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The map label for this gene is hemA

Identifier: 138896213

GI number: 138896213

Start: 2681107

End: 2682474

Strand: Reverse

Name: hemA

Synonym: GTNG_2576

Alternate gene names: 138896213

Gene position: 2682474-2681107 (Counterclockwise)

Preceding gene: 138896215

Following gene: 138896212

Centisome position: 75.56

GC content: 53.36

Gene sequence:

>1368_bases
GTGCAGATCATCGTAGTTGGCGTCAATTATAAAACTGCCCCTGTAGAAATTCGTGAAAAGTTGGCGTTTGGTGAGGCAGA
GCTCGGCGAGGCGATGAAACAGCTCGCCAAGCAAAAAAGCATCCTCGAAAACGTCATCGTTTCCACATGCAATCGGACGG
AAATTTACGCGGTCGTCGATCAACTGCATACCGGCCGTTACTATATAAAAGCATTTTTAGCCGAATGGTTTGACATCGAA
GCGGAGGCGATCGCCCCGTATTTGCGCGTGCTCGAAGGGGAAGCGGCCGCGGGGCATTTGTTCCGCGTAGCAGCCGGCCT
TGACTCCATGGTGCTTGGAGAAACGCAAATTTTAGGACAAGTGAAAGGGAGCTATTTGCTCGCTCAAGAGATTGGAACGA
GCGGCACGATTTTGAACCACCTGTTTAAACAGGCAGTGACGTTTGCCAAACGCGCCCATTCGGAAACCGGGATCGGTGCG
CATGCCGTGTCGGTCAGTTATGCAGCTGTCGAGTTGGCGAAGAAAATTTTCGGCCATCTCAACGGCAAGCATGTTTTGAT
TATCGGTGCCGGCAAAATGGGGACGTTGGCGGCGCAAAACTTGTACGGCAACGGTGTCGGTAAAGTGACCGTCGTCAACC
GGACGCTTGAAAAAGCGAAGCAGCTCGCGGCGCAGTTTGACGGTGAGGCGAAGTCGCTTGGCGAATTGTCATGTGCGCTG
CTTGAAGCGGATATCGTCATCAGCTCGACGGGAGCGAAAGGCTACATGTTAACGAAAGAGGAGATGGCTCCGCTTGAGAA
AATGCGTAAAGGCCGCCCGTTGTTTATGGTCGATATTGCCGTGCCGCGCGATTTAGACCCGGCGCTCGCTGAACTAGAGA
CGGTCTTTTTGTACGACATTGATGACTTGCAAGACGTCGTCGCAGCGAATTTGGCGGAACGGCAAAAAGCTGCCGCCCTC
ATTGAGGAGATGATTGAAGGGGAGCTAGTGGCGTTTGGCCAATGGTTGCAGACGCTCGGCGTTGTGCCAGTCATCGCGGC
GCTGCGGGAAAAAGCGCTCGCCATTCAGGCGGAAACGATGAAAAGCTTGGAGCGAAAGTTGCCGCATTTGTCGGAGCGCG
ATCGGAAAGTGTTGAACAAACATACGAAAAGCATTATTAACCAGCTGCTCCGCGACCCGATTTTGCAGGTGAAGGAACTT
GCCGCTGGTCCGAACGCTGACGAAGCGCTTCAGCTGTTTATGAAAATTTTTAATATCGAAGATGCAGTCAAAGCAGAGCA
ACGGAGCGCGCAGCGAGCAGAAGTGCAGTTGAGGGATGAACAGCAAGCGGAAGCGGTTCGCGCCGCCCGCCCATCATGGC
AGCTGTAA

Upstream 100 bases:

>100_bases
CATAGCTCGTGAGGGATGTTCACAATTTTTTCAAATCGGAATGATAGACGTTTATGGTATAATAGTGGAAGGGATTGGGC
TAAGAAGGGGGGATTGCACC

Downstream 100 bases:

>100_bases
GGTGGGATAGATGGTGGCGTTGTATGAACTGTCTATTTTGCTCTACATTGCTTCGATTCTTTTCTATTTTATCGATTTTT
TGCAGCAAAACCGGAAGGCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVDQLHTGRYYIKAFLAEWFDIE
AEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQVKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGA
HAVSVSYAAVELAKKIFGHLNGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCAL
LEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDIDDLQDVVAANLAERQKAAAL
IEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETMKSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKEL
AAGPNADEALQLFMKIFNIEDAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL

Sequences:

>Translated_455_residues
MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVDQLHTGRYYIKAFLAEWFDIE
AEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQVKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGA
HAVSVSYAAVELAKKIFGHLNGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCAL
LEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDIDDLQDVVAANLAERQKAAAL
IEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETMKSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKEL
AAGPNADEALQLFMKIFNIEDAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL
>Mature_455_residues
MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVDQLHTGRYYIKAFLAEWFDIE
AEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQVKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGA
HAVSVSYAAVELAKKIFGHLNGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCAL
LEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDIDDLQDVVAANLAERQKAAAL
IEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETMKSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKEL
AAGPNADEALQLFMKIFNIEDAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=364, Percent_Identity=37.6373626373626, Blast_Score=234, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_GEOTN (A4IRG7)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126666.1
- ProteinModelPortal:   A4IRG7
- SMR:   A4IRG7
- STRING:   A4IRG7
- GeneID:   4967502
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2576
- NMPDR:   fig|420246.5.peg.2482
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A4IRG7
- ProtClustDB:   PRK00045
- BioCyc:   GTHE420246:GTNG_2576-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 49772; Mature: 49772

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00747 GLUTR; PS01037 SBP_BACTERIAL_1

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVD
CEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKAFLAEWFDIEAEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
VKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGAHAVSVSYAAVELAKKIFGHL
HCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCAL
CCCEEEEEECCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDI
HHHCEEEECCCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHEEEEH
DDLQDVVAANLAERQKAAALIEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKELAAGPNADEALQLFMKIFNIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVD
CEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKAFLAEWFDIEAEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
VKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGAHAVSVSYAAVELAKKIFGHL
HCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCAL
CCCEEEEEECCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDI
HHHCEEEECCCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHEEEEH
DDLQDVVAANLAERQKAAALIEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKELAAGPNADEALQLFMKIFNIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA