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The map label for this gene is napA [H]

Identifier: 138895259

GI number: 138895259

Start: 1688668

End: 1689693

Strand: Reverse

Name: napA [H]

Synonym: GTNG_1601

Alternate gene names: 138895259

Gene position: 1689693-1688668 (Counterclockwise)

Preceding gene: 138895263

Following gene: 138895251

Centisome position: 47.59

GC content: 36.55

Gene sequence:

>1026_bases
GTGTTAATACTTCAGTTAGTCATAATTTTAGTTGCTACCAAAATAGCTGGGAGCCTAAGTGTAAGATTGGGGCAGCCTTC
AGTTCTTGGTAAACTCCTGATCGGGATTGTATTAGGTCCATCGGTTTTAGGATTAGTGAATGAGACAGAAACTTTAGCAG
AATTAAGTAAAATCGGTGTTATTTTGTTGATGTTTATTGCTGGGGTGGAAACAGATATTGATGAATTCAAACAAACTGGG
AAAGCCTCCATCTTTGTAGGTTTTGGTGGTATTATCGTACCAGTTGTTTTGGGTTATTTTGTTGGAATAATGTTGAATCT
TACCACGATGCAATCCTGTTTTTTAGGGCTATTGCTTTCGGCTACCAGTGTAAGTATTTCAGTTCAGGCACTTAAAGAGA
TGGATCAATTAAATAGCCGCGAAGGAACCACTATCTTAGGAGCAGCTGTCATCGATGATGTGGTAGGAATTATTGCTTTG
GCATTCTTAATGAGTTTTGCTGGTGAAGATGTTAATTTAACCACGGTTATATTAAAGAAAGTATTATTCTTTGCAGGAGC
TATTCTGGTTGGCTGGAAAGTAGTTCCTTGGTTTTTGAATAAGTTTTCATCATTAAAAGTAACAGAAACTGTAATTTCAT
CTGCTCTAATTATCTGTTTTGCTTATGCATACCTAGCAGAATACACAGGGGTCGCTGCAATAATCGGAGCATATATAGCA
GGTGTGGCGATCAGTGTAACAAACTTCAAACATGAGATATTTGAGAAAGTGGAAACGATTAGTTATTCTATCTTTGTTCC
TGTATTCTTTACTTCTATTGGTGTTACTGCTCAATTCCGGTATTACTCAAAATTTAGGTCTAATCGTTTTATTAAGTATT
ATAGCTATACTAACAAAATTAATTGGTGCATCTATTGGGGCAAAATTGGCTGGATTCAATTGGAACAGCTCATTAGGAAT
TGGTTCAGCAATGGTGTCCAGAGGGGAAGTAGCACTGATTATTGCAACTATTGGTTTAGAATCTAA

Upstream 100 bases:

>100_bases
TTTAGGAGGAGCCTGTCACCAAGGGATAACTATGTCCCTTAGTGACAGGCTCTTTTTAAGTTTGAAAAAAATCATAAATA
ATGAAGGGTGGGATTTTTAG

Downstream 100 bases:

>100_bases
ACTGCTAGCGCAAGATATGTTTGCTGTCATTGTTGTTGTGATATTGGTTACAACGATTGTTACTCCCCCAATGATGAAAT
GGTTTTTTCGGAATCTAATA

Product: Na+/H+ antiporter NapA-like protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLILQLVIILVATKIAGSLSVRLGQPSVLGKLLIGIVLGPSVLGLVNETETLAELSKIGVILLMFIAGVETDIDEFKQTG
KASIFVGFGGIIVPVVLGYFVGIMLNLTTMQSCFLGLLLSATSVSISVQALKEMDQLNSREGTTILGAAVIDDVVGIIAL
AFLMSFAGEDVNLTTVILKKVLFFAGAILVGWKVVPWFLNKFSSLKVTETVISSALIICFAYAYLAEYTGVAAIIGAYIA
GVAISVTNFKHEIFEKVETISYSIFVPVFFTSIGVTAQFRYYSKFRSNRFIKYYSYTNKINWCIYWGKIGWIQLEQLIRN
WFSNGVQRGSSTDYCNYWFRI

Sequences:

>Translated_341_residues
MLILQLVIILVATKIAGSLSVRLGQPSVLGKLLIGIVLGPSVLGLVNETETLAELSKIGVILLMFIAGVETDIDEFKQTG
KASIFVGFGGIIVPVVLGYFVGIMLNLTTMQSCFLGLLLSATSVSISVQALKEMDQLNSREGTTILGAAVIDDVVGIIAL
AFLMSFAGEDVNLTTVILKKVLFFAGAILVGWKVVPWFLNKFSSLKVTETVISSALIICFAYAYLAEYTGVAAIIGAYIA
GVAISVTNFKHEIFEKVETISYSIFVPVFFTSIGVTAQFRYYSKFRSNRFIKYYSYTNKINWCIYWGKIGWIQLEQLIRN
WFSNGVQRGSSTDYCNYWFRI
>Mature_341_residues
MLILQLVIILVATKIAGSLSVRLGQPSVLGKLLIGIVLGPSVLGLVNETETLAELSKIGVILLMFIAGVETDIDEFKQTG
KASIFVGFGGIIVPVVLGYFVGIMLNLTTMQSCFLGLLLSATSVSISVQALKEMDQLNSREGTTILGAAVIDDVVGIIAL
AFLMSFAGEDVNLTTVILKKVLFFAGAILVGWKVVPWFLNKFSSLKVTETVISSALIICFAYAYLAEYTGVAAIIGAYIA
GVAISVTNFKHEIFEKVETISYSIFVPVFFTSIGVTAQFRYYSKFRSNRFIKYYSYTNKINWCIYWGKIGWIQLEQLIRN
WFSNGVQRGSSTDYCNYWFRI

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=285, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786685, Length=278, Percent_Identity=28.0575539568345, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789749, Length=273, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322367, Length=313, Percent_Identity=26.517571884984, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 37524; Mature: 37524

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILQLVIILVATKIAGSLSVRLGQPSVLGKLLIGIVLGPSVLGLVNETETLAELSKIGV
CHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILLMFIAGVETDIDEFKQTGKASIFVGFGGIIVPVVLGYFVGIMLNLTTMQSCFLGLLLS
HHHHHHHCCCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSVSISVQALKEMDQLNSREGTTILGAAVIDDVVGIIALAFLMSFAGEDVNLTTVILKK
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VLFFAGAILVGWKVVPWFLNKFSSLKVTETVISSALIICFAYAYLAEYTGVAAIIGAYIA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAISVTNFKHEIFEKVETISYSIFVPVFFTSIGVTAQFRYYSKFRSNRFIKYYSYTNKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCE
NWCIYWGKIGWIQLEQLIRNWFSNGVQRGSSTDYCNYWFRI
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEC
>Mature Secondary Structure
MLILQLVIILVATKIAGSLSVRLGQPSVLGKLLIGIVLGPSVLGLVNETETLAELSKIGV
CHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILLMFIAGVETDIDEFKQTGKASIFVGFGGIIVPVVLGYFVGIMLNLTTMQSCFLGLLLS
HHHHHHHCCCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSVSISVQALKEMDQLNSREGTTILGAAVIDDVVGIIALAFLMSFAGEDVNLTTVILKK
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VLFFAGAILVGWKVVPWFLNKFSSLKVTETVISSALIICFAYAYLAEYTGVAAIIGAYIA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAISVTNFKHEIFEKVETISYSIFVPVFFTSIGVTAQFRYYSKFRSNRFIKYYSYTNKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCE
NWCIYWGKIGWIQLEQLIRNWFSNGVQRGSSTDYCNYWFRI
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]