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The map label for this gene is mro [H]

Identifier: 138895433

GI number: 138895433

Start: 1882092

End: 1883141

Strand: Reverse

Name: mro [H]

Synonym: GTNG_1777

Alternate gene names: 138895433

Gene position: 1883141-1882092 (Counterclockwise)

Preceding gene: 138895434

Following gene: 138895432

Centisome position: 53.04

GC content: 47.52

Gene sequence:

>1050_bases
TTGGATATTTCCAAAAAAATATGGACTCAACTTCATGAAAAAGACGTTCTTTTGTTCACGTTGATGAATGACCGCGGCAT
GGAACTATCGGCGACGAATTATGGCTGCATTGTGACGAAACTGCTTGTCCCGGATCGGAATGGAAACGTCGAGAACGTTG
TACTTGGATTTAACGACTTTGATCCATATTTGACGAATACCCCTTACTTTGGGGCGGTGATCGGCCGGGTAGCAGGACGT
ATTCAAGGGGCTAGCTTTGAACTTGATGGCGTCACGTATCAATTAGCGAAAAACGAAAACAACAACCATCTGCATGGCGG
TCCGAATGGATTCCACCGCGTACTTTGGGAGGCGGAGCCCATCCAGCGCGACAATGGGGTCGGGGTGATCTTTTCCTATA
CGAGTCCAGACGGGGAAGAAGGATATCCTGGAACAGTGAATGTTCAAGTGACGTATTGGCTTAATAATGACAACGAATGG
ATCGTCACCTATCGAGCCCATTCGGACCAAACGACATTGTTCAACTTGACAAATCATACGTATTTTAACTTAAGCGGTAA
CTTAAAAAGGGATATTTTGGACCATACGTTAACGATCCAAAGTTCGCGCGTGTTAGAGTTGAATAAGGAATTGATTCCAA
CCGGAGCAGTCATCGATGTCGCCGGCACACCGTTTGATTTGCGTCAAGGAAAGAGAGTAAGAGAGGCAGTCGAATCGGGA
CATCCGCAAATTGAACTTGTCGGGCAAGGATACGATCATCCGTTTTGGCTTGACCGGCATCATGACAAAGAAATTGTGCT
CTATGACGACGAGAGTGGGAGGATGCTGACAGTCGAGACGGATGAAGTCGGTGTGGTGGTGTACACGTCAAACCAATTGC
CGGAAGGGCTCGATCTTAACGGTGCGCCATCGCGAAAATATTTGGGCATCTGCCTTGAAACCCAAGGGTTGCCAGATGCG
ATTCACCATGCACAGTTTCCGTCTTGGGTACTGTCAGCAAATGAGGAGCGGGTATCAACGACGATGTATCGGTTTGGCAT
AGCTGAATAA

Upstream 100 bases:

>100_bases
GTCGTTATATAAAGTTTGTTTGTGATATATACAAACTATTCTAACCACAGTATAAACGTAGAAAGGATTGCTTTGCTCAG
TTGGGAAAGGGGGAGGAATT

Downstream 100 bases:

>100_bases
ATGGGAGGATGGCATGTCTAGATTGGAAATGATTGAACATGTTGAGACGCCTCGCAAGGTGGTCGCCATAACGTTCGATG
ATGGACCAAATCCGGTTTAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MDISKKIWTQLHEKDVLLFTLMNDRGMELSATNYGCIVTKLLVPDRNGNVENVVLGFNDFDPYLTNTPYFGAVIGRVAGR
IQGASFELDGVTYQLAKNENNNHLHGGPNGFHRVLWEAEPIQRDNGVGVIFSYTSPDGEEGYPGTVNVQVTYWLNNDNEW
IVTYRAHSDQTTLFNLTNHTYFNLSGNLKRDILDHTLTIQSSRVLELNKELIPTGAVIDVAGTPFDLRQGKRVREAVESG
HPQIELVGQGYDHPFWLDRHHDKEIVLYDDESGRMLTVETDEVGVVVYTSNQLPEGLDLNGAPSRKYLGICLETQGLPDA
IHHAQFPSWVLSANEERVSTTMYRFGIAE

Sequences:

