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The map label for this gene is zwf [H]

Identifier: 138895905

GI number: 138895905

Start: 2378345

End: 2379784

Strand: Direct

Name: zwf [H]

Synonym: GTNG_2264

Alternate gene names: 138895905

Gene position: 2378345-2379784 (Clockwise)

Preceding gene: 138895903

Following gene: 138895906

Centisome position: 66.99

GC content: 52.01

Gene sequence:

>1440_bases
TTGGCAAAACGGAAATTGTTTCCGTCCCTTTACCGCCTGTATGAAAAAGGGCATTTGAACGAGCGATTTGCCGTCGTCGG
CGTCGCGCGCCGCCCGCTGTCGGCCGATGAGTTCCGCCATTACGTGCGCGACTCAGTCGAAACAGCACTCAACCAAGAGC
TTACTGACGGCAACTTCATCTCCCATTTTTATTATCACCCGTTTGATGTGACCGAAGCTGAGTCCTATCAGCGCTTAAAA
GCGTTGCTTGAACAGCTCGATGAGACGTATCAAACGGAGGGCAACTGCATCTTTTATTTGGCGATGGCACCGGAATTTTT
CGGCACGGTTACATCGCGCCTACAGTCGGAGCGGCTGACCGATACGCGCGGCTTTAAACGGCTTGTCATTGAAAAGCCGT
TCGGCCATGACTTAGTGAGCGCCCAAAAGCTGAATGAAGAAATCCGCCGTGTCTTTTCTGAACGGGAAATTTACCGGATC
GACCATTACCTTGGCAAAGAAATGGTGCAAAATATCGAAGTGATTCGCTTCTCGAACGCCATTTTCGAGCCGCTTTGGAA
CAACCGCTTTATTTCGAACATTCAAATTACCTCAAGCGAAACGCTTGGCGTTGAGGACCGCGGCCGCTATTACGACCATT
CCGGAGCGCTGCGCGACATGGTGCAAAACCATATGCTGCAAATGGTCGCCCTGTTGGCCATGGAGCCGCCGATTAAACTG
ACGACCGATGACATCCGCCATGAAAAAGTGAAAGTGTTGCGCGCATTGCGTCCGGTTGCGCATGACGAAGTCGACCAGTA
TTTCGTGCGCGGCCAATACGGGCGTGGGGTGATCCGCGGCCAAGCCGTACCAGCGTACCGCGAAGAGCCGAACGTCGATC
CGAATTCAAACACGGAAACGTTTGTCGCTGGAAAACTGATGATCGACAACTTCCGCTGGGCCGGCGTACCATTTTACATC
CGCACCGGCAAACGAATGGCGGAAAAATCGACGAAAATCGTCGTTCAATTTAAAGATGTGCCGATGAACTTATACTACCG
GACGAACGAGACGATCGCTCCGAATTTGCTCGTCATTCACATTCAGCCCGATGAAGGCATCACCCTTCATTTAAACGGCA
AAAAAACCGGGGAATCGTCGACAATAACCGCCCCGTTTAAACTCGATTATTGCAACAACTGCATCGACGGCATCAACACA
CCGGAAGCATACGAAAAGCTGCTGTACGACTGCATGCGCGGCGATGCGACGAACTTCACCCATTGGGATGAAGTAGCAGC
GTCATGGCAGTTTGTCGATCCGATTTCTGACGTTTGGGCGAACACAAAAGCCGACGACTTCCCGAACTATGAAGCAGGCT
CGATGGGCCCGGCAGCAGCCGATGAACTGTTGCGAAAAGACGGTTTCCATTGGTGGCCGATTGAGCATCCGAAACCATAA

Upstream 100 bases:

>100_bases
ATGATTTAGTTGAAGAGACAAAATTGGCTAAAGCGAGGTACATATGGTGGATAACATGAACCCGAAATCGATCATCGTCA
TTTTTGGGGCGACGGGAGAT

Downstream 100 bases:

>100_bases
CAAGCAAGGCGGCGCCAACCATTGTTTTCTTTTTTGACTACCTAGCCCTTGACAATCGATCACTCACGGGGCCGAACCGG
CCCTTTCTATCCTTGAATGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MAKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSADEFRHYVRDSVETALNQELTDGNFISHFYYHPFDVTEAESYQRLK
ALLEQLDETYQTEGNCIFYLAMAPEFFGTVTSRLQSERLTDTRGFKRLVIEKPFGHDLVSAQKLNEEIRRVFSEREIYRI
DHYLGKEMVQNIEVIRFSNAIFEPLWNNRFISNIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKL
TTDDIRHEKVKVLRALRPVAHDEVDQYFVRGQYGRGVIRGQAVPAYREEPNVDPNSNTETFVAGKLMIDNFRWAGVPFYI
RTGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIHIQPDEGITLHLNGKKTGESSTITAPFKLDYCNNCIDGINT
PEAYEKLLYDCMRGDATNFTHWDEVAASWQFVDPISDVWANTKADDFPNYEAGSMGPAAADELLRKDGFHWWPIEHPKP

