Click here to switch to the map view.

The map label for this gene is copA [H]

Identifier: 138895274

GI number: 138895274

Start: 1703113

End: 1704696

Strand: Reverse

Name: copA [H]

Synonym: GTNG_1618

Alternate gene names: 138895274

Gene position: 1704696-1703113 (Counterclockwise)

Preceding gene: 138895276

Following gene: 138895263

Centisome position: 48.02

GC content: 38.95

Gene sequence:

>1584_bases
ATGAAAAAATTATTGGTTGGAACCATTTTAGCGGGAGTCGTTGTTATTGGTGCAGCCTGCTCAAATAATGCTTCGCACAG
TTCCATGCAAGGACACGATATGTCAAACATGAATATGAAGGAGGAAAACACCACCAAGGACTCCAGTAAGCAACTGCCTT
TAGCAATAAACACAGAAGTTTTATCCGGTAAAGAGATTAATCTTACTGCTAAAGAAGCATTATTACAAATAAATGATAAA
GTAAAACTTCCGGTCTACACGTATAATGGATCTGTTCCCGGAGCACAAATCCGTATTAAACAGGGGGACAGAGTTAAAAT
CAATTTCAAAAATGAATTACCGGAACCGACTACCATTCATTGGCACGGCTACCCTGTTCCAAATAGTCAAGATGGAGTTC
CGGGCGTCACGATGAACGCAATTAAACCGGGGGAAACCTTTACGTATGAATTTACTGCAACCGTACCGGGAACGTATTTT
TATCATTCCCATCAAGACAGCTCTAAACAATTGGACAAAGGGTTATACGGCACGTTAATCGTAGAGCCTAAGAATGAGGA
AAAAGTAGATCGAGACTACACACTTGTGTTAGATGAATGGATGAGCAATCCAGATGAAGGAAATATGCATATGAGTGGAA
TGGATCATAGCAATATGGGACATGGAAATAGCTCGAATAACCAACATATGGATATGAGCAGCATGGGCCATGATATGAGT
ATGTATGATATTTTCACGATTAACGGGAAAAGCGGTTCCGCTGTCAAACCTTTAAAAGTGAAGAAAGGCGAAAAGGTGCG
GCTTCGCCTTGTAAACGCAGGATACATGTCCCACAAACTTCACCTGCATGGTCATGAGTTTAAAATTGTCGCAACTGACG
GGCAGCCGTTAAAAGATCCGCAACCAATCAAAGATGAACTTTTAAATATTGCTCCGGGTGAACGTTATGATATTGAATTT
ATCGCGAATAACCCGGGTGAATGGTTATTAGAATGTCATGGTGATATGGAAGGTACCGATGGCATGAAAGTGAAAATTCA
ATACGAAGACCAGACAAACAATACGGATAAAGAAAATGCAAAAAAAGACCTCCCTATCGTTGATATGACAAAATACGGAA
AACATGAATTAGGTCAATTTACGTTAGACCAAAAATATGATGTAGAGTACACAATGGATTTAGGAACAGCGATGGGCAAA
GATGGCATGATCTTCACGATTAATGGGAAAACTTATCCTGAAACAGCACCTGTAAATGTGAATAAAGGAGATCTAGTAAA
AGTAAAATTAGTAAACAATTCACCGAAAGATTTACATCCTATGCATTTACACGGACACTTCTTCCAAGTATTAAGTAAAA
ATGGCAAACCAATTACAGGTTCTCCATTGATTAAGGATACCTTGAATTTAAAACCGGGTGAAGAATATGTAGTCGCATTT
AAAGCTGACAATCCGGGAAATTGGATGTTCCATTGCCATGACTTGCACCATGCTTCAGCCGGAATGGTTACAGAAGTAAA
ATATAAAGATTACAAATCTGACTATACACCAAACCCGAATGACACAACAAATAAACCTGAATAA

Upstream 100 bases:

>100_bases
TTAAATTGCTTATATAACTTTCTTCTCCATAAATTTTGCACATTTATTTTTTATGATGATGTTAGTATGATTTACATCAC
AAGTTTATGGAGGGAAATAC

Downstream 100 bases:

