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The map label for this gene is serA [H]

Identifier: 138895825

GI number: 138895825

Start: 2309267

End: 2310664

Strand: Direct

Name: serA [H]

Synonym: GTNG_2184

Alternate gene names: 138895825

Gene position: 2309267-2310664 (Clockwise)

Preceding gene: 138895824

Following gene: 138895857

Centisome position: 65.04

GC content: 53.51

Gene sequence:

>1398_bases
ATGAAGAACTTGAAAATTGTCGGTCGCGCCGGTGTCGGTGTTGACAACATTGATATCGACGCGGCGACAAAACGCGGCAT
CGTCGTTATTAACGCACCAAACGGCAATACAATTTCCGCTGCTGAACACACATTTGCGATGATGGCGGCGCTTGTTCGCC
ATATCCCGCAGGCGCACATTTCCGTCAAATCGCGGGAATGGAATCGCTCAGCGTTTGTCGGCAAAGAACTGTTTGGCAAG
AAGCTTGGCGTAATTGGCTTTGGCCGCATCGGATCAGAAGTCGCCAAACGGGCGCGCGCGTTTGGCATGACCGTGCACGT
ATATGACCCGTTTTTAACGAAAGAGCGGGCGGAAAAACTCGGTGTCTCCATCCATTCGCTCGATGAAGTGCTTGCTTCCG
CCGACATCATCACCGTCCATACACCGCTGACAAAAGAAACGCGGGGGCTGCTTGGCACGGAAAACTTGGCAAAAACGAAA
AAAGGAGTTTATCTGATCAACTGCGCCCGCGGCGGCATCATCGATGAACAGGCGCTCATTCCGTTTTTAGAAAGCGGCCA
CGTCGCTGGCGTCGCCCTTGACGTCTTTGAACAAGAGCCGCCAGGCGACCATCCGCTTTTGGCGTTCTCCAATGTCATCG
CTACGCCGCACCTAGGGGCATCGACCGTTGAGGCGCAATTGAACGTTGCCACGCAGGTCGCTGAAGAGTTGCTTCACTTT
GTCGAAGGACAGCCGGTCACGTCGTCGATTAACTTGCCGGCCTTGTCAAAAGACGTCTATGAAAAAATTCAATCATTCTA
TCATTTAGGACGGAAGCTCGGCTTAATCGCGTCGCAATTTATGAACATCCCGGTGCAAGAGCTGTCCGTCACCTATGCCG
GCACAGTCGCTGATTTGGAAACGACGTATATCACCCGCAGCTTGCTCGCGGGCTTCTTGCAACCGCGCGTCGCCTCCACC
GTCAATGAGGTAAACGCCGCCATGGTCGCCAAAGAGCGCGGCATTACGTACGGCGAAAAATTTTCTGATGAAACGCATGG
GTATGCGAACTGCATTTCGCTTACCGTCCATGGCGAGAACAAAACGTTCACGATTAAAGGGACGCACGTGCCGAACTACG
GCGATCGCATCGTCCACTTCGACGGCGTCGCCATTGATTTCGCTCCGGAAGGCCATCTTCTTTACATCCAGCATCAAGAC
CGTCCGGGGATGATCGGGAAAGTCGGGAACATTCTCGGAGCCCACGACGTCAACATCGCAACGATGCAAGTCGGTCGTCA
AGAGGCAGGGGGAAAAGCGATGATGATCCTCTCGCTGGACAAACCTGTTGACGATGCCGTGTTAAAAACATTGGCGCAAA
TTGATGATATTGAGACCGTCAAACGCCTTGAGGCGTAG

Upstream 100 bases:

>100_bases
TGTGCAAAAAAAAGTTGGCGAAGTTGAAGACGAATTACATACGTTCGACGCCTTGCTTGTGCGCAGCGCGACGAAAGTGA
CGGAAGACCTATTGGAAAAA

Downstream 100 bases:

>100_bases
TCATAAAAAACGCAGGCTTCTTGTTTCGAAGCCTGCGTTTTTTCGGCCGTTACGTCAAACAGTGAAACGGCGTCCGTCCC
CCACCGGAATTTCTCTTGCA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKNLKIVGRAGVGVDNIDIDAATKRGIVVINAPNGNTISAAEHTFAMMAALVRHIPQAHISVKSREWNRSAFVGKELFGK
KLGVIGFGRIGSEVAKRARAFGMTVHVYDPFLTKERAEKLGVSIHSLDEVLASADIITVHTPLTKETRGLLGTENLAKTK
KGVYLINCARGGIIDEQALIPFLESGHVAGVALDVFEQEPPGDHPLLAFSNVIATPHLGASTVEAQLNVATQVAEELLHF
VEGQPVTSSINLPALSKDVYEKIQSFYHLGRKLGLIASQFMNIPVQELSVTYAGTVADLETTYITRSLLAGFLQPRVAST
VNEVNAAMVAKERGITYGEKFSDETHGYANCISLTVHGENKTFTIKGTHVPNYGDRIVHFDGVAIDFAPEGHLLYIQHQD
RPGMIGKVGNILGAHDVNIATMQVGRQEAGGKAMMILSLDKPVDDAVLKTLAQIDDIETVKRLEA

Sequences:

>Translated_465_residues
MKNLKIVGRAGVGVDNIDIDAATKRGIVVINAPNGNTISAAEHTFAMMAALVRHIPQAHISVKSREWNRSAFVGKELFGK
KLGVIGFGRIGSEVAKRARAFGMTVHVYDPFLTKERAEKLGVSIHSLDEVLASADIITVHTPLTKETRGLLGTENLAKTK
KGVYLINCARGGIIDEQALIPFLESGHVAGVALDVFEQEPPGDHPLLAFSNVIATPHLGASTVEAQLNVATQVAEELLHF
VEGQPVTSSINLPALSKDVYEKIQSFYHLGRKLGLIASQFMNIPVQELSVTYAGTVADLETTYITRSLLAGFLQPRVAST
VNEVNAAMVAKERGITYGEKFSDETHGYANCISLTVHGENKTFTIKGTHVPNYGDRIVHFDGVAIDFAPEGHLLYIQHQD
RPGMIGKVGNILGAHDVNIATMQVGRQEAGGKAMMILSLDKPVDDAVLKTLAQIDDIETVKRLEA
>Mature_465_residues
MKNLKIVGRAGVGVDNIDIDAATKRGIVVINAPNGNTISAAEHTFAMMAALVRHIPQAHISVKSREWNRSAFVGKELFGK
KLGVIGFGRIGSEVAKRARAFGMTVHVYDPFLTKERAEKLGVSIHSLDEVLASADIITVHTPLTKETRGLLGTENLAKTK
KGVYLINCARGGIIDEQALIPFLESGHVAGVALDVFEQEPPGDHPLLAFSNVIATPHLGASTVEAQLNVATQVAEELLHF
VEGQPVTSSINLPALSKDVYEKIQSFYHLGRKLGLIASQFMNIPVQELSVTYAGTVADLETTYITRSLLAGFLQPRVAST
VNEVNAAMVAKERGITYGEKFSDETHGYANCISLTVHGENKTFTIKGTHVPNYGDRIVHFDGVAIDFAPEGHLLYIQHQD
RPGMIGKVGNILGAHDVNIATMQVGRQEAGGKAMMILSLDKPVDDAVLKTLAQIDDIETVKRLEA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=355, Percent_Identity=41.9718309859155, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=34.6456692913386, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=34.6456692913386, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=34.6456692913386, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=35.4330708661417, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=32.156862745098, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1789279, Length=279, Percent_Identity=36.5591397849462, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=34.8837209302326, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1787645, Length=261, Percent_Identity=29.1187739463602, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788660, Length=259, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=245, Percent_Identity=52.2448979591837, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=33.4558823529412, Blast_Score=155, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=284, Percent_Identity=34.1549295774648, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322116, Length=268, Percent_Identity=33.2089552238806, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=235, Percent_Identity=33.1914893617021, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=254, Percent_Identity=30.7086614173228, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=28.1914893617021, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=32.183908045977, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=284, Percent_Identity=25.7042253521127, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=261, Percent_Identity=49.0421455938697, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62472511, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=29.0836653386454, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571528, Length=258, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=27.5303643724696, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574284, Length=252, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 50191; Mature: 50191

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLKIVGRAGVGVDNIDIDAATKRGIVVINAPNGNTISAAEHTFAMMAALVRHIPQAHI
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHE
SVKSREWNRSAFVGKELFGKKLGVIGFGRIGSEVAKRARAFGMTVHVYDPFLTKERAEKL
EEECCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHH
GVSIHSLDEVLASADIITVHTPLTKETRGLLGTENLAKTKKGVYLINCARGGIIDEQALI
CCHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCHHHHCCCCEEEEEECCCCCCCCHHHH
PFLESGHVAGVALDVFEQEPPGDHPLLAFSNVIATPHLGASTVEAQLNVATQVAEELLHF
HHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEGQPVTSSINLPALSKDVYEKIQSFYHLGRKLGLIASQFMNIPVQELSVTYAGTVADLE
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHH
TTYITRSLLAGFLQPRVASTVNEVNAAMVAKERGITYGEKFSDETHGYANCISLTVHGEN
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCC
KTFTIKGTHVPNYGDRIVHFDGVAIDFAPEGHLLYIQHQDRPGMIGKVGNILGAHDVNIA
EEEEEECCCCCCCCCEEEEECCEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEE
TMQVGRQEAGGKAMMILSLDKPVDDAVLKTLAQIDDIETVKRLEA
EEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLKIVGRAGVGVDNIDIDAATKRGIVVINAPNGNTISAAEHTFAMMAALVRHIPQAHI
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHE
SVKSREWNRSAFVGKELFGKKLGVIGFGRIGSEVAKRARAFGMTVHVYDPFLTKERAEKL
EEECCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHH
GVSIHSLDEVLASADIITVHTPLTKETRGLLGTENLAKTKKGVYLINCARGGIIDEQALI
CCHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCHHHHCCCCEEEEEECCCCCCCCHHHH
PFLESGHVAGVALDVFEQEPPGDHPLLAFSNVIATPHLGASTVEAQLNVATQVAEELLHF
HHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEGQPVTSSINLPALSKDVYEKIQSFYHLGRKLGLIASQFMNIPVQELSVTYAGTVADLE
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHH
TTYITRSLLAGFLQPRVASTVNEVNAAMVAKERGITYGEKFSDETHGYANCISLTVHGEN
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCC
KTFTIKGTHVPNYGDRIVHFDGVAIDFAPEGHLLYIQHQDRPGMIGKVGNILGAHDVNIA
EEEEEECCCCCCCCCEEEEECCEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEE
TMQVGRQEAGGKAMMILSLDKPVDDAVLKTLAQIDDIETVKRLEA
EEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]