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The map label for this gene is ilvA [H]

Identifier: 138895324

GI number: 138895324

Start: 1759659

End: 1760711

Strand: Reverse

Name: ilvA [H]

Synonym: GTNG_1668

Alternate gene names: 138895324

Gene position: 1760711-1759659 (Counterclockwise)

Preceding gene: 138895325

Following gene: 138895323

Centisome position: 49.59

GC content: 51.85

Gene sequence:

>1053_bases
ATGAGGAGCGAAGAAACGGGGTCGTATGCGCCAGCGCCGGCAACCATGCCCCAAGGAGTCGCCTATTCGTGCCGGGCACT
CGGGGTGCACGGAAAAATTTATATGCCGGCGACAACACCTCGACAAAAAGTGTCGCAAGTCCAGTTGTTTGGCAAAGACA
AGGTCGAGATCGTCCTTGTGGGCGACACGTTTGACGACTCGTACAGCGAAGCGGTAAAATGTGCGGAAGCGGAAGGGCGC
ACGTTTATCCACCCGTTTGATGACGAATACGTCATCGCCGGGCAAGGAACAATCGGTGTTGAGGTATTAAACGACTGTGA
TGAACCGATCGATTTTTTGTTTGCCAGCATCGGCGGCGGCGGACTGATGGCCGGGTTGGGAACATATGTAAAAAGCATCT
CGCCGGCGACCAAGGTGATCGGCGTCGAACCAGGCGGCGCTCCGTCGATGAAAGCGGCGCTTGAGCAAGGGCATGTTGTG
ACGCTTGGGGAGATTGATAAGTTTGTTGATGGTGCCGCGGTCAAAACGGTCGGGGAAAAAACGTTTGCTCTATGCCGTGA
GGTGCTCGATGATATCATTGTCGTTCCGGAAGGGAAAGTATGCACAACGATTTTAGAGCTGTACAACGAAAACGCGATTG
TCGCTGAACCGGCGGGAGCGCTGCCGATCGCTGCTCTTGAGTTTTACAAAGAGCAAATTCGCGACAAAACAGTGGTTTGC
GTTGTGAGCGGCGGTAATAACGACATCGACCGGATGCAGGAAATTAAGGAGCGCTCGATGATTTATGAAGGGTTGCAACA
CTATTTCATCGTTAATTTCCCGCAGCGGGCCGGGGCGCTGCGCGAATTTTTAGATGAAGTGCTCGGTCCAACTGATGACA
TCACCCGCTTTGAATATACGAAGAAAAACAATAAAGAAAGCGGACCGGCGCTCGTCGGCATCGAGCTAAAACGGCGTGAA
GACTACGCACCGCTCATTGAACGGATGAAGAAAAAAGGGTTTCCGTTCCAGGAAGTAAATAAAGACCAGAACTTATTCCA
TTTGCTGATTTGA

Upstream 100 bases:

>100_bases
GAGCGTTACGAGTGCAATGTGTACTTGAAGCGCGAAGACTTGCAAGTTGTGCGCTCATTTAAGTTGCGCGGAGCGTACAA
CCGGATGAAACATTTAACTG

Downstream 100 bases:

>100_bases
GCAAAAAAGCGCGAAAAAAGTCGGAAAGTTTTCGGTGTATTCCGACATACTTTTTCACCGGTTTGGTGTATAATATAAAT
AAATCGGTGAAAAAGAGGAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRSEETGSYAPAPATMPQGVAYSCRALGVHGKIYMPATTPRQKVSQVQLFGKDKVEIVLVGDTFDDSYSEAVKCAEAEGR
TFIHPFDDEYVIAGQGTIGVEVLNDCDEPIDFLFASIGGGGLMAGLGTYVKSISPATKVIGVEPGGAPSMKAALEQGHVV
TLGEIDKFVDGAAVKTVGEKTFALCREVLDDIIVVPEGKVCTTILELYNENAIVAEPAGALPIAALEFYKEQIRDKTVVC
VVSGGNNDIDRMQEIKERSMIYEGLQHYFIVNFPQRAGALREFLDEVLGPTDDITRFEYTKKNNKESGPALVGIELKRRE
DYAPLIERMKKKGFPFQEVNKDQNLFHLLI

Sequences:

>Translated_350_residues
MRSEETGSYAPAPATMPQGVAYSCRALGVHGKIYMPATTPRQKVSQVQLFGKDKVEIVLVGDTFDDSYSEAVKCAEAEGR
TFIHPFDDEYVIAGQGTIGVEVLNDCDEPIDFLFASIGGGGLMAGLGTYVKSISPATKVIGVEPGGAPSMKAALEQGHVV
TLGEIDKFVDGAAVKTVGEKTFALCREVLDDIIVVPEGKVCTTILELYNENAIVAEPAGALPIAALEFYKEQIRDKTVVC
VVSGGNNDIDRMQEIKERSMIYEGLQHYFIVNFPQRAGALREFLDEVLGPTDDITRFEYTKKNNKESGPALVGIELKRRE
DYAPLIERMKKKGFPFQEVNKDQNLFHLLI
>Mature_350_residues
MRSEETGSYAPAPATMPQGVAYSCRALGVHGKIYMPATTPRQKVSQVQLFGKDKVEIVLVGDTFDDSYSEAVKCAEAEGR
TFIHPFDDEYVIAGQGTIGVEVLNDCDEPIDFLFASIGGGGLMAGLGTYVKSISPATKVIGVEPGGAPSMKAALEQGHVV
TLGEIDKFVDGAAVKTVGEKTFALCREVLDDIIVVPEGKVCTTILELYNENAIVAEPAGALPIAALEFYKEQIRDKTVVC
VVSGGNNDIDRMQEIKERSMIYEGLQHYFIVNFPQRAGALREFLDEVLGPTDDITRFEYTKKNNKESGPALVGIELKRRE
DYAPLIERMKKKGFPFQEVNKDQNLFHLLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=239, Percent_Identity=30.5439330543933, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1790207, Length=329, Percent_Identity=34.6504559270517, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1789505, Length=251, Percent_Identity=38.6454183266932, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17537387, Length=345, Percent_Identity=28.695652173913, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71991565, Length=281, Percent_Identity=29.1814946619217, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508781, Length=249, Percent_Identity=23.2931726907631, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320930, Length=314, Percent_Identity=31.8471337579618, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322631, Length=245, Percent_Identity=32.2448979591837, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21355833, Length=281, Percent_Identity=29.8932384341637, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=31.6, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 38279; Mature: 38279

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSEETGSYAPAPATMPQGVAYSCRALGVHGKIYMPATTPRQKVSQVQLFGKDKVEIVLV
CCCCCCCCCCCCCCCCCCCCCEEHEEECCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEE
GDTFDDSYSEAVKCAEAEGRTFIHPFDDEYVIAGQGTIGVEVLNDCDEPIDFLFASIGGG
ECCCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHCCCC
GLMAGLGTYVKSISPATKVIGVEPGGAPSMKAALEQGHVVTLGEIDKFVDGAAVKTVGEK
HHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHCCCEEEHHHHHHHHCCHHHHHHHHH
TFALCREVLDDIIVVPEGKVCTTILELYNENAIVAEPAGALPIAALEFYKEQIRDKTVVC
HHHHHHHHHHCEEECCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEE
VVSGGNNDIDRMQEIKERSMIYEGLQHYFIVNFPQRAGALREFLDEVLGPTDDITRFEYT
EEECCCCCHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHCCCCCCCHHEEEC
KKNNKESGPALVGIELKRREDYAPLIERMKKKGFPFQEVNKDQNLFHLLI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCCCCEEEEEC
>Mature Secondary Structure
MRSEETGSYAPAPATMPQGVAYSCRALGVHGKIYMPATTPRQKVSQVQLFGKDKVEIVLV
CCCCCCCCCCCCCCCCCCCCCEEHEEECCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEE
GDTFDDSYSEAVKCAEAEGRTFIHPFDDEYVIAGQGTIGVEVLNDCDEPIDFLFASIGGG
ECCCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHCCCC
GLMAGLGTYVKSISPATKVIGVEPGGAPSMKAALEQGHVVTLGEIDKFVDGAAVKTVGEK
HHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHCCCEEEHHHHHHHHCCHHHHHHHHH
TFALCREVLDDIIVVPEGKVCTTILELYNENAIVAEPAGALPIAALEFYKEQIRDKTVVC
HHHHHHHHHHCEEECCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEE
VVSGGNNDIDRMQEIKERSMIYEGLQHYFIVNFPQRAGALREFLDEVLGPTDDITRFEYT
EEECCCCCHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHCCCCCCCHHEEEC
KKNNKESGPALVGIELKRREDYAPLIERMKKKGFPFQEVNKDQNLFHLLI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]