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The map label for this gene is hisI [H]

Identifier: 138896657

GI number: 138896657

Start: 3116894

End: 3117541

Strand: Reverse

Name: hisI [H]

Synonym: GTNG_3020

Alternate gene names: 138896657

Gene position: 3117541-3116894 (Counterclockwise)

Preceding gene: 138896658

Following gene: 138896656

Centisome position: 87.81

GC content: 52.01

Gene sequence:

>648_bases
ATGATAGCGGACATTCGGTTTGACGAGAAGGGGCTTGTGCCTGCCATCGTTCAAGATGCGCAAAGCAAAGAAGTGCTCAT
GCTTGCGTATATGAACAAAGAATCGCTCGAAAAAACGCTCGAGACAGGGGAAACGTGGTTTTACAGCCGCTCTCGTCAAG
AACTTTGGCATAAAGGAGCGACGTCAGGAAACGTGCAGCGTGTCGTGGACATTCGCTACGACTGTGACGCCGATACGCTC
CTTGTGCTTGTTGAGCCGGCCGGCCCGGCTTGCCATACCGGGTCGTATTCCTGCTTTTCCCGCTCGCTAAATGGCGAGGC
GCGCACGCCAACCGCCGATCGGTTCACGATTTTGAATGAGCTTGAACAAATTATTGCCCAGCGCGACGCTGAACGGCCGG
AAGGCGCGTATACGACGTATTTGTTTGAAAAAGGCGTCGATAAAATTTTGAAAAAGGTCGGTGAAGAGGCGGCAGAGGTG
ATTATCGCCGCGAAAAATCGGAGCCATGATGAGTTAAAATGGGAAGCGGCCGACTTGCTGTATCATTTGCTTGTGCTGTT
GCGTGAACAAAAACTGCCGCTTGACGCGGTGCTGGCAACGCTTGTCGAGCGGCATGCGCAAAAAACAGGAGCAGTCGAAA
ATAAATAA

Upstream 100 bases:

>100_bases
GGAAAGCCGATGCGGCGTTGGCAGCGTCTATTTTCCATTATAAAGAAACGTCCGTCGGGCAAGTGAAGGCGTACTTAAGA
GAGAGGGGGGTCAACGTGCG

Downstream 100 bases:

>100_bases
TTAAGAACTAATCGGGAACGACGCTTGTTTCCGAGGGGAAAACAGGATGCCCGTTGATGCCCGCCTGCACGGTCCATTGT
TCATCTTGACGAACGATGGG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIADIRFDEKGLVPAIVQDAQSKEVLMLAYMNKESLEKTLETGETWFYSRSRQELWHKGATSGNVQRVVDIRYDCDADTL
LVLVEPAGPACHTGSYSCFSRSLNGEARTPTADRFTILNELEQIIAQRDAERPEGAYTTYLFEKGVDKILKKVGEEAAEV
IIAAKNRSHDELKWEAADLLYHLLVLLREQKLPLDAVLATLVERHAQKTGAVENK

Sequences:

>Translated_215_residues
MIADIRFDEKGLVPAIVQDAQSKEVLMLAYMNKESLEKTLETGETWFYSRSRQELWHKGATSGNVQRVVDIRYDCDADTL
LVLVEPAGPACHTGSYSCFSRSLNGEARTPTADRFTILNELEQIIAQRDAERPEGAYTTYLFEKGVDKILKKVGEEAAEV
IIAAKNRSHDELKWEAADLLYHLLVLLREQKLPLDAVLATLVERHAQKTGAVENK
>Mature_215_residues
MIADIRFDEKGLVPAIVQDAQSKEVLMLAYMNKESLEKTLETGETWFYSRSRQELWHKGATSGNVQRVVDIRYDCDADTL
LVLVEPAGPACHTGSYSCFSRSLNGEARTPTADRFTILNELEQIIAQRDAERPEGAYTTYLFEKGVDKILKKVGEEAAEV
IIAAKNRSHDELKWEAADLLYHLLVLLREQKLPLDAVLATLVERHAQKTGAVENK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=50.7692307692308, Blast_Score=192, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319819, Length=213, Percent_Identity=36.150234741784, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24193; Mature: 24193

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADIRFDEKGLVPAIVQDAQSKEVLMLAYMNKESLEKTLETGETWFYSRSRQELWHKGA
CCCCCEECCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHCCC
TSGNVQRVVDIRYDCDADTLLVLVEPAGPACHTGSYSCFSRSLNGEARTPTADRFTILNE
CCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHH
LEQIIAQRDAERPEGAYTTYLFEKGVDKILKKVGEEAAEVIIAAKNRSHDELKWEAADLL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
YHLLVLLREQKLPLDAVLATLVERHAQKTGAVENK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIADIRFDEKGLVPAIVQDAQSKEVLMLAYMNKESLEKTLETGETWFYSRSRQELWHKGA
CCCCCEECCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHCCC
TSGNVQRVVDIRYDCDADTLLVLVEPAGPACHTGSYSCFSRSLNGEARTPTADRFTILNE
CCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHH
LEQIIAQRDAERPEGAYTTYLFEKGVDKILKKVGEEAAEVIIAAKNRSHDELKWEAADLL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
YHLLVLLREQKLPLDAVLATLVERHAQKTGAVENK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]