Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 138896911

GI number: 138896911

Start: 3388127

End: 3389731

Strand: Reverse

Name: ywrD [H]

Synonym: GTNG_3280

Alternate gene names: 138896911

Gene position: 3389731-3388127 (Counterclockwise)

Preceding gene: 138896912

Following gene: 138896910

Centisome position: 95.48

GC content: 58.26

Gene sequence:

>1605_bases
ATGGACTACTTATACCACCCATATCCATCACAGCGGATGACAGTGTTCGCCAAAAACGGTATTGTCGCGACATCGCAACC
GCTCGCTGCTCAGGCCGGGCTTGAAGTGCTGAAAAAAGGCGGCAATGCCATCGATGCGGCGATTGCCACCGCGGCTTGCC
TGACGGTCGTTGAGCCGACGTCCAACGGCATCGGCGGTGATGCGTTCGCGCTCGTCTGGACGAACGGGAAGTTGTACGGG
TTAAACGCCAGCGGCTATGCACCAGCTGCCATTTCGCTCGACGTGTTAAAAGAGCGCGGCTATACGGAAATGCCGAAATA
CGGGTTCGCCCCGGTGACGGTTCCGGGAGCGCCGGCGGCGTGGGCGGCGCTGTCGAAGCGCTTTGGACGTCTGTCGCTTG
CCGAAACGCTCGCGCCGGCCATCGCTTATGCCGAAAACGGCTATCCGGTATCGCCTGTGCTCGGAAAGTACTGGGCGAAC
GCCTACCGAGTGTACAAAGAAGCGCTCCATGGGCCGGAGTTCGGTTCGTGGTTTGAGACGTTTGCGCCGGCCGGTCGCGC
CCCGAACATCGGTGAAGTGTGGGCTTCACCCGATCATGCGGCGACGCTTCGTTCGATTGCGGAGACCGAAGCGGAAAGCT
TCTATCGCGGCGAGTTGGCGGAAAAAATCGTCGCCTTCTCGAAGCAATACAACGGCTTTTTGACGCTTGAAGATCTTGCC
GAGTATGAACCGGAATGGGTCGAACCGATTTCCGTTTCTTACCACGGCTACGACGTATGGGAAATCCCGCCGAACGGCCA
GGGACTTGTCGCCTTAATGGCGTTAAACATCATGAACGGGTTTGACGTACCGAATGTTCCGGATGTAGAGACATACCACC
GACAAATTGAGGCGATGAAGCTCGCCTTTGCCGACGGGAAAGCATATATCGCCGACCGTCGCTATATGAACTATCGCGTA
GACGAGCTGTTATCTGAATCGTTTGCTGCGATGCGCCGGGCGCAAATCGGCACCGAAGCGCTTACGCCGGAGCCGGGGAC
GCCGCCAAAAGGCGGGACGGTCTATTTGGCTGCCGCTGACGGCGAGGGCAATATGGTATCGTTCATCCAAAGCAACTATA
TGGGCTTCGGTTCCGGCCTCGTTGTGCCGGGCACGGGGATTGCCTTGCACAACCGCGGTCATAACTTTGTCTTTGATGAG
AACCATCCAAATGGGCTCGCACCGCGGAAAAAGCCGTACCATACGATCATCCCCGGATTTTTAACAAAGGGAGGCAAACC
GATCGGCCCGTTTGGTGTCATGGGCGGGTTTATGCAGCCACAAGGACATATGCAAGTGATCATGAACACGGTCGATTTTG
CTTTGAATCCGCAAGCAGCGCTCGATGCGCCTCGTTGGCAGTGGATGGAAGGGAAAACAGTGCTCGTTGAGCCGCACTTC
CCACGTCATATCGCTGAAGCGCTCGCCCGCAAAGGGCACGACATCTGCGTCGCGTTGGACGGCGGCCCGTTCGGCCGCGG
GCAAATCATTTGGCGCGATCCTGATACCGGCGTGCTTGCCGCAGGGACGGAGCCGCGCACGGATGGAGCGGTCGCCGCTT
GGTGA

Upstream 100 bases:

>100_bases
GGTGGCGACCGAACGATGCAAACAAGAACGGCCGGAGTGGAAAGAAGCGGCTCCAGGTCATTTTGTTGCTTGTCATGAAG
TGAAGTGAGGAGGAGTTTCT

Downstream 100 bases:

>100_bases
AACTAGCGATAAAGGAATGACAACGATGAATCAATGGCATTTGTTTCTCGCGTTTTTTCGCGTCGGCATGCTCGGGTACG
GAGGCGGTCCGTCCTCGATC

Product: cephalosporin acylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MDYLYHPYPSQRMTVFAKNGIVATSQPLAAQAGLEVLKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTNGKLYG
LNASGYAPAAISLDVLKERGYTEMPKYGFAPVTVPGAPAAWAALSKRFGRLSLAETLAPAIAYAENGYPVSPVLGKYWAN
AYRVYKEALHGPEFGSWFETFAPAGRAPNIGEVWASPDHAATLRSIAETEAESFYRGELAEKIVAFSKQYNGFLTLEDLA
EYEPEWVEPISVSYHGYDVWEIPPNGQGLVALMALNIMNGFDVPNVPDVETYHRQIEAMKLAFADGKAYIADRRYMNYRV
DELLSESFAAMRRAQIGTEALTPEPGTPPKGGTVYLAAADGEGNMVSFIQSNYMGFGSGLVVPGTGIALHNRGHNFVFDE
NHPNGLAPRKKPYHTIIPGFLTKGGKPIGPFGVMGGFMQPQGHMQVIMNTVDFALNPQAALDAPRWQWMEGKTVLVEPHF
PRHIAEALARKGHDICVALDGGPFGRGQIIWRDPDTGVLAAGTEPRTDGAVAAW

Sequences:

>Translated_534_residues
MDYLYHPYPSQRMTVFAKNGIVATSQPLAAQAGLEVLKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTNGKLYG
LNASGYAPAAISLDVLKERGYTEMPKYGFAPVTVPGAPAAWAALSKRFGRLSLAETLAPAIAYAENGYPVSPVLGKYWAN
AYRVYKEALHGPEFGSWFETFAPAGRAPNIGEVWASPDHAATLRSIAETEAESFYRGELAEKIVAFSKQYNGFLTLEDLA
EYEPEWVEPISVSYHGYDVWEIPPNGQGLVALMALNIMNGFDVPNVPDVETYHRQIEAMKLAFADGKAYIADRRYMNYRV
DELLSESFAAMRRAQIGTEALTPEPGTPPKGGTVYLAAADGEGNMVSFIQSNYMGFGSGLVVPGTGIALHNRGHNFVFDE
NHPNGLAPRKKPYHTIIPGFLTKGGKPIGPFGVMGGFMQPQGHMQVIMNTVDFALNPQAALDAPRWQWMEGKTVLVEPHF
PRHIAEALARKGHDICVALDGGPFGRGQIIWRDPDTGVLAAGTEPRTDGAVAAW
>Mature_534_residues
MDYLYHPYPSQRMTVFAKNGIVATSQPLAAQAGLEVLKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTNGKLYG
LNASGYAPAAISLDVLKERGYTEMPKYGFAPVTVPGAPAAWAALSKRFGRLSLAETLAPAIAYAENGYPVSPVLGKYWAN
AYRVYKEALHGPEFGSWFETFAPAGRAPNIGEVWASPDHAATLRSIAETEAESFYRGELAEKIVAFSKQYNGFLTLEDLA
EYEPEWVEPISVSYHGYDVWEIPPNGQGLVALMALNIMNGFDVPNVPDVETYHRQIEAMKLAFADGKAYIADRRYMNYRV
DELLSESFAAMRRAQIGTEALTPEPGTPPKGGTVYLAAADGEGNMVSFIQSNYMGFGSGLVVPGTGIALHNRGHNFVFDE
NHPNGLAPRKKPYHTIIPGFLTKGGKPIGPFGVMGGFMQPQGHMQVIMNTVDFALNPQAALDAPRWQWMEGKTVLVEPHF
PRHIAEALARKGHDICVALDGGPFGRGQIIWRDPDTGVLAAGTEPRTDGAVAAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=507, Percent_Identity=27.6134122287968, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI73915090, Length=507, Percent_Identity=27.6134122287968, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI73915096, Length=507, Percent_Identity=27.6134122287968, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI73915094, Length=507, Percent_Identity=27.6134122287968, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI153266885, Length=514, Percent_Identity=25.875486381323, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI153266901, Length=515, Percent_Identity=25.8252427184466, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI113429324, Length=496, Percent_Identity=26.8145161290323, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI113429326, Length=498, Percent_Identity=26.3052208835341, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI109148539, Length=505, Percent_Identity=27.9207920792079, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI153266907, Length=514, Percent_Identity=24.5136186770428, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789856, Length=551, Percent_Identity=28.1306715063521, Blast_Score=189, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI212646519, Length=504, Percent_Identity=26.1904761904762, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI72000294, Length=504, Percent_Identity=26.1904761904762, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193208247, Length=531, Percent_Identity=25.0470809792844, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=531, Percent_Identity=25.0470809792844, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17506189, Length=513, Percent_Identity=25.3411306042885, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17542894, Length=518, Percent_Identity=24.1312741312741, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17564448, Length=411, Percent_Identity=25.5474452554745, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642670, Length=508, Percent_Identity=26.9685039370079, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642666, Length=508, Percent_Identity=26.9685039370079, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077880, Length=508, Percent_Identity=26.9685039370079, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45551474, Length=508, Percent_Identity=26.9685039370079, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161077878, Length=508, Percent_Identity=26.9685039370079, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18859741, Length=516, Percent_Identity=24.4186046511628, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI18859893, Length=517, Percent_Identity=25.9187620889749, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161077496, Length=532, Percent_Identity=24.4360902255639, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57669; Mature: 57669