>100_bases
CAATGATAAATCCCCTCCAAGTTTTACTTGGAGGGGATTTTATGTTACTTCACATCGTAACCTTGCTCTTCAATCGCTTC
TTTGAGTTTTTCTACACTTA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MKKLLVGTILAGVVVIGAACSNNASHSSMQGHDMSNMNMKEENTTKDSSKQLPLAINTEVLSGKEINLTAKEALLQINDK
VKLPVYTYNGSVPGAQIRIKQGDRVKINFKNELPEPTTIHWHGYPVPNSQDGVPGVTMNAIKPGETFTYEFTATVPGTYF
YHSHQDSSKQLDKGLYGTLIVEPKNEEKVDRDYTLVLDEWMSNPDEGNMHMSGMDHSNMGHGNSSNNQHMDMSSMGHDMS
MYDIFTINGKSGSAVKPLKVKKGEKVRLRLVNAGYMSHKLHLHGHEFKIVATDGQPLKDPQPIKDELLNIAPGERYDIEF
IANNPGEWLLECHGDMEGTDGMKVKIQYEDQTNNTDKENAKKDLPIVDMTKYGKHELGQFTLDQKYDVEYTMDLGTAMGK
DGMIFTINGKTYPETAPVNVNKGDLVKVKLVNNSPKDLHPMHLHGHFFQVLSKNGKPITGSPLIKDTLNLKPGEEYVVAF
KADNPGNWMFHCHDLHHASAGMVTEVKYKDYKSDYTPNPNDTTNKPE

Sequences:

>Translated_527_residues
MKKLLVGTILAGVVVIGAACSNNASHSSMQGHDMSNMNMKEENTTKDSSKQLPLAINTEVLSGKEINLTAKEALLQINDK
VKLPVYTYNGSVPGAQIRIKQGDRVKINFKNELPEPTTIHWHGYPVPNSQDGVPGVTMNAIKPGETFTYEFTATVPGTYF
YHSHQDSSKQLDKGLYGTLIVEPKNEEKVDRDYTLVLDEWMSNPDEGNMHMSGMDHSNMGHGNSSNNQHMDMSSMGHDMS
MYDIFTINGKSGSAVKPLKVKKGEKVRLRLVNAGYMSHKLHLHGHEFKIVATDGQPLKDPQPIKDELLNIAPGERYDIEF
IANNPGEWLLECHGDMEGTDGMKVKIQYEDQTNNTDKENAKKDLPIVDMTKYGKHELGQFTLDQKYDVEYTMDLGTAMGK
DGMIFTINGKTYPETAPVNVNKGDLVKVKLVNNSPKDLHPMHLHGHFFQVLSKNGKPITGSPLIKDTLNLKPGEEYVVAF
KADNPGNWMFHCHDLHHASAGMVTEVKYKDYKSDYTPNPNDTTNKPE
>Mature_527_residues
MKKLLVGTILAGVVVIGAACSNNASHSSMQGHDMSNMNMKEENTTKDSSKQLPLAINTEVLSGKEINLTAKEALLQINDK
VKLPVYTYNGSVPGAQIRIKQGDRVKINFKNELPEPTTIHWHGYPVPNSQDGVPGVTMNAIKPGETFTYEFTATVPGTYF
YHSHQDSSKQLDKGLYGTLIVEPKNEEKVDRDYTLVLDEWMSNPDEGNMHMSGMDHSNMGHGNSSNNQHMDMSSMGHDMS
MYDIFTINGKSGSAVKPLKVKKGEKVRLRLVNAGYMSHKLHLHGHEFKIVATDGQPLKDPQPIKDELLNIAPGERYDIEF
IANNPGEWLLECHGDMEGTDGMKVKIQYEDQTNNTDKENAKKDLPIVDMTKYGKHELGQFTLDQKYDVEYTMDLGTAMGK
DGMIFTINGKTYPETAPVNVNKGDLVKVKLVNNSPKDLHPMHLHGHFFQVLSKNGKPITGSPLIKDTLNLKPGEEYVVAF
KADNPGNWMFHCHDLHHASAGMVTEVKYKDYKSDYTPNPNDTTNKPE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557485, Length=327, Percent_Identity=24.7706422018349, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI281485618, Length=264, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI195947365, Length=264, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI7662254, Length=264, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786314, Length=254, Percent_Identity=25.5905511811024, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539950, Length=266, Percent_Identity=27.0676691729323, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=474, Percent_Identity=27.0042194092827, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6320714, Length=505, Percent_Identity=24.7524752475248, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI221330000, Length=306, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585842, Length=306, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281360167, Length=306, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221329998, Length=306, Percent_Identity=27.4509803921569, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859919, Length=288, Percent_Identity=27.4305555555556, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650186, Length=260, Percent_Identity=25.3846153846154, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574104, Length=115, Percent_Identity=37.3913043478261, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 58760; Mature: 58760

