Click here to switch to the map view.

The map label for this gene is gltT [H]

Identifier: 138895990

GI number: 138895990

Start: 2467617

End: 2468849

Strand: Direct

Name: gltT [H]

Synonym: GTNG_2351

Alternate gene names: 138895990

Gene position: 2467617-2468849 (Clockwise)

Preceding gene: 138895984

Following gene: 138895996

Centisome position: 69.5

GC content: 46.47

Gene sequence:

>1233_bases
ATGAAGTTATCGTTAAAAATCATTATCGCACTCGTACTTGGATCCATCGTCGGACTGGCCTTCAACCTTCTTTTCCCCCA
ATCATTTGATATAGTCAACACATATGTGTTTACGCCTCTCGGTAAACTCTTTTTAAATTTAATTAATATGATCGTCGTAC
CTATCGTCTTTTTTTCCATCGTATTAGGGACAGCCGGACTAGGAGATCCAAAAAAACTCGGACGAATCGGAATCAAAACC
ATTTCGTATTTCCTCATCACTACAGCCATCGCCATTGTTATCGGCATTTCATTAGCGTTAGTAACCAAACCTGGGAGCGT
CGGCGACTTTAACATCAGCCAGGCTCAATTTGAACCAAAAGAGGCACCACCTGTGTCAGAAACTTTATTAAACATTATTC
CAAAAAACCCTGTTCAAGCGTTTGCAGAAGGAAACATGCTGCAAATTATCGCTTTTTCCATCTTTGTCGGGTTTGCGCTT
TCGATGTTGCGAGAAAAAACAGCTGGCTTGTTCAAACTCATGGAGCAAGGCAATGAAGTGATGATGTATTTAGTCACTGT
CATTATGCGGTTTGCCCCGTATGGTGCATTCGGCTTAATCGCCTCCGCCGTCGGCAGCCAAGGAATGGACGCCATCCGCT
CGATGGGAATGTACATGTTTGTCGTTCTTTTCAGTTTGATCCTTCATATGCTGTTCACATACGGCTCATCGCTCTACCTG
TTTGCCAAGCGCAATCCGTTCTCCTTTTTCAAACAGTTCGCTCCGGCGATGGGAGTGGCGTTCAGCACATCGAGCAGTAA
CGCGACACTGCCGATTTCAATGAACGTGGCCCAAACAAAACTCGGTGTGCCTAAACACATTAGCAGTTTCGTGCAGCCAT
TAGGAGCAACCATCAATATGGATGGCACGGCCATTATGCAAGGGGTCGCCACTATATTTATCGCTCAAGCTTACGGTATT
GACCTTACTATCTCGCAATTAGCAACGGTTGTATTAACGGCTGTATTGGCCAGCATTGGAACGGCGGGTGTGCCCGGTGT
CGGATTAGTGATGCTGGCGATGGTGCTGAATTCCGTCAACCTCCCTGTCGAAGGGATCGCATTGATCATCGGCATCGACC
GGCTTTTAGACATGGCCCGCACTGCTGTCAATACTACCGGTGATGCCGCTTGTGCCGTAATCGTTGCTGAAACAGAGAAG
AAGTACGCAGAAGTTGGTACAAAAGCGTCCTAA

Upstream 100 bases:

>100_bases
TATTCTAACTAAACAAAAAATTTTTTGTTTCTACCTTGTTAAGGCACGAAATGTAAGATACAATAACATTACATTTTGTT
AAAAGAATTGGAGGGATTGT

Downstream 100 bases:

>100_bases
TTAGGACGCTTTTTTTCTTCCTTCGTTCACACTGTGAATCCATAGGGAAAAGACGCGAAGCCATTTTAAAAAACAAGAAC
GAGCGAACCGGCGAGCATTG

Product: H(+)/sodium-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKLSLKIIIALVLGSIVGLAFNLLFPQSFDIVNTYVFTPLGKLFLNLINMIVVPIVFFSIVLGTAGLGDPKKLGRIGIKT
ISYFLITTAIAIVIGISLALVTKPGSVGDFNISQAQFEPKEAPPVSETLLNIIPKNPVQAFAEGNMLQIIAFSIFVGFAL
SMLREKTAGLFKLMEQGNEVMMYLVTVIMRFAPYGAFGLIASAVGSQGMDAIRSMGMYMFVVLFSLILHMLFTYGSSLYL
FAKRNPFSFFKQFAPAMGVAFSTSSSNATLPISMNVAQTKLGVPKHISSFVQPLGATINMDGTAIMQGVATIFIAQAYGI
DLTISQLATVVLTAVLASIGTAGVPGVGLVMLAMVLNSVNLPVEGIALIIGIDRLLDMARTAVNTTGDAACAVIVAETEK
KYAEVGTKAS