Sequences:

>Translated_479_residues
MAKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSADEFRHYVRDSVETALNQELTDGNFISHFYYHPFDVTEAESYQRLK
ALLEQLDETYQTEGNCIFYLAMAPEFFGTVTSRLQSERLTDTRGFKRLVIEKPFGHDLVSAQKLNEEIRRVFSEREIYRI
DHYLGKEMVQNIEVIRFSNAIFEPLWNNRFISNIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKL
TTDDIRHEKVKVLRALRPVAHDEVDQYFVRGQYGRGVIRGQAVPAYREEPNVDPNSNTETFVAGKLMIDNFRWAGVPFYI
RTGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIHIQPDEGITLHLNGKKTGESSTITAPFKLDYCNNCIDGINT
PEAYEKLLYDCMRGDATNFTHWDEVAASWQFVDPISDVWANTKADDFPNYEAGSMGPAAADELLRKDGFHWWPIEHPKP
>Mature_478_residues
AKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSADEFRHYVRDSVETALNQELTDGNFISHFYYHPFDVTEAESYQRLKA
LLEQLDETYQTEGNCIFYLAMAPEFFGTVTSRLQSERLTDTRGFKRLVIEKPFGHDLVSAQKLNEEIRRVFSEREIYRID
HYLGKEMVQNIEVIRFSNAIFEPLWNNRFISNIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKLT
TDDIRHEKVKVLRALRPVAHDEVDQYFVRGQYGRGVIRGQAVPAYREEPNVDPNSNTETFVAGKLMIDNFRWAGVPFYIR
TGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIHIQPDEGITLHLNGKKTGESSTITAPFKLDYCNNCIDGINTP
EAYEKLLYDCMRGDATNFTHWDEVAASWQFVDPISDVWANTKADDFPNYEAGSMGPAAADELLRKDGFHWWPIEHPKP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=477, Percent_Identity=36.4779874213836, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI108773793, Length=477, Percent_Identity=36.4779874213836, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI52145310, Length=400, Percent_Identity=29.75, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1788158, Length=478, Percent_Identity=38.7029288702929, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=473, Percent_Identity=34.2494714587738, Blast_Score=293, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324088, Length=495, Percent_Identity=35.1515151515151, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=34.6638655462185, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=34.6638655462185, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI221513548, Length=480, Percent_Identity=30, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55401; Mature: 55270

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSADEFRHYVRDSVETALNQELTDGNFI
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
SHFYYHPFDVTEAESYQRLKALLEQLDETYQTEGNCIFYLAMAPEFFGTVTSRLQSERLT
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
DTRGFKRLVIEKPFGHDLVSAQKLNEEIRRVFSEREIYRIDHYLGKEMVQNIEVIRFSNA
HHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHEEECHH
IFEPLWNNRFISNIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKL
HHHHHCCCCEECEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCEE
TTDDIRHEKVKVLRALRPVAHDEVDQYFVRGQYGRGVIRGQAVPAYREEPNVDPNSNTET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
FVAGKLMIDNFRWAGVPFYIRTGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIH
EEEEEEEEECCEECCCCEEEECCHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCEEEEE
IQPDEGITLHLNGKKTGESSTITAPFKLDYCNNCIDGINTPEAYEKLLYDCMRGDATNFT
EECCCCEEEEECCCCCCCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
HWDEVAASWQFVDPISDVWANTKADDFPNYEAGSMGPAAADELLRKDGFHWWPIEHPKP
CHHHHHCCCEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCC
>Mature Secondary Structure 
AKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSADEFRHYVRDSVETALNQELTDGNFI
CCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
SHFYYHPFDVTEAESYQRLKALLEQLDETYQTEGNCIFYLAMAPEFFGTVTSRLQSERLT
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
DTRGFKRLVIEKPFGHDLVSAQKLNEEIRRVFSEREIYRIDHYLGKEMVQNIEVIRFSNA
HHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHEEECHH
IFEPLWNNRFISNIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKL
HHHHHCCCCEECEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCEE
TTDDIRHEKVKVLRALRPVAHDEVDQYFVRGQYGRGVIRGQAVPAYREEPNVDPNSNTET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
FVAGKLMIDNFRWAGVPFYIRTGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIH
EEEEEEEEECCEECCCCEEEECCHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCEEEEE
IQPDEGITLHLNGKKTGESSTITAPFKLDYCNNCIDGINTPEAYEKLLYDCMRGDATNFT
EECCCCEEEEECCCCCCCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
HWDEVAASWQFVDPISDVWANTKADDFPNYEAGSMGPAAADELLRKDGFHWWPIEHPKP
CHHHHHCCCEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]