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The map label for this gene is speE [H]

Identifier: 138895293

GI number: 138895293

Start: 1723291

End: 1724163

Strand: Direct

Name: speE [H]

Synonym: GTNG_1637

Alternate gene names: 138895293

Gene position: 1723291-1724163 (Clockwise)

Preceding gene: 138895292

Following gene: 138895301

Centisome position: 48.54

GC content: 50.4

Gene sequence:

>873_bases
ATGAAACACCAAGGAAACGCTTTGCCACCATATGTGCATTTGGACAATGGGGAGCTTTGGCTCACCGAAGATGACCGCGA
CAATTTAAAAATCAGCTATCGCATCAAAGAAGTAATCTTTGCCGAGCCGTCCGATTACCAGCATGTTATGATTTTGGATT
CGTACGATTTTGGACGCATGCTTGTTCTTGACGGCGTCGTGCAAACGACTTCGATTGATGGCCATATTTATAACGAAATG
ATTACACACGTGCCGCTGCAGCTTCATCCAGAGGCAAAACAGGCGCTCATCATCGGCGGTGGCGACTGTGGAGCGGCTCG
TGAAGCGGCCAAGTATGACCGTTTAGAGACGATCGAGATGGTCGAAATCGACAAAAAGGTCGTCCATGCATGCAAAGAAC
ATTTACCGGCCGTCTCCGGCAACTTGTCTGATCCGCGCGTGAAGTTTATTTATGATGACGGCGTCGCGTTTGTACAAGGA
AAAGAAGGCGTGTACAACGTCATTATGATCGACTCATCCGACCCAGTCGGCCCAGCCGAAGCGCTGTTTTCGTCGGAGTT
TTATGCGAACGTGCACCGCGCGTTAAAAGAGGACGGGCTGATGGTGTGCCAAAGCCAGTCCCCGATTTTCCACCTAGATA
TTTTAAAGCGCACATACCGCAACATTCGTGAATTGTTCCCGCATGTGCTCGTGTATACGGCGGTCGTGCCGACATACCCG
GGCGGAATGTGGAGCTTTACGATCGGCTCGAAACGGCCGCTAGATTTCCCGGCACAGACGACGATTCCAAACGATACGAA
ATACGTCAATGATGCCGTTTTCCGCCAATGTTTCTCCTTGCCGGAATTTTTGCGTTCGGCACTAGAGGAGTAA

Upstream 100 bases:

>100_bases
CATCCGATACCGGCCGATAATCCCCTTTGTTTGCCACATTTCGCATAATATATTAAGATTAGAAAGGTGTGAGAAAATCT
GCAAGACTAAGGAGGTAACA

Downstream 100 bases:

>100_bases
TGGTGCCAAAAAGAAGGGTGTCTCAAAAAAACAACGAGACACCCTCTTTTTTATATACACGTTAAATGATTTTGCTGTTC
TATATAGGTGTTTAGCCGGC

Product: spermidine synthase-like protein

Products: NA

Alternate protein names: Putrescine aminopropyltransferase; PAPT; SPDSY [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKHQGNALPPYVHLDNGELWLTEDDRDNLKISYRIKEVIFAEPSDYQHVMILDSYDFGRMLVLDGVVQTTSIDGHIYNEM
ITHVPLQLHPEAKQALIIGGGDCGAAREAAKYDRLETIEMVEIDKKVVHACKEHLPAVSGNLSDPRVKFIYDDGVAFVQG
KEGVYNVIMIDSSDPVGPAEALFSSEFYANVHRALKEDGLMVCQSQSPIFHLDILKRTYRNIRELFPHVLVYTAVVPTYP
GGMWSFTIGSKRPLDFPAQTTIPNDTKYVNDAVFRQCFSLPEFLRSALEE

Sequences:

