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The map label for this gene is comEA [H]

Identifier: 138896090

GI number: 138896090

Start: 2561924

End: 2562535

Strand: Reverse

Name: comEA [H]

Synonym: GTNG_2453

Alternate gene names: 138896090

Gene position: 2562535-2561924 (Counterclockwise)

Preceding gene: 138896092

Following gene: 138896089

Centisome position: 72.18

GC content: 57.03

Gene sequence:

>612_bases
ATGTGGGAAGCAGTTAAGGCAAGATGGAAAACTGGATTGCTTGTGCTGTTTGTTGGAGTGGCAGGACTATGGGTGTTCAG
CCGCCCGTCTGCCGAAGGGGAGTCCGTCGCCTTGCCGGCTGCAGTTGAAACGGACACCACCAGACCGGAGGAAGCAGGGA
TGGAGGCGTCGAAAATCGTTGTCATTGATGTCAAAGGAGCGGTCGTCAAACCAGGGGTGTACGAGATGCCGGCTGATGCC
CGCGTCCGTGATGTGATCGCCAGAGCGGGCGGATTGACGGAAGAGGCGGACGCGGCAAGAGTCAACTTAGCGGCTAAAGT
GCGCGATGAAATGATGATTTACGTGCCAGCGAAAGGTGAAGCGGCGCCAGCACCAGAAGCAGTCGAGGCAGCGCCGGAAG
CCGGAACGGAGAGCGGTCTGCAAGTGGCGGTCAATACGGCGACAGCAGAGGAACTCATGCAAGTCCCCGGCATTGGGCCG
GCGAAGGCAAAAGCAATCATCGCCTACCGTGAAGAGCATGGGCCGTTTCAACGAGTTGAAGACTTACTGCGGGTCAACGG
CATCGGGGAAAAAACGCTGGAAAAATTAAAGCCGTATTTGCTTGTGCCGTAA

Upstream 100 bases:

>100_bases
CCGATAACGCCGATGTTCATATGCAGTCCCCTCCTCCCTCTTTTCGATATGTATGAATATCTTCTTCATTTTATGACTCC
GTTTAGAAAGGACGAGTGCG

Downstream 100 bases:

>100_bases
AGTCAGAGGGAGGAACGATGATAACCAACTTTTTTCAGCATTGACGGCGCTTTAGGTGACCGATAGACTAAAATTATCGA
GACAAGCGGAGGGACATGAT

Product: late competence protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MWEAVKARWKTGLLVLFVGVAGLWVFSRPSAEGESVALPAAVETDTTRPEEAGMEASKIVVIDVKGAVVKPGVYEMPADA
RVRDVIARAGGLTEEADAARVNLAAKVRDEMMIYVPAKGEAAPAPEAVEAAPEAGTESGLQVAVNTATAEELMQVPGIGP
AKAKAIIAYREEHGPFQRVEDLLRVNGIGEKTLEKLKPYLLVP

Sequences:

>Translated_203_residues
MWEAVKARWKTGLLVLFVGVAGLWVFSRPSAEGESVALPAAVETDTTRPEEAGMEASKIVVIDVKGAVVKPGVYEMPADA
RVRDVIARAGGLTEEADAARVNLAAKVRDEMMIYVPAKGEAAPAPEAVEAAPEAGTESGLQVAVNTATAEELMQVPGIGP
AKAKAIIAYREEHGPFQRVEDLLRVNGIGEKTLEKLKPYLLVP
>Mature_203_residues
MWEAVKARWKTGLLVLFVGVAGLWVFSRPSAEGESVALPAAVETDTTRPEEAGMEASKIVVIDVKGAVVKPGVYEMPADA
RVRDVIARAGGLTEEADAARVNLAAKVRDEMMIYVPAKGEAAPAPEAVEAAPEAGTESGLQVAVNTATAEELMQVPGIGP
AKAKAIIAYREEHGPFQRVEDLLRVNGIGEKTLEKLKPYLLVP

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

Organism=Escherichia coli, GI1786646, Length=76, Percent_Identity=47.3684210526316, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 21526; Mature: 21526

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEAVKARWKTGLLVLFVGVAGLWVFSRPSAEGESVALPAAVETDTTRPEEAGMEASKIV
CCCHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCEECCEEECCCCCCCHHHCCCCCEEE
VIDVKGAVVKPGVYEMPADARVRDVIARAGGLTEEADAARVNLAAKVRDEMMIYVPAKGE
EEEECCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHEEECCCEEEEEECCCC
AAPAPEAVEAAPEAGTESGLQVAVNTATAEELMQVPGIGPAKAKAIIAYREEHGPFQRVE
CCCCCHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHEEEEEEECCCCCHHHHH
DLLRVNGIGEKTLEKLKPYLLVP
HHHHHCCCCHHHHHHCCCEEECC
>Mature Secondary Structure
MWEAVKARWKTGLLVLFVGVAGLWVFSRPSAEGESVALPAAVETDTTRPEEAGMEASKIV
CCCHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCEECCEEECCCCCCCHHHCCCCCEEE
VIDVKGAVVKPGVYEMPADARVRDVIARAGGLTEEADAARVNLAAKVRDEMMIYVPAKGE
EEEECCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHEEECCCEEEEEECCCC
AAPAPEAVEAAPEAGTESGLQVAVNTATAEELMQVPGIGPAKAKAIIAYREEHGPFQRVE
CCCCCHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHEEEEEEECCCCCHHHHH
DLLRVNGIGEKTLEKLKPYLLVP
HHHHHCCCCHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]