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLYHPYPSQRMTVFAKNGIVATSQPLAAQAGLEVLKKGGNAIDAAIATAACLTVVEPT
CCCCCCCCCCCCEEEEEECCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC
SNGIGGDAFALVWTNGKLYGLNASGYAPAAISLDVLKERGYTEMPKYGFAPVTVPGAPAA
CCCCCCCEEEEEEECCEEEEECCCCCCCCEEEHHHHHHCCCCCCCCCCCCEEECCCCCHH
WAALSKRFGRLSLAETLAPAIAYAENGYPVSPVLGKYWANAYRVYKEALHGPEFGSWFET
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
FAPAGRAPNIGEVWASPDHAATLRSIAETEAESFYRGELAEKIVAFSKQYNGFLTLEDLA
HCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
EYEPEWVEPISVSYHGYDVWEIPPNGQGLVALMALNIMNGFDVPNVPDVETYHRQIEAMK
HCCCCCCCEEEEEECCEEEEEECCCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHE
LAFADGKAYIADRRYMNYRVDELLSESFAAMRRAQIGTEALTPEPGTPPKGGTVYLAAAD
EEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEC
GEGNMVSFIQSNYMGFGSGLVVPGTGIALHNRGHNFVFDENHPNGLAPRKKPYHTIIPGF
CCCCEEHHHHHCCCCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCCCCCCCCEECCHH
LTKGGKPIGPFGVMGGFMQPQGHMQVIMNTVDFALNPQAALDAPRWQWMEGKTVLVEPHF
HHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEECCCC
PRHIAEALARKGHDICVALDGGPFGRGQIIWRDPDTGVLAAGTEPRTDGAVAAW
HHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MDYLYHPYPSQRMTVFAKNGIVATSQPLAAQAGLEVLKKGGNAIDAAIATAACLTVVEPT
CCCCCCCCCCCCEEEEEECCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC
SNGIGGDAFALVWTNGKLYGLNASGYAPAAISLDVLKERGYTEMPKYGFAPVTVPGAPAA
CCCCCCCEEEEEEECCEEEEECCCCCCCCEEEHHHHHHCCCCCCCCCCCCEEECCCCCHH
WAALSKRFGRLSLAETLAPAIAYAENGYPVSPVLGKYWANAYRVYKEALHGPEFGSWFET
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
FAPAGRAPNIGEVWASPDHAATLRSIAETEAESFYRGELAEKIVAFSKQYNGFLTLEDLA
HCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
EYEPEWVEPISVSYHGYDVWEIPPNGQGLVALMALNIMNGFDVPNVPDVETYHRQIEAMK
HCCCCCCCEEEEEECCEEEEEECCCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHE
LAFADGKAYIADRRYMNYRVDELLSESFAAMRRAQIGTEALTPEPGTPPKGGTVYLAAAD
EEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEC
GEGNMVSFIQSNYMGFGSGLVVPGTGIALHNRGHNFVFDENHPNGLAPRKKPYHTIIPGF
CCCCEEHHHHHCCCCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCCCCCCCCEECCHH
LTKGGKPIGPFGVMGGFMQPQGHMQVIMNTVDFALNPQAALDAPRWQWMEGKTVLVEPHF
HHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEECCCC
PRHIAEALARKGHDICVALDGGPFGRGQIIWRDPDTGVLAAGTEPRTDGAVAAW
HHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]