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLVGTILAGVVVIGAACSNNASHSSMQGHDMSNMNMKEENTTKDSSKQLPLAINTEV
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECEE
LSGKEINLTAKEALLQINDKVKLPVYTYNGSVPGAQIRIKQGDRVKINFKNELPEPTTIH
ECCCEEEEEHHHHHEEECCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCEEE
WHGYPVPNSQDGVPGVTMNAIKPGETFTYEFTATVPGTYFYHSHQDSSKQLDKGLYGTLI
EECCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHCCCEEEEE
VEPKNEEKVDRDYTLVLDEWMSNPDEGNMHMSGMDHSNMGHGNSSNNQHMDMSSMGHDMS
ECCCCCCCCCCCEEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHCCCCCE
MYDIFTINGKSGSAVKPLKVKKGEKVRLRLVNAGYMSHKLHLHGHEFKIVATDGQPLKDP
EEEEEEEECCCCCCCCCEEECCCCEEEEEEEECCCEEEEEEEECCEEEEEECCCCCCCCC
QPIKDELLNIAPGERYDIEFIANNPGEWLLECHGDMEGTDGMKVKIQYEDQTNNTDKENA
CCHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHH
KKDLPIVDMTKYGKHELGQFTLDQKYDVEYTMDLGTAMGKDGMIFTINGKTYPETAPVNV
HHCCCEEEHHHCCCHHCCCEECCCEECEEEEEECCHHCCCCCEEEEECCCCCCCCCCEEC
NKGDLVKVKLVNNSPKDLHPMHLHGHFFQVLSKNGKPITGSPLIKDTLNLKPGEEYVVAF
CCCCEEEEEEECCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEE
KADNPGNWMFHCHDLHHASAGMVTEVKYKDYKSDYTPNPNDTTNKPE
ECCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLLVGTILAGVVVIGAACSNNASHSSMQGHDMSNMNMKEENTTKDSSKQLPLAINTEV
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECEE
LSGKEINLTAKEALLQINDKVKLPVYTYNGSVPGAQIRIKQGDRVKINFKNELPEPTTIH
ECCCEEEEEHHHHHEEECCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCEEE
WHGYPVPNSQDGVPGVTMNAIKPGETFTYEFTATVPGTYFYHSHQDSSKQLDKGLYGTLI
EECCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHCCCEEEEE
VEPKNEEKVDRDYTLVLDEWMSNPDEGNMHMSGMDHSNMGHGNSSNNQHMDMSSMGHDMS
ECCCCCCCCCCCEEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHCCCCCE
MYDIFTINGKSGSAVKPLKVKKGEKVRLRLVNAGYMSHKLHLHGHEFKIVATDGQPLKDP
EEEEEEEECCCCCCCCCEEECCCCEEEEEEEECCCEEEEEEEECCEEEEEECCCCCCCCC
QPIKDELLNIAPGERYDIEFIANNPGEWLLECHGDMEGTDGMKVKIQYEDQTNNTDKENA
CCHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHH
KKDLPIVDMTKYGKHELGQFTLDQKYDVEYTMDLGTAMGKDGMIFTINGKTYPETAPVNV
HHCCCEEEHHHCCCHHCCCEECCCEECEEEEEECCHHCCCCCEEEEECCCCCCCCCCEEC
NKGDLVKVKLVNNSPKDLHPMHLHGHFFQVLSKNGKPITGSPLIKDTLNLKPGEEYVVAF
CCCCEEEEEEECCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEE
KADNPGNWMFHCHDLHHASAGMVTEVKYKDYKSDYTPNPNDTTNKPE
ECCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]