>Translated_349_residues
MDISKKIWTQLHEKDVLLFTLMNDRGMELSATNYGCIVTKLLVPDRNGNVENVVLGFNDFDPYLTNTPYFGAVIGRVAGR
IQGASFELDGVTYQLAKNENNNHLHGGPNGFHRVLWEAEPIQRDNGVGVIFSYTSPDGEEGYPGTVNVQVTYWLNNDNEW
IVTYRAHSDQTTLFNLTNHTYFNLSGNLKRDILDHTLTIQSSRVLELNKELIPTGAVIDVAGTPFDLRQGKRVREAVESG
HPQIELVGQGYDHPFWLDRHHDKEIVLYDDESGRMLTVETDEVGVVVYTSNQLPEGLDLNGAPSRKYLGICLETQGLPDA
IHHAQFPSWVLSANEERVSTTMYRFGIAE
>Mature_349_residues
MDISKKIWTQLHEKDVLLFTLMNDRGMELSATNYGCIVTKLLVPDRNGNVENVVLGFNDFDPYLTNTPYFGAVIGRVAGR
IQGASFELDGVTYQLAKNENNNHLHGGPNGFHRVLWEAEPIQRDNGVGVIFSYTSPDGEEGYPGTVNVQVTYWLNNDNEW
IVTYRAHSDQTTLFNLTNHTYFNLSGNLKRDILDHTLTIQSSRVLELNKELIPTGAVIDVAGTPFDLRQGKRVREAVESG
HPQIELVGQGYDHPFWLDRHHDKEIVLYDDESGRMLTVETDEVGVVVYTSNQLPEGLDLNGAPSRKYLGICLETQGLPDA
IHHAQFPSWVLSANEERVSTTMYRFGIAE

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=333, Percent_Identity=44.4444444444444, Blast_Score=247, Evalue=9e-66,
Organism=Escherichia coli, GI1786971, Length=337, Percent_Identity=33.2344213649852, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17557428, Length=333, Percent_Identity=27.9279279279279, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533334, Length=333, Percent_Identity=27.9279279279279, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322004, Length=354, Percent_Identity=27.4011299435028, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=211, Percent_Identity=29.3838862559242, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324399, Length=355, Percent_Identity=25.3521126760563, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24659048, Length=347, Percent_Identity=37.7521613832853, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24668278, Length=344, Percent_Identity=34.8837209302326, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24583720, Length=345, Percent_Identity=34.4927536231884, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24668282, Length=349, Percent_Identity=35.243553008596, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24641876, Length=352, Percent_Identity=30.3977272727273, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39250; Mature: 39250

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISKKIWTQLHEKDVLLFTLMNDRGMELSATNYGCIVTKLLVPDRNGNVENVVLGFNDF
CCCCHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEEEEECCCCCCCCEEEEECCCC
DPYLTNTPYFGAVIGRVAGRIQGASFELDGVTYQLAKNENNNHLHGGPNGFHRVLWEAEP
CCCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCCEECCCCCHHHEEEECCCC
IQRDNGVGVIFSYTSPDGEEGYPGTVNVQVTYWLNNDNEWIVTYRAHSDQTTLFNLTNHT
CCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCE
YFNLSGNLKRDILDHTLTIQSSRVLELNKELIPTGAVIDVAGTPFDLRQGKRVREAVESG
EEEECCCCHHHHHCEEEEECCCEEEEECHHHCCCCCEEEECCCCHHHHCCHHHHHHHHCC
HPQIELVGQGYDHPFWLDRHHDKEIVLYDDESGRMLTVETDEVGVVVYTSNQLPEGLDLN
CCEEEEEECCCCCCEEECCCCCCEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCC
GAPSRKYLGICLETQGLPDAIHHAQFPSWVLSANEERVSTTMYRFGIAE
CCCCCEEEEEEEECCCCCHHHHHCCCCCEEECCCCHHHHEEEEEEECCC
>Mature Secondary Structure
MDISKKIWTQLHEKDVLLFTLMNDRGMELSATNYGCIVTKLLVPDRNGNVENVVLGFNDF
CCCCHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEEEEECCCCCCCCEEEEECCCC
DPYLTNTPYFGAVIGRVAGRIQGASFELDGVTYQLAKNENNNHLHGGPNGFHRVLWEAEP
CCCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCCEECCCCCHHHEEEECCCC
IQRDNGVGVIFSYTSPDGEEGYPGTVNVQVTYWLNNDNEWIVTYRAHSDQTTLFNLTNHT
CCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCE
YFNLSGNLKRDILDHTLTIQSSRVLELNKELIPTGAVIDVAGTPFDLRQGKRVREAVESG
EEEECCCCHHHHHCEEEEECCCEEEEECHHHCCCCCEEEECCCCHHHHCCHHHHHHHHCC
HPQIELVGQGYDHPFWLDRHHDKEIVLYDDESGRMLTVETDEVGVVVYTSNQLPEGLDLN
CCEEEEEECCCCCCEEECCCCCCEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCC
GAPSRKYLGICLETQGLPDAIHHAQFPSWVLSANEERVSTTMYRFGIAE
CCCCCEEEEEEEECCCCCHHHHHCCCCCEEECCCCHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]