Sequences:

>Translated_410_residues
MKLSLKIIIALVLGSIVGLAFNLLFPQSFDIVNTYVFTPLGKLFLNLINMIVVPIVFFSIVLGTAGLGDPKKLGRIGIKT
ISYFLITTAIAIVIGISLALVTKPGSVGDFNISQAQFEPKEAPPVSETLLNIIPKNPVQAFAEGNMLQIIAFSIFVGFAL
SMLREKTAGLFKLMEQGNEVMMYLVTVIMRFAPYGAFGLIASAVGSQGMDAIRSMGMYMFVVLFSLILHMLFTYGSSLYL
FAKRNPFSFFKQFAPAMGVAFSTSSSNATLPISMNVAQTKLGVPKHISSFVQPLGATINMDGTAIMQGVATIFIAQAYGI
DLTISQLATVVLTAVLASIGTAGVPGVGLVMLAMVLNSVNLPVEGIALIIGIDRLLDMARTAVNTTGDAACAVIVAETEK
KYAEVGTKAS
>Mature_410_residues
MKLSLKIIIALVLGSIVGLAFNLLFPQSFDIVNTYVFTPLGKLFLNLINMIVVPIVFFSIVLGTAGLGDPKKLGRIGIKT
ISYFLITTAIAIVIGISLALVTKPGSVGDFNISQAQFEPKEAPPVSETLLNIIPKNPVQAFAEGNMLQIIAFSIFVGFAL
SMLREKTAGLFKLMEQGNEVMMYLVTVIMRFAPYGAFGLIASAVGSQGMDAIRSMGMYMFVVLFSLILHMLFTYGSSLYL
FAKRNPFSFFKQFAPAMGVAFSTSSSNATLPISMNVAQTKLGVPKHISSFVQPLGATINMDGTAIMQGVATIFIAQAYGI
DLTISQLATVVLTAVLASIGTAGVPGVGLVMLAMVLNSVNLPVEGIALIIGIDRLLDMARTAVNTTGDAACAVIVAETEK
KYAEVGTKAS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=451, Percent_Identity=32.8159645232816, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI194239697, Length=464, Percent_Identity=32.3275862068966, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI66773030, Length=454, Percent_Identity=33.0396475770925, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI169790839, Length=461, Percent_Identity=32.3210412147505, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI21314632, Length=418, Percent_Identity=32.7751196172249, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI5032093, Length=393, Percent_Identity=34.8600508905852, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI4827012, Length=272, Percent_Identity=38.6029411764706, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=37.6344086021505, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI262359914, Length=379, Percent_Identity=29.5514511873351, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI301601644, Length=194, Percent_Identity=35.5670103092784, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1790514, Length=417, Percent_Identity=38.6091127098321, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789947, Length=376, Percent_Identity=34.3085106382979, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1788024, Length=405, Percent_Identity=29.3827160493827, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1789473, Length=280, Percent_Identity=31.7857142857143, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=443, Percent_Identity=35.2144469525959, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71983099, Length=443, Percent_Identity=35.2144469525959, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17537407, Length=445, Percent_Identity=33.4831460674157, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=411, Percent_Identity=33.0900243309002, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=32.1120689655172, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=30.6733167082294, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17541374, Length=412, Percent_Identity=29.6116504854369, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583025, Length=404, Percent_Identity=29.9504950495049, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137668, Length=404, Percent_Identity=29.9504950495049, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24583023, Length=404, Percent_Identity=29.9504950495049, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI281360481, Length=449, Percent_Identity=29.1759465478842, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281360483, Length=449, Percent_Identity=29.1759465478842, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17137666, Length=449, Percent_Identity=29.1759465478842, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43525; Mature: 43525

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]