>Translated_290_residues
MKHQGNALPPYVHLDNGELWLTEDDRDNLKISYRIKEVIFAEPSDYQHVMILDSYDFGRMLVLDGVVQTTSIDGHIYNEM
ITHVPLQLHPEAKQALIIGGGDCGAAREAAKYDRLETIEMVEIDKKVVHACKEHLPAVSGNLSDPRVKFIYDDGVAFVQG
KEGVYNVIMIDSSDPVGPAEALFSSEFYANVHRALKEDGLMVCQSQSPIFHLDILKRTYRNIRELFPHVLVYTAVVPTYP
GGMWSFTIGSKRPLDFPAQTTIPNDTKYVNDAVFRQCFSLPEFLRSALEE
>Mature_290_residues
MKHQGNALPPYVHLDNGELWLTEDDRDNLKISYRIKEVIFAEPSDYQHVMILDSYDFGRMLVLDGVVQTTSIDGHIYNEM
ITHVPLQLHPEAKQALIIGGGDCGAAREAAKYDRLETIEMVEIDKKVVHACKEHLPAVSGNLSDPRVKFIYDDGVAFVQG
KEGVYNVIMIDSSDPVGPAEALFSSEFYANVHRALKEDGLMVCQSQSPIFHLDILKRTYRNIRELFPHVLVYTAVVPTYP
GGMWSFTIGSKRPLDFPAQTTIPNDTKYVNDAVFRQCFSLPEFLRSALEE

Specific function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor [H]

COG id: COG0421

COG function: function code E; Spermidine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the spermidine/spermine synthase family [H]

Homologues:

Organism=Homo sapiens, GI63253298, Length=268, Percent_Identity=36.9402985074627, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1786312, Length=275, Percent_Identity=37.4545454545455, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25154106, Length=267, Percent_Identity=38.9513108614232, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI212645616, Length=221, Percent_Identity=39.3665158371041, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325326, Length=265, Percent_Identity=35.8490566037736, Blast_Score=178, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6323175, Length=269, Percent_Identity=33.8289962825279, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24645443, Length=286, Percent_Identity=36.013986013986, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355941, Length=217, Percent_Identity=35.4838709677419, Blast_Score=141, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001045 [H]

Pfam domain/function: PF01564 Spermine_synth [H]

EC number: =2.5.1.16 [H]

Molecular weight: Translated: 32721; Mature: 32721

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS51006 SPERMIDINE_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHQGNALPPYVHLDNGELWLTEDDRDNLKISYRIKEVIFAEPSDYQHVMILDSYDFGRM
CCCCCCCCCCEEEECCCEEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEEECCCCCCE
LVLDGVVQTTSIDGHIYNEMITHVPLQLHPEAKQALIIGGGDCGAAREAAKYDRLETIEM
EEECCCCEEECCCCHHHHHHHHHCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
VEIDKKVVHACKEHLPAVSGNLSDPRVKFIYDDGVAFVQGKEGVYNVIMIDSSDPVGPAE
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEECCCCEEEEEEEECCCCCCHHH
ALFSSEFYANVHRALKEDGLMVCQSQSPIFHLDILKRTYRNIRELFPHVLVYTAVVPTYP
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGMWSFTIGSKRPLDFPAQTTIPNDTKYVNDAVFRQCFSLPEFLRSALEE
CCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHQGNALPPYVHLDNGELWLTEDDRDNLKISYRIKEVIFAEPSDYQHVMILDSYDFGRM
CCCCCCCCCCEEEECCCEEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEEECCCCCCE
LVLDGVVQTTSIDGHIYNEMITHVPLQLHPEAKQALIIGGGDCGAAREAAKYDRLETIEM
EEECCCCEEECCCCHHHHHHHHHCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
VEIDKKVVHACKEHLPAVSGNLSDPRVKFIYDDGVAFVQGKEGVYNVIMIDSSDPVGPAE
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEECCCCEEEEEEEECCCCCCHHH
ALFSSEFYANVHRALKEDGLMVCQSQSPIFHLDILKRTYRNIRELFPHVLVYTAVVPTYP
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGMWSFTIGSKRPLDFPAQTTIPNDTKYVNDAVFRQCFSLPEFLRSALEE
CCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA