTACTTGAGCAATTTTCATGGCACTCGGCATTTTTAATTAATGTACCGTTTGCGATAATAGC
AGTTGTAGCAGGTTTATTTTTATTACCAGAGTCTAAGTTATCAAAAGAAAAGTCTCACTCGTGGGATATTCCTTCTACAA
TTTTATCAATTGCAGGCATGATTGGACTGGTATGGAGTATCAAAGAATTTTCAAAAGAAGGACTAGCAGATATTATTCCA
TGGGTTGTAATAGTATTAGCAATTACCATGATAGTGATATTTGTTAAACGTAATTTATCAAGTTCTGATCCAATGTTAGA
CGTAAGACTTTTTAAAAAGAGATCATTTTCAGCTGGTACAATTGCTGCATTTATGACAATGTTTGCAATGGCATCTGTTT
TGTTATTAGCTTCACAATGGTTACAGGTTGTGGAAGAACTTTCTCCTTTTAAAGCTGGCTTATACCTATTACCTATGGCA
ATAGGAGATATGGTGTTTGCACCAATTGCACCCGGATTAGCGGCGCGATTTGGACCGAAAATAGTGTTACCTTCCGGAAT
TGGAATTGCAGCCATTGGCATGTTTATTATGTATTTCTTTGGTCATCCATTATCATATTCTACAATGGCTTTAGCATTAA
TTTTAGTTGGAGCTGGTATGGCTTCACTAGCAGTTGCATCTGCTCTAATAATGTTAGAAACACCTACATCAAAAGCAGGT
AATGCAGCTGCTGTTGAAGAGTCTATGTATGACCTTGGAAATGTTTTTGGTGTAGCAGTACTTGGTAGCCTATCTTCTAT
GCTTTATCGTGTATTTTTAGATATTTCATCTTTTTCATCAAAAGGTATAGTTGGAGATTTAGCTCATGTAGCTGAAGAAT
CTGTAGTGGGCGCTGTCGAAGTAGCTAAAGCTACGGGGATAAAACAGCTTGCAAACGAGGCTGTAACATCATTTAATGAT
GCTTTTGTAGCAACTGCTTTAGTAGGTGGGATTATCATGATTATCATTTCAATAGTTGTCTATTTGTTAATTCCCAAATC
ACTTGATATAACTAAACAAAAATAG

Upstream 100 bases:

>100_bases
CATTTAAATTTCGCAAGATTTTTTGTTGTAATATGTAAAAAAATAGATTATAATCCTTATAGACCGATCGCACGGTCTAT
AAGGATTGGAGGGAACTTAA

Downstream 100 bases:

>100_bases
TACTAAACATATATTTTTAGATATTGTAGATTAGTTTATTTTTAAAATTAGTAATAGTTAAAAAGTAGAACCATTAATTT
TAAATGGTTCTACTTTTTTA

Product: QacA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIVDIYSLVLAGFIIPLSAFADK
WGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIAGALIMPTTLSMIRVIFENPKERATALAVWSIASSIGAVFG
PIIGGALLEQFSWHSAFLINVPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIP
WVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMASVLLLASQWLQVVEELSPFKAGLYLLPMA
IGDMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFFGHPLSYSTMALALILVGAGMASLAVASALIMLETPTSKAG
NAAAVEESMYDLGNVFGVAVLGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFND
AFVATALVGGIIMIIISIVVYLLIPKSLDITKQK

Sequences:

>Translated_514_residues
MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIVDIYSLVLAGFIIPLSAFADK
WGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIAGALIMPTTLSMIRVIFENPKERATALAVWSIASSIGAVFG
PIIGGALLEQFSWHSAFLINVPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIP
WVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMASVLLLASQWLQVVEELSPFKAGLYLLPMA
IGDMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFFGHPLSYSTMALALILVGAGMASLAVASALIMLETPTSKAG
NAAAVEESMYDLGNVFGVAVLGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFND
AFVATALVGGIIMIIISIVVYLLIPKSLDITKQK
>Mature_514_residues
MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIVDIYSLVLAGFIIPLSAFADK
WGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIAGALIMPTTLSMIRVIFENPKERATALAVWSIASSIGAVFG
PIIGGALLEQFSWHSAFLINVPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIP
WVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMASVLLLASQWLQVVEELSPFKAGLYLLPMA
IGDMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFFGHPLSYSTMALALILVGAGMASLAVASALIMLETPTSKAG
NAAAVEESMYDLGNVFGVAVLGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFND
AFVATALVGGIIMIIISIVVYLLIPKSLDITKQK

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily

Homologues:

Organism=Escherichia coli, GI87081983, Length=416, Percent_Identity=25.2403846153846, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790195, Length=426, Percent_Identity=27.6995305164319, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=24.5283018867925, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788392, Length=338, Percent_Identity=28.1065088757396, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789042, Length=326, Percent_Identity=26.3803680981595, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): QACA_STAAM (P0A0J8)

Other databases:

- EMBL:   AP003367
- RefSeq:   NP_115321.1
- ProteinModelPortal:   P0A0J8
- STRING:   P0A0J8
- EnsemblBacteria:   EBSTAT00000008294
- GeneID:   1119948
- GenomeReviews:   AP003367_GR
- KEGG:   sav:SAVP032
- eggNOG:   COG0477
- GeneTree:   EBGT00050000023931
- HOGENOM:   HBG679341
- ProtClustDB:   CLSK507148
- BioCyc:   SAUR158878:SAVP032-MONOMER
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 55017; Mature: 55017

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xac99cdc)-; HASH(0xac9a2a0)-; HASH(0xac99f40)-; HASH(0xac99eb0)-; HASH(0xac9a078)-; HASH(0xac98f5c)-; HASH(0xac9a570)-; HASH(0xac9a1f8)-; HASH(0xac9a900)-; HASH(0xac998bc)-; HASH(0xac98d1c)-; HASH(0xac9997c)-; HASH(0xac9a138)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHH
DIYSLVLAGFIIPLSAFADKWGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GALIMPTTLSMIRVIFENPKERATALAVWSIASSIGAVFGPIIGGALLEQFSWHSAFLIN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIP
HHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
WVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMASVLLLASQW
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQVVEELSPFKAGLYLLPMAIGDMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFF
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCHHHHHHHHHHHHH
GHPLSYSTMALALILVGAGMASLAVASALIMLETPTSKAGNAAAVEESMYDLGNVFGVAV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFND
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFVATALVGGIIMIIISIVVYLLIPKSLDITKQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHH
DIYSLVLAGFIIPLSAFADKWGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GALIMPTTLSMIRVIFENPKERATALAVWSIASSIGAVFGPIIGGALLEQFSWHSAFLIN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIP
HHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
WVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMASVLLLASQW
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQVVEELSPFKAGLYLLPMAIGDMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFF
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCHHHHHHHHHHHHH
GHPLSYSTMALALILVGAGMASLAVASALIMLETPTSKAGNAAAVEESMYDLGNVFGVAV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFND
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFVATALVGGIIMIIISIVVYLLIPKSLDITKQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146